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38,696 grants matching “als”
Biotyping placebo and treatment-specific responses for precision medicine
$527,651Eva Petkova · New York University School Of Medicine · R01 · FY2020 · MH
Biotyping placebo and treatment-specific responses for precision medicine
$527,651Eva Petkova · New York University School Of Medicine · R01 · FY2019 · MH
Biotyping placebo and treatment-specific responses for precision medicine
$527,651Thaddeus Tarpey · New York University School Of Medicine · R01 · FY2021 · MH
Infant Brain and Behavioral Signatures of Later Emerging Risk for Psychopathology
$527,572Jed Thomas Elison · University Of Minnesota · R01 · FY2017 · MH
Multi-level HIV Prevention for Pregnant Drug Abusers
$527,457Robert Michael Malow · Florida International University · R01 · FY2007 · DA
Adapting an Evidence-Based Program that Improves Oral Hygiene and Health for Assisted Living Residents with Dementia
$527,375Sheryl Zimmerman · Univ Of North Carolina Chapel Hill · R01 · FY2019 · AG
Implicit Attitudes and HIV Risk Behavior in Virtual Environments
$527,331Kerry L Marsh · University Of Connecticut Storrs · R01 · FY2008 · MH
Mechanisms of RNA and Protein Dysregulations in ALS/FTD Associated with FUS and Ubiquilin 2
$527,280Jiou Wang · Johns Hopkins University · R01 · FY2022 · NS
Computer Adapted Standardized Patient Instrument for MI Skills Assessment
$527,269John S Baer · Talaria, Inc. · R42 · FY2008 · DA
Motivating Smokers with Mobility Impairments to Quit Smoking
$527,223Belinda Borrelli · Miriam Hospital · R01 · FY2013 · CA
RNAi-Based Therapy of ALS
$527,212Tariq M Rana · Sanford Burnham Prebys Medical Discovery Institute · R01 · FY2009 · NS
Overview: Multisystemic Approach to Early Math Development and Math Learning Disability
$527,171David C Geary · University Of Missouri-Columbia · P20 · FY2023 · HD
Glycomic Modulation of Inflammaging and Immune Functions during HIV Infection
$527,129Mohamed Abdel Mohsen · Northwestern University At Chicago · R01 · FY2025 · AG
Multidisciplinary Approach to Reduce Injury and Alcohol Use
$527,014Craig A. Field · University Of Texas At Austin · R01 · FY2009 · AA
BUILDING ON PREVIOUSLY FUNDED NASA SUPPORT THE ULTIMATE GOAL OF THIS RESEARCH IS TO IMPROVE ANALYSIS AND PREDICTION OF TROPICAL CYCLONES AND HEAVY RAINFALL THROUGH INTEGRATED ENSEMBLE-BASED DATA ASSIMILATION OF ALL-SKY BRIGHTNESS TEMPERATURE (BT) OBSERVATIONS INTO THE CONVECTION-PERMITTING WEATHER RESEARCH AND FORECAST (WRF) MODEL USING THE PENN STATE UNIVERSITY (PSU) WRF-BASED ENSEMBLE KALMAN FILTER (WRF-ENKF) HURRICANE ANALYSIS AND FORECAST SYSTEM. OBSERVATIONS TO BE ASSIMILATED INCLUDE ALL-SKY BRIGHTNESS TEMPERATURE OBSERVATIONS FROM BOTH NEW-GENERATION HIGH-RESOLUTION POLAR-ORBITING MICROWAVE (E.G. GPM SSMIS) AND GEOSTATIONARY INFRARED (E.G. GOES-R HIMAWARI 8) SENSORS AS WELL AS OTHER IN SITU AND REMOTELY SENSED DATA IN ADDITION TO ALL AVAILABLE ROUTINE OBSERVATIONS AT THE SURFACE AND FROM SOUNDINGS. A FIRST STEP IN OUR EFFECTIVE ASSIMILATION OF ALL-SKY MICROWAVE RADIANCE