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65,743 grants matching “single cell sequencing”
Molecular Regulation of the IL-2 Gene
$820,954Ronald Schwartz · National Institute Of Allergy And Infectious Diseases · ZIA · FY2009 · AI
Genetics of novelty seeking and propensity for drug abuse in outbred rats
$820,863Huda Akil · University Of Michigan At Ann Arbor · U01 · FY2023 · DA
Transcriptomics-based identification of cell type specific host genes and gene networks perturbed by HSV-1 in cerebral organoids.
$820,743Teng-Ting Elaine Lim · Univ Of Massachusetts Med Sch Worcester · R01 · FY2025 · AG
The Role of Transcription Factor Isoforms in Eye and Neural Crest Development
$820,742Heinz Arnheiter · Neurological Disorders And Stroke · Z01 · FY2007 · NS
Examining the effect of cadmium metal exposure on Alzheimer's disease genetic alleles using herpes viral infected cerebral organoids
$820,735Ying Leong Chan · Univ Of Massachusetts Med Sch Worcester · U01 · FY2025 · AG
Collaborative Research: Single Cell Proteomics
$820,721Steven A Soper · Louisiana State University · · FY2002 · BIO
DNA-damage-induced transcription errors provide a constant stream of amyloid and prion-like proteins in human cells
$820,674Marc Vermulst · University Of Southern California · R01 · FY2024 · AG
A dual-beta-lactam strategy for treating multidrug resistant M abscessus
$820,613Barry Neal Kreiswirth · Hackensack University Medical Center · R01 · FY2020 · AI
Long Non-coding RNAs as Therapeutic Targets and Biomarkers of Alzheimer's Disease and Related Dementias
$820,553Ivana Delalle · Boston University Medical Campus · R01 · FY2024 · AG
VISTA is a negative checkpoint regulator of innate immunity
$820,549Randolph J. Noelle · Dartmouth College · R01 · FY2020 · AI
Characterization of European American and African American Sarcoidosis via Immunogenetics
$820,522Courtney Montgomery · Oklahoma Medical Research Foundation · R01 · FY2019 · HL
Immunologic and Metabolic Profiles of T cells that control diverse HCV infections
$820,384Andrea L Cox · Johns Hopkins University · U19 · FY2023 · AI
Immunologic and Antigenic Drivers of Immune Checkpoint Inhibitor-Associated Myocarditis
$820,373Justin M Balko · Vanderbilt University Medical Center · R01 · FY2022 · HL
Targeting Biotin Metabolism in Mycobacterium Tuberculosis
$820,039Courtney C Aldrich · University Of Minnesota · R01 · FY2019 · AI
Molecular Regulation of Atherosclerosis Regression - Renewal
$819,950Edward A Fisher · New York University School Of Medicine · R01 · FY2024 · HL
Immunophenotyping for precision medicine for cardiovascular disease in people living with HIV
$819,924Robert C Kaplan · Albert Einstein College Of Medicine · R01 · FY2022 · HL
High Throughput CRISPR/Cas9 cell line generation using the CellRaft Array
$819,896Jessica Hartman · Cell Microsystems, Inc. · R44 · FY2020 · GM
Comprehensive and Robust Tools for Analysis of Tumor Heterogeneity and Evolution
$819,682Benjamin Raphael · Princeton University · U24 · FY2020 · CA
Mechanisms of Enhanced Neutralizing Antibody Responses to Rhinovirus C
$819,421Yury A Bochkov · University Of Wisconsin-Madison · R01 · FY2020 · AI
Regulation of CTCF Functions and Target Sites by Cancer/Testis-specific CTCF Like BORIS Factor
$819,364Victor Lobanenkov · National Institute Of Allergy And Infectious Diseases · ZIA · FY2019 · AI
Deciphering CTCF code in mammalian host and viral epigenomes
$819,364Victor Lobanenkov · National Institute Of Allergy And Infectious Diseases · ZIA · FY2019 · AI
Insight into the Ebola virus glycoprotein fusion mechanism gleaned from the 2013-2016 epidemic GP-A82V variant
$819,319Jeremy Luban · Univ Of Massachusetts Med Sch Worcester · R01 · FY2024 · AI
Insight into the Ebola virus glycoprotein fusion mechanism gleaned from the 2013-2016 epidemic GP-A82V variant
$819,319Jeremy Luban · Univ Of Massachusetts Med Sch Worcester · R01 · FY2023 · AI
Insight into the Ebola virus glycoprotein fusion mechanism gleaned from the 2013-2016 epidemic GP-A82V variant
$819,319Jeremy Luban · Univ Of Massachusetts Med Sch Worcester · R01 · FY2022 · AI
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** PLANT-COLONIZING BENEFICIAL BACTERIA HAVE LONG BEEN HARNESSED TO BOOST THE PRODUCTIVITY AND RESILIENCE OF CROPS, AND BACTERIAL CROP TREATMENTS REPRESENT A RAPIDLY GROWING INDUSTRY IN THE US. THE BENEFIT OF THESE BACTERIA CAN BE LIMITED BY UNPREDICTABLE SURVIVAL IN THE ENVIRONMENT, WHERE PREDATORS, INCLUDING SINGLE-CELLED MICROBES KNOWN AS PROTISTS, ARE A MAJOR CAUSE OF BACTERIAL DEATH. SOME PLANT BENEFICIAL BACTERIA CAN DEFEND THEMSELVES AGAINST PROTIST ATTACK, AND PROTISTS MAY HELP THESE GROUPS OF BACTERIA THRIVE AND BECOME MORE EFFECTIVE IN PROMOTING PLANT GROWTH. HOWEVER, NOT MUCH IS KNOWN ABOUT WHICH TYPES OF BACTERIA BENEFIT MOST FROM THE PRESENCE OF PROTISTS ON THE PLANT, OR THE STRATEGIES THEY USE TO SURVIVE. IN THIS PROJECT, WE WILL USE DNA SEQUENCING TECHNIQUES TO IDENTIFY WHICH BACTERIA FROM PLANTS AND SOILS ARE ENRICHED BY DIFFERENT TYPES OF PROTISTS, AND TO UNDERSTAND WHICH BACTERIAL GENES AND FUNCTIONS ARE USED IN COOPERATING WITH OR DEFENDING AGAINST PROTISTS. WE WILL ALSO STUDY WHETHER BACTERIA AND PROTISTS HELP EACH OTHER COLONIZE PLANT ROOTS, AND HOW THEIR INTERACTIONS AFFECT PLANT GROWTH AND HEALTH. BY HELPING RESEARCHERS UNDERSTAND HOW PROTIST INTERACTIONS AFFECT THE SUCCESS OF BENEFICIAL BACTERIA, THIS RESEARCH COULD ONE DAY BE APPLIED TOWARD PROTIST-INFORMED SCREENING OR DESIGN OF IMPROVED MICROBIAL COMMUNITIES.?
$819,300Connecticut Agricultural Experimental Station · · FY2022 · National Institute of Food and Agriculture