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17,054 grants matching “genome editing”
Environmentally-modulated cytosine deamination in genome instability and cancer
$300,173Steven A Roberts · Washington State University · R00 · FY2017 · ES
Training of the Pediatric Physician-Scientist
$300,167Gary Arthur Silverman · Washington University · T32 · FY2022 · HD
Project 3
$300,058Todd Michael Brusko · University Of Florida · P01 · FY2023 · AI
Beyond cell shape: Actin exerts systems-level control during morphogenesis
$300,039Anna Sokac · University Of Illinois At Urbana-Champaign · R01 · FY2019 · GM
EAGER: spRNA-seq: high-throughput transcriptome analysis of single plastids
$300,000Meng Chen · University Of California-Riverside · · FY2020 · BIO
Multi-organism platform for functional analysis of Undiagnosed Diseases Network (UDN) variants
$300,000Lilianna Solnica-Krezel · Washington University · U54 · FY2021 · NS
Collaborative Research: PlantTransform: Novel methods of plant genome editing enabled by the parasitic plant Cuscuta campestris
$300,000Michael J Axtell · Pennsylvania State Univ University Park · · FY2024 · BIO
A MAJORITY OF WINE AND TABLE GRAPE CULTIVARS CURRENTLY CULTIVATED WORLDWIDE HAVE BEEN GROWN FOR CENTURIES AND ARE PROPAGATED THROUGH ASEXUAL/CLONAL MEANS USING CUTTINGS, GRAFTING OR BUDDING. ALTHOUGH THESE CULTIVARS POSSESS HIGHLY DESIRABLE VITICULTURAL AND ENOLOGICAL CHARACTERISTICS, THEY ARE EXTREMELY SUSCEPTIBLE TO A NUMBER OF BIOTIC STRESSES INCLUDING FUNGAL, BACTERIAL AND VIRAL DISEASES. THE HETEROZYGOUS NATURE OF THE GRAPEVINE GENOME AND SEVERE INBREEDING DEPRESSION LIMITS TRAIT IMPROVEMENT IN COMMERCIAL GRAPEVINE CULTIVARS WITHOUT CAUSING MAJOR DISRUPTIONS IN EXISTING CHARACTERISTICS. THUS IT IS DIFFICULT TO IMPROVE EXISTING CULTIVARS FOR DESIRED TRAITS SUCH AS DISEASE RESISTANCE. IMPROVEMENTS IN GRAPE PRODUCTIVITY AND QUALITY ARE POSSIBLE WITH A BETTER UNDERSTANDING OF THE MOLECULAR GENETICS OF VINE RESPONSE TO BIOTIC STRESS IN CONCERT WITH GENOME EDITING TECHNOLOGY FOR RAPID DEVELOPMENT OF NEW CULTIVARS. GENOME EDITING TECHNOLOGIES NOW MAKE IT POSSIBLE TO IMPROVE SPECIFIC TRAITS IN GRAPE CULTIVARS WHILE KEEPING EXISTING DESIRABLE CHARACTERISTICS INTACT. WE HYPOTHESIZE THAT DEVELOPMENT OF TRANSIENT GENE EXPRESSION/GENOME EDITING SYSTEMS CAN ENABLE RAPID TRAIT IMPROVEMENT IN GRAPEVINE WITHOUT THE INSERTION AND INTEGRATION OF FOREIGN DNA SEQUENCES IN RESULTING CULTIVARS. SUCH CULTIVARS ARE EXPECTED TO BE REGULATED IN A MANNER SIMILAR TO THOSE OBTAINED THROUGH CONVENTIONAL BREEDING AND WILL HELP OVERCOME CUMBERSOME REGULATORY PROCEDURES THAT ARE CURRENTLY APPLIED TO COMMERCIALIZATION OF GENETICALLY MODIFIED CROPS.