OBSERVATIONS SUCH AS FROM GPM WAS THE DEVELOPMENT OF MICROPHYSICS-SPECIFIC FORWARD RADIATIVE TRANSFER CAPABILITIES WITHIN THE COMMUNITY RADIATIVE TRANSFER MODEL (CRTM) USING SCATTERING PROPERTY LOOKUP TABLES WITH BOTH SPHERICAL AND NON-SPHERICAL PARTICLES (SIERON ET AL. 2017 2018). THE PRIMARY FOCUS OF THIS CONTINUATION PROPOSAL WILL BE ON THE ADVANCED ANALYSIS AND PREDICTION OF TROPICAL CYCLONES AND HEAVY RAINFALL THROUGH INTEGRATED ASSIMILATION OF ALL-SKY RADIANCES AND IMPROVED UNDERSTANDING AND REPRESENTATION OF MODEL MICROPHYSICAL PROCESSES AND FORWARD RADIATIVE TRANSFER MODELING. MAJOR OBJECTIVES OF THE PROPOSED RESEARCH INCLUDE: 1) FURTHER DEVELOP AND REFINE MICROPHYSICS-CONSISTENT SCATTERING PROPERTY LOOKUP TABLES BY INCLUDING DIFFERENT REPRESENTATIONS OF PARTICLE SHAPES IN THE RADIATIVE TRANSFER MODELING OF MICROWAVE RADIANCES (IN PARTICULAR FOR THE FORWARD MODEL OF GMI) EXPANDING TO SELECTED MICROPHYSICS PARAMETERIZATION SCHEMES AND ASSESSING THE EFFECTIVENESS CROSS-CHANNEL CONSISTENCY AND POTENTIAL BIASES OF USING DIFFERENT COMBINATIONS OF SPHERICAL AND NON-SPHERICAL PARTICLE SHAPES FOR DIFFERENT HYDROMETEORS. 2) FURTHER OPTIMIZE ADVANCED STATISTICAL AND PHYSICALLY-BASED DATA ASSIMILATION ALGORITHMS IN ASSIMILATING ALL-SKY SATELLITE RADIANCES FROM BOTH GEOSTATIONARY INFRARED AND POLAR-ORBITING MICROWAVE REMOTE SENSING OBSERVATIONS (E.G. FROM ABI ON GOES-R AND GMI ON GPM) VIA IMPROVED CHANNEL SELECTION AND SYNTHETIZATION DATA THINNING AND QUALITY CONTROL ASSIMILATION INTERVALS ADAPTIVE COVARIANCE LOCALIZATION AND INFLATION TECHNIQUES ENSEMBLE SIZE AND MODEL RESOLUTION AND REPRESENTATION OF UNCERTAINTIES IN MODEL PHYSICS. 3) WITH INTEGRATED ASSIMILATION OF ALL-SKY RADIANCES AND ALL OTHER APPLICABLE OBSERVATIONS IN HAND PERFORM SYSTEMATIC DETERMINISTIC AND ENSEMBLE PREDICTIONS TO EXAMINE THE PREDICTABILITY OF TROPICAL CYCLONES IN PARTICULAR THE RAPID INTENSIFICATION PROCESS AND HEAVY RAINFALL EVENTS OVER DIFFERENT OCEAN BASINS MOST OF WHICH ARE NOT COVERED BY ROUTINE AIRCRAFT RECONNAISSANCE. 4) PERFORM SYSTEMATIC ENSEMBLE PARAMETER SENSITIVITY EXPERIMENTS WITH SELECTED MICROPHYSICS SCHEMES TO EXAMINE ASSUMPTIONS AND QUANTIFY UNCERTAINTIES IN KEY PHYSICAL PROCESSES AND PARAMETERS IN PARTICULAR WITH REGARDS TO PARTICLE FALL SPEEDS AND PARTICLE SIZE DISTRIBUTIONS AND TO EXPLORE THE POTENTIAL AND EFFECTIVENESS OF ASSIMILATING ALL-SKY RADIANCES IN ESTIMATING THESE PARAMETERS. THE PROPOSED WORK IS RELEVANT TO NASA S CONSTELLATION OF SATELLITES THAT ACQUIRE CRITICAL ATMOSPHERIC DATA. THE PROPOSED RESEARCH IS IN DIRECT RESPONSE TO CATEGORY 2.3 OF THE NRA METHODOLOGY DEVELOPMENT FOR IMPROVED APPLICATION OF SATELLITE DATA PRODUCTS PRIMARILY UNDER THE ANNOUNCED TOPICS: (1) DEVELOPMENT AND IMPLEMENTATION OF DATA ASSIMILATION TECHNIQUES FOR IMPROVED ANALYSES AND FORECASTS OF SIGNIFICANT WEATHER (E.G. TROPICAL CYCLONES AND FLOODS) ; AND (2) QUANTITATIVE ERROR CHARACTERIZATIONS OF PRECIPITATIONAFFECTED RADIANCES AND INSTANTANEOUS PRECIPITATION RATES AND THEIR USE IN WEATHER FORECASTING AND DATA ASSIMILATION SYSTEMS .
