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38,696 grants matching “als”
Ultra-Low Background NIR Fluorophores for In Vivo Imaging and Image-Guided Surger
$327,932John V Frangioni · Beth Israel Deaconess Medical Center · R01 · FY2013 · EB
THE GREAT LAKES BASIN (GLB) HAS BEEN A REGIONAL HOTSPOT OF CLIMATE CHANGE IMPACTS INCLUDING LAKE WARMING DECLINING ICE COVER AND INCREASED LAKE-EFFECT SNOWFALL. MODELING STUDIES HAVE DEMONSTRATED THE SUBSTANTIAL CONTRIBUTION OF LAKE-ATMOSPHERE INTERACTIONS AND UNCERTAINTY IN LAKE-EFFECT SNOWFALL PROJECTIONS. DESPITE THE VAST SOCIO-ECONOMIC IMPACTS OF LAKE-EFFECT SNOWSTORMS (LES) THESE EXTREME EVENTS HAVE RECEIVED MINIMAL ATTENTION FROM IPCC AND NATIONAL CLIMATE ASSESSMENT. THE INSUFFICIENT INVESTIGATION OF PROJECTED CHANGES IN THESE COLD SEASON EXTREMES IS PARTLY DUE TO THE GENERAL LACK OF APPROPRIATE MODELING TOOLS THAT PROPERLY REPRESENT THE GREAT LAKES AND LAKE-ATMOSPHERE INTERACTIONS. THERE HAVE BEEN RECENT ADVANCES IN THE REPRESENTATION OF LAKE-ATMOSPHERE INTERACTIONS AMONG REGIONAL CLIMATE MODELS THROUGH 2-WAY COUPLING WITH 1D LAKE MODELS PERMITTING THE SIMULATION OF BROAD-SCALE LAKE-EFFECT SNOW FEATURES. HOWEVER SUCH LAKE MODELS ARE INAPPROPRIATE FOR DEEP LAKES LEADING TO LARGE BIASES IN LAKE SURFACE TEMPERATURE (LST) ICE COVER AND EVAPORATION. XUE ET AL. EMPLOYED OFFLINE AND 2-WAY COUPLING OF THE 3D FINITE VOLUME COMMUNITY OCEAN MODEL (FVCOM) TO WRF AND REGCM4 AND DEMONSTRATED THE BENEFITS OF INCORPORATING 3D MODELS TO REPRESENT GREAT LAKES HYDRODYNAMICS INCLUDING DRAMATIC BIAS REDUCTIONS AND ACCURATE TURBULENT FLUX REPRESENTATION WITH IMPLICATIONS FOR LES. RECENT ADVANCES IN DATA COLLECTION INCLUDING OVER-LAKE FLUX MEASUREMENTS THROUGH THE GREAT LAKES EVAPORATION NETWORK (GLEN) AND ONTARIO WINTER LAKE- EFFECT SYSTEMS FIELD CAMPAIGN ALONG WITH IMPROVED SPACEBORNE COLD SEASON CLOUD/PRECIPITATION DETECTION BY CLOUDSAT AND GLOBAL PRECIPITATION MEASUREMENT (GPM) PLATFORMS HAVE DEEPENED THE UNDERSTANDING OF LAKE-ATMOSPHERE INTERACTIONS LES DYNAMICS AND SHALLOW CUMULIFORM SNOW MICROPHYSICS. WE PROPOSED TO EVALUATE AND ADVANCE THE REPRESENTATION OF LAKE-ATMOSPHERE INTERACTIONS AND HEAVY LES IN THE GLB BY NU-WRF. NUWRF PERMITS 2 CRUDE LAKE TREATMENTS: REMOTELY-SENSED LSTS ARE PROVIDED AS BOUNDARY CONDITIONS OR THE ATMOSPHERE IS 2-WAY COUPLED TO THE 1D FLAKE MODEL. IN ADDITION TO EXPLORING LSTS TURBULENT FLUXES CLOUDS AND LES IN THESE CONFIGURATIONS WE WILL ENHANCE THE REPRESENTATION OF 3D LAKE PROCESSES AND LAKE-ATMOSPHERE INTERCONNECTIONS BY DEVELOPING A 2-WAY COUPLED LAKE-ATMOSPHERE-LAND MODEL NU-WRF/FVCOM WHICH PERMITS THE DEVELOPMENT OF DYNAMICALLY DOWNSCALED LES PROJECTIONS. HISTORICAL NU-WRF RUNS WILL BE PRODUCED FOR THE AFOREMENTIONED LAKE TREATMENTS AND EVALUATED AGAINST OBSERVATIONS TO QUANTIFY ADDED VALUE TO OVER-LAKE TURBULENT FLUXES AND LES FREQUENCY/INTENSITY FROM INCORPORATING 3D LAKE PROCESSES AND ADVANCED LAKE-ATMOSPHERE COUPLING. GLEN MEASUREMENTS WILL BE USED TO EVALUATE TURBULENT FLUX RESPONSES TO ICE COVER AND TEMPORAL DISTRIBUTION OF EVAPORATION EVENTS. FOR A SET OF OBSERVED LES WE WILL CREATE A NU-WRF/FVCOM ENSEMBLE EXPLORING THE IMPACT OF MICROPHYSICAL BOUNDARY LAYER CONVECTIVE AND RADIATION SCHEMES; VERTICAL RESOLUTION; AND GRID SPACING ON MORPHOLOGIES OF LAKE-INDUCED MESOSCALE CIRCULATIONS. BY VARYING PARAMETERIZATIONS AND PERFORMING RUNS WITH IMPOSED LAKE TEMPERATURE ANOMALIES THE SENSITIVITY OF SPATIO-TEMPORAL PATTERNS OF LAKEEFFECT SNOWFALL AND RESULTING SNOWFALL BIASES CAN BE ATTRIBUTED TO LST OR MICROPHYSICS BIASES. EVALUATING THE REPRESENTATION OF HEAVY LES IN NU-WRF WILL BE GROUNDED IN CLOUDSAT/GPM PRODUCTS. WE WILL EVALUATE CLOUDSAT/GPM SNOWFALL RETRIEVALS AGAINST STATION OBSERVATIONS. IN ADDITION TO EVALUATING NU-WRF AGAINST CLOUDSAT/GPM VERTICAL RADAR REFLECTIVITY TRANSECTS FOR CASE STUDIES WE WILL EXAMINE THE SPECTRUM OF SNOW EVENTS THROUGH DENSITY FUNCTIONS OF RADAR REFLECTIVITY-BASED ESTIMATES OF SNOWFALL INTENSITY/FREQUENCY AND CLOUD ATTRIBUTES ALLOWING FOR THE EVALUATION OF THE MODEL S MICROPHYSICS. RADAR SIMULATORS WILL BE APPLIED TO MODEL OUTPUT TO COMPARE RADAR REFLECTIVITY DISTRIBUTIONS AND CHARACTERISTICS BETWEEN SIMULATED AND OBSERVED LES DATASETS.
