← Leaderboards
Dennis J Selkoe
Brigham And Women'S Hospital
$33,298,694
Attributed
$36,683,595
Total exposure
24
Grants
21
Lead (contact PI)
Attributed= this PI's even-split share of every grant they're on (the fair, additive number). Exposure = full size of all those grants.
Funding over time
peak $5.8M · FY2005–23$10M$7.5M$5M$2.5M$0
'05
'06
'07
'08
'09
'10
'11
'12
'13
'14
'15
'16
'17
'18
'19
'20
'21
'22
'23
Funding mix
By agency
NIH$87,971,350 · 25
By mechanism
P01$64,332,554 · 9
R01$13,079,145 · 6
RF1$5,091,275 · 2
R37$3,967,219 · 1
R21$1,201,645 · 3
P50$277,299 · 1
Top collaborators
- Oksana Berezovska21 shared
- Rudolph Emile Tanzi21 shared
- Dora M Kovacs16 shared
- Silke Nuber2 shared
Most similar at Brigham And Women'S Hospital
Same institution · by research overlap
- Clara Franzini-Armstrong$5,577,412
- David S Milstone$4,550,500
- Kurt G Beam$8,588,098
- Joseph E Italiano$15,371,019
- David B. Teplow$13,939,277
Others in their field
Top investigators on “Proteins”
- David Heimbrook · Leidos Biomedical Research, Inc.$354,061,551
- Randall J Bateman · Washington University$187,292,085
- Paul S. Aisen · Cognition Therapeutics, Inc.$175,382,342
- Reisa A. Sperling · Banner Health$145,046,481
- Barton F Haynes · Duke University$136,029,850
- Joseph L Goldstein · University Of Texas Sw Med Ctr/Dallas$102,433,280
Research focus
ProteinsAlzheimer&AposBaseS DiseasePresenilinBrainBiologyCellsComplexNeuronsProteolysisGrantReportingBiologicalPeptide HydrolasesMediatingStructureLifeSecretasePlayProductionMolecularDesignLaboratories
Grant awards (121)
Presenilin Biology and the Mechanisms of Alzheimer's Disease$1,694,365
P01 · FY2023 · AG · contact PI
Project 1: Structure-Function Relationships in Presenilin and Gamma-Secretase$486,925
P01 · FY2023 · AG · contact PI
Administrative Core$263,591
P01 · FY2023 · AG · contact PI
Presenilin Biology and the Mechanisms of Alzheimer's Disease$1,693,684
P01 · FY2022 · AG · contact PI
Project 1: Structure-Function Relationships in Presenilin and Gamma-Secretase$486,755
P01 · FY2022 · AG · contact PI
Administrative Core$263,421
P01 · FY2022 · AG · contact PI
Presenilin Biology and the Mechanisms of Alzheimer's Disease$1,693,685
P01 · FY2021 · AG · contact PI
Project 1: Structure-Function Relationships in Presenilin and Gamma-Secretase$486,755
P01 · FY2021 · AG · contact PI
Administrative Core$263,421
P01 · FY2021 · AG · contact PI
Biology of Native Alpha-Synuclein Tetramers in Parkinson's Disease$2,884,925
RF1 · FY2020 · NS · contact PI
Presenilin Biology and the Mechanisms of Alzheimer's Disease$1,692,325
P01 · FY2020 · AG · contact PI
Project 1: Structure-Function Relationships in Presenilin and Gamma-Secretase$486,415
P01 · FY2020 · AG · contact PI
Administrative Core$263,081
P01 · FY2020 · AG · contact PI
Presenilin Biology and the Mechanisms of Alzheimer's Disease$1,733,185
P01 · FY2019 · AG · contact PI
Project 1: Structure-Function Relationships in Presenilin and Gamma-Secretase$433,297
P01 · FY2019 · AG · contact PI
Administrative Core$433,297
P01 · FY2019 · AG · contact PI
A new look at mechanism-based Alzheimer's Disease biomarkers in blood$223,750
R21 · FY2019 · AG · contact PI
