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15,273 grants matching “antimicrobial resistance”
Innate immune defense against community associated methicillin-resistant S.aureus
$337,500William Michael Nauseef · University Of Iowa · R01 · FY2008 · AI
Role of Natural Killer Lytic-Associated Molecule (NKLAM) in Natural Killer Functi
$337,500Jacki Kornbluth · Saint Louis University · R56 · FY2010 · AI
Salmonella Antimicrobial Peptide Resistance
$337,500John S Gunn · Ohio State University · R01 · FY2009 · AI
Innate immune defense against community associated methicillin-resistant S.aureus
$337,500William Michael Nauseef · University Of Iowa · R01 · FY2009 · AI
Targeting Non-mammalian Isoprenoid Biosynthesis
$337,272Caren L. Freel Meyers · Johns Hopkins University · R01 · FY2015 · GM
BOVINE RESPIRATORY DISEASE (BRD) IS PROBLEMATIC THROUGHOUT THE BEEF INDUSTRY, ESPECIALLY IN THE BEEF CATTLE FINISHING PHASE OF PRODUCTION, CONTRIBUTING TO 70 TO 80% OF FEEDLOT DISEASES AND 40 TO 50% OF FEEDLOT DEATH. CURRENT THERAPEUTIC OPTIONS FOR CONTROLLING AND TREATING BRD IN HIGH-RISK ANIMALS INCLUDE VACCINATING AGAINST SOME OF THE VIRUSES THAT INITIATE THE SYNDROME AND PROVIDING ANTIMICROBIAL TREATMENT TO CONTROL SECONDARY BACTERIAL INFECTIONS, WHICH LEADS TO A WIDESPREAD USE OF ANTIMICROBIALS AND THUS INCREASES THE CONCERNS OF ANTIBIOTIC RESISTANCE. TRADITIONAL CULTURE-DEPENDENT STUDIES OF BRD HAVE FOCUSED ON THE FOUR OPPORTUNISTIC BACTERIAL BRD PATHOGENS INCLUDING MANNHEIMIA HAEMOLYTICA, PASTEURELLA MULTOCIDA, HISTOPHILUS SOMNI AND MYCOPLASMA BOVIS. HOWEVER, THESE BACTERIA HAVE BEEN ISOLATED FROM BOTH HEALTHY AND SICK ANIMALS, RAISING QUESTIONS REGARDING THEIR ROLES IN BRD. THERE IS A PAUCITY OF INFORMATION ON THE STRUCTURE OF THE BOVINE RESPIRATORY MICROBIOME AND ITS ROLE INHEALTH AND DISEASE. THE SLOW SCIENTIFIC PROGRESS IN UNDERSTANDING THE BOVINE AIRWAY MICROBIOME COULD BE ATTRIBUTED TO MANY FACTORS. FOR EXAMPLE, CALVES ENTERING FEEDLOTS ARE OFTEN EXTREMELY HETEROGENEOUS, WITH LITTLE INFORMATION REGARDING THEIR GENETICS, SOURCE, HEALTH HISTORY, DISEASE AND ANTIMICROBIAL TREATMENT, DIET, LIVING ENVIRONMENT, AND COMMINGLING TIMES, WHICH SIGNIFICANTLY CONFOUND MICROBIOME STUDIES. IN ADDITION, THUS FAR MOST STUDIES HAVE USED A MORE INVASIVE NASOPHARYNGEAL SAMPLING APPROACH, WHICH IS LESS IDEAL FOR QUICKLY SAMPLING LARGE GROUPS OF ANIMALS IN LARGE-SCALE EPIDEMIOLOGICAL STUDIES THAN NASAL SWABS.IN THIS STUDY, WE WILL USE THREE COHORTS (N=30 EACH) OF CALVES FROM THREE UNIVERSITY OF ARKANSAS RESEARCH STATIONS WITH A KNOWN BACKGROUND (E.G., GENETICS, DIET, ANTIMICROBIALS, ENVIRONMENT) AND MONITOR THE DYNAMICS OF THEIR NASAL MICROBIOMES AFTER BIRTH, WEANING, SHIPPING, MARKETING, AND ENTERING THE FEEDLOT. THIS UNIQUE LONGITUDINAL DESIGN AND NON-INVASIVE NASAL SWAB SAMPLING WILL ALLOW US TO DEFINE A HEALTHY BOVINE NASAL MICROBIOME, AND EXAMINE HOW THE BOVINE NASAL MICROBIOME CHANGES AFTER SHIPPING, COMMINGLING WITH OTHER ANIMALS AND ADAPTING TO A NEW FEEDLOT ENVIRONMENT. BY FOLLOWING A LARGE NUMBER OF CALVES FROM BIRTH TO FEEDLOT AND CHARACTERIZING CHANGES IN THE NASAL MICROBIOME WE WILL BE ABLE TO IDENTIFY MICROBIOME BIOMARKERS FOR ACCURATE DIAGNOSIS, PROGNOSIS, AND TREATMENT OF BRD. IN ADDITION, WE WILL ALSO COLLECT NASOPHARYNGEAL SWABS AND BRONCHOALVEOLAR LAVAGE FROM A SUBSET OF THESE ANIMALS (N=36). BY COMPARING THE MICROBIOME FROM THREE LOCATIONS OF THE BOVINE RESPIRATORY SYSTEM WE WILL BE ABLE TO