← Leaderboards
David M Holtzman
Washington University
$51,909,630
Attributed
$61,198,274
Total exposure
40
Grants
30
Lead (contact PI)
Attributed= this PI's even-split share of every grant they're on (the fair, additive number). Exposure = full size of all those grants.
Funding over time
peak $16.1M · FY2005–25$20M$15M$10M$5M$0
'05
'06
'07
'08
'09
'10
'11
'12
'13
'14
'15
'16
'17
'18
'19
'20
'21
'22
'23
'24
'25
Funding mix
By agency
NIH$126,205,072 · 44
By mechanism
U19$35,451,905 · 2
P01$28,521,937 · 16
P30$22,507,550 · 6
RF1$17,816,951 · 4
R01$12,881,596 · 6
R37$3,756,859 · 1
Top collaborators
- Marc I Diamond7 shared
- Alison M Goate5 shared
- Takahisa Kanekiyo4 shared
- Jason D Ulrich2 shared
- Guojun Bu1 shared
- Nicole Gabriele Coufal1 shared
- Christopher K Glass1 shared
- Bradley T Hyman1 shared
Most similar at Washington University
Same institution · by research overlap
- Chia-Ling Phuah$2,474,421
- Marco Colonna$45,277,211
- Chihiro Sato$2,409,633
- Gilbert Gallardo$3,015,401
Others in their field
Top investigators on “Alzheimer&Apos”
- Jose A Luchsinger · Columbia University Health Sciences$56,595,040
- Eric M Reiman · Banner Health$48,982,487
- Yadong Huang · J. David Gladstone Institutes$40,311,515
- Lindsay A. Farrer · Boston University Medical Campus$34,189,802
- Michael W Weiner · Northern California Institute Res &Educ$28,197,224
- Denis A Evans · Rush University Medical Center$28,117,218
Research focus
Alzheimer&AposS DiseaseBrainPathologyPathogenesisNeuronsSynapsesTau ProteinsApolipoprotein ECellsAmyloid Beta-ProteinLinkIn VivoAmyloidProteinsMouse ModelCollaborationsDementiaInsightNerve DegenerationMetabolismIntercellular FluidResearch PersonnelLead
Grant awards (183)
Biology and pathobiology of apoE in aging and Alzheimer's disease$6,293,390
U19 · FY2025 · AG
Alzheimer's Disease Research Center$4,437,230
P30 · FY2025 · AG · contact PI
Effect of APOE on CNS Neurons: Role of LRP$2,868,920
RF1 · FY2025 · NS · contact PI
Role of T cells in tau-mediated neurodegeneration$735,616
R01 · FY2025 · AG · contact PI
Cerebral amyloid angiopathy: Role of ApoE, innate immunity, and meningeal lymphatics$605,486
P01 · FY2025 · AG · contact PI
APOE effects on glial lipid metabolism and 25-hydroxycholesterol: Effects on aging and AD-related pathology$585,110
U19 · FY2025 · AG · contact PI
Administrative Core$559,800
P30 · FY2025 · AG · contact PI
Biology and pathobiology of apoE in aging and Alzheimer's disease$6,474,838
U19 · FY2024 · AG
Perturbing the LXR/SREBP axis to decipher protective and pathogenic AD/ADRD microglial phenotypes$3,840,870
RF1 · FY2024 · AG
Alzheimer's Disease Research Center$3,076,264
P30 · FY2024 · AG · contact PI
Role of T cells in tau-mediated neurodegeneration$750,628
R01 · FY2024 · AG · contact PI
Administration Core$667,526
P30 · FY2024 · AG · contact PI
Cerebral amyloid angiopathy: Role of ApoE, innate immunity, and meningeal lymphatics$620,024
