Sort
15,273 grants matching “antimicrobial resistance”
ANTIMICROBIAL RESISTANCE (AMR) IN FUNGAL PATHOGENS OF AGRICULTURAL CROPS AND HUMANS IS EXPECTED TO INCREASE.BIORATIONAL FUNGICIDES HAVE BEEN SUGGESTED AS RESISTANCE MANAGEMENT TOOLS, BUT VERY LITTLE SCIENTIFIC EVIDENCE HAS BEEN PRESENT. USING PEACH AS A MODEL SYSTEM WE WILL DEVELOP NEW IPM TACTICS THAT INTEGRATE BIORATIONAL FUNGICIDES WITH CONVENTIONAL FUNGICIDES TO MANAGE BLOSSOM BLIGHT, GREEN FRUIT ROT, AND PREHARVEST BROWN ROT CAUSED BY MONILINIA FRUCTICOLA IN PEACH ORCHARDS. WE WILL REDUCE SELECTION OF AMR IN THE ENVIRONMENT BY REDUCING THEIR APPLICATION FREQUENCY AND DOSE RATE. WE WILL SUBSTITUTE AZOLES WITH A BIOLOGICAL CONTROL AGENT AT KEYTIMES DURING PEACH PRODUCTION AND STRATEGICALLY USE THEM AT LOWER DOSE RATES IN MIXTURES WHEN ABSOLUTELY NEEDED DURING PREHARVEST SEASON. RESULTS OBTAINED IN THIS SEED GRANT WILL BE USED IN A FOLLOW UP GRANT TO REDUCE OR ELIMINATE SELECTION FOR AZOLE RESISTANCE IN NON-TARGET (E.G. ASPERGILLUS FUMIGATUS AND CANDIDA SPP.) AND TARGET (E.G. M. FRUCTICOLA) ORGANISMS IN EASTERN STONE FRUIT ORCHARDS.
$300,000Clemson University · · FY2025 · National Institute of Food and Agriculture
COPROPHAGOUS FLIES ARE UNIQUELY SUITED TO BE USED AS ONE HEALTH BIOMONITORS OF TERRESTRIAL ANTIMICROBIAL RESISTANCE. WHERE MULTIPLE SOURCES OF FECAL MATERIAL ARE ACCESSIBLE TO THEM, COPROPHAGOUS FLIES ACT AS COMPOSITE SAMPLERS OF LOCALIZED TERRESTRIAL AMR BY REPEATEDLY FEEDING ON UNCONTAINED WASTES. IN AGRICULTURAL SETTINGS, FLIES ALSO POSE A RISK OF TRANSPORTING ARBS AND ARGS FROM FECAL WASTES TO AGRICULTURAL PRODUCTS. WE PROPOSE FURTHER STUDY OF COPROPHAGOUS FLIES TO BETTER UNDERSTAND THE PERSISTENCE AND EMISSION OF ARB AND ARGS AS PART OF A NOVEL APPROACH TO MONITOR AND MITIGATE AMR IN TERRESTRIAL ENVIRONMENTS. OUR THREE RESEARCH OBJECTIVES INCLUDE, (1) DETERMINE THE RATE OF INGESTION AND PERSISTENCE OF ARB AND ARGS IN COPROPHAGOUS FLIES UNDER A RANGE OF ENVIRONMENTAL CONDITIONS; (2) DETERMINE THE EXCRETION OF ARB AND ARGS FROM COPROPHAGOUS FLIES TO SURFACES UNDER A RANGE OF ENVIRONMENTAL CONDITIONS; AND (3) DETERMINE THE RELATIONSHIP BETWEEN ARB AND ARGS IN WILD CAUGHT COPROPHAGOUS FLIES WITH TEMPORALLY AND GEOGRAPHICALLY MATCHED AGRICULTURAL PRODUCTS AND IRRIGATION WATER. WE WILL CONDUCT CONTROLLED FEEDING STUDIES USING COPROPHAGOUS FLIES TO ACCOMPLISH OBJECTIVES 1 AND 2. WE WILL INCORPORATE OBJECTIVE 3 INTO OUR ONGOING FIELD WORK IN MAPUTO, MOZAMBIQUE. THIS FUNDAMENTAL WORK ADVANCES OUR UNDERSTANDING HOW COPROPHAGOUS FLIES CAN BE USED AS ONE HEALTH BIOMONITORS OF TERRESTRIAL ANTIMICROBIAL RESISTANCE. THE VALUABLE INSIGHTS INTO THE SPREAD AND PREVALENCE OF AMR, WILL ENABLE TARGETED INTERVENTIONS TO REDUCE ITS IMPACT IN THE FOOD CHAIN AND HELP BREAK THE TRANSMISSION CYCLE OF RESISTANT BACTERIA, IMPROVING PUBLIC HEALTH.
