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84,503 grants matching “bioinformatics”
Systems Biology Core
$822,747Alan A Aderem · Scripps Research Institute, The · U19 · FY2012 · AI
RNAi Screening in Hematopoietic Cells
$822,670Iain Fraser · National Institute Of Allergy And Infectious Diseases · ZIA · FY2018 · AI
Bioinformatics Core at UCSD
$822,467John C Wooley · Scripps Research Institute, The · U54 · FY2013 · GM
Administrative Core
$822,420Konstantin G Kousoulas · Louisiana State Univ A&M Col Baton Rouge · P20 · FY2025 · GM
A Community Zebrafish Resource for Modeling GWAS Biology
$822,405Calum A. Macrae · Brigham And Women'S Hospital · R24 · FY2016 · OD
Viral and host determinants of donor-specific anti-HIV/SIV immunity mediated by APOBEC3-enzyme
$822,404Diako Ebrahimi · Texas Biomedical Research Institute · R01 · FY2025 · AI
Diverse drug lead compounds from bacterial symbionts in tropical marine mollusks
$822,315Margo Genevieve Haygood · Oregon Health & Science University · U01 · FY2009 · TW
Leadership, Planning and Evaluation
$822,283Robert H Vonderheide · University Of Pennsylvania · P30 · FY2022 · CA
Cell-cell and cell-matrix interactions driving progressive fibrosis in interstitial lung diseases
$822,275Brigitte N Gomperts · University Of California Los Angeles · U01 · FY2024 · HL
The contribution folate and vitamin B12 genes to disease.
$822,181Lawrence Brody · National Human Genome Research Institute · ZIA · FY2019 · HG
Coordinating Center for Population-based Research to Optimize Cancer Screening (PROSPR) (U24)
$822,171Christopher I Li · Fred Hutchinson Cancer Center · U24 · FY2022 · CA
Genetic Control of Cardiac Development: Congenital Heart Disease Gene Discovery in Drosophila
$822,148Rolf Bodmer · Sanford Burnham Prebys Medical Discovery Institute · R01 · FY2024 · HL
Suicidal Behavior in Mood Disorders:Genes and Intermediate Phenotypes
$822,137Joseph J Mann · New York State Psychiatric Institute Dba Research Foundation For Mental Hygiene, Inc · R01 · FY2009 · MH
Regulation of Oxytocin and Vasopressin Gene Expression in the hypothalamus.
$822,108Harold Gainer · National Institute Of Neurological Disorders And Stroke · ZIA · FY2011 · NS
Microbial Genome Sequencing: Complete Genome Sequences of Green Bacteria
$822,038Donald A Bryant · Pennsylvania State Univ University Park · · FY2005 · BIO
Initiation of immune responses to SARS COV2 in the oral cavity and upper airway
$822,036Sarah C Glover · University Of Mississippi Med Ctr · R01 · FY2022 · DE
Screening Complete TB Proteome for Protective Antigens
$822,028Alan Greener · Gene Therapy Systems, Inc. · R44 · FY2006 · AI
Yale Cooperative Hematology Specialized Core Center
$822,013Diane S. Krause · Yale University · U54 · FY2016 · DK
Structural Genetic Variation in Asthma
$822,008Benjamin Alexander Raby · Brigham And Women'S Hospital · R01 · FY2011 · HL
Named Entity Recognition and Relationship Extraction in Biomedicine
$821,852Zhiyong Lu · National Library Of Medicine · ZIA · FY2013 · LM
Generation of Hematopoietic Stem and Progenitor Cells from Human iPSCs
$821,757Andre Larochelle · National Heart, Lung, And Blood Institute · ZIA · FY2020 · HL
Gene Therapy for Inherited Blood Disorders
$821,757Andre Larochelle · National Heart, Lung, And Blood Institute · ZIA · FY2020 · HL