DETERMINE IF THE NON-INVASIVE NASAL SWAB COULD BE USED TO REPLACE THE NASOPHARYNGEAL SWABS IN BRD STUDIES. FINALLY, WE WILL EXAMINE THE BACTERIAL-HOST INTERACTIONS IN THE BOVINE AIRWAY AND HOW SUCH INTERACTIONS CORRELATE WITH BRD BY SEQUENCING ALL THE FUNCTIONAL GENES FROM THE HOST AND BACTERIA EXPRESSED DURING BRD (METATRANSCRIPTOME ANALYSIS). CHARACTERIZATION OF THE BIOGEOGRAPHY OF THE BOVINE RESPIRATORY TRACT MICROBIOME AND METATRANSCRIPTOME WILL PROVIDE IMPORTANT INSIGHTS INTO THE PATHOBIOLOGY OF BRD AND WILL EVENTUALLY LEAD TO BETTER STRATEGIES TO MODULATE THE BOVINE RESPIRATORY TRACT MICROBIOME TO IMPROVE ANIMAL HEALTH.
$337,128Division Of Agriculture Of The University Of Arkansas · · FY2019 · National Institute of Food and Agriculture
Mechanisms of Biofilm Antibiotic Resistance
$337,079George A. O'Toole · Dartmouth College · R01 · FY2007 · AI
Chemically diverse antimicrobials from silent biosynthetic pathways
$337,000Robert Henry Cichewicz · University Of Oklahoma · R01 · FY2010 · AI
Biosynthesis of Marine Polyketide Antibiotics
$336,990Bradley S Moore · University Of California, San Diego · R56 · FY2017 · AI
Structure and Function of Drosophila NF-kappaB Signaling Pathways
$336,980Steven Alexander Wasserman · University Of California, San Diego · R01 · FY2017 · GM
Strategies to Investigate Synergy in Botanical Medicines
$336,971Nadja B Cech · University Of North Carolina Greensboro · R01 · FY2014 · AT
Envelope Biogenesis in Gram-negative Bacteria
$336,926Natividad Ruiz · Ohio State University · R01 · FY2022 · GM
Envelope Biogenesis in Gram-negative Bacteria
$336,926Natividad Ruiz · Ohio State University · R01 · FY2021 · GM
Nanoparticle-based host-directed therapies for eradication of Mycobacterium tuberculosis
$336,887Samantha Leigh Sampson · Stellenbosch University · R01 · FY2021 · AI
Prophylactic Antimicrobials in Children with Vesicoure
$336,851Children'S Hosp Pittsburgh/Upmc Hlth Sys · U01 · FY2005 · DK
Molecular Pathogenesis of Infectious Diseases
$336,837Albert Einstein Col Of Med Yeshiva Univ · T32 · FY2004 · AI
Task A24: Establishment of Chronic Pseudomonas aeruginosa and Staphylococcus aureus Infection in Mouse Models of Cystic Fibrosis
$336,721Bruce Blough · Univ Of North Carolina Chapel Hill · N01 · FY2020 · AI
Linking Nicotinic Activation with Skin Innate Immunity and Atopic Dermatitis
$336,375Katherine Amanda Radek · Loyola University Chicago · R01 · FY2015 · AR
Linking Nicotinic Activation with Skin Innate Immunity and Atopic Dermatitis
$336,375Katherine Amanda Radek · Loyola University Chicago · R01 · FY2016 · AR
Linking Nicotinic Activation with Skin Innate Immunity and Atopic Dermatitis
$336,375Katherine Amanda Radek · Loyola University Chicago · R01 · FY2012 · AR
Creating an Infection-Free Intraosseus Transcutaneous Amputation Prosthesis
$336,353Noreen J Hickok · Thomas Jefferson University · R01 · FY2010 · HD
Conserved Proteus mirabilis genetic requirements for colonization of the catheterized urinary tract
$336,344Chelsie Elizabeth Armbruster · State University Of New York At Buffalo · R01 · FY2020 · DK
Evolution of antibiotic resistance
$336,161Anupama Khare · Division Of Basic Sciences - Nci · ZIA · FY2024 · CA
Assembling an understanding of ribosome biosynthesis
$336,081Gloria M Culver · University Of Rochester · R01 · FY2015 · GM
Understanding Nano-Microbial Interactions in a Bacterial Biofilm
$336,000Zhiqiang Hu · University Of Missouri-Columbia · · FY2010 · ENG