$300,000Trustees Of Indiana University · · FY2025 · National Institute of Food and Agriculture
New therapeutics for the treatment of Acinetobactor baumannii infections.
$300,000Allen Bernard Reitz · Fox Chase Chemical Diversity Center, Inc · R41 · FY2013 · AI
Epicenters III: Translational Research to Prevent Healthcare Associated Infection
$300,000Richard Platt · Harvard Pilgrim Health Care, Inc. · U54 · FY2013 · CK
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** ANTIMICROBIAL RESISTANCE IS A GLOBAL THREAT TO HUMAN AND ANIMAL HEALTH AND INCREASED ADOPTION OF ANTIMICROBIAL STEWARDSHIP (AMS) IS NEEDED TO MAINTAIN EFFICACY OF ANTIMICROBIALS. VETERINARIANS ARE A SOURCE OF ADVICE ABOUT ANTIMICROBIAL USAGE (AMU), BUT FARM WORKERS DETECT AND TREAT MOST DISEASES OF DAIRY COWS WITHOUT DIRECT VETERINARY SUPERVISION, THUS IMPROVING AMU REQUIRES INCREASED COLLABORATION BETWEEN VETERINARIANS AND PRODUCERS. MASTITIS AND METRITIS ACCOUNT FOR MOST AMU ON DAIRY FARMS AND SMALL CHANGES IN TREATMENT OF THESE DISEASES CAN RESULT IN REDUCTIONS IN AMU. HOWEVER, MANY PRODUCERS ARE SKEPTICAL ABOUT BENEFITS OF CHANGING ANTIBIOTIC TREATMENTS. MOST DAIRY FARMERS BELIEVE THAT THEY ARE CURRENTLY USING AN APPROPRIATE AMOUNT OF ANTIBIOTICS AND DO NOT HAVE ACCESS TO BENCHMARKS THAT DEFINE NORMAL AMU. ENHANCING KNOWLEDGE ABOUT APPROPRIATE AMU REQUIRES INCREASED ENGAGEMENT OF VETERINARIANS AND PRODUCERS TO RECOGNIZE POTENTIAL BENEFITS OF ENHANCED AMS. WE HYPOTHESIZE THAT PROVIDING BENCHMARKS FOR AMU AND EDUCATIONAL RESOURCES TO OVERCOME BARRIERS WILL INCREASE ENGAGEMENT OF VETERINARIANS AND DAIRY PRODUCERS IN AMS PROGRAMS. TO ACHIEVE THIS, WE WILL:DETERMINE BARRIERS TO CHANGING AMU BY SURVEYING FARMERS AND VETERINARIANS IN MI AND WI TO IDENTIFY THEIR BELIEFS, ATTITUDES, AND PRACTICES ABOUT AMU.PROMOTE AWARENESS OF APPROPRIATE AMU BY INCREASING ACCESS AND VALUE OF BENCHMARKING AMU. THIS AIM WILL EXPAND ACCESS TO AMU BENCHMARKING, PROVIDE ECONOMIC ASSESSMENTS OF CURRENTLY USED TREATMENT PROTOCOLS AND TRAIN VETERINARIANS AND DAIRY PROFESSIONALS ON HOW TO OVERCOME BARRIERS TO AMS.
