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**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THE PREVALENCE OF ANTIMICROBIAL-RESISTANT SALMONELLA DUBLIN (S. DUBLIN) INFECTIONS IN DAIRY CATTLE INCREASED IN THE US AND IS PERCEIVED AS A MAJOR HEALTH CHALLENGE IN BOTH THE DAIRY AND BEEF INDUSTRIES. CURRENTLY, NO EFFECTIVE DRUG IS ALLOWED FOR TREATING THIS INFECTION. MOREOVER, S. DUBLIN CAN CAUSE FATAL INFECTIONS IN HUMANS. THUS, S. DUBLIN IS ALSO A PUBLIC HEALTH CONCERN DUE TO THE POTENTIAL TRANSMISSION OF MULTI-RESISTANT BACTERIA TO HUMANS. THEREFORE, RELIABLE CONTROL STRATEGIES FOR S. DUBLIN ARE URGENTLY NEEDED IN DAIRY FARMS. VACCINATION OF COWS AND CALVES COULD CONTRIBUTE TO PREVENTING AND CONTROLLING S. DUBLIN IN DAIRY HERDS. HOWEVER, THE ONLY COMMERCIALLY AVAILABLE S. DUBLIN VACCINE IS LICENSED ONLY FOR CALVES OLDER THAN 2 WEEKS OF AGE, BUT CALVES GET INFECTED BEFORE THAT TIME. EVIDENCE REGARDING EXTRA-LABEL S. DUBLIN VACCINATION OF YOUNGER CALVES OR ADULT COWS IS SCARCE. AUTOLOGOUS VACCINES COULD ALSO BE DEVELOPED, BUT THERE IS NO EVIDENCE OF THEIR EFFICACY. THUS, WE PROPOSE TO (1) EVALUATE THE EFFECTIVENESS OF POTENTIAL EXTRA-LABEL USAGES OF COMMERCIAL AND AUTOLOGOUS VACCINES TO PREVENT AND CONTROL S. DUBLIN INFECTIONS IN DAIRY FARMS, AND (2) PROVIDE U.S. DAIRY STAKEHOLDERS WITH THE KNOWLEDGE AND TOOLS NEEDED TO EFFECTIVELY CONTROL S. DUBLIN THROUGH EVIDENCE-BASED VACCINATION PROGRAMS. OUR PROJECT WILL FILL THE EVIDENCE AND TRAINING GAP TO GIVE DAIRY PRODUCERS AND VETERINARIANS THE TOOLS NEEDED TO CONTROL THIS DEVASTATING INFECTIOUS DISEASE. ULTIMATELY, THIS WILL RESULT IN LOWER ANTIMICROBIAL USAGE AND RESISTANCE, HELPING TO ENSURE THE LONG-TERM SUSTAINABILITY OF US DAIRY PRODUCTION.

$300,000FY2022National Institute of Food and AgricultureUSDA

Michigan State University, East Lansing MI

Investigators

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**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THE PREVALENCE OF ANTIMICROBIAL-RESISTANT SALMONELLA DUBLIN (S. DUBLIN) INFECTIONS IN DAIRY CATTLE INCREASED IN THE US AND IS PERCEIVED AS A MAJOR HEALTH CHALLENGE IN BOTH THE DAIRY AND BEEF INDUSTRIES. CURRENTLY, NO EFFECTIVE DRUG IS ALLOWED FOR TREATING THIS INFECTION. MOREOVER, S. DUBLIN CAN CAUSE FATAL INFECTIONS IN HUMANS. THUS, S. DUBLIN IS ALSO A PUBLIC HEALTH CONCERN DUE TO THE POTENTIAL TRANSMISSION OF MULTI-RESISTANT BACTERIA TO HUMANS. THEREFORE, RELIABLE CONTROL STRATEGIES FOR S. DUBLIN ARE URGENTLY NEEDED IN DAIRY FARMS. VACCINATION OF COWS AND CALVES COULD CONTRIBUTE TO PREVENTING AND CONTROLLING S. DUBLIN IN DAIRY HERDS. HOWEVER, THE ONLY COMMERCIALLY AVAILABLE S. DUBLIN VACCINE IS LICENSED ONLY FOR CALVES OLDER THAN 2 WEEKS OF AGE, BUT CALVES GET INFECTED BEFORE THAT TIME. EVIDENCE REGARDING EXTRA-LABEL S. DUBLIN VACCINATION OF YOUNGER CALVES OR ADULT COWS IS SCARCE. AUTOLOGOUS VACCINES COULD ALSO BE DEVELOPED, BUT THERE IS NO EVIDENCE OF THEIR EFFICACY. THUS, WE PROPOSE TO (1) EVALUATE THE EFFECTIVENESS OF POTENTIAL EXTRA-LABEL USAGES OF COMMERCIAL AND AUTOLOGOUS VACCINES TO PREVENT AND CONTROL S. DUBLIN INFECTIONS IN DAIRY FARMS, AND (2) PROVIDE U.S. DAIRY STAKEHOLDERS WITH THE KNOWLEDGE AND TOOLS NEEDED TO EFFECTIVELY CONTROL S. DUBLIN THROUGH EVIDENCE-BASED VACCINATION PROGRAMS. OUR PROJECT WILL FILL THE EVIDENCE AND TRAINING GAP TO GIVE DAIRY PRODUCERS AND VETERINARIANS THE TOOLS NEEDED TO CONTROL THIS DEVASTATING INFECTIOUS DISEASE. ULTIMATELY, THIS WILL RESULT IN LOWER ANTIMICROBIAL USAGE AND RESISTANCE, HELPING TO ENSURE THE LONG-TERM SUSTAINABILITY OF US DAIRY PRODUCTION. · GrantIndex