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24,576 grants matching “microbiome”
THE HUMAN VIROME IN CHILDREN AND ITS RELATIONSHIP TO FEBRILE ILLNESS
$250,000Gregory A. Storch · Washington University · UH2 · FY2010 · AI
Antigen specific strategies for treatment of HIV+ cancer patients in the Montefiore/Einstein Cancer Center Catchment Area (Immuno/microenvironment)
$249,999Edward Chu · Albert Einstein College Of Medicine · P30 · FY2022 · CA
Tuberculosis in households with infectious cases in Kampala city: Harnessing health data science for new insights on TB transmission and treatment response (DS-IAFRICA-TB)
$249,999David Patrick Kateete · Makerere University College Of Health Sciences · U01 · FY2023 · TW
Breast Milk Microbiota Influence on Infant Immunity and Growth (BEAMING)
$249,999Alash'le G. Abimiku · Institute Of Human Virology · U01 · FY2021 · HD
Collaborative Research: IIBR Informatics: Keeping up with the genomes - Continual Learning of Metagenomic Data
$249,999Andreas Wilke · University Of Chicago · · FY2020 · BIO
Tuberculosis in households with infectious cases in Kampala city: Harnessing health data science for new insights on TB transmission and treatment response (DS-IAFRICA-TB)
$249,999David Patrick Kateete · Makerere University College Of Health Sciences · U01 · FY2024 · TW
Surviving the HIV Epidemic (S/HE) in metropolitan Washington DC - Advancing knowledge through cohort studies
$249,999Seble G Kassaye · Georgetown University · U01 · FY2019 · HL
Tuberculosis in households with infectious cases in Kampala city: Harnessing health data science for new insights on TB transmission and treatment response (DS-IAFRICA-TB)
$249,999David Patrick Kateete · Makerere University College Of Health Sciences · U01 · FY2025 · TW
Breast Milk Microbiota Influence on Infant Immunity and Growth (BEAMING)
$249,999Alash'le G. Abimiku · Institute Of Human Virology · U01 · FY2020 · HD
OUR RESULTS WILL GO BEYOND MICROBIAL MEASUREMENT TO PREDICT MOISTURE-RELATED CHANGES TO THE INDOOR MICROBIOME AND ASTRONAUT EXPOSURE. OUR WORK WILL PROVIDE ADDED VALUE TO MICROBIAL DATA COLLECTED PREVIOUSLY ON THE ISS. FOR INSTANCE MICROBIAL TRACKING 1 CHARACTERIZED AIRBORNE AND SURFACE-ASSOCIATED POPULATIONS OF MICROORGANISMS ABOARD THE ISS. HUMID COMPLEMENTS THIS DATA THROUGH USE OF A CHAMBER STUDY OBSERVING FUNDAMENTAL MICROBIAL PROCESSES THAT MAY OCCUR UNDER CONDITIONS OF INCREASED MOISTURE IN OCCUPIED SPACECRAFT. WE NEED TO UNDERSTAND HOW TO CHARACTERIZE THE SPACECRAFT MICROBIOME AS EITHER HEALTHY OR UNHEALTHY. ULTIMATELY WE WILL BE ABLE TO DEVELOP IMPROVED MICROBIAL CLEARANCE PROTOCOLS THAT ARE MORE RELEVANT TO ASTRONAUT HEALTH PLANETARY PROTECTION AND SPACECRAFT INTEGRITY. OUR DESIGN DECISIONS IN SPACE HAVE IMPORTANT IMPLICATIONS IN CONTROLLING THE MICROBES THAT ARE PRESENT. BY UNDERSTANDING THE FUNDAMENTAL PROCESSES THAT OCCUR IN THIS ENVIRONMENT WE CAN DESIGN FOR A HEALTHY MICROBIOME INSTEAD OF BEING SUBJECT TO UNINTENDED CONSEQUENCES.
