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Rudolph Emile Tanzi

Massachusetts Institute Of Technology

Google Scholar ↗PubMed ↗ORCID ↗
$37,301,297
Attributed
$51,940,635
Total exposure
23
Grants
13
Lead (contact PI)

Attributed= this PI's even-split share of every grant they're on (the fair, additive number). Exposure = full size of all those grants.

Funding over time

peak $7.8M · FY2005–25
$10M$7.5M$5M$2.5M$0
'05
'06
'07
'08
'09
'10
'11
'12
'13
'14
'15
'16
'17
'18
'19
'20
'21
'22
'23
'24
'25

Funding mix

By agency

NIH$73,012,269 · 24

By mechanism

P01$37,349,771 · 11
R01$22,407,064 · 8
R37$7,611,096 · 1
RF1$5,349,039 · 2
P50$277,299 · 1
R13$18,000 · 1

Top collaborators

Others in their field

Top investigators on “Alzheimer&Apos”

Research focus

Alzheimer&AposS DiseaseBaseNeuronsPresenilinCellsReportingPathway InteractionsBrainGamma SecretaseGeneticAmyloid Beta-ProteinBiologyMutationFamilySecretasePathogenesisAffectProteinsMolecularGenerationsGenesMediatingIn Vivo

Grant awards (117)