Pathological Changes of Alpha-Synuclein Structure in the Brain$223,750
R21 · FY2019 · NS · contact PI
Presenilin Biology and the Mechanisms of Alzheimer's Disease$2,095,236
P01 · FY2018 · AG · contact PI
Biology of Native Alpha-Synuclein Tetramers in Parkinson's Disease$368,828
R01 · FY2018 · NS · contact PI
Water-soluble Abeta and its role in Alzheimer's disease$354,897
R01 · FY2018 · AG · contact PI
A new look at mechanism-based Alzheimer's Disease biomarkers in blood$268,500
R21 · FY2018 · AG · contact PI
Shifting Multimers: New mouse and culture models of α-synuclein truncation by calpain in PD$220,635
R21 · FY2018 · NS
Aging in the Brain: Role of the Fibrous Proteins$2,206,350
RF1 · FY2017 · AG · contact PI
Presenilin Biology and the Mechanisms of Alzheimer's Disease$2,096,690
P01 · FY2017 · AG · contact PI
STRUCTURE, FUNCTION AND REGULATION OF GAMMA-SECRETASE$699,153
P01 · FY2017 · AG · contact PI
Biology of Native Alpha-Synuclein Tetramers in Parkinson's Disease$368,828
R01 · FY2017 · NS · contact PI
Shifting Multimers: New mouse and culture models of α-synuclein truncation by calpain in PD$265,010
R21 · FY2017 · NS
ADMINISTRATIVE AND EDUCATIONAL CORE$145,550
P01 · FY2017 · AG · contact PI
Presenilin Biology and the Mechanisms of Alzheimer's Disease$2,096,690
P01 · FY2016 · AG · contact PI
STRUCTURE, FUNCTION AND REGULATION OF GAMMA-SECRETASE$699,153
P01 · FY2016 · AG · contact PI
Aging in the Brain: Role of the Fibrous Proteins$430,428
R01 · FY2016 · AG · contact PI
Biology of Native Alpha-Synuclein Tetramers in Parkinson's Disease$368,828
R01 · FY2016 · NS · contact PI
ADMINISTRATIVE AND EDUCATIONAL CORE$145,550
P01 · FY2016 · AG · contact PI
Presenilin Biology and the Mechanisms of Alzheimer's Disease$2,033,235
P01 · FY2015 · AG · contact PI
STRUCTURE, FUNCTION AND REGULATION OF GAMMA-SECRETASE$677,724
P01 · FY2015 · AG · contact PI
Aging in the Brain: Role of the Fibrous Proteins$417,516
R01 · FY2015 · AG · contact PI
Biology of Native Alpha-Synuclein Tetramers in Parkinson's Disease$368,828
R01 · FY2015 · NS · contact PI
ADMINISTRATIVE AND EDUCATIONAL CORE$141,085
P01 · FY2015 · AG · contact PI
Presenilin Biology and the Mechanisms of Alzheimer's Disease$2,093,246
P01 · FY2014 · AG · contact PI
STRUCTURE, FUNCTION AND REGULATION OF GAMMA-SECRETASE$696,221
P01 · FY2014 · AG · contact PI
Aging in the Brain: Role of the Fibrous Proteins$430,428
R01 · FY2014 · AG · contact PI
Biology of Native Alpha-Synuclein Tetramers in Parkinson's Disease$368,179
R01 · FY2014 · NS · contact PI
ADMINISTRATIVE AND EDUCATIONAL CORE$145,038
P01 · FY2014 · AG · contact PI
Presenilin Biology and the Mechanisms of Alzheimer's Disease$2,149,293
P01 · FY2013 · AG · contact PI
STRUCTURE, FUNCTION AND REGULATION OF GAMMA-SECRETASE$695,267
P01 · FY2013 · AG · contact PI
Aging in the Brain: Role of the Fibrous Proteins$406,754
R01 · FY2013 · AG · contact PI
ADMINISTRATIVE AND EDUCATIONAL CORE$144,697
P01 · FY2013 · AG · contact PI
Presenilin Biology and the Mechanism of Alzheimer's Disease$1,220,961
P01 · FY2012 · AG · contact PI
Structure-Function Relationships in Presenilin/y-Secretase$451,587
P01 · FY2012 · AG · contact PI
