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38,696 grants matching “als”
Determinants of End-of-Life Care Experiences among Assisted Living Residents with Alzheimer's Disease and Related Dementia
$524,911Emmanuelle Belanger · Brown University · R01 · FY2023 · AG
Functional studies of DICER1 and Alu RNA in geographic atrophy
$524,861Jayakrishna Ambati · University Of Kentucky · R01 · FY2013 · EY
Development of NMUR2 Antagonists as Novel Analgesics
$524,835Neil Cutshall · Omeros Corporation · R44 · FY2012 · DA
Investigation of ALS caused by mutant CHCHD10
$524,743Teepu Siddique · Northwestern University At Chicago · R01 · FY2016 · NS
3/3 Genomics of Schizophrenia in the South African Xhosa
$524,661Dan Joseph Stein · University Of Cape Town · U01 · FY2025 · MH
Investigating Regulatory Networks that Control Cell Proliferation and Apoptosis
$524,637Kurt Kohn · Division Of Basic Sciences - Nci · ZIA · FY2010 · CA
Rescue of cortical inhibitory synapses following developmental hearing loss
$524,599Dan Harvey Sanes · New York University · R01 · FY2019 · DC
WE PROPOSE TO IMPLEMENT KEY PICKUP ION (PUI) DYNAMICS OUTSIDE THE HELIOPAUSE IN A STATE-OF-THE-ART 3D MODEL OF THE HELIOSPHERE CONSTRAINED BY THE LATEST INTERSTELLAR BOUNDARY EXPLORER (IBEX) OBSERVATIONS IN ORDER TO QUANTIFY THE DOMINANT PHYSICAL PROCESSES GOVERNING PUIS IN THE OUTER HELIOSHEATH (OHS) AND UNDERSTAND THEIR POSSIBLE ROLE IN FORMING THE IBEX RIBBON (MCCOMAS ET AL. 2009). THESE PROCESSES WHICH INCLUDE FIELD LINE PROPAGATION MAGNETIC MIRRORING ADVECTION ADIABATIC ACCELERATION AND SPATIAL RETENTION VIA PITCH ANGLE SCATTERING REGULATE THE DISTRIBUTION OF PUIS IN THE OHS OVER A SPAN OF SEVERAL YEARS AND DEPENDING ON WHICH PROCESSES DOMINATE MAY FORM THE "RIBBON" OF ENA FLUXES DISCOVERED BY IBEX. NUMEROUS MECHANISMS UTILIZING VARIOUS PHYSICAL ASSUMPTIONS HAVE BEEN PROPOSED TO EXPLAIN THE RIBBON'S EXISTENCE (FOR REVIEW MCCOMAS ET AL. 2014; SEE ALSO ISENBERG 2014; GIACALONE&JOKIPII 2015). THE SOURCE OF THE RIBBON VIA SECONDARY ENAS FROM THE OHS HAS RECEIVED MUCH ATTENTION BUT IT HAS MULTIPLE VARIANTS THAT DEPEND ON THE LEVEL OF PITCH ANGLE SCATTERING IN THE OHS. MOREOVER MOST MODELS IMPLEMENT LIMITED DYNAMICS IN THE "STRONG" OR "WEAK" PITCH ANGLE SCATTERING LIMITS WITH SIMPLIFIED ASSUMPTIONS FOR THE SOLAR WIND (SW) AND LOCAL INTERSTELLAR MEDIUM (LISM) PROPERTIES YIELDING VARYING RESULTS. WITHOUT A CONSISTENT IMPLEMENTATION OF ALL KEY PROCESSES IT IS DIFFICULT TO DETERMINE IF EITHER STRONG OR WEAK SCATTERING OF PUIS IN THE OHS ARE A VIABLE SOURCE FOR THE RIBBON. IT IS THE GOAL OF THIS PROPOSAL TO IMPROVE OUR UNDERSTANDING OF THE RELATION BETWEEN PUIS IN THE OHS AND THE IBEX RIBBON BY IMPLEMENTING KEY PHYSICAL PROCESSES IN THE STRONG AND WEAK SCATTERING LIMITS IN A 3D FRAMEWORK. FOCUSING ON THESE LIMITS ALLOWS US TO EXPLORE THE RANGE OF PUI DYNAMICS THAT EXIST OR ARE MISSING IN CURRENT MODELS AND SIMPLIFIES THEIR IMPLEMENTATION IN A 3D SIMULATION.
