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17,828 grants matching “crispr”
Targeted aberrant signaling in CBL-mutant leukemia
$388,111Benjamin Levine Ebert · Dana-Farber Cancer Inst · P01 · FY2021 · CA
Structure and Function of DNA Polymerase Theta
$387,899Richard T Pomerantz · Thomas Jefferson University · R01 · FY2022 · GM
Structure and Function of DNA Polymerase Theta
$387,897Richard T Pomerantz · Thomas Jefferson University · R01 · FY2021 · GM
Explore the signaling mechanisms of acquired resistance to tyrosine kinase inhibitors in AML
$387,863Jian Huang · Coriell Institute For Medical Research · R01 · FY2024 · CA
Combinational targeting the feed forward epigenetic circuitry in mixed lineage leukemia
$387,823Chun-Wei David Chen · Beckman Research Institute/City Of Hope · R37 · FY2023 · CA
Role of BAZ2A in MLL-r leukemia and therapeutic response
$387,823Chun-Wei David Chen · Beckman Research Institute/City Of Hope · R01 · FY2023 · CA
Dissecting and engineering reversible cell cycle states
$387,750Kristin A Knouse · Massachusetts Institute Of Technology · DP5 · FY2021 · OD
Dissecting and engineering reversible cell cycle states
$387,750Kristin A Knouse · Massachusetts Institute Of Technology · DP5 · FY2022 · OD
Investigating Syngap1 as a regulator of striatal synaptic function
$387,745Helen S. Bateup · University Of California Berkeley · R01 · FY2024 · MH
Identifying molecular vulnerabilities of ALT-dependent cancers
$387,731Hongwu Zheng · Weill Medical Coll Of Cornell Univ · R01 · FY2025 · CA
Identifying molecular vulnerabilities of ALT-dependent cancers
$387,731Hongwu Zheng · Weill Medical Coll Of Cornell Univ · R01 · FY2024 · CA
Open chromatin and transcriptional regulation of dermal myofibroblasts in SSc
$387,696Robert A Lafyatis · University Of Pittsburgh At Pittsburgh · R61 · FY2019 · AR
Evolutionary Conserved Mechanisms that Control Central Nervous System Development Regeneration and Degeneration
$387,688Ayelet Voskoboynik · Stanford University · R01 · FY2023 · AG
Oxytocin-dependent Social Salience Network Activity evoked by targeting melanocortin receptors
$387,570Larry J Young · Emory University · P50 · FY2019 · MH
INCREASING SEED OIL YIELD IS ONE OF THE MOST IMPORTANT GOALS FOR OILSEED CROP IMPROVEMENT. THIS PROJECT AIMS TO ENHANCING SEED OIL CONTENT AND EXTRACTABILITY OF OILSEED CROPS BY METABOLIC ENGINEERING OF PHENYLPROPANOID METABOLISM. WE WILL MANIPULATE FLAVONOID AND LIGNIN BIOSYNTHESIS TO ENHANCE SEED OIL ACCUMULATION AND TEST THE HYPOTHESIS THAT MODIFICATION OF LIGNIN IN SEED COAT WILL FACILITATE THE EXTRACTION OF OIL FROM SEEDS. TWO EMERGING PROMISING BIOFUEL OILSEED CROPS, CAMELINA AND PENNYCRESS, WILL BE ENGINEERED BY THE CRISPR-CAS9 AND RNAI TECHNOLOGY. IMPROVEMENT OF THESE CROPS WILL CONTRIBUTE TO SUSTAINABLE BIOFUEL PRODUCTION WITHOUT COMPETITION WITH FOOD SUPPLIES. OILSEEDS WITH HIGH EXTRACTABILITY AND OIL CONTENT WILL ENABLE LOCAL SEED PRESSING PRACTICE ON SMALL AND MEDIUM-SIZED FARMS, FOSTERING RURAL ECONOMIC GROWTH. SUCCESSFUL COMPLETION OF THIS PROJECT WILL ALSO PROVIDE NEW TOOLS AND STRATEGIES THAT CAN BE USED TO INCREASE THE OIL PRODUCTION OF OTHER OILSEED CROPS. THIS PROJECT ADDRESSES PROGRAM AREA PRIORITIES A1103, FOUNDATIONAL KNOWLEDGE OF PLANT PRODUCTS; AND A1531, BIOPROCESSING AND BIOENGINEERING.
$387,518North Carolina State University · · FY2020 · National Institute of Food and Agriculture
Targeting p300 to Overcome PARP inhibitor resistance induced by acidic tumor microenvironment
$387,508Rugang Zhang · University Of Tx Md Anderson Can Ctr · P50 · FY2025 · CA
Investigation of DUF1220 domains in human brain function and disease
$387,504James M Sikela · University Of Colorado Denver · R01 · FY2017 · MH
Dysregulation of Wnt signaling in subretinal fibrosis in AMD
$387,501Yusuke Takahashi · Wake Forest University Health Sciences · R01 · FY2023 · EY
Dysregulation of Wnt signaling in subretinal fibrosis in AMD
$387,501Yusuke Takahashi · Wake Forest University Health Sciences · R01 · FY2024 · EY
Dysregulation of Wnt signaling in subretinal fibrosis in AMD
$387,501Yusuke Takahashi · Wake Forest University Health Sciences · R01 · FY2025 · EY
Oxidative stress and RNA methylation
$387,500Ricardo C Aguiar · University Of Texas Hlth Science Center · R01 · FY2023 · ES
Unraveling the mammalian secretory pathway through systems biology and algorithm development
$387,500Nathan Enoch Lewis · University Of California, San Diego · R35 · FY2016 · GM
Oxidative stress and RNA methylation
$387,500Ricardo C Aguiar · University Of Texas Hlth Science Center · R01 · FY2024 · ES
Development, characterization and application of CRISPR/Cas9 gene drive technologies and related active genetic elements to benefit research and society at large
$387,500Valentino Matteo Gantz · University Of California, San Diego · DP5 · FY2019 · OD
Regulating retinal cell fate with microRNAs
$387,500David L Turner · University Of Michigan At Ann Arbor · R01 · FY2016 · EY