Single-cell multi-region dissection of AD-pathogen interactions for HSV-1 and CMV$727,847
R01 · FY2025 · AG
Studying the pathogenic roles of human CD8+ T cells in Alzheimer's disease using a 3D human Peripheral immune Chip.$673,258
R01 · FY2025 · AG
Single-cell multi-region dissection of AD-pathogen interactions for HSV-1 and CMV$752,834
R01 · FY2024 · AG
Studying the pathogenic roles of human CD8+ T cells in Alzheimer's disease using a 3D human Peripheral immune Chip.$688,000
R01 · FY2024 · AG
Presenilin Biology and the Mechanisms of Alzheimer's Disease$1,694,365
P01 · FY2023 · AG
Single-cell multi-region dissection of AD-pathogen interactions for HSV-1 and CMV$786,088
R01 · FY2023 · AG
The impact of AD-associated genetic variants in 3D human mixed neural-glial models of AD$756,000
R01 · FY2023 · AG · contact PI
The Alzheimer's Disease Resiliome: Pathway Analysis and Drug Discovery.$653,770
R01 · FY2023 · AG · contact PI
Project 3-Mechanistic Studies of Novel Gamma Secretase Modulators$471,924
P01 · FY2023 · AG · contact PI
Presenilin Biology and the Mechanisms of Alzheimer's Disease$1,693,684
P01 · FY2022 · AG
The impact of AD-associated genetic variants in 3D human mixed neural-glial models of AD$756,000
R01 · FY2022 · AG · contact PI
The Alzheimer's Disease Resiliome: Pathway Analysis and Drug Discovery.$656,115
R01 · FY2022 · AG · contact PI
Project 3-Mechanistic Studies of Novel Gamma Secretase Modulators$471,754
P01 · FY2022 · AG · contact PI
Role of MAMs in stabilization and BACE1-mediated processing of palAPP.$408,920
R01 · FY2022 · NS · contact PI
Presenilin Biology and the Mechanisms of Alzheimer's Disease$1,693,685
P01 · FY2021 · AG
The impact of AD-associated genetic variants in 3D human mixed neural-glial models of AD$756,000
R01 · FY2021 · AG · contact PI
The Alzheimer's Disease Resiliome: Pathway Analysis and Drug Discovery.$658,414
R01 · FY2021 · AG · contact PI
Project 3-Mechanistic Studies of Novel Gamma Secretase Modulators$471,754
P01 · FY2021 · AG · contact PI
Role of MAMs in stabilization and BACE1-mediated processing of palAPP.$408,920
R01 · FY2021 · NS · contact PI
Presenilin Biology and the Mechanisms of Alzheimer's Disease$1,692,325
P01 · FY2020 · AG
The impact of AD-associated genetic variants in 3D human mixed neural-glial models of AD$756,000
R01 · FY2020 · AG · contact PI
The Alzheimer's Disease Resiliome: Pathway Analysis and Drug Discovery.$660,668
R01 · FY2020 · AG · contact PI
Project 3-Mechanistic Studies of Novel Gamma Secretase Modulators$471,414
P01 · FY2020 · AG · contact PI
Role of MAMs in stabilization and BACE1-mediated processing of palAPP.$408,920
R01 · FY2020 · NS · contact PI
Antimicrobial activities of Abeta in Alzheimer's disease brain$3,229,539
RF1 · FY2019 · AG · contact PI
Presenilin Biology and the Mechanisms of Alzheimer's Disease$1,733,185
P01 · FY2019 · AG
The impact of AD-associated genetic variants in 3D human mixed neural-glial models of AD$749,200
R01 · FY2019 · AG · contact PI
The Alzheimer's Disease Resiliome: Pathway Analysis and Drug Discovery.$686,190
R01 · FY2019 · AG · contact PI
Project 3-Mechanistic Studies of Novel Gamma Secretase Modulators$433,295
P01 · FY2019 · AG · contact PI
Role of MAMs in stabilization and BACE1-mediated processing of palAPP.$408,920
R01 · FY2019 · NS · contact PI
Role of MAMs in stabilization and BACE1-mediated processing of palAPP.$51,115
R01 · FY2019 · NS · contact PI
Presenilin Biology and the Mechanisms of Alzheimer's Disease$2,095,236