P01 · FY2024 · AG · contact PI
APOE effects on glial lipid metabolism and 25-hydroxycholesterol: Effects on aging and AD-related pathology$547,318
U19 · FY2024 · AG · contact PI
Biology and pathobiology of apoE in aging and Alzheimer's disease$6,523,942
U19 · FY2023 · AG
Alzheimer's Disease Research Center$3,076,264
P30 · FY2023 · AG · contact PI
Administration Core$802,655
P30 · FY2023 · AG · contact PI
Cerebral amyloid angiopathy: Role of ApoE, innate immunity, and meningeal lymphatics$620,024
P01 · FY2023 · AG · contact PI
APOE effects on glial lipid metabolism and 25-hydroxycholesterol: Effects on aging and AD-related pathology$530,189
U19 · FY2023 · AG · contact PI
Biology and pathobiology of apoE in aging and Alzheimer's disease$6,571,383
U19 · FY2022 · AG
Cerebral amyloid angiopathy: Role of ApoE, innate immunity, and meningeal lymphatics$627,998
P01 · FY2022 · AG · contact PI
APOE effects on glial lipid metabolism and 25-hydroxycholesterol: Effects on aging and AD-related pathology$540,068
U19 · FY2022 · AG · contact PI
Biology and pathobiology of apoE in aging and Alzheimer's disease$6,820,292
U19 · FY2021 · AG
Regional, Synaptic, Cellular Modulation of Abeta Metabolism$1,408,551
P01 · FY2021 · NS · contact PI
APOE effects on glial lipid metabolism and 25-hydroxycholesterol: Effects on aging and AD-related pathology$565,375
U19 · FY2021 · AG · contact PI
Neuronal LRP1 and HSPG in Pathological Spreading of A-Beta and Tau$393,590
P01 · FY2021 · NS · contact PI
Effects of the Sleep/Wake Cycle on A-Beta, Tau and Spreading$375,077
P01 · FY2021 · NS · contact PI
Administrative Core$67,949
P01 · FY2021 · NS · contact PI
Effect of APOE on CNS Neurons: Role of LRP$3,652,704
RF1 · FY2020 · NS · contact PI
Regional, Synaptic, Cellular Modulation of Abeta Metabolism$1,437,764
P01 · FY2020 · NS · contact PI
Neuronal LRP1 and HSPG in Pathological Spreading of A-Beta and Tau$399,109
P01 · FY2020 · NS · contact PI
Effects of the Sleep/Wake Cycle on A-Beta, Tau and Spreading$382,665
P01 · FY2020 · NS · contact PI
Administrative Core$70,117
P01 · FY2020 · NS · contact PI
Novel Strategies and Mechanisms to Target APOE and Alzheimer's Disease$3,760,149
RF1 · FY2019 · AG · contact PI
Sleep and Circadian Rhythms in Alzheimer Disease: Potential bi-directional relationship with tau$3,694,308
RF1 · FY2019 · AG
Regional, Synaptic, Cellular Modulation of Abeta Metabolism$1,466,153
P01 · FY2019 · NS · contact PI
DEVELOPMENT OF NOVEL THERAPEUTIC ANTI-TAU ANTIBODIES$652,597
R01 · FY2019 · AG
Neuronal LRP1 and HSPG in Pathological Spreading of A-Beta and Tau$404,468
P01 · FY2019 · NS · contact PI
Effects of the Sleep/Wake Cycle on A-Beta, Tau and Spreading$390,029
P01 · FY2019 · NS · contact PI
Administrative Core$72,223
P01 · FY2019 · NS · contact PI
Regional, Synaptic, Cellular Modulation of Abeta Metabolism$1,490,630
P01 · FY2018 · NS · contact PI