$249,998Ohio State University, The · · FY2020 · National Aeronautics and Space Administration
Gut barrier function in Alzheimer's Disease
$249,997Barbara Brigitta Bendlin · University Of Wisconsin-Madison · R01 · FY2024 · AG
MUCH OF THE UNITED STATES AGRICULTURAL SYSTEM RELIES ON BREEDING DESIRABLE TRAITS THAT INCLUDE HIGH YIELD, DISEASE SUPPRESSION, AND DROUGHT TOLERANCE, AMONG OTHERS. ONE OF THE CONSTRAINTS OF RELYING ON BREEDING TECHNIQUES TO IMPROVE CROP TRAITS IS THE ISSUE OF TIME. FOR MOST BREEDING PROGRAMS, ONE SELECTION CYCLE OCCURS ANNUALLY, WHICH MEANS THAT WE HAVE ONLY 35 BREEDING CYCLES UNTIL 2050--A CRITICAL GLOBAL TIME POINT THAT CENTERS ON THE QUESTION OF HOW TO FEED OVER 9 BILLION PEOPLE. IT IS UNLIKELY THAT BREEDING ALONE WILL PROVIDE THE SOLUTIONS TO INCREASE YIELDS FOR SUSTAINING HUMAN POPULATION GROWTH, WHILE ALSO RESPONDING TO CHANGES IN CLIMATE. OUR RESEARCH PROJECT ADDRESSES THIS CONCERN BY INITIATING RESEARCH THAT FOCUSES ON ASSEMBLING COLLECTIONS OF SOIL MICROBIOTA--BACTERIA, FUNGI, AND VIRUSES--THAT ALTOGETHER, REINFORCE DESIRABLE CROP TRAITS. IN ESSENCE, WE ARE "BREEDING" GROUPS OF PLANT-ASSOCIATED MICROBIOTA THAT ARE ABLE TO ENHANCE PLANT YIELD BY ENRICHING PLANT ROOT ZONES WITH BENEFICIAL MICROORGANISMS. AT PRESENT, MANY TOP AGRIBUSINESS COMPANIES, INCLUDING MONSANTO, SYNGENTA, DUPONT, AND BASF, ARE INVESTING IN MICROBIAL-BASED METHODS THAT INFLUENCE CROP TRAITS. INDUSTRY IS RELYING PRIMARILY ON A SINGLE SPECIES OR STRAIN OF MICROORGANISM AS AN INOCULANT IN PLANT SEEDS OR DIRECTLY INTO SOILS. OUR APPROACH DIFFERS IN THAT IT INCLUDES COMPLEX COMMUNITIES OF MICROORGANISMS THAT ARE ASSEMBLED THROUGH REPEATED SELECTIONS ON THE PLANT HOST TRAIT, SUCH AS BIOMASS OR SEED YIELD. THE SHORT LIFECYCLE OF BACTERIA AND THEIR ABILITY TO SHIFT POPULATION STRUCTURE RAPIDLY, IN RESPONSE TO SELECTION, FACILITATES THE BREEDING OF SOIL MICROBIOTA FOR PLANT PRODUCTION SYSTEMS.BY 2050, THE HUMAN POPULATION IS EXPECTED TO REACH OVER 9 BILLION PEOPLE, WITH THE MAJORITY CONCENTRATED IN AFRICA, SOUTHERN ASIA, AND EASTERN ASIA. FOR PARTS OF THESE SECTIONS OF THE WORLD, IT IS CHALLENGING TO DEVELOP INTENSIVE AGRICULTURAL SYSTEMS ROUTINELY USING INDUSTRIAL AMMONIA FERTILIZERS TO SUSTAIN HIGH YIELDS. SYNTHETIC FERTILIZERS (BASED ON THE HABER-BOSCH PROCESS) CONSUME HIGH AMOUNTS OF FOSSIL FUEL ENERGY IN THEIR MANUFACTURE AND CONTRIBUTE TO CHRONIC NONPOINT SOURCE POLLUTION IN HOTSPOTS OF AGRICULTURAL PRODUCTION, SUCH AS FOUND IN THE SALINAS VALLEY AREA OF CALIFORNIA. DEVELOPING A PLANT MICROBIOME FOCUS TO INTERNATIONAL CROP PRODUCTION WILL HELP PROMOTE SUSTAINED YIELDS IN MAJOR PARTS OF THE WORLD LACKING THE CAPACITY FOR INDUSTRIAL-BASED AGRICULTURE, IN ADDITION TO MAINTAINING CROP PRODUCTIVITY IN THE U.S. MANY CROPPING SYSTEMS ALREADY INCLUDE A FOCUS ON THE MICROBIOME FOR IMPROVED NUTRIENT MANAGEMENT; THESE INCLUDE RHIZOBIA FOR LEGUMES AND SEVERAL ARBUSCULAR MYCORRHIZAL FUNGI (AMF) FOR CEREAL CROPS. HOWEVER, PLANTS THAT DO NOT FORM ASSOCIATIONS WITH SYMBIONTS RELY HEAVILY ON FERTILIZER ADDITIONS. BRASSICA CROP PRODUCTION (MANY CULTIVARS OF WHICH SERVE AS THE GREEN VEGETABLE STAPLE OF MANY POPULATIONS