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Aß MICRODIALYSIS CORE

$120,934P01FY2015NSNIH

Washington University, Saint Louis MO

Investigators

David M Holtzmancontact

Linked publications, trials & patents

Paper 37605285Paper 37127299Paper 37099634Paper 36056345Paper 34586832Paper 34453582Paper 33894211Paper 33278025Paper 33139712Paper 33074098Paper 32913022Paper 32827351Paper 32024798Paper 31564456Paper 31408876Paper 31367008Paper 30770921Paper 30741718Paper 30741255Paper 30679382Paper 30626715Paper 30597615Paper 30348994Paper 30143564Paper 29888311Paper 29887160Paper 29764453Paper 29600961Paper 29382695Paper 29379963Paper 29361890Paper 29216449Paper 29161341Paper 28899014Paper 28701379Paper 28680398Paper 28536241Paper 28478762Paper 28444230Paper 28434655Paper 28381441Paper 28298456Paper 28275652Paper 28275161Paper 28217760Paper 28209725Paper 28137305Paper 28077724Paper 28070126Paper 28019658Paper 27931217Paper 27885006Paper 27328687Paper 27315796Paper 27179972Paper 27151330Paper 27143430Paper 27129429Paper 27128959Paper 27069115Paper 27030769Paper 27030596Paper 26933942Paper 26884068Paper 26883501Paper 26801396Paper 26688581Paper 26502977Paper 26374899Paper 26373282Paper 26337043Paper 26335643Paper 26108720Paper 26007213Paper 26005850Paper 25957402Paper 25903128Paper 25871773Paper 25855193Paper 25766617Paper 25644714Paper 25540323Paper 25500815Paper 25437557Paper 25405649Paper 25242217Paper 25218899Paper 24625695Paper 24607147Paper 24599963Paper 24559670Paper 24386905Paper 24366271Paper 24305823Paper 24270424Paper 24144318Paper 23998393Paper 23620513Paper 23524343Paper 23479184

Abstract

instnjctions): The Synaptic Aß Microdialysis Core will serve projects within this PPG to assess dynamic changes in extracellular, or interstitial fluid (ISF), Aß levels in living mice. Microdialysis enables us to measure Aß levels in the context of a living brain with intact neural networks, a functioning blood-brain barrier, and a normal extracellular milieau. This means that studies are performed in a physiologic setting. Having a core facility organize and conduct these studies, particularly for an intricate technique such as microdialysis, ensures experiments and data across all projects can be combined and compared. RELEVANCE (See instructions): Alzheimer's disease is characterized and likely caused by accumulation of the Aß peptide within the bran extracellular space. Understanding how extracellular Aß changes over time will be critical for determining what factors contribute to disease risk as well as for developing therapeutic interventions. Microdialysis enables us to measure how genes, proteins, or behaviors rapidly change the levels of extracellular Aß.

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