← Leaderboards
Michael S Wolfe
Brigham And Women'S Hospital
$15,472,448
Attributed
$19,310,905
Total exposure
12
Grants
9
Lead (contact PI)
Attributed= this PI's even-split share of every grant they're on (the fair, additive number). Exposure = full size of all those grants.
Funding over time
peak $4.9M · FY2005–25$5M$3.8M$2.5M$1.3M$0
'05
'06
'07
'08
'09
'10
'11
'12
'13
'14
'15
'16
'17
'18
'19
'20
'21
'22
'23
'24
'25
Funding mix
By agency
NIH$19,310,905 · 12
By mechanism
R01$13,502,844 · 6
RF1$4,352,115 · 1
R21$938,691 · 2
R03$348,758 · 2
R29$168,497 · 1
Top collaborators
- Jasmeer P Chhatwal2 shared
- Lei Liu2 shared
Most similar at Brigham And Women'S Hospital
Same institution · by research overlap
- Dennis J Selkoe$33,298,694
- Richard L Stevens$8,274,576
- Joshua A Boyce$54,050,346
- Mark A Perrella$18,447,731
- K. Frank Austen$8,663,173
Others in their field
Top investigators on “Alzheimer&Apos”
- Jose A Luchsinger · Columbia University Health Sciences$56,595,040
- Eric M Reiman · Banner Health$48,982,487
- Yadong Huang · J. David Gladstone Institutes$40,311,515
- Lindsay A. Farrer · Boston University Medical Campus$34,189,802
- David M Holtzman · Washington University$28,985,806
- Michael W Weiner · Northern California Institute Res &Educ$28,197,224
Research focus
Alzheimer&AposPresenilinS DiseaseProteolysisComplexPeptidesEnzymesTransmembrane DomainGamma SecretaseAspartic EndopeptidasesPeptide HydrolasesStructureMembraneAnalogCleaved CellAspartateBiochemicalMutationMutantInhibitor/AntagonistActive SitesSiteProteinsCrosslink
Grant awards (45)
Leveraging Heterogeneity in Autosomal Dominant AD to Elucidate Pathophysiology and Improve AD Biomarkers$1,405,570
R01 · FY2025 · AG
Structure and Function of Gamma-Secretase in Familial Alzheimer's Disease$582,098
R01 · FY2024 · AG · contact PI
Structure and Function of Gamma-Secretase in Familial Alzheimer's Disease$582,098
R01 · FY2023 · AG · contact PI
Leveraging Heterogeneity in Autosomal Dominant AD to Elucidate Pathophysiology and Improve AD Biomarkers$4,352,115
RF1 · FY2022 · AG
Structure and Function of Gamma-Secretase in Familial Alzheimer's Disease$582,098
R01 · FY2022 · AG · contact PI
Structure and Function of Gamma-Secretase in Familial Alzheimer's Disease$582,098
R01 · FY2021 · AG · contact PI
Structure and Function of Gamma-Secretase in Familial Alzheimer's Disease$582,098
R01 · FY2020 · AG · contact PI
Mechanisms of Gamma-Secretase$291,638
R01 · FY2020 · GM · contact PI
Mechanisms of Gamma-Secretase$291,638
R01 · FY2019 · GM · contact PI
Mechanisms of Gamma-Secretase$291,638
R01 · FY2018 · GM · contact PI
Mechanisms of Gamma-Secretase$291,638
R01 · FY2017 · GM · contact PI
Membrane-anchored amyloid peptides in Alzheimer's disease$189,375
R21 · FY2017 · AG · contact PI
Membrane-anchored amyloid peptides in Alzheimer's disease$266,250
R21 · FY2016 · AG · contact PI
Determinants of Notch-Sparing Gamma-Secretase Inhibition$87,492
R03 · FY2014 · NS · contact PI
Targeting Tau Splicing for Dementia$215,316
R21 · FY2013 · NS · contact PI
Determinants of Notch-Sparing Gamma-Secretase Inhibition$88,125
R03 · FY2013 · NS · contact PI
Trimming of Amyloid Peptides by Gamma-Secretase$85,141
R03 · FY2013 · NS · contact PI
Targeting Tau Splicing for Dementia$267,750
R21 · FY2012 · NS · contact PI
Trimming of Amyloid Peptides by Gamma-Secretase$88,000
R03 · FY2012 · NS · contact PI
Molecular Probes for Alzheimer's Gamma-Secretase$375,156
R01 · FY2011 · NS · contact PI
Molecular Probes for Alzheimer's Gamma-Secretase$378,985
R01 · FY2010 · NS · contact PI
Structure and mechanism of signal peptide peptidase$329,175
R01 · FY2010 · GM · contact PI
The Role of Presenilin in Gamma-Secretase Activity$429,350
R01 · FY2009 · AG · contact PI
Molecular Probes for Alzheimer's Gamma-Secretase$382,813
R01 · FY2009 · NS · contact PI
Structure and mechanism of signal peptide peptidase$332,500
R01 · FY2009 · GM · contact PI
The Role of Presenilin in Gamma-Secretase Activity$429,350
R01 · FY2008 · AG · contact PI
Molecular Probes for Alzheimer's Gamma-Secretase$382,813
R01 · FY2008 · NS · contact PI
Structure and mechanism of signal peptide peptidase$332,500
R01 · FY2008 · GM · contact PI
Molecular Probes for Alzheimer's Gamma-Secretase$382,813
R01 · FY2007 · NS · contact PI
The Role of Presenilin in Gamma-Secretase Activity$340,162
R01 · FY2007 · AG · contact PI
Structure and mechanism of signal peptide peptidase$332,500
R01 · FY2007 · GM · contact PI
The Role of Presenilin in Gamma-Secretase Activity$97,951
R01 · FY2007 · AG · contact PI
The Role of Presenilin in Gamma-Secretase Activity$350,320
R01 · FY2006 · AG · contact PI
The Role of Presenilin in Gamma-Secretase Activity$358,579
R01 · FY2005 · AG
Molecular Probes for Alzheimer's Gamma-Secretase$292,803
R01 · FY2005 · NS
Molecular Probes for Alzheimer's Gamma-Secretase$292,803
R01 · FY2004 · NS
ROLE OF PRESENILIN IN GAMMA-SECRETASE ACTIVITY$254,250
R01 · FY2004 · AG
Molecular Probes for Alzheimer's Gamma-Secretase$292,803
R01 · FY2003 · NS
ROLE OF PRESENILIN IN GAMMA-SECRETASE ACTIVITY$254,250
R01 · FY2003 · AG
Molecular Probes for Alzheimer's Gamma-Secretase$292,803
R01 · FY2002 · NS
ROLE OF PRESENILIN IN GAMMA-SECRETASE ACTIVITY$254,250
R01 · FY2002 · AG
Molecular Probes for Alzheimer's Gamma-Secretase$317,803
R01 · FY2001 · NS
ROLE OF PRESENILIN IN GAMMA-SECRETASE ACTIVITY$254,250
R01 · FY2001 · AG
ROLE OF PRESENILIN IN GAMMA-SECRETASE ACTIVITY$279,250
R01 · FY2000 · AG
MOLECULAR PROBES FOR ALZHEIMERS GAMMA-SECRETASES$168,497
R29 · FY2000 · NS