$524,570The Trustees Of Princeton University · · FY2020 · National Aeronautics and Space Administration
Integrin β4 and Paxillin in EC Focal Adhesion Dynamics and Barrier Responses
$524,543Anne Elizabeth Cress · University Of Arizona · P01 · FY2017 · HL
Core B
$524,455Bjorn E Oskarsson · Mayo Clinic Jacksonville · P01 · FY2021 · NS
Decision Support Training for Advanced Cancer Family Caregivers: The CASCADE Factorial Trial
$524,446James N. Odom · University Of Alabama At Birmingham · R01 · FY2023 · CA
Proteolytic Regulation of Troponin T & Cardiac Function
$524,400Jian-Ping Jin · Wayne State University · R01 · FY2011 · HL
Novel roles of PCSK9 in regulating the tumor immune microenvironment during radiotherapy
$524,375Yunyan Jennifer Jennifer Zhang · Duke University · R01 · FY2023 · CA
Influence of Fitness and Cognitive Training on Brain and Cognition
$524,297Arthur F. Kramer · University Of Illinois At Urbana-Champaign · R37 · FY2011 · AG
A trial of Connecting to prevent drug abuse and risky behaviors in foster teens
$524,284Kevin P Haggerty · University Of Washington · R01 · FY2019 · DA
Role of a lactate-derived signaling metabolite in tissue crosstalk and energy balance
$524,275Jonathan Z Long · Stanford University · R01 · FY2023 · DK
Genomic Screen To Identify Alzheimers Disease Genes
$524,265Duke University · R01 · FY2003 · NS
TMC gene function in sensory hair cells
$524,260Jeffrey R Holt · Boston Children'S Hospital · R01 · FY2019 · DC
Structural-environmental factors, alcohol and HIV risk in Latino migrant laborers
$524,235Kurt C. Organista · University Of California Berkeley · R01 · FY2011 · AA
Burden, depression, and health in dementia caregivers: The role of emotion
$524,112Robert W. Levenson · University Of California Berkeley · R01 · FY2015 · AG
The role of Spo11 in mammalian meiosis
$524,101Rafael Camerini-Otero · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2012 · DK
Understanding SOD1 Kinetics in Amyotrophic Lateral Sclerosis
$524,052Timothy M. Miller · Washington University · R01 · FY2016 · NS
Study the role(s) of p53 in embryonic stem cells
$524,002Jing Huang · Division Of Basic Sciences - Nci · ZIA · FY2013 · CA
Immune Regulation of Neuronal Injury and Repair
$524,000Kathryn Jane Jones · Indiana University Indianapolis · R01 · FY2015 · NS
LIBS BASED TOOL FOR VERIFICATION AND DECONTAMINATION OF SPACECRAFT. IN SOME CASES THE APPROVED CLEANING METHODS PRESCRIBED BY THE NASA PLANETARY PROTECTION OFFICE (PPO) TO MEET THE MAXIMUM BIOLOADING REQUIREMENT ON HIGHER CATEGORY MISSIONS MAY BE NOT BE POSSIBLE WITH CURRENT LIFE-DETECT INSTRUMENTS THAT CARRY BIO CHIPS. THIS IS BECAUSE THE CHIPS CANNOT BE BAKED OR EXPOSED TO CHEMICALS. MOREOVER A HARDWARE RE-CONTAMINATION OF BIOLOGICAL MATERIALS REQUIRES RE-CLEANING WHICH MAY NOT BE PRACTICAL AFTER SYSTEMS INTEGRATION. WE WILL PROPOSE THE APPLICATION OF MULTI-PULSE MODULATED LASER INDUCED BREAKDOWN SPECTROSCOPY (LIBS) TO DESTROY BIOLOGICAL CONTAMINATION WITHOUT SUBSTRATE DAMAGE AND TO CREATE A LIBS SPECTRAL LIBRARY FOR SPACECRAFT MATERIALS THAT WILL ENABLE IN SITU VERIFICATION OF THE