$300,000Michigan State University · · FY2024 · National Institute of Food and Agriculture
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** EVERY TIME THAT WE USE ANTIBIOTICS IN ANIMALS OR PEOPLE, WE MAY CONTRIBUTE TO THE RISE OF ANTIMICROBIAL-RESISTANT BACTERIA. THESE BACTERIA CAN SURVIVE ANTIBIOTIC TREATMENT, THREATENING HUMAN AND ANIMAL HEALTH. NATIONAL SURVEILLANCE SYSTEMS ARE ESSENTIAL TOOLS FOR DETECTING AND RESPONDING TO RESISTANT BACTERIA. SURVEILLANCE CAN ALSO SHOW US WHEN ANTIBIOTIC USE POLICIES ARE SUCCESSFUL IN REDUCING RESISTANCE. HOWEVER, VARIATION IN LABORATORY PROCESSES ACROSS TIME AND INSTITUTIONS MAKES IT DIFFICULT TO ASSESS TRENDS IN RESISTANCE OVER MANY YEARS. IN ADDITION, WE HAVE LIMITED TOOLS FOR ANALYZING MULTIDRUG RESISTANCE.THIS SEED GRANT SUPPORTS THE DEVELOPMENT OF NEW ANALYTIC TOOLS FOR ANTIMICROBIAL RESISTANCE SURVEILLANCE. WE WILL EXAMINE ESCHERICHIA COLI IN CATTLE AND THE RESTRICTIONS ON CEPHALOSPORIN USE. RESISTANT E. COLI CAN BE TRANSMITTED FROM CATTLE TO HUMANS THROUGH BEEF PRODUCTS, DIRECT CONTACT, OR THE ENVIRONMENT. FIRST, WE WILL FILL IN GAPS THAT ARISE FROM VARIED LABORATORY PROCESSES. RANDOM FORESTS, A MACHINE LEARNING METHOD, WILL PREDICT MISSING RESISTANCE DATA (I.E., MINIMUM INHIBITORY CONCENTRATIONS, MIC). THEN, STATISTICAL MODELS CAN IDENTIFY PREVIOUSLY HIDDEN TRENDS IN RESISTANCE DATA OVER TIME. WE WILL ALSO INVESTIGATE THE IMPACT OF UNCERTAINTY IN RESISTANCE TESTING ON OUR CONCLUSIONS. ASSOCIATION MINING, ANOTHER MACHINE LEARNING TOOL, WILL ANALYZE MICS AND GENOMIC SEQUENCING DATA TO REVEAL CHANGES IN MULTIDRUG RESISTANCE. OVERALL, OUR RESEARCH WILL IMPROVE ANTIMICROBIAL RESISTANCE SURVEILLANCE AND HELP IDENTIFY SUCCESSFUL RESISTANCE MITIGATION STRATEGIES.
$300,000Cornell University · · FY2023 · National Institute of Food and Agriculture
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** LISTERIA MONOCYTOGENES (LM) IS A HUMAN PATHOGEN AND WORLD-WIDE, THE LEADING CAUSE OF BACTERIAL LINKED FOODBORNE MORTALITY. OUTBREAKS OF LISTERIOSIS AFFECT PRIMARILY AT- RISK PEOPLE (PREGNANT WOMEN, ELDERLY, IMMUNOCOMPROMISED INDIVIDUALS) AND CAN BE TRACED TO CONSUMPTION OF SMOKED MEATS, SEAFOOD, AND DAIRY PRODUCTS AS WELL AS PREHARVEST FRESH PRODUCE (CABBAGE, CORN, LETTUCE, CELERY, RADISH, AND SPINACH) AND THE PRESENCE OF LM IN THE FARM ENVIRONMENT. ANTIBIOTICS HAVE BEEN USED TO INHIBIT THE GROWTH OF PATHOGENIC BACTERIA FOR MANY DECADES, REDUCING THEIR THREAT TO HUMAN HEALTH. HOWEVER, DUE TO THE INCREASING NUMBER OF ANTIBIOTIC RESISTANT AND MULTI-DRUG RESISTANT STRAINS OF BACTERIA IT HAS BECOME NECESSARY TO EXPLORE NEW ALTERNATIVES FOR ERADICATING PATHOGENS. BACTERIOPHAGE (PHAGE) ENDOLYSINS ARE ENZYME ANTIMICROBIALS THAT DIGEST THE MAJOR BUILDING BLOCKS OF THE BACTERIAL CELL WALL. IN GRAM-POSITIVE BACTERIA INCLUDING LM, THE CELL WALL IS SURFACE EXPOSED, SO THE PURIFIED ENDOLYSIN WHEN EXPOSED EXTERNALLY, CAN CAUSE DEATH OF THE PATHOGEN BY DEGRADING THE CELL WALL. ENDOLYSINS ARE HIGHLY SPECIES-SPECIFIC AND REFRACTORY TO RESISTANT STRAIN DEVELOPMENT. DESPITE NUMEROUS