DEVELOPMENT OF NOVEL THERAPEUTIC ANTI-TAU ANTIBODIES$655,219
R01 · FY2018 · AG
Effect of APOE on CNS Neurons: Role of LRP$573,611
R01 · FY2018 · NS · contact PI
Novel Strategies and Mechanisms to Target APOE and Alzheimer's Disease$537,829
R01 · FY2018 · AG · contact PI
Project 2: Sleep: Potential Prognostic and Theranostic Marker for Preclinical AD$438,889
P01 · FY2018 · AG · contact PI
Neuronal LRP1 and HSPG in Pathological Spreading of A-Beta and Tau$409,673
P01 · FY2018 · NS · contact PI
Effects of the Sleep/Wake Cycle on A-Beta, Tau and Spreading$397,183
P01 · FY2018 · NS · contact PI
Administrative Core$74,265
P01 · FY2018 · NS · contact PI
DEVELOPMENT OF NOVEL THERAPEUTIC ANTI-TAU ANTIBODIES$73,721
R01 · FY2018 · AG
2018 Neurobiology of Brain Disorders GRC and GRS$49,992
R13 · FY2018 · AG · contact PI
Regional, Synaptic, Cellular Modulation of Abeta Metabolism$1,528,223
P01 · FY2017 · NS · contact PI
DEVELOPMENT OF NOVEL THERAPEUTIC ANTI-TAU ANTIBODIES$654,953
R01 · FY2017 · AG
Effect of APOE on CNS Neurons: Role of LRP$584,503
R01 · FY2017 · NS · contact PI
Novel Strategies and Mechanisms to Target APOE and Alzheimer's Disease$545,523
R01 · FY2017 · AG · contact PI
Project 2: Sleep: Potential Prognostic and Theranostic Marker for Preclinical AD$448,401
P01 · FY2017 · AG · contact PI
Neuronal LRP1 and HSPG in Pathological Spreading of A-Beta and Tau$427,850
P01 · FY2017 · NS · contact PI
Effects of the Sleep/Wake Cycle on A-Beta, Tau and Spreading$404,123
P01 · FY2017 · NS · contact PI
BRAIN MEASURES OF AÃ METABOLIC MOLECULES AND CONNECTIVITY$279,272
P01 · FY2017 · NS · contact PI
Administrative Core$76,250
P01 · FY2017 · NS · contact PI
Nervous System Development and Injury$8,338
T32 · FY2017 · NS · contact PI
Regional, Synpatic, Cellular Modulation of Abeta Metabolism$1,119,939
P01 · FY2016 · NS · contact PI
Effect of APOE on CNS Neurons: Role of LRP$595,092
R01 · FY2016 · NS · contact PI
DEVELOPMENT OF NOVEL THERAPEUTIC ANTI-TAU ANTIBODIES$578,134
R01 · FY2016 · AG
Novel Strategies and Mechanisms to Target APOE and Alzheimer's Disease$553,045
R01 · FY2016 · AG · contact PI
Project 2: Sleep: Potential Prognostic and Theranostic Marker for Preclinical AD$313,516
P01 · FY2016 · AG · contact PI
Dynamic Regulation of Amyloid-^ in the CNS$298,400
P01 · FY2016 · NS · contact PI
BRAIN MEASURES OF AÃ METABOLIC MOLECULES AND CONNECTIVITY$278,905
P01 · FY2016 · NS · contact PI
Nervous System Development and Injury$136,741
T32 · FY2016 · NS · contact PI
A^ MICRODIALYSIS CORE$119,054
P01 · FY2016 · NS · contact PI
Nervous System Development and Injury$114,571
T32 · FY2016 · NS · contact PI
DEVELOPMENT OF NOVEL THERAPEUTIC ANTI-TAU ANTIBODIES$76,343
R01 · FY2016 · AG
Administrative Core$74,874
P01 · FY2016 · NS · contact PI
Regional, Synpatic, Cellular Modulation of Abeta Metabolism$1,129,362
P01 · FY2015 · NS · contact PI
Effect of APOE on CNS Neurons: Role of LRP$605,341