Aging in the Brain: Role of the Fibrous Proteins$430,428
R01 · FY2012 · AG · contact PI
Protein-Protein Interactions in the Biology of Beta-APP$325,214
R01 · FY2012 · AG · contact PI
ADMINISTRATIVE AND EDUCATIONAL CORE$72,341
P01 · FY2012 · AG · contact PI
Presenilin Biology and the Mechanism of Alzheimer's Disease$2,741,597
P01 · FY2011 · AG · contact PI
Structure-Function Relationships in Presenilin/y-Secretase$816,854
P01 · FY2011 · AG · contact PI
Aging in the Brain: The Role of the Fibrous Proteins$389,594
R37 · FY2011 · AG · contact PI
Protein-Protein Interactions in the Biology of Beta-APP$325,214
R01 · FY2011 · AG · contact PI
Pathogenic Mechanisms of Cell-Derived Abeta Oligomers$135,687
R01 · FY2011 · AG · contact PI
ADMINISTRATIVE AND EDUCATIONAL CORE$130,861
P01 · FY2011 · AG · contact PI
Presenilin Biology and the Mechanism of Alzheimer's Disease$2,701,921
P01 · FY2010 · AG · contact PI
Structure-Function Relationships in Presenilin/y-Secretase$805,037
P01 · FY2010 · AG · contact PI
Pathogenic Mechanisms of Cell-Derived Abeta Oligomers$529,460
R01 · FY2010 · AG · contact PI
Aging in the Brain: The Role of the Fibrous Proteins$393,520
R37 · FY2010 · AG · contact PI
Protein-Protein Interactions in the Biology of Beta-APP$338,342
R01 · FY2010 · AG · contact PI
Alpha-Synuclein, PUFA and Membrane Vesicles in Health and Parkinson's Disease$310,377
R01 · FY2010 · NS · contact PI
ADMINISTRATIVE AND EDUCATIONAL CORE$128,966
P01 · FY2010 · AG · contact PI
Presenilin Biology and the Mechanism of Alzheimer's Disease$2,180,073
P01 · FY2009 · AG · contact PI
Structure-Function Relationships in Presenilin/y-Secretase$649,721
P01 · FY2009 · AG · contact PI
Pathogenic Mechanisms of Cell-Derived Abeta Oligomers$519,231
R01 · FY2009 · AG · contact PI
Aging in the Brain: The Role of the Fibrous Proteins$385,912
R37 · FY2009 · AG · contact PI
Protein-Protein Interactions in the Biology of Beta-APP$341,759
R01 · FY2009 · AG · contact PI
Alpha-Synuclein, PUFA and Membrane Vesicles in Health and Parkinson's Disease$310,890
R01 · FY2009 · NS · contact PI
ADMINISTRATIVE AND EDUCATIONAL CORE$104,085
P01 · FY2009 · AG · contact PI
Presenilin Biology and the Mechanism of Alzheimer's Disease$2,116,155
P01 · FY2008 · AG · contact PI
Structure-Function Relationships in Presenilin/y-Secretase$630,796
P01 · FY2008 · AG · contact PI
Pathogenic Mechanisms of Cell-Derived Abeta Oligomers$504,108
R01 · FY2008 · AG · contact PI
Aging in the Brain: The Role of the Fibrous Proteins$374,675
R37 · FY2008 · AG · contact PI
Protein-Protein Interactions in the Biology of Beta-APP$341,759
R01 · FY2008 · AG · contact PI
Alpha-Synuclein, PUFA and Membrane Vesicles in Health and Parkinson's Disease$308,268
R01 · FY2008 · NS · contact PI
ADMINISTRATIVE AND EDUCATIONAL CORE$101,054
P01 · FY2008 · AG · contact PI
AMYLOID B-PROTEIN AND IMMUNE MARKERS IN HUMAN BLOOD$1,277
M01 · FY2008 · RR · contact PI
Presenilin Biology and Mechanism of Alzheimer's Disease$2,850,456
P01 · FY2007 · AG · contact PI
Pathogenic Mechanisms of Cell-Derived Abeta Oligomers$441,904
R01 · FY2007 · AG · contact PI
PURIFICATION AND RECONSTITUTION OF ACTIVE GAMMA SECRETASE COMPLEX$427,929