$327,923Michigan Technological University · · FY2020 · National Aeronautics and Space Administration
Language Development Following Early Focal Brain Injury
$327,881Doris A Trauner · University Of California, San Diego · R01 · FY2007 · DC
Optogenetic Pain Modulator for non-opioid chronic pain management
$327,864Darryl J Narcisse · Opsin Biotherapeutics Inc. · R43 · FY2023 · NS
Intrinsic plasticity and information storage in cerebellar Purkinje cells
$327,803Christian Robert Hansel · University Of Chicago · R01 · FY2009 · NS
How do Cortical regions selective for visual scenes develop in human infants?
$327,779Rebecca R Saxe · Massachusetts Institute Of Technology · R01 · FY2021 · HD
Dynamic Regulation of Tuning in Adult Auditory Cortex
$327,731University Of California Irvine · R01 · FY2004 · DC
GENETIC ANALYSIS OF RETINAL GANGLION CELL FUNCTION
$327,727University Of Michigan At Ann Arbor · R01 · FY2002 · EY
Immunoglobulin Structure, Stability and Aging
$327,640Yair Argon · Children'S Hosp Of Philadelphia · R01 · FY2008 · AG
Differential Regulation of RNA processing by Akt isoforms
$327,615Philip N Tsichlis · Ohio State University · R01 · FY2019 · CA
Replacement of Motor Neurons and Astrocytes in ALS Using Human Embryonic Stem Cel
$327,611Su-Chun Zhang · University Of Wisconsin-Madison · P01 · FY2008 · NS
Variance Component Models for Mapping QTLs
$327,607John K Hewitt · University Of Colorado · R01 · FY2006 · EY
Ethanol Effects on Neurotransmission
$327,604University Of North Carolina Chapel Hill · R01 · FY2005 · AA
Electric Field as Novel Neuronal Interface
$327,596Bruce J Gluckman · Pennsylvania State Univ Hershey Med Ctr · R01 · FY2006 · EB
Depression Treatment for Urban Low Income Minority Substance Users
$327,564Stacey B Daughters · Univ Of Maryland, College Park · R01 · FY2011 · DA
Core 3: Epigenomics Core
$327,558Charles B Epstein · Dana-Farber Cancer Inst · P01 · FY2017 · CA
High-content light sheet microscopy of cleared tissue for mental health research
$327,553Samouil Farhi · Broad Institute, Inc. · S10 · FY2021 · MH
BIOMARKERS AND PATHOGENESIS OF MS: FROM MOUSE TO HUMAN
$327,551Dorothy Anne Cross · Washington University · P01 · FY2017 · NS
Molecular Characterization of Stage I Lung Cancer
$327,529Ming You · Washington University · R01 · FY2009 · CA
Benzofurazan sulfide fluorogenic agents for live cell subcellular thiol imaging
$327,503Xiangming Guan · South Dakota State University · R15 · FY2014 · GM
Enhancing operational efficiency and animal welfare through the use of digital ventilated caging for laboratory mice in an ABSL3 Select Agent biocontainment program
$327,477Harshan Pisharath · St. Jude Children'S Research Hospital · R24 · FY2024 · OD
Developing Novel Deep-Learning Based Methods for Deciphering Non-Coding Gene Regulatory Code
$327,406Ramana V Davuluri · State University New York Stony Brook · R01 · FY2025 · LM
The Role of AKT in Prostate Cancer
$327,393William R Sellers · Beth Israel Deaconess Medical Center · P01 · FY2009 · CA
Mechanisms regulating autophagy in alcohol-induced liver injury
$327,375Wen-Xing Ding · University Of Kansas Medical Center · R01 · FY2015 · AA
Mechanisms regulating autophagy in alcohol-induced liver injury
$327,375Wen-Xing Ding · University Of Kansas Medical Center · R01 · FY2014 · AA