R01 · FY2015 · NS · contact PI
DEVELOPMENT OF NOVEL THERAPEUTIC ANTI-TAU ANTIBODIES$593,025
R01 · FY2015 · AG
Novel Strategies and Mechanisms to Target APOE and Alzheimer's Disease$544,196
R01 · FY2015 · AG · contact PI
Project 2: Sleep: Potential Prognostic and Theranostic Marker for Preclinical AD$304,110
P01 · FY2015 · AG · contact PI
Dynamic Regulation of Amyloid-^ in the CNS$298,400
P01 · FY2015 · NS · contact PI
BRAIN MEASURES OF A^ METABOLIC MOLECULES AND CONNECTIVITY$278,906
P01 · FY2015 · NS · contact PI
Nervous System Development and Injury$264,518
T32 · FY2015 · NS · contact PI
AÃ MICRODIALYSIS CORE$120,934
P01 · FY2015 · NS · contact PI
Administrative Core$74,874
P01 · FY2015 · NS · contact PI
Regional, Synpatic, Cellular Modulation of Abeta Metabolism$1,129,400
P01 · FY2014 · NS · contact PI
Effect of APOE on CNS Neurons: Role of LRP$628,431
R01 · FY2014 · NS · contact PI
Novel Strategies and Mechanisms to Target APOE and Alzheimer's Disease$594,614
R01 · FY2014 · AG · contact PI
Nervous System Development and Injury$327,579
T32 · FY2014 · NS · contact PI
Project 2: Sleep: Potential Prognostic and Theranostic Marker for Preclinical AD$313,516
P01 · FY2014 · AG · contact PI
BRAIN MEASURES OF A^ METABOLIC MOLECULES AND CONNECTIVITY$276,418
P01 · FY2014 · NS · contact PI
Dynamic Regulation of Amyloid-^ in the CNS$245,551
P01 · FY2014 · NS · contact PI
A^ MICRODIALYSIS CORE$130,446
P01 · FY2014 · NS · contact PI
Administrative Core$98,493
P01 · FY2014 · NS · contact PI
Regional, Synpatic, Cellular Modulation of Abeta Metabolism$2,128
P01 · FY2014 · NS · contact PI
Regional, Synpatic, Cellular Modulation of Abeta Metabolism$1,106,922
P01 · FY2013 · NS · contact PI
Effect of apoE on CNS neurons: Role of LRP$430,403
R37 · FY2013 · AG · contact PI
BRAIN MEASURES OF A^ METABOLIC MOLECULES AND CONNECTIVITY$278,905
P01 · FY2013 · NS · contact PI
Nervous System Development and Injury$267,324
T32 · FY2013 · NS · contact PI
Dynamic Regulation of Amyloid-^ in the CNS$240,915
P01 · FY2013 · NS · contact PI
ANTECEDENT BIOMAKERS OF AD IN CSF AND PLASMA$168,988
P01 · FY2013 · AG · contact PI
A^ MICRODIALYSIS CORE$127,584
P01 · FY2013 · NS · contact PI
Administrative Core$93,858
P01 · FY2013 · NS · contact PI
Nervous System Development and Injury$67,532
T32 · FY2013 · NS · contact PI
Regional, Synpatic, Cellular Modulation of Abeta Metabolism$1,167,286
P01 · FY2012 · NS · contact PI
Effect of apoE on CNS neurons: Role of LRP$455,479
R37 · FY2012 · AG · contact PI
Dynamic Regulation of Amyloid-^ in the CNS$298,400
P01 · FY2012 · NS · contact PI
Nervous System Development and Injury$258,906
T32 · FY2012 · NS · contact PI
ANTECEDENT BIOMAKERS OF AD IN CSF AND PLASMA$179,927
P01 · FY2012 · AG · contact PI
A^ MICRODIALYSIS CORE$129,901
P01 · FY2012 · NS · contact PI
Administrative Core$74,872
P01 · FY2012 · NS · contact PI
Washington University Center for Translational Neuroscience$760,000