P01 · FY2018 · AG
Role of MAMs in stabilization and BACE1-mediated processing of palAPP.$357,805
R01 · FY2018 · NS · contact PI
Presenilin Biology and the Mechanisms of Alzheimer's Disease$2,096,690
P01 · FY2017 · AG
Identification of Functional Genomic Variants in Alzheimer's Disease$781,434
R01 · FY2017 · MH · contact PI
STRUCTURE, FUNCTION AND REGULATION OF GAMMA-SECRETASE$699,153
P01 · FY2017 · AG
ROLE OF PRESENILIN 1 AT THE SYNAPSE$426,525
P01 · FY2017 · AG
ROLE OF SYNAPTOTAGMINS IN APP PROCESSING$418,739
P01 · FY2017 · AG
EFFECTS OF APP-SELECTIVE GSMS AND ADAMIO MUTATIONS ON Y-SECRETASE ACTIVITY$406,723
P01 · FY2017 · AG · contact PI
ADMINISTRATIVE AND EDUCATIONAL CORE$145,550
P01 · FY2017 · AG
Presenilin Biology and the Mechanisms of Alzheimer's Disease$2,096,690
P01 · FY2016 · AG
Identification of Functional Genomic Variants in Alzheimer's Disease$781,434
R01 · FY2016 · MH · contact PI
STRUCTURE, FUNCTION AND REGULATION OF GAMMA-SECRETASE$699,153
P01 · FY2016 · AG
ROLE OF PRESENILIN 1 AT THE SYNAPSE$426,525
P01 · FY2016 · AG
ROLE OF SYNAPTOTAGMINS IN APP PROCESSING$418,739
P01 · FY2016 · AG
EFFECTS OF APP-SELECTIVE GSMS AND ADAMIO MUTATIONS ON Y-SECRETASE ACTIVITY$406,723
P01 · FY2016 · AG · contact PI
ACAT inhibitors regulate palmitoylated APP and Abeta production$368,970
R01 · FY2016 · NS · contact PI
Characterization of Alzheimer's Mutations in ADAM10.$345,778
R01 · FY2016 · AG · contact PI
ADMINISTRATIVE AND EDUCATIONAL CORE$145,550
P01 · FY2016 · AG
Presenilin Biology and the Mechanisms of Alzheimer's Disease$2,033,235
P01 · FY2015 · AG
Identification of Functional Genomic Variants in Alzheimer's Disease$781,434
R01 · FY2015 · MH · contact PI
STRUCTURE, FUNCTION AND REGULATION OF GAMMA-SECRETASE$677,724
P01 · FY2015 · AG
ROLE OF PRESENILIN 1 AT THE SYNAPSE$413,729
P01 · FY2015 · AG
ROLE OF SYNAPTOTAGMINS IN APP PROCESSING$406,175
P01 · FY2015 · AG
EFFECTS OF APP-SELECTIVE GSMS AND ADAMIO MUTATIONS ON Y-SECRETASE ACTIVITY$394,522
P01 · FY2015 · AG · contact PI
ACAT inhibitors regulate palmitoylated APP and Abeta production$368,970
R01 · FY2015 · NS · contact PI
Characterization of Alzheimer's Mutations in ADAM10.$335,404
R01 · FY2015 · AG · contact PI
ADMINISTRATIVE AND EDUCATIONAL CORE$141,085
P01 · FY2015 · AG
A novel human 3D neural cell culture system for the characterization of AD genes$2,119,500
RF1 · FY2014 · AG · contact PI
Presenilin Biology and the Mechanisms of Alzheimer's Disease$2,093,246
P01 · FY2014 · AG
Identification of Functional Genomic Variants in Alzheimer's Disease$781,434
R01 · FY2014 · MH · contact PI
STRUCTURE, FUNCTION AND REGULATION OF GAMMA-SECRETASE$696,221
P01 · FY2014 · AG
ROLE OF PRESENILIN 1 AT THE SYNAPSE$426,525
P01 · FY2014 · AG
ROLE OF SYNAPTOTAGMINS IN APP PROCESSING$418,739
P01 · FY2014 · AG
EFFECTS OF APP-SELECTIVE GSMS AND ADAMIO MUTATIONS ON Y-SECRETASE ACTIVITY$406,723
P01 · FY2014 · AG · contact PI
ACAT inhibitors regulate palmitoylated APP and Abeta production$365,281
R01 · FY2014 · NS · contact PI
Characterization of Alzheimer's Mutations in ADAM10.$345,778
R01 · FY2014 · AG · contact PI
ADMINISTRATIVE AND EDUCATIONAL CORE$145,038
P01 · FY2014 · AG
Presenilin Biology and the Mechanisms of Alzheimer's Disease$2,149,293
P01 · FY2013 · AG
Identification of Functional Genomic Variants in Alzheimer's Disease$862,710
R01 · FY2013 · MH · contact PI
STRUCTURE, FUNCTION AND REGULATION OF GAMMA-SECRETASE$695,267
P01 · FY2013 · AG
ROLE OF PRESENILIN 1 AT THE SYNAPSE$445,639
