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38,696 grants matching “als”
The Molecular, Cellular, and Genetic characterization of Human Adipose Tissue and its Role in Metabolism
$440,255Aaron Cypess · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2025 · DK
Detecting Crack and Other Cocaine Use With FastPatches
$440,249Social Sciences Innovations Corporation · R44 · FY2005 · DA
Computational Tools for Proteomics
$440,054Mark Knepper · National Heart, Lung, And Blood Institute · ZIA · FY2016 · HL
Pharmacologic inhibition of ribonucleoprotein droplet maturation
$440,000Allan Chris Ferreon · Baylor College Of Medicine · R21 · FY2019 · NS
Using EPIS in the Iterative Development of Outreach Materials and Support Group Curricula for Families of Children with DLD
$440,000Amanda Jean Owen Van Horne · University Of Delaware · R21 · FY2025 · DC
Profiles of Common and Unique aspects of Upper Motor Neuron degeneration in HSP and ALS
$440,000Pembe Hande Ozdinler · Northwestern University At Chicago · R21 · FY2022 · NS
Center for Integrative Biomedical Computing
$439,945Christopher R. Johnson · University Of Utah · P41 · FY2011 · RR
Clinical Research Sites for the Network of Excellence in Neuroscience Clinical Trials (NeuroNEXT sites) (U24 Clinical Trial Not Allowed)
$439,931Karen S Marder · Columbia University Health Sciences · U24 · FY2025 · NS
Reinforcing Therapist Performance
$439,927Bryan R Garner · Chestnut Health Systems, Inc. · R01 · FY2008 · AA
Computational Population Genetics
$439,926Andrew D Kern · University Of Oregon · R35 · FY2023 · GM
TOPOGRAPHY AND GENETICS OF SMOKING AND NICOTINE DEPENDENCE IN AMERICAN INDIANS
$439,907Jeffrey A Henderson · University Of Washington · P50 · FY2011 · CA
fcMRI in Infants at High Risk for Autism
$439,808John R Pruett · Washington University · R01 · FY2015 · MH
Structural and functional analyses of the RIG-I filament in innate immunity
$439,792Sun Hur · Boston Children'S Hospital · R01 · FY2014 · AI
EXECUTIVE SUMMARY WE RECENTLY DEMONSTRATED THE POTENTIAL APPLICATION OF AN INNOVATIVE ELECTROSTATIC ANALYZER (ESA) WITH VARIABLE RADIUS OF CURVATURE THAT INCREASES SENSITIVITY OF A SUPRATHERMAL ION INSTRUMENT(ALLEGRINI ET AL. REV. SCI. INSTRUM. 2009; ALLEGRINI ET AL. J. GEOPHYS. RES. 2016). THE ADVANCED MASS AND IONIC CHARGE COMPOSITION EXPERIMENT (AMICCE) COMBINES THIS ESA WITH A PROVEN DESIGN FOR MEASURING TIME-OF- FLIGHT (TOF) AND RESIDUAL ENERGY (E) TO UNIQUELY DETERMINE ELEMENTAL ISOTOPIC AND IONIC CHARGE COMPOSITION OVER A WIDE ENERGY RANGE. AMICCE WILL MEASURE IONIC CHARGE STATES OF HEAVY IONS (HE-FE; 10-500 KEV/Q) WITH RESOLUTION OF ?Q/Q0.2. THE ESA USES ONLY FOUR VOLTAGE STEPS TO COVER THE ENTIRE E/Q RANGE DECREASING DUTY CYCLE AND YIELDING NEARLY 10X SENSITIVITY GAIN OVER CURRENT SUPRATHERMAL ION INSTRUMENTS. AMICCE HAS MASS RESOLUTION ?M/M0.15 TO SEPARATE RARE ISOTOPES LIKE 3HE FROM THE MORE ABUNDANT 4HE. WE PROPOSE TO ENHANCE AMICCE S CAPABILITIES WITH A HIGH ENERGY CHANNEL USING ITS ORIGINAL TOF SECTION TO MEASURE ISOTOPIC AND ELEMENTAL COMPOSITION OF IONS FROM ~0.1 5 MEV/NUCLEON. THE NEW TOF-E DESIGN COMBINES TWO CHANNELS: 1) LO FOR SUPRATHERMAL IONS (DESCRIBED ABOVE) AND 2) HI FOR ENERGETIC PARTICLES ENTERING THE TOF-E SECTION THROUGH A COLLIMATOR AND C-FOIL. THE TOF DESIGN USES ELECTROSTATIC MIRRORING OF SECONDARY ELECTRONS EMITTED FROM THIN C-FOILS OR SI DETECTORS. THE LO AND HI CHANNELS SHARE THE SAME START AND STOP MCP DETECTORS. ION RESIDUAL ENERGY IS MEASURED WITH AVALANCHE PHOTODIODES (LO) AND SSDS (HI) ENABLING SIMULTANEOUS MEASUREMENT OF 1) IONIC CHARGE STATE ISOTOPIC AND ELEMENTAL COMPOSITION OF THE LARGELY UNEXPLORED SUPRATHERMAL IONS AND 2) ISOTOPIC AND ELEMENTAL COMPOSITION OF HELIOSPHERIC ENERGETIC IONS. OBJECTIVES AND METHODOLOGY THE GOAL IS TO DEMONSTRATE FEASIBILITY OF A DUAL TOF-E SECTION FOR AMICCE. WE HAVE A FULLY CHARACTERIZED PROTOTYPE OF THE ESA AND A PARTIAL PROTOTYPE OF THE TOF SECTION. WE THEREFORE DEFINE THREE OBJECTIVES: 1. ELECTRO-OPTICS DESIGN AND MODIFICATIONS TO PROTOTYPE: INCORPORATE THE HI CHANNEL INTO THE CURRENT TOF DESIGN ITERATE THE DESIGN AND FABRICATE THE MODIFIED PARTS. WE LL USE SIMION FOR ELECTRO-OPTICS SIMULATION. 