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65,743 grants matching “single cell sequencing”
Modeling functional genomics of susceptibility to the persistent effects of environmental toxins in an elderly rural Indiana neurodegenerative cohort
$742,044Aaron B Bowman · Purdue University · R01 · FY2024 · AG
Studies in the Pathogenesis of Systemic Capillary Leak Syndrome
$742,042Kirk Druey · National Institute Of Allergy And Infectious Diseases · ZIA · FY2021 · AI
Mechanism of estrogen independent proliferation in ER+ breast cancer cells
$742,035Andrea Hope Bild · Beckman Research Institute/City Of Hope · U01 · FY2022 · CA
Developing Informatics Technologies to Model Cancer Gene Regulation
$742,021Clifford Meyer · Dana-Farber Cancer Inst · U24 · FY2021 · CA
Hydrogel microparticle technology for high-throughout screening of chimeric antigen receptor-T cells based on single cell effector function
$741,926Joseph De Rutte · Partillion Bioscience Corporation · R44 · FY2024 · GM
Role of inflammation, innate resistance, and immunity in carcinogenesis
$741,872Giorgio Trinchieri · Division Of Basic Sciences - Nci · ZIA · FY2022 · CA
Microphysiological Model of Human Cardiac Sympathetic Innervation
$741,815Deok-Ho Kim · Johns Hopkins University · R01 · FY2022 · HL
Initiation of immune responses to SARS COV2 in the oral cavity and upper airway
$741,811Sarah C Glover · Tulane University Of Louisiana · R01 · FY2025 · DE
Cell Identity Determination In Human Brain: Somatic mutation and cell lineage
$741,754Christopher A Walsh · Boston Children'S Hospital · R01 · FY2020 · NS
Transcriptomic and Circuitry Aberrations in Alzheimerâs Disease
$741,733Zhen Yan · State University Of New York At Buffalo · R01 · FY2024 · AG
Involvement Of Human Viruses Associated With Chronic Neurologic Disease
$741,698Steven Jacobson · National Institute Of Neurological Disorders And Stroke · ZIA · FY2023 · NS
Novel coenzyme Q6 variant reveals non-immune determinants of survival during pneumococcal sepsis
$741,695Sharon Celeste Morley · Washington University · R01 · FY2025 · HL
Influence of T cell genotype/phenotype in atherosclerotic cardiovascular disease
$741,684Richard J Gumina · Ohio State University · R01 · FY2023 · HL
WE PROPOSE TO IDENTIFY AND CHARACTERIZE POLYPHOSPHATE ACCUMULATING MICROORGANISMS (PAOS) WITHIN THE RHIZOMICROBIOME AND ELUCIDATE THEIR ROLES AND METABOLIC ACTIVITIES INVOLVED IN SOIL PHOSPHORUS (P) SEQUESTRATION, CYCLING AND PLANT P UPTAKE, WITH THE ULTIMATE GOAL TO EXPLOIT PAOS FOR THEIR MULTIPLE ROLES IN P RECOVERY AND STORAGE TO ENHANCE CROP PRODUCTION. THE SPECIFIC OBJECTIVES ARE: 1) DISCOVER IDENTITY AND FUNCTIONS OF PAOS IN THE RHIZOSPHERE WITH NOVEL FUNCTION-TARGETED PHENOTYPING AND GENOTYPING TECHNIQUES; 2)INVESTIGATING THE POPULATION AND ACTIVITY DYNAMICS OF PAOS IN THE RHIZOSPHERE ACROSS EDAPHIC GRADIENTS, IN RELATION TO PLANT GROWTH AND NUTRITION; 3) EXPLORING PAOS AUGMENTATION FOR ENHANCING BIOAVAILABLE P AND PLANT P UTILIZATION. TO CIRCUMVENT THE LIMITATIONS OF AMPLICON AND SHOTGUN METAGENOMICS SEQUENCING OF HYPERDIVERSE SOIL COMMUNITIES AND TO DEDUCE GENOTYPE-FUNCTION RELATIONSHIPS, WE WILL EMPLOY A NOVEL SEQUENTIAL FLOW CYTOMETRY CELL SORTING AND RAMAN MICROSPECTROSCOPY APPROACH THAT ENABLES PHENOTYPE-BASED CELL SORTING FOLLOWED BY "SINGLE CELL" METAGENOMICS ANALYSIS. THIS WILL ALLOW US TO INVESTIGATE A DIVERSE SELECTION OF AGRICULTURALLY IMPORTANT CROPS IN US TO IDENTIFY CROPS AND SOIL CONDITIONS THAT HAVE ASSOCIATIONS WITH HIGH PAO ABUNDANCE AND ACTIVITY, AND ELUCIDATE THE IMPORTANT AND VERSATILE FUNCTIONS AND ROLES OF POLYPHOSPHATE AND PAOS IN P CYCLE AND PLANT NUTRIENT UTILIZATION THAT PRESENT PROMISES IN ITS BENEFICIAL USE IN AGRICULTURAL ENHANCEMENT. THIS STUDY ADDRESSES FOUR OF THE PRIORITY AREAS IDENTIFIED BY AFRI THAT WILL SUPPORT SUSTAINABLE ANIMAL AND PLANT PRODUCTION PRACTICES THAT WILL, OVER THE LONG-TERM, ACHIEVE THE GOALS OF ACHIEVING ECONOMIC AND SUSTAINABLE AGRICULTURE FOR FOOD SECURITY WITH ENHANCED ENVIRONMENTAL QUALITY AND CONSERVATION OF NATURAL RESOURCE.
$741,681Cornell University · · FY2019 · National Institute of Food and Agriculture
Development of novel therapeutic approaches for treatment of Alveolar Capillary Dysplasia
$741,650Vladimir V Kalinichenko · University Of Arizona · R01 · FY2025 · HL
Defining the Role of Host Factors in Ebola Virus RNA Synthesis
$741,604Douglas J. Lacount · Washington University · P01 · FY2017 · AI
Methods for Genomic Analysis in Heterogeneous Tissues
$741,588Eran Halperin · University Of California Los Angeles · R01 · FY2019 · HG
Project 3: Identifying transcriptional driver genes and targeting transcription in TSC
$741,557David J. Kwiatkowski · Brigham And Women'S Hospital · P01 · FY2024 · CA
Omics analysis of HIV during synthetic opioid exposure
$741,485Jason T Blackard · University Of Cincinnati · R61 · FY2021 · DA
Generating Exogenic Organs for Transplantation without the Use of Immunosuppression
$741,456Clifford J. Steer · University Of Minnesota · R01 · FY2025 · AI
Mammalian L1 retrotransposon replication
$741,454Anthony V. Furano · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2021 · DK
PurSUiT: Biodiversity and Taxonomy of Apicomplexan Blood Parasites Infecting Coral Reef Fishes.
$741,302Paul C Sikkel · University Of Miami · · FY2025 · BIO
Integrated Genetic and Genomic Resources for a Model System
$741,227Nelson B Freimer · University Of California Los Angeles · R01 · FY2012 · OD
Single-Cell Transcriptional and Epigenomic Dissection to Identify Therapeutic Targets for ALS and FTD
$741,221Manolis Kellis · Massachusetts Institute Of Technology · R01 · FY2022 · AG
Multi-omic dissection of the transcriptional, epigenetic, and proteomic signatures of cells infected with latent HIV
$741,176Francisco J. Quintana · Brigham And Women'S Hospital · R01 · FY2024 · AI