P01 · FY2007 · AG · contact PI
Aging in the Brain: The Role of the Fibrous Proteins$370,917
R37 · FY2007 · AG · contact PI
Protein-Protein Interactions in the Biology of Beta APP$347,430
R01 · FY2007 · AG · contact PI
Alpha-Synuclein, PUFA and Membrane Vesicles in Health and Parkinson's Disease$305,647
R01 · FY2007 · NS · contact PI
Administrative Core$90,336
P01 · FY2007 · AG · contact PI
AMYLOID B-PROTEIN AND IMMUNE MARKERS IN HUMAN BLOOD$8,558
M01 · FY2007 · RR · contact PI
Presenilin Biology and Mechanism of Alzheimer's Disease$2,854,214
P01 · FY2006 · AG · contact PI
Pathogenic Mechanisms of Cell-Derived Abeta Oligomers$441,847
R01 · FY2006 · AG · contact PI
Aging in the Brain-Role of the Fibrous Proteins$401,220
R37 · FY2006 · AG · contact PI
Protein-Protein Interactions in the Biology of Beta APP$357,807
R01 · FY2006 · AG · contact PI
PURIFICATION /RECONSTITUTION OF ACTIVE GAMMA SECRETASE$355,135
P01 · FY2006 · AG · contact PI
Alpha-Synuclein, PUFA and Membrane Vesicles-Health/PD$312,075
R01 · FY2006 · NS · contact PI
Presenilin Biology and Mechanism of Alzheimer's Disease$2,842,655
P01 · FY2005 · AG
Aging in the Brain-Role of the Fibrous Proteins$410,875
R37 · FY2005 · AG
Protein-Protein Interactions in the Biology of Beta APP$366,418
R01 · FY2005 · AG
AMYLOID PRECURSOR PROTEIN IN HUMAN BLOOD$5,805
M01 · FY2005 · RR
Presenilin Biology and Mechanism of Alzheimer's Disease$2,969,562
P01 · FY2004 · AG
Aging in the Brain-Role of the Fibrous Proteins$410,875
R37 · FY2004 · AG
Protein-Protein Interactions in the Biology of Beta APP$366,418
R01 · FY2004 · AG
Amyloid Precursor Protein in Human Blood$6,573
M01 · FY2004 · RR
Presenilin Biology and Mechanism of Alzheimer's Disease$2,961,344
P01 · FY2003 · AG
Aging in the Brain-Role of the Fibrous Proteins$410,875
R37 · FY2003 · AG
Protein-Protein Interactions in the Biology of Beta APP$366,418
R01 · FY2003 · AG
PRESENILIN BIOLOGY &THE MECHANISM OF ALZHEIMERS DISEASE$1,651,429
P01 · FY2002 · AG
Aging in the Brain-Role of the Fibrous Proteins$409,886
R01 · FY2002 · AG
MECHANISM AND INHIBITION OF NATIVE AMYLOID BETA AGGREGATION IN CELLS$0
P50 · FY2002 · AG
MECHANISM AND INHIBITION OF NATIVE AMYLOID BETA AGGREGATION IN CELLS$0
P50 · FY2002 · AG
PRESENILIN GENOTYPE TO PHENOTYPE CONVERSION AND GAMMA SECRETASE$0
P01 · FY2002 · AG
PRESENILIN BIOLOGY &THE MECHANISM OF ALZHEIMERS DISEASE$586,274
P01 · FY2001 · AG
PROTEIN/PROTEIN INTERACTIONS IN THE BIOLOGY OF BETA AMYL$382,662
R01 · FY2001 · AG
MECHANISM AND INHIBITION OF NATIVE AMYLOID BETA AGGREGATION IN CELLS$0
P50 · FY2001 · AG
PRESENILIN GENOTYPE TO PHENOTYPE CONVERSION AND GAMMA SECRETASE$0
P01 · FY2001 · AG
PRESENILIN BIOLOGY &THE MECHANISM OF ALZHEIMERS DISEASE$2,539,480
P01 · FY2000 · AG
AGING IN THE BRAIN--ROLE OF THE FIBROUS PROTEINS$418,756
R37 · FY2000 · AG
PROTEIN/PROTEIN INTERACTIONS IN THE BIOLOGY OF BETA AMYL$376,382
R01 · FY2000 · AG
MECHANISM AND INHIBITION OF NATIVE AMYLOID BETA AGGREGATION IN CELLS$277,299
P50 · FY2000 · AG
PRESENILIN GENOTYPE TO PHENOTYPE CONVERSION AND GAMMA SECRETASE$223,701
P01 · FY2000 · AG
MECHANISM AND INHIBITION OF NATIVE AMYLOID BETA AGGREGATION IN CELLS$0
P50 · FY2000 · AG