$300,000University Of Maryland Es · · FY2021 · National Institute of Food and Agriculture
THIS PROJECT SEEKS TO IMPROVE THE EFFICIENCY OF PRODUCING NON-MOSAIC KNOCKOUTS, AND KNOCK-INS, USING GENOME EDITING IN FOUR MAMMALIAN FOOD ANIMAL SPECIES (BOVINE, OVINE, CAPRINE AND PORCINE). THE PROPOSED APPROACH SEEKS TO AVOID THE INEFFICIENCIES ASSOCIATED WITH THE USE OF SCNT, CPI OF EDITING REAGENTS INTO ZYGOTES, AND THE PRODUCTION OF MOSAIC OFFSPRING. THESE METHODOLOGIES AND THEIR INHERENT PROBLEMS CURRENTLY LIMIT THE SCALABILITY OF GENOME EDITING IN LIVESTOCK. OUTCOMES OF THIS PROPOSAL WILL INCLUDE AN ELECTROPORATION-BASED PROTOCOL FOR THE RAPID INTRODUCTION OF INTENDED GENOMIC ALTERATIONS VIA GENOME EDITING IN FOUR MAJOR MAMMALIAN FOOD ANIMAL (BOVINE, OVINE, CAPRINE AND PORCINE) SPECIES. OUR ABILITY TO WORK IN FOUR SPECIES WILL SPEED APPLICATION OF RESULTS IN THE MAIN LIVESTOCK SPECIES.
$300,000University Of California, Davis · · FY2020 · National Institute of Food and Agriculture
WITH THE GROWING GLOBAL DEMAND FOR SUSTAINABLE AND EFFICIENT FOOD PRODUCTION, THIS PROJECT AIMS TO ADDRESS KEY CHALLENGES IN LIVESTOCK FARMING TO IMPROVE DISEASE RESISTANCE AND WELFAREBY ADVANCING GENE EDITING AND GENETIC ENGINEERING TECHNOLOGIES. THE RESEARCH FOCUSES ON USING PRIME EDITING, A PRECISE AND INNOVATIVE GENOME-EDITING TOOL, TO INTRODUCE BENEFICIAL TRAITS SUCH AS DISEASE RESISTANCE AND HORNLESSNESS IN LIVESTOCK ANIMALS, SPECIFICALLY SHEEP AND CATTLE. BY OPTIMIZING THESE TOOLS, THE PROJECT SEEKS TO REDUCE OR ELIMINATE THE RISKS ASSOCIATED WITH UNINTENDED GENETIC CHANGES, THEREBY MAKING GENETIC ENGINEERING SAFER AND MORE APPLICABLE FOR AGRICULTURAL USE. THESE ADVANCEMENTS WILL NOT ONLY IMPROVE LIVESTOCK HEALTH AND PRODUCTIVITY BUT ALSO ENHANCE ANIMAL WELFARE BY REDUCING THE NEED FOR INVASIVE MANAGEMENT PRACTICES, SUCH AS DEHORNING. THE OUTCOMES OF THIS PROJECT ARE EXPECTED TO CONTRIBUTE TO GLOBAL FOOD SECURITY AND SUSTAINABILITY BY ENABLING MORE ETHICAL ANIMAL MANAGEMENT AND MORE EFFICIENT LIVESTOCK PRODUCTION.