P30 · FY2011 · NS · contact PI
Effect of apoE on CNS neurons: Role of LRP$455,511
R37 · FY2011 · AG · contact PI
Nervous System Development and Injury$210,777
T32 · FY2011 · NS · contact PI
ANTECEDENT BIOMAKERS OF AD IN CSF AND PLASMA$134,333
P01 · FY2011 · AG · contact PI
Washington University Center for Translational Neuroscience$1,592,190
P30 · FY2010 · NS · contact PI
Effect of apoE on CNS neurons: Role of LRP$460,201
R37 · FY2010 · AG · contact PI
LC-MS/MS ANALYSIS OF CSF AND ANTECEDENT BIOMARKERS OF AD$409,999
RC1 · FY2010 · AG · contact PI
Pathogenesis of CAA-induced neurovascular dysfunction$255,856
P01 · FY2010 · NS · contact PI
Nervous System Development and Injury$253,774
T32 · FY2010 · NS · contact PI
ANTECEDENT BIOMAKERS OF AD IN CSF AND PLASMA$229,278
P01 · FY2010 · AG · contact PI
Washington University Center for Translational Neuroscience$227,455
P30 · FY2010 · NS · contact PI
Nervous System Development and Injury$60,793
T32 · FY2010 · NS · contact PI
Washington University Center for Translational Neuroscience$1,639,584
P30 · FY2009 · NS · contact PI
Effect of apoE on CNS neurons: Role of LRP$451,404
R37 · FY2009 · AG · contact PI
LC-MS/MS ANALYSIS OF CSF AND ANTECEDENT BIOMARKERS OF AD$410,000
RC1 · FY2009 · AG · contact PI
Pathogenesis of CAA-induced neurovascular dysfunction$256,893
P01 · FY2009 · NS · contact PI
Nervous System Development and Injury$243,139
T32 · FY2009 · NS · contact PI
Washington University Center for Translational Neuroscience$234,226
P30 · FY2009 · NS · contact PI
ANTECEDENT BIOMAKERS OF AD IN CSF AND PLASMA$202,110
P01 · FY2009 · AG · contact PI
Washington University Center for Translational Neuroscience$1,470,975
P30 · FY2008 · NS · contact PI
Effect of apoE on CNS neurons: Role of LRP$287,896
R37 · FY2008 · AG · contact PI
Pathogenesis of CAA-induced neurovascular dysfunction$257,264
P01 · FY2008 · NS · contact PI
Nervous System Development and Injury$243,004
T32 · FY2008 · NS · contact PI
Washington University Center for Translational Neuroscience$210,139
P30 · FY2008 · NS · contact PI
NOVEL BIOMARKERS TO PREDICT ALZHEIMER DISEASE$174,932
P01 · FY2008 · AG · contact PI
Effects of polyphenols on neonatal HI brain injury$156,479
P50 · FY2008 · NS · contact PI
Washington University Center for Translational Neuroscience$1,673,178
P30 · FY2007 · NS · contact PI
Pathogenesis of CAA-induced neurovascular dysfunction$322,438
P01 · FY2007 · NS · contact PI
Effect of apoE on CNS neurons: Role of LRP$293,771
R37 · FY2007 · AG · contact PI
Washington University Center for Translational Neuroscience$239,025
P30 · FY2007 · NS · contact PI
Nervous System Development and Injury$217,946
T32 · FY2007 · NS · contact PI
NOVEL BIOMARKERS TO PREDICT ALZHEIMER DISEASE$173,349
P01 · FY2007 · AG · contact PI
HEALTHY AGING AND SENILE DEMENTIA$14,775
M01 · FY2007 · RR · contact PI
Washington University Center for Translational Neuroscience$1,610,910
