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17,828 grants matching “crispr”
Improving Anopheline fitness and resistance through fat body insulin signaling
$200,395Michael Allen Riehle · University Of Arizona · R21 · FY2016 · AI
Human Genetic Variation Regulating Cellular Susceptibility to Zika Virus
$200,269Dennis Chun-Yone Ko · Duke University · R21 · FY2025 · AI
Core B: Data Management and Bioinformatics Core
$200,231Aviv Regev · Harvard Medical School · U19 · FY2021 · AI
Autologous Non-viral CRISPR/Cas Homology-directed Repair for Artemis-deficient Severe Combined Immunodeficiency
$200,016Matthew J Kan · University Of California, San Francisco · K08 · FY2025 · AI
Mechanism and Function of Stress Induced Protein Translation
$200,002Qin M Chen · University Of Arizona · R01 · FY2018 · GM
RAPID: Point-of-Need Detection of COVID-19 using CRISPR-Enabled Cell-Free Synthetic Biology
$200,000Julius B Lucks · Northwestern University · · FY2020 · BIO
Investigation of energetics of sharp DNA bending
$200,000Harold D Kim · Georgia Institute Of Technology · R01 · FY2023 · GM
Silencer-enhancer transition dysregulates interleukin-6 in mucosal epithelial cell plasticity
$200,000Jun Yang · University Of Texas Med Br Galveston · R21 · FY2025 · AI
ERI: Integrating Non-Viral CRISPR Gene Activation and Deep Learning for Biomanufacturing Precision Stem Cell Products
$200,000Tomas Gonzalez-Fernandez · Lehigh University · · FY2024 · ENG
Deciphering how the Cas2 ribonuclease non-canonically controls Legionella pneumophila thermal tolerance and virulence
$200,000Nicholas Philip Cianciotto · Northwestern University At Chicago · R21 · FY2025 · AI
Collaborative Research: ENG-BIOTECH: Mechanism-Guided Engineering of Thermophilic CRISPR-Cas13 for Ultrasensitive and Robust RNA Detection
$200,000Yi Zhang · University Of Connecticut · · FY2024 · ENG
Cellular receptor for enterovirus D68
$200,000Vincent R Racaniello · Columbia University Health Sciences · R21 · FY2016 · AI
A CRISPRi screen of essential genes of Neisseria gonorrhoeae
$200,000H. Steven Seifert · Northwestern University At Chicago · R21 · FY2024 · AI
ACCURATE, SENSITIVE, AND RAPID ANIMAL DIAGNOSTICS WITH CRISPR BASED MOLECULAR DETECTION
$200,000Gloucester Marine Genomics Institute Incorporated · · FY2019 · National Institute of Food and Agriculture
THIS PROPOSAL IS GOING TO ADDRESS PROGRAM AREA 7: CROSSCUTTING PROGRAMS AND PROGRAM AREA PRIORITY (A): AGRICULTURAL INNOVATION THROUGH GENE EDITING OF THE USDA AFRI STANDARD RESEARCH PROGRAM. A PROBLEM IN THE USE OF GENE EDITING FOR CROP IMPROVEMENT IS THE EXISTENCE OF TECHNOLOGICAL BARRIERS THAT IMPEDE THE USE OF GENE EDITING IN SOME AGRICULTURALLY IMPORTANT CROPS. WE INTEND TO DEVELOP NOVEL TRANSFORMATION METHODS THAT DO NOT REQUIRE THE USE OF PLANT PEST SEQUENCES IN PLANTS AND DEVELOP GENE EDITING TECHNOLOGIES THAT DO NOT REQUIRE TRANSFORMATION. WE SEEK TO USE NANOPARTICLES TO DELIVER CAS9/GRNAS INTO TWO MINOR CROPS - TOMATO AND HEMP - FOR GENE EDITING. PHENOTYPIC AND MOLECULAR ANALYSIS WILL BE USED TO CONFIRM THAT THE EXPECTED PHENOTYPE IS DIRECTLY CAUSED BY THE EDITED GENES. THE OFF-TARGET EFFICIENCY OF THE CRISPR-CAS9 SYSTEM WILL BE EXAMINED BY NEXT-GENERATION SEQUENCING. GREENHOUSE EXPERIMENTS WILL BE USED TO TEST THE PHENOTYPIC STABILITY OF THE GENE EDITED MUTANTS. THE EXPECTED OUTCOME OF THIS PROJECT IS THE ESTABLISHMENT OF NOVEL GENE EDITING TECHNOLOGIES THAT WILL NOT REQUIRE THE USE OF PLANT PEST SEQUENCES OR PLANT TRANSFORMATION AND REGENERATION. THEY COULD BE ADAPTED TO OTHER SEXUALLY PROPAGATED, DICOTYLEDONOUS HORTICULTURAL CROPS FOR IMPROVEMENTS IN ANY TRAITS THAT NEED TO BE IMPROVED FOR SUSTAINABILITY. THEREFORE, THE RESEARCH DIRECTLY ADDRESSES KEY BARRIERS TO THE DEVELOPMENT OF NOVEL GENE EDITING TECHNOLOGY IN OTHER ECONOMICALLY IMPORTANT HORTICULTURAL CROPS WHICH ARE TRANSFORMATION RECALCITRANT AND CURRENTLY NOT AMENABLE TO GENE EDITING.
$200,000North Carolina State University · · FY2020 · National Institute of Food and Agriculture
RAPID: Exploring Covid-19 RNA Viral Targets By Graph-Theory-Based Modeling
$200,000Tamar Schlick · New York University · · FY2020 · MPS
A Functional Genomics Platform for the de novo Identification of Disease-relevant Alleles
$200,000Judd F Hultquist · Northwestern University At Chicago · R21 · FY2025 · TR
ERI: Enhancing CRISPR-Cas12a-Powered Biosensing Detection of the Microcystin Synthetase Gene for Early Warning of Harmful Algal Blooms Using Magnetic Bead-Based Reporter
$199,999Siwen Wang · Clarkson University · · FY2024 · ENG
Collaborative Research: ENG-BIOTECH: Mechanism-Guided Engineering of Thermophilic CRISPR-Cas13 for Ultrasensitive and Robust RNA Detection
$199,999Xue Gao · University Of Pennsylvania · · FY2024 · ENG
Collaborative Research: ENG-BIOTECH: Mechanism-Guided Engineering of Thermophilic CRISPR-Cas13 for Ultrasensitive and Robust RNA Detection
$199,997Yang Gao · William Marsh Rice University · · FY2024 · ENG
CRISPR inhibition as an alternate for Cre-loxP
$199,980Melda Onal · Univ Of Arkansas For Med Scis · R21 · FY2020 · AR
Genome Editing by Homologous Recombination to Create HIV Resistant Immune System
$199,958Matthew H Porteus · Stanford University · R01 · FY2015 · AI
Acquisition of a core research microscope for imaging long-term cellular signaling dynamics and optogenetic manipulation
$199,811Adam David Hoppe · South Dakota State University · P20 · FY2023 · GM
Mechanisms of Chromosomal Translocation
$199,741Peter Aplan · Division Of Clinical Sciences - Nci · ZIA · FY2022 · CA
Molecular Mechanisms Underlying Recombination at DNA Double-Strand Breaks and Stalled Replication Forks
$199,730Rodney J. Rothstein · Columbia University Health Sciences · R35 · FY2022 · GM