$526,986The Pennsylvania State University · · FY2020 · National Aeronautics and Space Administration
Lipid Nutrition and the Brain
$526,979Stanley I Rapoport · National Institute On Aging · Z01 · FY2008 · AG
Mechanisms of BDNF and Glucocorticoid Action
$526,854Moses Victor Chao · New York University School Of Medicine · R01 · FY2011 · MH
Overview: Multisystemic Approach to Early Math Development and Math Learning Disability
$526,849David C Geary · University Of Missouri-Columbia · P20 · FY2024 · HD
Characterization of Neural Stem Cells in Adult Brain
$526,778Arturo Alvarez-Buylla · University Of California, San Francisco · R01 · FY2015 · NS
Characterization of Neural Stem Cells in Adult Brain
$526,778Arturo Alvarez-Buylla · University Of California, San Francisco · R01 · FY2016 · NS
Characterization of Neural Stem Cells in Adult Brain
$526,778Arturo Alvarez-Buylla · University Of California, San Francisco · R01 · FY2018 · NS
Characterization of Neural Stem Cells in Adult Brain
$526,778Arturo Alvarez-Buylla · University Of California, San Francisco · R01 · FY2017 · NS
Spatially Resolved Dynamics of Molecular Pathology and Intercellular Interactions in Amytrophic Lateral Sclerosis
$526,777Hemali Phatnani · New York Genome Center · R01 · FY2024 · NS
THE ISPE A CONSORTIUM ORGANIZED TO CHARACTERIZE THE COLLECTION OF MATERIALS ON THE STARDUST INTERSTELLAR COLLECTOR IDENTIFIED THE IMPACTS OF SEVEN PARTICLES THAT ARE CONSISTENT WITH AN ORIGIN IN THE STREAM OF INTERSTELLAR DUST FROM THE LOCAL ISM. THE ISPE CONSISTED OF SIX COORDINATED EFFORTS: IDENTIFICATION OF IMPACTS IN THE AEROGEL COLLECTORS THROUGH A DISTRIBUTED SEARCH CALLED STARDUST@HOME; EXTRACTION OF CANDIDATE TRACKS; ANALYSES OF CANDIDATES USING SYNCHROTRON-BASED X-RAY AND INFRARED MICROPROBES; IDENTIFICATION AND ANALYSIS OF IMPACTS IN THE AL FOILS OF THE STARDUST COLLECTOR BY SEM IMAGING AND SEM/EDX; LABORATORY HYPERVELOCITY IMPACT EXPERIMENTS OF INTERSTELLAR DUST ANALOGS INTO AEROGEL AND FOILS; AND NUMERICAL MODELING OF INTERSTELLAR DUST PROPAGATION IN THE HELIOSPHERE. SINCE THE END OF THE ISPE MORE LEVEL 1 CANDIDATES HAVE BEEN IDENTIFIED AND ARE CURRENTLY UNDER STUDY. ALSO IN COLLABORATION WITH RHONDA STROUD AND BRAD DE GREGORIO AT NRL WE HAVE RECENTLY LAUNCHED A NEW ASPECT OF THE STARDUST@HOME PROJECT TO ENLIST THE HELP OF VOLUNTEERS IN THE EFFORT TO IDENTIFY IMPACTS IN THE AL FOILS. DURING THE PILOT PHASE OF FOILS@HOME -130 VOLUNTEERS CARRIED OUT -379 000 SEARCHES OF -152 000 INDIVIDUAL FIELDS OF VIEW. 36 NEW CANDIDATES RESULTING FROM THESE SEARCHES ARE CURRENTLY IN PROGRESS. THE EVIDENCE FOR INTERSTELLAR ORIGIN HAS BEEN INDIRECT. A MEASUREMENT OF THE ABUNDANCES OF OXYGEN ISOTOPES IS CRITICAL FOR IDENTIFYING PARTICLES OF INTERSTELLAR