$300,000Utah State University · · FY2025 · National Institute of Food and Agriculture
In vivo Sickle Cell Disease Gene Therapy Using a Novel Virus Like Particle
$300,000David Scott Johnson · Gigamune, Inc. · R43 · FY2024 · HL
BTT EAGER: Clean genome editing through the use of nonintegrating T-DNA technology
$300,000Stanton B Gelvin · Purdue University · · FY2019 · BIO
EAGER: Enabling Efficient Genome Editing for Advanced Biomanufacturing Applications
$300,000Kelvin H Lee · University Of Delaware · · FY2015 · BIO
EDGE: Expanding the functional genetics toolkit to link genes to phenotypes in cichlid fish
$300,000Scott A Juntti · University Of Maryland, College Park · · FY2018 · BIO
Development of STAR Editors (CRISPR-Cas9/lgRNA-ssDNA) for the cure of chronic hepatitis B
$300,000Minghong Zhong · Genelancet Biosciences Inc · R43 · FY2022 · AI
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** BIOLOGICAL NITROGEN FIXATION IN ROOT NODULES OF SOYBEAN HELPS REDUCE THE NEED FOR EXPENSIVE, ENERGY-INTENSIVE, AND ENVIRONMENTALLY DAMAGING SYNTHETIC NITROGEN FERTILIZERS. NODULE NITROGEN SUPPLY PEAKS DURING EARLY REPRODUCTIVE STAGES (R1-R3) AND DECLINES THEREAFTER, WHEREAS GRAIN NITROGEN DEMAND INCREASES IN THE LATER REPRODUCTIVE STAGES (R5-R7). THEREFORE, HIGH-YIELDING SOYBEAN VARIETIES TAKE UP NITROGEN FROM THE SOIL, DEPLETING SOIL NITROGEN RESERVES THAT WOULD OTHERWISE BE AVAILABLE FOR THE FUTURE CROPS NECESSITATING RESEARCH TO INCREASE NODULE NITROGEN SUPPLY IN LATER REPRODUCTIVE STAGES. WE HYPOTHESIZE THAT SOYBEAN GENOTYPES WITH A HIGHER NUMBER OF NODULES WITH DELAYED MATURATION CAN CONTINUE TO FIX NITROGEN AT THESE REPRODUCTIVE STAGES AND HELP MEET NITROGEN NEEDS IN A SUSTAINABLE MANNER. PRIOR RESULTS AND PRELIMINARY DATA FROM THE PD'S LABORATORY AS WELL AS THOSE FROM OTHER RESEARCH SUGGEST THAT ALTERING THE BALANCE BETWEEN TWO PLANT HORMONES AUXIN AND CYTOKININ CAN LEAD TO HIGHER NODULE NUMBERS WITH DELAYED MATURITY. THIS RESEARCH PROJECT WILL (1) EVALUATE GENOME SEQUENCES OF 1,110 ACCESSIONS FROM THE USDA SOYBEAN GERMPLASM COLLECTION TO IDENTIFY NATURAL GENETIC VARIANTS IN GENES ASSOCIATED WITH AUXIN AND CYTOKININ BIOSYNTHESIS, (2) VALIDATE THEIR ROLES THOROUGH GENOME EDITING AND LABORATORY ANALYSIS, AND (3) CHARACTERIZE SOYBEAN GERMPLASM WITH SPECIFIC GENETIC MODIFICATION FOR OPTIMAL NITROGEN FIXATION. THE ACCESSIONS OR DERIVATIVES INCLUDING KNOWLEDGE WOULD HELP DEVELOP SOYBEAN VARIETIES WITH OPTIMAL NITROGEN FIXATION THAT DO NOT DEPLETE SOIL NITROGEN OR REQUIRED ADDITIONAL NITROGEN FERTILIZER APPLICATION.