IN DEVELOPING COUNTRIES) WOULD BENEFIT HEAVILY FROM GREATER NITROGENMANAGEMENT VIA SOIL BIOTIC MANIPULATIONS, AND SERVE AS A MODEL FOR ADDITIONAL CROPS THAT DO NOT FORM SYMBIOTIC RELATIONSHIPS.THE PROPOSED RESEARCH WILL INCLUDE SEQUENCING OF THE MICROBIOMES IN AN EFFORT TO IDENTIFY WHO COMPRISES THE MICROBIOMES THAT ARE ASSOCIATED WITH AN ENHANCED SEED YIELD PHENOTYPE AND CORRESPONDING HIGH NITROGEN CAPTURE TRAITS. WE WILL BE USING 16S AND 18S BAR-CODED PAIRED-END READS FOR CHARACTERIZATION OF THE SOIL MICROBIOME USING THE ILLUMINA HISEQ PLATFORM. THE SEQUENCING METHODS WILL ALLOW US TO ASSESS HOW THE MICROBIOMES CHANGE IN COMMUNITY COMPOSITION OVER GENERATIONS OF SELECTION, IN RELATION TO THE DEVELOPMENT OF HIGHER SEED YIELD IN THE HOST PLANTS. FUNCTIONAL ANALYSIS USING PLANT RNA-SEQ, SOIL EXTRACELLULAR ENZYME ACTIVITY, PLANT TISSUE 15N ENRICHMENT, AND NITROGEN MINERALIZATION WILL HELP EXPLAIN HOW THE MICROBIOMES ARE MODIFYING PLANT PHENOTYPES VIA PLANT GENE EXPRESSION AND COORDINATED RESOURCE GAIN. THESE FUNDAMENTAL INVESTIGATIONS INTO THE INTERACTIONS OF PLANTS AND THEIR ASSOCIATED MICROBIOTA WILL HELP PAVE THE WAY FOR MICROBIOME-ENHANCEMENT OF AGRICULTURAL PRODUCTION SYSTEMS.
$249,997Cornell University · · FY2020 · National Institute of Food and Agriculture
Singular Genomics ; G4 Sequencing Platform
$249,995Romonia Renee Reams · Florida Agricultural And Mechanical Univ · S10 · FY2024 · AG
Alteration & Renovation Core
$249,993Khrystyne Duddleston · University Of Alaska Fairbanks · P20 · FY2019 · GM
LEAPS-MPS: Getting modeling precision right for data with measurement errors
$249,989Pei Geng · Board Of Trustees Of Illinois State University · · FY2023 · MPS
LEAPS-MPS: Getting modeling precision right for data with measurement errors
$249,989Pei Geng · University Of New Hampshire · · FY2023 · MPS
Dust-Induced Microbiome Changes Alter Allergic Immune Responses
$249,971Susan Veronica Lynch · Henry Ford Health System · P01 · FY2016 · AI
LSUHSC CARC Alzheimer's Disease Supplement
$249,949Patricia E Molina · Lsu Health Sciences Center · P60 · FY2023 · AA
Elucidation of the first interspecies chemical signaling mechanisms in Capsaspora owczarzaki--the predator of a human pathogen and a model for the evolution of animal multicellularity
$249,935Joseph P. Gerdt · Trustees Of Indiana University · R35 · FY2023 · GM
Skin probiotics to treat Netherton Syndrome
$249,935Amin Zargar · Resvita Bio, Inc. · R43 · FY2022 · AR
Skin probiotics to treat atopic dermatitis
$249,935Amin Zargar · Resvita Bio, Inc. · R43 · FY2023 · AI
Single-molecule analysis of how birth and death of mRNAs are regulated inside a bacterial cell
$249,917Sangjin Kim · University Of Illinois At Urbana-Champaign · R35 · FY2022 · GM
Project 4: Evaluating mediation effects of the microbiome and epigenetics using high dimensional assays
$249,832Zhigang Li · Dartmouth College · P20 · FY2020 · GM
Effect of piezoelectric charges on oral microbiome modulation
$249,818Santiago Orrego · Temple Univ Of The Commonwealth · R21 · FY2021 · DE
Training in Microbial Pathogenesis and Genomics
$249,808Jun Zhu · University Of Pennsylvania · T32 · FY2020 · AI