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65,743 grants matching “single cell sequencing”
Assessing Genomic, Regulatory and Transcriptional Variation at Single Nuclei Resolution in the Brains of Individuals with Autism Spectrum Disorder
$749,882Tomasz Nowakowski · University Of California, San Francisco · R01 · FY2022 · MH
CAREER: Algorithms and Tools for Allele-Specific Transcript Assembly
$749,867Mingfu Shao · Pennsylvania State Univ University Park · · FY2022 · BIO
Biological Aging Contributions to Molecular Pathology and Neurodegeneration
$749,867Corey T McMillan · University Of Pennsylvania · R01 · FY2021 · AG
Functional Analysis of Complement Variants in a Genotyped iPSC Epithelial Cell Model System
$749,831Dwight E Stambolian · University Of Pennsylvania · R01 · FY2025 · AI
MICROBES HAVE THE POTENTIAL TO PROVIDE HUGE BENEFITS FOR CROP GROWTH, NUTRITION, AND DISEASE RESISTANCE. IN RECENT YEARS, SCIENTISTS HAVE ISOLATED SCORES OF BACTERIA AND FUNGI THAT MAY BE BENEFICIAL FOR AGRICULTURE, AND THE GLOBAL MARKET FOR PRODUCTS BASED ON THESE ORGANISMS IS OVER $2 BILLION. HOWEVER, ANOTHER GROUP OF ORGANISMS THAT ARE ABUNDANT IN AGRICULTURAL SOILS, MADE UP OF THE SINGLE-CELLED EUKARYOTES KNOWN AS PROTISTS, HAS BEEN LARGELY OVERLOOKED IN THESE EFFORTS. STUDIES HAVE SHOWN THAT TREATING A PLANT WITH CERTAIN PROTISTS CAN QUADRUPLE ITS ACCESS TO NITROGEN, REMODEL ITS ROOT ARCHITECTURE, AND GREATLY ENHANCE ITS GROWTH AND PRODUCTIVITY. BY FEEDING ON CERTAIN GROUPS OF BACTERIA, PROTISTS CAN ALSO INCREASE THE ACTIVITY AND SURVIVAL OF OTHER BENEFICIAL MICROORGANISMS. HOWEVER, EXTREMELY LITTLE IS KNOWN ABOUT WHICH PROTISTS ARE PRESENT OR ENRICHED IN ROOT SOILS, WHAT THEY ARE DOING, OR HOW MUCH PLANTS AFFECT THEM.IN THIS PROJECT, WE WILL SEQUENCE DNA FROM THE SOIL ATTACHED TO CORN ROOTS TO UNDERSTAND HOW MANY TYPES PROTISTS ARE PRESENT, WHICH ONES ARE ABUNDANT, AND WHETHER THE PLANT CHANGES THE COMPOSITION OF THE PROTIST COMMUNITY. WE WILL ALSO ISOLATE A COLLECTION OF PROTISTS FROM THE SAME ROOT SOIL AND STUDY THEIR FEEDING AND SURVIVAL CHARACTERISTICS, AS WELL AS HOW THEY AFFECT THE PLANT'S GROWTH AND PRODUCTIVITY AND INFLUENCE THE ROOT BACTERIAL COMMUNITY. THIS PROJECT WILL RESULT IN A NEW UNDERSTANDING OF WHICH GROUPS OF PROTISTS MIGHT BE AFFECTING US CROP PRODUCTION AND BY WHAT MEANS, AND WILL ENABLE RESEARCH FOCUSED ONNEW STRATEGIES FOR IMPROVING SOIL NUTRIENT AVAILABILITY, CROP PRODUCTION, AND THE EFFECTIVENESS OF MICROBIAL PRODUCTS.
$749,825Connecticut Agricultural Experimental Station · · FY2019 · National Institute of Food and Agriculture
A NOVEL STRATEGY TO INHIBIT SARS-COV-2 INFECTION AND COVID-19
$749,787Philippe Andre Gallay · Scripps Research Institute, The · R01 · FY2025 · AI
Targeting Dysregulated Maturation Program in PSC-Cardiomyocytes
$749,769Chulan Kwon · Johns Hopkins University · R01 · FY2024 · HL
Targeting Dysregulated Maturation Program in PSC-Cardiomyocytes
$749,769Chulan Kwon · Johns Hopkins University · R01 · FY2025 · HL
CANCER AND INFLAMMATION GENETICS
$749,761Michael Dean · Division Of Basic Sciences - Nci · ZIA · FY2013 · CA
Theoretical Studies On The Dynamic Aspects Of Macromolecular Function
$749,721Attila Szabo · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2022 · DK
Design and directed evolution of an 'Edmanase' enzyme for high-throughput peptide sequencing.
$749,718Kevin L Gunderson · Encodia, Inc. · R44 · FY2020 · GM
Deciphering the function and mechanisms of lncRNA-mediated organization of nuclear compartments
$749,623Mitchell Guttman · California Institute Of Technology · U01 · FY2016 · DA
Deciphering the function and mechanisms of lncRNA-mediated organization of nuclear compartments
$749,623Mitchell Guttman · California Institute Of Technology · U01 · FY2017 · DA
Deciphering the function and mechanisms of lncRNA-mediated organization of nuclear compartments
$749,623Mitchell Guttman · California Institute Of Technology · U01 · FY2019 · DA
Deciphering the function and mechanisms of lncRNA-mediated organization of nuclear compartments
$749,622Mitchell Guttman · California Institute Of Technology · U01 · FY2015 · DA
SINGLE SUTURE CRANIOSYNOSTOSIS: CANDIDATE GENE AND PATHWAY DISCOVERY
$749,608Michael L Cunningham · Seattle Children'S Hospital · R01 · FY2015 · DE
The Lung DNA Virome in Health and Disease
$749,556Ronald G Collman · University Of Pennsylvania · R33 · FY2020 · HL
Human immune signatures of natural immunity to DENV infection, severe disease, and vaccination with attenuated live vaccine
$749,544Alessandro Sette · La Jolla Institute For Immunology · U19 · FY2016 · AI
PanKbase: a community hub for integrated pancreas knowledge
$749,543Stephen Cj Parker · University Of Michigan At Ann Arbor · U24 · FY2024 · DK
Cilia in Heart Development and Disease
$749,505Martina Brueckner · Yale University · R35 · FY2021 · HL
Aerosol delivery of HDAd into Primate Lungs: Preclinical CF Gene Therapy Studies
$749,436Philip Ng · Baylor College Of Medicine · R01 · FY2007 · HL
Functions of thyroid hormone in retinal development
$749,429Douglas Forrest · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2019 · DK
Project 1: Manipulating E-cigarette Nicotine to Promote Public Health
$749,410Theodore Lee Wagener · Ohio State University · U54 · FY2024 · CA
In vivo Characterization of Regulatory Variant Pathogenicity in Congenital Heart Disease
$749,365Axel Visel · University Of Calif-Lawrenc Berkeley Lab · R01 · FY2025 · HL
Role of CEBPb in flow-dependent endothelial dysfunction and atherosclerosis
$749,342Hanjoong Jo · Emory University · R01 · FY2025 · HL