EFFORTS TO FIND THEM, NOT A SINGLE ENDOLYSIN-RESISTANT BACTERIAL STRAIN HAS BEEN IDENTIFIED SO FAR. WE BELIEVE THAT ENDOLYSINS CAN PREVENT OR ERADICATE LM ON LEAFY VEGETABLES. THIS PROPOSAL WILL EXAMINE THE KNOWN LM PHAGE ENDOLYSINS FOR THEIR EFFICACY AGAINST LM STRAINS FOUND ON SPINACH. HOWEVER, ENDOLYSIN PURIFICATION IS NOT COST-EFFECTIVE FOR TREATING LARGE QUANTITIES OF LEAFY VEGETABLES WITH A PURIFIED LM PHAGE ENDOLYSIN, AND THIS TREATMENT ALONE WOULD NOT CONTROL OTHER FOOD-BORNE BACTERIAL PATHOGENS SUCH AS SALMONELLA OR E. COLI. TO ADDRESS THIS CONCERN, CURRENT TREATMENTS TO ERADICATE FOOD BORNE PATHOGENS INCLUDE CHEMICAL SANITIZERS. HOWEVER, FOOD BORNE PATHOGENS HAVE BEEN REPORTED TO DEVELOP RESISTANCE TO CHEMICAL SANITIZERS, INDICATING THAT LM MIGHT ALSO EVENTUALLY DEVELOP RESISTANCE TO THESE CHEMICAL AGENTS. THUS, IT IS THE GOAL OF THIS PROJECT TO IDENTIFY INDIVIDUAL OR PAIRED LM ENDOLYSINS WITH THE HIGHEST EFFICACY AGAINST SPINACH BORN LM AND TO THEN TEST FOR INCREASED KILLING EFFICACY BY PAIRING THE ENDOLYSIN TREATMENT WITH EXISTING FOOD INDUSTRY CHEMICAL TREATMENTS. THIS SHOULD IDENTIFY A MORE SUSTAINABLE TREATMENT OF FOOD BORNE PATHOGENS THAT DOES NOT INCUR SIGNIFICANTLY INCREASED TREATMENT COSTS WHILE REDUCING THE RISK OF CREATING TREATMENT-RESISTANT STRAINS OF LM.
$300,000Tuskegee University · · FY2023 · National Institute of Food and Agriculture
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THE PREVALENCE OF ANTIMICROBIAL-RESISTANT SALMONELLA DUBLIN (S. DUBLIN) INFECTIONS IN DAIRY CATTLE INCREASED IN THE US AND IS PERCEIVED AS A MAJOR HEALTH CHALLENGE IN BOTH THE DAIRY AND BEEF INDUSTRIES. CURRENTLY, NO EFFECTIVE DRUG IS ALLOWED FOR TREATING THIS INFECTION. MOREOVER, S. DUBLIN CAN CAUSE FATAL INFECTIONS IN HUMANS. THUS, S. DUBLIN IS ALSO A PUBLIC HEALTH CONCERN DUE TO THE POTENTIAL TRANSMISSION OF MULTI-RESISTANT BACTERIA TO HUMANS. THEREFORE, RELIABLE CONTROL STRATEGIES FOR S. DUBLIN ARE URGENTLY NEEDED IN DAIRY FARMS. VACCINATION OF COWS AND CALVES COULD CONTRIBUTE TO PREVENTING AND CONTROLLING S. DUBLIN IN DAIRY HERDS. HOWEVER, THE ONLY COMMERCIALLY AVAILABLE S. DUBLIN VACCINE IS LICENSED ONLY FOR CALVES OLDER THAN 2 WEEKS OF AGE, BUT CALVES GET INFECTED BEFORE THAT TIME. EVIDENCE REGARDING EXTRA-LABEL S. DUBLIN VACCINATION OF YOUNGER CALVES OR ADULT COWS IS SCARCE. AUTOLOGOUS VACCINES COULD ALSO BE DEVELOPED, BUT THERE IS NO EVIDENCE OF THEIR EFFICACY. THUS, WE PROPOSE TO (1) EVALUATE THE EFFECTIVENESS OF POTENTIAL EXTRA-LABEL USAGES OF COMMERCIAL AND AUTOLOGOUS VACCINES TO PREVENT AND CONTROL S. DUBLIN INFECTIONS IN DAIRY FARMS, AND (2) PROVIDE U.S. DAIRY STAKEHOLDERS WITH THE KNOWLEDGE AND TOOLS NEEDED TO EFFECTIVELY CONTROL S. DUBLIN THROUGH EVIDENCE-BASED VACCINATION PROGRAMS. OUR PROJECT WILL FILL THE EVIDENCE AND TRAINING GAP TO GIVE DAIRY PRODUCERS AND VETERINARIANS THE TOOLS NEEDED TO CONTROL THIS DEVASTATING INFECTIOUS DISEASE. ULTIMATELY, THIS WILL RESULT IN LOWER ANTIMICROBIAL USAGE AND RESISTANCE, HELPING TO ENSURE THE LONG-TERM SUSTAINABILITY OF US DAIRY PRODUCTION.