2. TOF-E TEST AND CHARACTERIZATION: TEST AND CHARACTERIZE THE TOF-E SECTION WITH ION BEAMS (H THROUGH FE ~5 TO 450 KEV/Q) MEASURING TOF AND RESIDUAL ENERGY FOR BOTH LO AND HI CHANNELS. 3. AMICCE TEST AND CHARACTERIZATION: PERFORM END-TO-END TEST OF THE FULL AMICCE PROTOTYPE (ESA MOUNTED TO THE TOF-E SECTION) CHARACTERIZING ITS RESPONSE TO KNOWN ION BEAMS. RELEVANCE TO NASA AND THE SCIENCE COMMUNITY AN AMICCE-TYPE FLIGHT INSTRUMENT WILL ADVANCE UNDERSTANDING OF THE POORLY EXPLORED SUPRATHERMAL PARTICLE POPULATION AND THEREFORE OF PROCESSES THAT ACCELERATE PARTICLES DURING SEP EVENTS AND THAT GOVERN THEIR TRANSPORT THROUGH THE SOLAR CORONA AND HELIOSPHERE. AMICCE WILL SATISFY THE REQUIREMENTS OF SUPRATHERMAL AND ENERGETIC PARTICLE INSTRUMENTS TO ADDRESS NASA S STRATEGIC OBJECTIVE TO UNDERSTAND THE SUN AND ITS INTERACTIONS WITH EARTH AND THE SOLAR SYSTEM INCLUDING SPACE WEATHER. UNDERSTANDING THE SUPRATHERMAL POPULATION DIRECTLY ADDRESSES AIMS OF THE 2014 ROADMAP INCLUDING: UNDERSTAND THE PLASMA PROCESSES THAT ACCELERATE AND TRANSPORT PARTICLES (F2) UNDERSTANDING THE ROLE OF THE SUN AND ITS VARIABILITY IN DRIVING CHANGE IN THE EARTH S ATMOSPHERE THE SPACE ENVIRONMENT AND PLANETARY OBJECTS (H2) DETERMINE THE INTERACTION OF THE SUN WITH THE SOLAR SYSTEM AND THE INTERSTELLAR MEDIUM (GOAL 3) AND DISCOVER AND CHARACTERIZE FUNDAMENTAL PROCESSES THAT OCCUR BOTH WITHIN THE HELIOSPHERE AND THROUGHOUT THE UNIVERSE (GOAL 4). THIS PROPOSAL IS WITHIN THE SCOPE OF THE H-TIDES PROGRAM IMPROVING PERFORMANCE OF AN EXISTING INSTRUMENT CONCEPT BY COMBINING THE LO AND HI CHANNELS INTO A SINGLE DETECTOR SECTION SAVING MASS AND POWER AND PROVIDING HIGHER SENSITIVITY THAN PRESENT INSTRUMENTS IN A SIMILAR ENERGY RANGE.
$439,650Southwest Research Institute · · FY2020 · National Aeronautics and Space Administration
Characterization of Serum Extracellular Vesicles with Human Age
$439,622Michele K Evans · National Institute On Aging · ZIA · FY2018 · AG
The role of Spo11 in mammalian meiosis
$439,616Rafael Camerini-Otero · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2013 · DK
Scientific Core: Perturb-seq library generation, sequencing, and data analysis
$439,599Jesse M Engreitz · Stanford University · P01 · FY2025 · HL
Efficacy Evaluation of Transdiagnostic CBT for Comorbid Alcohol Use and Anxiety Disorder
$439,583Todd J. Farchione · Boston University (Charles River Campus) · R01 · FY2020 · AA
Efficacy Evaluation of Transdiagnostic CBT for Comorbid Alcohol Use and Anxiety Disorder
$439,583Todd J. Farchione · Boston University (Charles River Campus) · R01 · FY2018 · AA
Efficacy Evaluation of Transdiagnostic CBT for Comorbid Alcohol Use and Anxiety Disorder
$439,583Todd J. Farchione · Boston University (Charles River Campus) · R01 · FY2019 · AA
Deciphering the tumor suppressive functions of macroH2A
$439,563Emily Bernstein · Icahn School Of Medicine At Mount Sinai · R01 · FY2017 · CA
State-dependent modulation of retinothalamic axonal boutons
$439,500Mark L Andermann · Beth Israel Deaconess Medical Center · R01 · FY2024 · EY
State-dependent modulation of retinothalamic axonal boutons
$439,500Mark L Andermann · Beth Israel Deaconess Medical Center · R01 · FY2023 · EY
Identifying Optimal, Translatable Tobacco Cessation Interention Components
$439,454Timothy B Baker · University Of Wisconsin-Madison · P50 · FY2012 · CA
Senescence, Proliferation and Invasion- What is the link?
$439,301Ashani Weeraratna · National Institute On Aging · Z01 · FY2008 · AG