ORIGIN. A MEASUREMENT THAT IS SIGNIFICANTLY DIFFERENT FROM THE SOLAR SYSTEM VALUES IS A SMOKING GUN FOR INTERSTELLAR ORIGIN. SUCH MEASUREMENTS ARE POSSIBLE NOW IN RESIDUES IN IMPACT CRATERS. HOWEVER SUCH MEASUREMENTS ARE NOT YET POSSIBLE ON THE LARGEST PARTICLES WHICH ARE CAPTURED IN AEROGEL BECAUSE THE SAMPLE PREPARATION IS NOT YET AT A SUFFICIENTLY MATURE STAGE. UNDER PREVIOUS SUPPORT WE HAVE BEEN REFINING AND EXTENDING CURRENT SAMPLE PREPARATION TECHNIQUES BASED ON THE SAMPLE PREPARATION PROTOCOLS DEVELOPED FOR THE COMETARY STARDUST SAMPLES WHICH ARE MUCH LARGER THAN THE INTERSTELLAR DUST SAMPLES. HERE TRACKS IN AEROGEL KEYSTONES ARE COMPRESSED EMBEDDED IN EPOXY AND ULTRAMICROTOMED TO PRODUCED ULTRAMICROTOMED THIN SECTIONS AND PARTICLES IN POTTED BUTTS. FOR THE PURPOSE OF DEVELOPING THE PROTOCOLS STEVE JONES AT JPL PRODUCED AEROGEL TILES IMPREGNATED WITH ALLENDE SPINEL SEPARATES WHICH HAVE OXYGEN ISOTOPIC COMPOSITION WELL DOWN THE CCAM LINE. WHILE WE SHOWED THAT WE COULD MEASURE THESE PARTICLES SUCCESSFULLY OUR ASSESSMENT IS THAT THIS TECHNIQUE IS FUNDAMENTALLY TOO UNRELIABLE TO BE USED FOR SAMPLE PREPARATION FOR INTERSTELLAR DUST CANDIDATES. HERE WE SEEK SUPPORT TO CONTINUE THE STARDUST@HOME PROJECT TO COMPLETE THE SEARCH FOR IMPACTS IN THE REMAINING INTERSTELLAR COLLECTOR AEROGEL TILES AND TO CONTINUE THE IDENTIFICATION OF IMPACTS IN THE FOILS. WE ALSO PROPOSE TO DEVELOP A COMPLETELY NEW SAMPLE PREPARATION TECHNIQUE BASED ON FOCUSED ION-BEAM (FIB) MILLING. ALL OF THE INDIVIDUAL COMPONENTS HAVE BEEN DEMONSTRATED BUT HAVE NOT YET BEEN INTEGRATED INTO A RELIABLE SAMPLE PREPARATION PROTOCOL. WE WILL USE HIGH-ANGLE ION MILLING IN THE FIB SIMILAR TO THAT USED FOR ION-BEAM POLISHING FOR EBSD. DURING MILLING WE WILL USE THE CAPABILITY OF A NEW FIB CURRENTLY BEING ACQUIRED BY THE NATIONAL CENTER FOR ELECTRON MICROSCOPY AT LBL TO SIMULTANEOUSLY MONITORING THE SAMPLE BY SEM BACKSCATTER IMAGING AND EDX. TO MITIGATE THE PROBLEM OF SAMPLE CHARGING WE WILL USE ATOMIC LAYER DEPOSITION TO DEPOSIT CONDUCTIVE LAYERS INSIDE THE AEROGEL PICOKEYSTONES. THE RESULTING SAMPLE WILL BE IDEALLY SUITED FOR OXYGEN ISOTOPIC ANALYSIS USING SIMS OR NANOSIMS AND SUFFICIENT MATERIAL SHOULD BE AVAILABLE TO ALLOW FOR SUBSEQUENT ANALYSES. AFTER VERIFICATION THROUGH EXTENSIVE TESTING WE WILL MEASURE OXYGEN ISOTOPIC COMPOSITION OF EXISTING AND FUTURE INTERSTELLAR DUST CANDIDATES. THE PROJECT IS HIGHLY RELEVANT TO THE LARS PROGRAM.
$526,684Regents Of The University Of California, The · · FY2017 · National Aeronautics and Space Administration
Environmentally Induced Alterations In Neuron And Glia Development and Aging
$526,651Gaylia Jean Harry · National Institute Of Environmental Health Sciences · ZIA · FY2012 · ES