$300,000Michigan State University · · FY2022 · National Institute of Food and Agriculture
Structure-Based Design of Sortase Inhibitors for Anti-Infective Therapy
$299,999Bing Li · Microbiotix, Inc · R43 · FY2011 · AI
Enabling comprehensive diagnosis of sub-acute infection in chronic respiratory disease via high sensitivity next generation sequencing
$299,999Tasha E. Fingerlin · Peak Diagnostic Partners Llc · R41 · FY2020 · AI
Rapid, Highly Multiplexed and Sensitive Blood Test for Drug-resistant Bacteria
$299,999Taiho Kim · Nesher Technologies, Inc. · R43 · FY2009 · AI
Delivery of chemically modified PNA oligomers
$299,999Dev Priya Arya · Nubad, Llc · R41 · FY2020 · AI
A NOVEL BIS-INDOLE COMPOUND AGAINST CATHETER COLONIZATION
$299,999Timothy J Opperman · Microbiotix, Inc · R41 · FY2011 · AI
A vaccine against Clostridium difficile infections
$299,999Barbara A Swanson · Sorrento Therapeutics, Inc. · R41 · FY2011 · AI
Development of a Designer Proline-rich antimicrobial peptide Chaperone protein inhibitor (DPC) for treating sepsis
$299,999Carl Neil Kraus · Arrevus, Inc. · R41 · FY2020 · AI
A NOVEL BIS-INDOLE COMPOUND AGAINST CATHETER COLONIZATION
$299,999Timothy J Opperman · Microbiotix, Inc · R41 · FY2012 · AI
Detection of Antibiotic Resistance Genes in Bacterial Agents of Hospital-Acquired
$299,999Andrew E. Levin · Immunetics, Inc. · R43 · FY2009 · AI
Detection of Antibiotic Resistance Genes in Bacterial Agents of Hospital-Acquired
$299,999Andrew E. Levin · Immunetics, Inc. · R43 · FY2008 · AI
New Antimicrobials that Act Via Membrane Remodeling for Critical Gram-Negative Pathogens
$299,995Alex Sajovic Moreland · Xiretsa Inc. · R43 · FY2024 · AI
Automatically Resisting, Releasing, and Killing Bacteria Using a Single Peptide
$299,993Zhiqiang Cao · Wayne State University · · FY2014 · MPS
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** RIO GRANDE WATERS ARE THE PRIMARY SOURCE OF IRRIGATION FOR SOUTH TEXAS AND RECHARGED WITH CHEMICALS OF EMERGING CONCERN FROM BINATIONAL SOURCES OF RECYCLED WATERS AND SEWAGE OUTFALLS. ALTHOUGH THIS IS UNIQUE TO BORDER REGIONS, ELEVATED CONTAMINANT LEVELS WILL BECOME SIMILAR IN THE U.S. WITH INCREASING WATER DEFICITS, AND BORDER REGION CROPS ARE DISTRIBUTED NATIONALLY FOR HUMAN CONSUMPTION. THIS PROJECT AIMS TO ASSESS THE CONTRIBUTION OF RECYCLED WATER TO ANTIMICROBIAL RESISTANCE IN AGRICULTURAL FIELDS AND TO MITIGATE SOIL AND CROP CONTAMINATION USING PLANT BENEFICIAL BACTERIA TO DEGRADE ANTIMICROBIALS. ULTIMATELY, THIS WORK WILL OFFER INSIGHTS INTO STRATEGIES FOR PROTECTING HUMAN HEALTH FROM LONG-TERM RISKS OF ANTIMICROBIAL RESISTANCE ASSOCIATED WITH REUSED IRRIGATION WATER IN AGRICULTURAL PRODUCTION.
$299,986Texas A&M International University · · FY2023 · National Institute of Food and Agriculture
Development of Antibiotic-Free Clostridium difficile Therapeutics
$299,984Raquel Hontecillas · Biotherapeutics, Inc. · R43 · FY2019 · AI
PA21259, SBIR Phase I, Developing a RIG-I agonist to prevent COVID-19
$299,984Bryan Berube · Hdt Bio Corporation · R43 · FY2022 · IP
Development and Pre-Clinical Testing of PEKK/Silicon Nitride Composite Craniomaxillofacial Implants
$299,980Ryan Bock · Sintx Technologies, Inc. · R43 · FY2022 · DE
UV-Based Approach for Accessing New Antibiotics
$299,973Losee Lucy Ling · Novobiotic Pharmaceuticals, Llc · R43 · FY2012 · AI