P30 · FY2006 · NS · contact PI
Effect of apoE on CNS neurons: Role of LRP$302,544
R37 · FY2006 · AG · contact PI
Pathogenesis of CAA-induced neurovascular dysfunction$255,491
P01 · FY2006 · NS · contact PI
Washington University Center for Translational Neuroscience$230,129
P30 · FY2006 · NS · contact PI
NOVEL BIOMARKERS TO PREDICT ALZHEIMER DISEASE$161,051
P01 · FY2006 · AG · contact PI
NERVOUS SYSTEM DEVELOPMENT AND INJURY$127,382
T32 · FY2006 · NS · contact PI
HEALTHY AGING AND SENILE DEMENTIA$30,403
M01 · FY2006 · RR · contact PI
Effect of apoE on CNS neurons: Role of LRP$309,825
R37 · FY2005 · AG
NERVOUS SYSTEM DEVELOPMENT AND INJURY$236,677
T32 · FY2005 · NS
NOVEL BIOMARKERS TO PREDICT ALZHEIMER DISEASE$156,364
P01 · FY2005 · AG
NERVOUS SYSTEM DEVELOPMENT AND INJURY$61,178
T32 · FY2005 · NS
FUNCTIONAL ANALYSIS OF ASTROCYTE-DERIVED APOE3 AND APOE4$30,808
M01 · FY2005 · RR
NERVOUS SYSTEM DEVELOPMENT AND INJURY$337,844
T32 · FY2004 · NS
Effect of apoE on CNS neurons: Role of LRP$309,825
R37 · FY2004 · AG
NOVEL BIOMARKERS TO PREDICT ALZHEIMER DISEASE$151,808
P01 · FY2004 · AG
CNS/plasma ABeta clearance of anti-ABeta antibody$394,500
R01 · FY2003 · AG
APOE EFFECT ON CNS NEURONS--ROLE OF LRP$300,938
R01 · FY2003 · AG
CNS/plasma ABeta clearance of anti-ABeta antibody$394,500
R01 · FY2002 · AG
APOE EFFECT ON CNS NEURONS--ROLE OF LRP$292,172
R01 · FY2002 · AG
CNS apolipoprotein J--Role in A beta deposition$0
P50 · FY2002 · AG
CASPASE DEPENDENT AND INDEPENDENT INJURY$0
P50 · FY2002 · NS
CNS apolipoprotein J--Role in A beta deposition$0
P50 · FY2002 · AG
CORE--STEREOLOGY$0
P01 · FY2002 · NS
CORE--TRANSGENIC MOUSE FACILITY AND MORPHOMETRIC CENTER$0
P01 · FY2002 · AG
FUNCTIONAL ANALYSIS OF ASTROCYTE DERIVED APOE3 AND APOE4$0
M01 · FY2002 · RR
CNS apolipoprotein J--Role in A beta deposition$0
P50 · FY2002 · AG
CNS/plasma ABeta clearance of anti-ABeta antibody$408,000
R01 · FY2001 · AG
APOE EFFECT ON CNS NEURONS--ROLE OF LRP$283,664
R01 · FY2001 · AG
CNS apolipoprotein J--Role in A beta deposition$264,341
P50 · FY2001 · AG
FUNCTIONAL ANALYSIS OF ASTROCYTE DERIVED APOE3 AND APOE4$0
M01 · FY2001 · RR
MECHANISMS OF NEONATAL ISCHEMIC BRAIN INJURY$0
P50 · FY2001 · NS
CNS apolipoprotein J--Role in A beta deposition$0
P50 · FY2001 · AG
CNS apolipoprotein J--Role in A beta deposition$0
P50 · FY2001 · AG
CNS apolipoprotein J--Role in A beta deposition$0
P50 · FY2001 · AG
CORE--STEREOLOGY$0
P01 · FY2001 · NS
CORE--TRANSGENIC MOUSE FACILITY AND MORPHOMETRIC CENTER$0
P01 · FY2001 · AG
APOE EFFECT ON CNS NEURONS--ROLE OF LRP$275,401
R01 · FY2000 · AG
CNS apolipoprotein J--Role in A beta deposition$264,341
P50 · FY2000 · AG
MECHANISMS OF NEONATAL ISCHEMIC BRAIN INJURY$199,113
P50 · FY2000 · NS
CORE--TRANSGENIC MOUSE FACILITY AND MORPHOMETRIC CENTER$0
P01 · FY2000 · AG
CORE--STEREOLOGY$0
P01 · FY2000 · NS
FUNCTIONAL ANALYSIS OF ASTROCYTE DERIVED APOE3 AND APOE4$0
M01 · FY2000 · RR