P01 · FY2013 · AG
ROLE OF SYNAPTOTAGMINS IN APP PROCESSING$437,853
P01 · FY2013 · AG
EFFECTS OF APP-SELECTIVE GSMS AND ADAMIO MUTATIONS ON Y-SECRETASE ACTIVITY$425,837
P01 · FY2013 · AG · contact PI
Characterization of Alzheimer's Mutations in ADAM10.$326,760
R01 · FY2013 · AG · contact PI
ADMINISTRATIVE AND EDUCATIONAL CORE$144,697
P01 · FY2013 · AG
Identification and Characterization of Novel AD Genes$757,946
R37 · FY2012 · MH · contact PI
Characterization of Alzheimer's Mutations in ADAM10.$345,936
R01 · FY2012 · AG · contact PI
Genetic Analyses of Genes in Presenilin-Related Pathways$171,619
P01 · FY2012 · AG · contact PI
Identification and Characterization of Novel AD Genes$757,946
R37 · FY2011 · MH · contact PI
Genetic Analyses of Genes in Presenilin-Related Pathways$469,873
P01 · FY2011 · AG · contact PI
Identification and Characterization of Novel AD Genes$770,405
R37 · FY2010 · MH · contact PI
Genetic Analyses of Genes in Presenilin-Related Pathways$463,079
P01 · FY2010 · AG · contact PI
Identification and Characterization of Novel AD Genes$761,480
R37 · FY2009 · MH · contact PI
Genetic Analyses of Genes in Presenilin-Related Pathways$373,558
P01 · FY2009 · AG · contact PI
Identification and Characterization of Novel AD Genes$785,119
R37 · FY2008 · MH · contact PI
Genetic Analyses of Genes in Presenilin-Related Pathways$360,630
P01 · FY2008 · AG · contact PI
Identification and Characterization of Novel AD Genes$729,025
R37 · FY2007 · MH · contact PI
GENETIC ANALYSES OF GENES IN PRESENILIN RELATED PATHWAYS$471,112
P01 · FY2007 · AG · contact PI
Identification and Characterization of Novel AD Genes$745,540
R37 · FY2006 · MH · contact PI
GENETIC ANALYSES OF GENES IN PRESENILIN RELATED PATHWAYS$406,437
P01 · FY2006 · AG · contact PI
CORE--GENETICS$52,771
P01 · FY2006 · AG · contact PI
Identification and Characterization of Novel AD Genes$742,591
R37 · FY2005 · MH
Alzheimer's Disease Genes, Cellular Pathways and Therapies$18,000
R13 · FY2005 · AG
Identification and Characterization of Novel AD Genes$745,967
R37 · FY2004 · MH
Role of the g-secretase/PS1 complex in APP processing$403,940
R01 · FY2004 · AG
Identification and Characterization of Novel AD Genes$815,077
R37 · FY2003 · MH
Role of the g-secretase/PS1 complex in APP processing$403,940
R01 · FY2003 · AG
SEARCH FOR NOVEL ALZHEIMERS DISEASE GENES$542,447
R01 · FY2002 · MH
CORE--GENETICS$51,634
P01 · FY2002 · AG
GENETIC ANALYSIS OF ALZHEIMERS DISEASE$0
P50 · FY2002 · AG
GENETIC ANALYSIS OF ALZHEIMERS DISEASE$0
P50 · FY2002 · AG
CORE--TISSUE CULTURE, REAGENTS, AND ELISA$0
P01 · FY2002 · AG
ALTERNATIVE CASPASE MEDIATED CLEAVAGE OF THE PRESENILINS$0
P01 · FY2002 · AG
SEARCH FOR NOVEL ALZHEIMERS DISEASE GENES$543,183
R01 · FY2001 · MH
MECHANISM OF PRESENILIN 1--ASSOCIATED CELL DEATH$318,400
R01 · FY2001 · AG
CORE--GENETICS$0
P01 · FY2001 · AG
GENETIC ANALYSIS OF ALZHEIMERS DISEASE$0
P50 · FY2001 · AG
CORE--TISSUE CULTURE, REAGENTS, AND ELISA$0
P01 · FY2001 · AG
ALTERNATIVE CASPASE MEDIATED CLEAVAGE OF THE PRESENILINS$0
P01 · FY2001 · AG
SEARCH FOR NOVEL ALZHEIMERS DISEASE GENES$331,615
R01 · FY2000 · MH
MECHANISM OF PRESENILIN 1--ASSOCIATED CELL DEATH$311,232
R01 · FY2000 · AG
GENETIC ANALYSIS OF ALZHEIMERS DISEASE$277,299
P50 · FY2000 · AG
ALTERNATIVE CASPASE MEDIATED CLEAVAGE OF THE PRESENILINS$223,701
P01 · FY2000 · AG
CORE--TISSUE CULTURE, REAGENTS, AND ELISA$223,701
P01 · FY2000 · AG
CORE--GENETICS$220,727
P01 · FY2000 · AG
GENETIC ANALYSIS OF ALZHEIMERS DISEASE$0
P50 · FY2000 · AG