Computational Tools for Proteomics

$440,054ZIAFY2016HLNIH

National Heart, Lung, And Blood Institute

Investigators

Linked publications & trials

Paper 39032602 Paper 39024358 Paper 38374071 Paper 38234298 Paper 38205543 Paper 37916285 Paper 37328470 Paper 37114282 Paper 36758122 Paper 36727945 Paper 36571566 Paper 35918145 Paper 35907887 Paper 35858400 Paper 35659261 Paper 34757121 Paper 34579536 Paper 34308668 Paper 34191628 Paper 34029142 Paper 33769951 Paper 33769948 Paper 33346914 Paper 33213365 Paper 33017189 Paper 32245905 Paper 32219907 Paper 31318409 Paper 31313956 Paper 31253652 Paper 31146973 Paper 30826016 Paper 30808967 Paper 30377224 Paper 30182799 Paper 30089029 Paper 29932826 Paper 29854824 Paper 29572403 Paper 29408997 Paper 29046292 Paper 28843412 Paper 28701313 Paper 28336531 Paper 28298358 Paper 28039431 Paper 27974320 Paper 27784696 Paper 27725713 Paper 27279488 Paper 27199454 Paper 26884507 Paper 26779425 Paper 26584918 Paper 26508704 Paper 26310817 Paper 26310816 Paper 25893597 Paper 25830425 Paper 25817355 Paper 25355853 Paper 25328345 Paper 25088762 Paper 25066408 Paper 25056354 Paper 25045604 Paper 24786704 Paper 24598363 Paper 24565028 Paper 24429064 Paper 24386107 Paper 24305472 Paper 24277952 Paper 24259510 Paper 24085853 Paper 24029424 Paper 23728001 Paper 23584881 Paper 23527152 Paper 23471519 Paper 23471471 Paper 23428628 Paper 23136001 Paper 23130944 Paper 23001821 Paper 22992673 Paper 22932685 Paper 22723110 Paper 22647629 Paper 22641613 Paper 22440904 Paper 22114206 Paper 22108457 Paper 21956165 Paper 21940666 Paper 21881557 Paper 21525134 Paper 21501009 Paper 21209370 Paper 20940332

Abstract

We have developed software for phosphoproteomic site-assignment and for clustering of dynamic data. We have also developed and published software to aid in the design of peptide-directed and fusion protein-directed antibodies called <i>NHLBI-AbDesigner</i> (http://helixweb.nih.gov/AbDesigner/). A paper describing this tool and illustrating its use has been published (Pisitkun et al. PMID: 21956165). A second paper describing its application to development of antibodies for several glomerular marker proteins has also been published (Pisitkun et al. PMID: 25328345). NHLBI-AbDesigner is currently utilized by many commercial antibody production companies. An expansion of AbDesigner is under development. We have also developed software called <i>PhosphoLogo</i> to produce sequence logos from phosphoproteomic data. Current efforts are aimed at the development of practical tools for application of Bayesian statistical approaches, data-mining approaches, and machine learning to large-scale physiological data. A list of available software programs can be found at http://helixweb.nih.gov/ESBL/. We have also developed several databases of proteomic and transcriptomic data to be used in kidney research (http://helixweb.nih.gov/ESBL/Database/index.html). Tools are under development for cross-referencing these databases for studies in integrative biology that are based on the Big Data concept.

View original record on NIH RePORTER →