GALACTIC COSMIC RAYS (GCR) AND SOLAR PARTICLE EVENTS (SPES) ARE A MAJOR SOURCE OF CARCINOGENIC RISK FOR ASTRONAUTS ON PROLONGED SPACE MISSIONS. LARGE UNCERTAINTIES EXIST IN THE EXACT ESTIMATION OF CANCER RISKS FROM CHARGED PARTICLES DUE TO THE PAUCITY OF EPIDEMIOLOGICAL DATA IN THIS AREA. FURTHERMORE A MECHANISTIC UNDERSTANDING OF GENETIC CHANGES UNDERLYING TRANSFORMATION BY PARTICLE RADIATION IS NECESSARY FOR THE DEVELOPMENT OF APPROPRIATE COUNTERMEASURES. THUS EXPERIMENTAL ANIMAL MODELS THAT CLOSELY MIMIC THE PROCESS OF CARCINOGENESIS IN HUMANS ARE ESSENTIAL FOR ONCOGENIC RISK ASSESSMENT. IN THE COURSE OF OUR CURRENTLY FUNDED 3 YR. NASA PROJECT (2013 2016) WE CHARACTERIZED TWO SENSITIVE AND COMPLEMENTARY MOUSE MODELS THAT CAN BE USED TO ELUCIDATE MOLECULAR MECHANISMS UNDERLYING THE PROCESS OF PARTICLE RADIATION-INDUCED GLIOBLASTOMA (GBM) DEVELOPMENT. GBMS ARE LETHAL BRAIN TUMORS WITH VERY DISMAL PROGNOSIS FOR WHICH RADIATION IS THE ONLY KNOWN RISK FACTOR. GBMS REPRESENT THE THIRD LEADING CAUSE OF CANCER-RELATED DEATH AMONG ADULTS AGED 30 50 YEARS (THE AVERAGE AGE OF ASTRONAUTS) THE MEAN SURVIVAL AFTER DIAGNOSIS BEING ONLY ABOUT 14 MONTHS. GBM WAS THE FIRST CANCER TO BE ANALYZED BY THE CANCER GENOME ATLAS NETWORK (TCGA) AND THE KEY GENETIC ALTERATIONS OCCURRING IN GBM ARE NOW WELL DEFINED. BASED ON THIS INFORMATION WE UTILIZED TRANSGENIC MICE WITH BRAIN-RESTRICTED DELETIONS OF GBM-RELEVANT TUMOR SUPPRESSORS IN LOGICAL COMBINATIONS TO ANALYZE THE PROCESS OF CHARGED PARTICLE-INDUCED CARCINOGENESIS. WE IDENTIFIED AND CHARACTERIZED TWO COMPLEMENTARY MOUSE GBM MODELS THAT WOULD BE IDEAL FOR STUDYING PARTICLE RADIATION-INDUCED CARCINOGENESIS - NESTIN-CRE INK4AB-/-ARF F/F AND NESTIN-CRE P53F/+PTENF/+. THESE MODELS EXHIBIT A LOW FREQUENCY OF SPONTANEOUS GBMS BUT READILY DEVELOP BRAIN TUMORS AFTER EXPOSURE TO HZE PARTICLES WHICH RESEMBLE HUMAN HIGH GRADE GLIOMAS IN THEIR GENETIC AND MOLECULAR SIGNATURES. USING THESE MICE WE HAVE CLEARLY DEMONSTRATED THAT HIGHLINEAR ENERGY TRANSFER (LET) CHARGED PARTICLES HAVE A GREATER TRANSFORMING POTENTIAL COMPARED TO LOW-LET RADIATION AND HAVE CHARACTERIZED THE MOLECULAR EVENTS UNDERLYING FE ION-INDUCED GLIOMAGENESIS IN THESE MODELS THIS WORK SETS THE STAGE FOR QUANTITATIVE STUDIES ON RADIATION QUALITY EFFECTS ON CARCINOGENESIS FOR AN ARRAY OF CHARGED PARTICLES REPRESENTING THE GCR (AS PROPOSED IN AIM 1). THESE CHARGED PARTICLES INDUCE COMPLEX DNA DOUBLE-STRAND BREAKS (DSBS) THE ACCURATE REPAIR OF WHICH IS CRITICAL FOR PREVENTING TRANSFORMATION. OUR MODELS WILL ALSO ALLOW US TO DETERMINE WHICH DSB REPAIR PATHWAY REPRESENTS A MAJOR BARRIER TO CHARGED PARTICLE-INDUCED GLIOMAGENESIS (AS PROPOSED IN AIM 2). THIS INFORMATION WOULD BE FUNDAMENTAL TO THE DEVELOPMENT OF A MECHANISTIC UNDERSTANDING OF CHARGED PARTICLE-INDUCED CARCINOGENESIS. WE WILL CROSS THE TRANSGENIC MICE CHARACTERIZED BY US WITH MICE HARBORING BRAIN-SPECIFIC ABLATION OF NON-HOMOLOGOUS END JOINING (NHEJ) OR HOMOLOGOUS RECOMBINATION (HR) REPAIR PATHWAYS - NESTIN-CRE LIGASE4F/F AND NESTIN-CRE BRCA2F/F THAT WERE ESTABLISHED IN THE LABORATORY OF PROF. PETER MCKINNON (COLLABORATOR ON PROJECT). FINALLY GENOMIC AND BIOINFORMATICS ANALYSES WILL BE USED TO DEFINE GENETIC SIGNATURES UNIQUE TO PARTICLE-RADIATION INDUCED GLIOBLASTOMAS AND TO DELINEATE KEY PATHWAYS THAT ARE DE-REGULATED DURING HZEINDUCED GLIOMAGENESIS (AS PROPOSED IN AIM 3). WE ARE HOPEFUL THAT AN IN-DEPTH MECHANISTIC ANALYSIS OF CHARGED PARTICLE-INDUCED GLIOMAGENESIS IN THESE VALIDATED MOUSE MODELS WILL HELP US TO MAKE SIGNIFICANT PROGRESS TOWARDS CANCER RISK ASSESSMENTS AND DEVELOPMENT OF PROTECTIVE STRATEGIES FOR CHARGED PARTICLE EXPOSURE.
$821,751The University Of Texas Health Science Center At San Antonio · · FY2020 · National Aeronautics and Space Administration
Carver Genomic Research Center (CGRC)-Building Next Generation Genomic Data Scientist in Rural Alabama
$821,733Deepa Bedi · Tuskegee University · UG3 · FY2024 · HG
Immune epigenetic biomarkers of survival in glioma epidemiology
$821,594John K. Wiencke · University Of California, San Francisco · R01 · FY2019 · CA