$300,000South Dakota State University · · FY2024 · National Institute of Food and Agriculture
Defining a molecular mechanism for paralogous compensation
$300,000Richard Cripps · University Of New Mexico · · FY2017 · BIO
Integrative computational-experimental approaches to stratify monogenic disease risk
$300,000Christopher Cassa · Brigham And Women'S Hospital · R56 · FY2023 · HG
EAGER: PUF-based Probe Design for Secure Access to DNA Storage
$300,000Leonidas Bleris · University Of Texas At Dallas · · FY2023 · ENG
GENOME EDITING FOR IMPROVING WHEAT YIELD AND YIELD-RELATED TRAITS
$300,000Kansas State University · · FY2017 · National Institute of Food and Agriculture
EAGER: Multimodal AI for Elucidating Genome Structure-Function Relationships in Human Brain Cells
$300,000Bin Zhang · Massachusetts Institute Of Technology · · FY2025 · BIO
THE CRISPR (CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS)/CAS (CRISPR-ASSOCIATED PROTEIN) SYSTEM HAS EMERGED AS A POWERFUL TOOL FOR GENOME EDITING AND GENETIC ENGINEERING DUE TO ITS SIMPLICITY, VERSATILITY AND BROAD APPLICABILITY. IN CONTRAST TO THE RAPID PROGRESS AND BROAD APPLICATIONS OF CRISPR/CAS TECHNOLOGIES IN BIOMEDICAL AND PLANT FIELDS, ONLY LIMITED CRISPR/CAS GENOME EDITING TOOLKITS HAVE BEEN TESTED AND AVAILABLE FOR PLANT PATHOGENIC FUNGI. THE OVERARCHING GOAL OF THIS PROJECT IS TO DEVELOP AND IMPROVE BIOINFORMATIC DATABASES AND CRISPR/CAS9 TOOLKITS FOR GUIDE RNA (GRNA) DESIGN AND GENOME EDITING IN PLANT PATHOGENIC FUNGI. THIS PROJECT WILL LEAD TO A SEARCHABLE DATABASE AND WEBSITE FOR FUNGAL GRNA DESIGN AND IMPROVED CRISPR/CAS9 GENOME EDITING TOOLKITS, WHICH ARE EXPECTED TO BENEFIT THE FUNGAL RESEARCH COMMUNITY AND ACCELERATE FUNCTIONAL GENOMICS ANALYSIS AND MECHANISTIC ELUCIDATION OF FUNGAL PATHOGENESIS.
$300,000The Pennsylvania State University · · FY2020 · National Institute of Food and Agriculture
EAGER: A Transformative Technology for Producing Transgenic Maize: Pollen Magnetofection
$300,000John E Fowler · Oregon State University · · FY2018 · BIO
THE MAJOR APPROACHES TO PLANT GENOME EDITING STILL REQUIRE PLANT TRANSFORMATION TO INTRODUCE THE REAGENTS REQUIRED FOR GENE EDITING INTO THE TARGET PLANT SPECIES. SORGHUM IS IMPORTANT FOR GRAIN AND FORAGE PRODUCTION AND BOTH SORGHUM AND SWITCHGRASS ARE IMPORTANT FEEDSTOCKS FOR BIOENERGY PRODUCTION. BOTH SPECIES CAN BE TRANSFORMED BY AGROBACTERIUM, BUT THE PROCESS IS CHALLENGING AND GENOTYPE-DEPENDENT, AND THUS, THE FULL POTENTIAL OF GENOME EDITING CANNOT YET BE FULLY REALIZED. THIS PROJECT PROPOSES TO USE VIRUSES TO OVERCOME THE TISSUE CULTURE BARRIER TO EDIT PLANT GENES. VIRUSES ARE NATURAL GENE DELIVERY VEHICLES THAT ARE USED TO EXPRESS PROTEINS AND NON-CODING SEQUENCES IN PLANTS AS THEY GROW AND DEVELOP, AND ARE THUS SUITABLE FOR DELIVERING GENE EDITING REAGENTS. THE METHODS TO BE DEVELOPED ARE EXPECTED TO SIMPLIFY AND ACCELERATE GENE EDITING APPLICATIONS IN SORGHUM AND SWITCHGRASS, WHICH WILL ENABLE MORE RAPID PROGRESS IN IMPROVING AGRICULTURAL TRAITS RELATED TO YIELD, STRESS ANDDISEASE RESISTANCE, NUTRIENT USE EFFICIENCY, AND END-USE APPLICATIONS.
$300,000Iowa State University Of Science And Technology · · FY2020 · National Institute of Food and Agriculture
CCR5 immunotoxins as components of HIV cure regimens
$300,000Dennis J Hartigan-O'Connor · Tendel Therapies Inc. · R41 · FY2022 · AI