DE-CONTAMINATION PROCESS DURING CLEANING. USING THE AEROSPACE CORPORATIONS RENOWNED LASER AND DETECTOR CAPABILITIES COUPLED WITH LASER AMPLITUDE MODULATION AND MULTIPULSE TECHNIQUES ALREADY DEVELOPED WE HAVE ASSEMBLED AN ADVANCED LIBS SYSTEM THAT COULD BE MINIATURIZED AT SOME POINT IN THE FUTURE. WE PLAN TO APPLY THE ADVANCED LIBS SYSTEM TO CREATE A SPECTRAL LIBRARY FOR SPACECRAFT MATERIALS AND KNOWN BIO-CONTAMINATION. KEY GOALS ARE CHARACTERIZING LIBS DAMAGE THRESHOLDS FOR LIKELY SUBSTRATES AND DEVELOPING A SPECTROSCOPIC PROCESS THAT UTILIZES MULTI-COLOR MULTIPULSE AND TIME DOMAIN DELAY EXCITATION TO ACHIEVE THE BEST DETECTION LIMIT FOR VERIFICATION OF REQUIREMENTS AT THE SAME TIME. LIBS (ALSO KNOWN AS EMMA) IS A MICROANALYSIS TOOL THAT OPERATES BY ANALYZING THE SIGNATURE OF THE LASER PRODUCED PLASMA TO CHARACTERIZE THE ELEMENTAL COMPOSITION IN METALS ROCKS (E.G. MARS 2020 ROVER) AND MATERIALS. LIBS RELIES ON FLORESCENCE SPECTROSCOPY WITH ITS INHERENTLY HIGH DETECTION LIMITS. LIBS IS USEFUL BECAUSE ONLY NANO TO PICOGRAMS OF MATERIAL NEED TO BE REMOVED WITH MINIMAL SAMPLE PREPARATION. A KEY BYPRODUCT IS THE FORMATION OF THE PLASMA WHICH THIS PROPOSAL WILL DEMONSTRATE AS A MEANS TO REMOVING BIOLOGICALS FROM SURFACES. IN MOST LIBS TOOLS THE LASER REPETITION RATE IS KEPT LOW TO ALLOW THE PLASMA TO QUENCH BETWEEN LASER SHOTS. THIS INCREASES THE SIGNAL TO NOISE FOR SPECTRUM GATHERING. OUR PROPOSED APPROACH INCORPORATES TIME-DOMAIN MODULATION OF THE LASER REPETITION RATE AND AMPLITUDE TO FEED THE PLASMA FOR BIOLOGICAL REMOVAL WITH IN-BETWEEN SPURTS OF LOWER-REPETITION RATE SPECTRUM GATHERING. MOREOVER WE INTEND TO ENHANCE THE LIBS TECHNIQUE BY FURTHER DEVELOPING OUR DOUBLE PULSE MULTI-COLOR EXPOSURE THAT WILL ALLOW CHARACTERIZATION OF SPECIES THAT ARE DIFFICULT TO IONIZE. THESE RESULTS ARE POSSIBLE BECAUSE THE AEROSPACE CORP HAS DEVELOPED A DEEP KNOWLEDGE BASE IN PRECISE FOCUSED NANOSCALE LASER ABLATION TECHNIQUES THAT IS WORLD CLASS. WE HAVE DESIGNED A LIBS SYSTEM WITH SIGNIFICANTLY MORE VERSATILITY (MULTIPLE WAVELENGTHS AND RELATION RATES) AND POTENTIALLY MUCH LOWER BACKGROUND WITH HIGHER DETECTION LIMITS THEN THAT FOUND IN THE LITERATURE. WE HAVE DEMONSTRATED ITS FUNCTIONAL USE ON AL SI AND KAPTON. WE WILL PROPOSE A PROGRAM TO CONTINUE TO INVESTIGATE WAVELENGTH AND REPETITION RATE EFFECTS TO OPTIMIZE THE SYSTEM FOR VARIOUS MATERIALS AND BIOLOGICAL CONTAMINATES THAT ARE SPECIFIC TO PLANETARY PROTECTION THE GOAL IS TO DEMONSTRATE A CLEANING AND VERIFICATION METHOD FOR PLANETARY PROTECTION REQUIREMENTS THROUGH THE FOLLOWING INVESTIGATION: TEST A NUMBER OF SPACECRAFT MATERIALS AND NATIVE BACTERIA WITH RESULTING SPECTRA COMPARED WITH THAT IN LITERATURE BEGIN TO ESTABLISH A SPECTRAL LIBRARY OF MATERIALS AND A PROCESS FOR OBTAINING THE BEST DETECTION LIMITS QUANTIFY DETECTION LIMITS PURPOSE OUR ADVANCED LIBS SYSTEM WITH SOFTWARE/HARDWARE CONTROL THAT COUPLES LASER AMPLITUDE MODULATION AND MULTIPULSE TECHNIQUES SUCH THAT THEY ARE OPTIMIZED FOR PLANETARY PROTECTION APPLICATIONS.
$523,896The Aerospace Corporation · · FY2020 · National Aeronautics and Space Administration