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38,696 grants matching “als”
Respiratory Control in Old Age
$605,695Gary C. Sieck · Mayo Clinic Rochester · R01 · FY2021 · AG
Electron Microscopy Core Facility
$605,603Jennifer Petersen · National Institute Of Neurological Disorders And Stroke · ZIC · FY2025 · NS
BACKGROUND: THE MIT-HAWAII NEAR EARTH OBJECT SURVEY (MITHNEOS) HAS BEEN SYSTEMATICALLY MEASURING NEO NEAR-INFRARED SPECTRA USING SPEX ON THE 3-METER NASA IRTF SINCE 2000. SINCE INCEPTION THIS PROGRAM HAS MEASURED NEAR-INFRARED SPECTRA OF OVER 700 NEAR-EARTH OBJECTS. WE HAVE OBSERVED ~3% OF THE KNOWN DELTA-V<7 KM/S POPULATION REPRESENTING ABOUT 270 NEOS 80 OF WHICH HAVE DELTA-V<6 KM/S. THE SURVEY HAS ALSO OBTAINED SPECTRA FOR ~15% OF THE KNOWN PHA POPULATION OR ABOUT 270 OBJECTS. ALL SPECTRAL OBSERVATIONS FROM THIS CAMPAIGN ARE MADE PUBLICLY AVAILABLE FOR THE COMMUNITY SHORTLY AFTER OBSERVATION AT HTTP://SMASS.MIT.EDU. OBSERVATIONS AND ANALYSIS FROM THIS PROGRAM HAVE HAD A LARGE IMPACT ON NEO SCIENCE SUCH AS: 1) ENHANCED UNDERSTANDING OF SPACE WEATHERING AND REFRESHING MECHANISMS (VERNAZZA ET AL. 2009 NATURE. BINZEL ET AL. 2010 NATURE DEMEO ET AL. 2014) 2) METEORITE-NEO LINKS AND NEO-MAIN BELT SOURCE REGION LINKS (VERNAZZA ET AL 2008 NATURE. THOMAS C.A.&BINZEL R. P. 2010) 3) CHARACTERIZATION OF EXTREMELY SMALL AND RAPIDLY ROTATING NEOS (POLISHOOK ET AL. 2012) 4) DEVELOPMENT OF TECHNIQUES TO DETERMINE ALBEDO AND SPIN ORIENTATION FROM THERMAL EMISSION PAST 2 MICRONS (RIVKIN ET AL. 2005 MOSKOVITZ ET AL. 2017) AND 5) THE VIS+NEAR-INFRARED SPECTRAL TAXONOMY USED BY THE COMMUNITY TO CLASSIFY ASTEROIDS (DEMEO ET AL. 2009). GOALS AND OBJECTIVES: THE PROGRAMMATIC OBJECTIVE OF THIS WORK IS TO SPECTRALLY CHARACTERIZE LOW DELTA-V NEOS AND PHAS. WE WILL MEASUREM 500 NEOS OVER A 5 YEAR PERIOD INCLUDING 150 LOW DELTA-V AND 150 PHA TARGETS. SCIENCE OBJECTIVES OF THIS PROGRAM ARE: 1) COMPOSITIONAL CHARACTERIZATION THROUGH TAXONOMIC CLASSIFICATION AND MINERALOGIC ANALYSIS 2) ALBEDO ESTIMATES FROM MODELING OF THERMAL EMISSION PAST TWO MICRONS. 3) IDENTIFICATION OF METEORITE ANALOGS 4) CHARACTERIZATION OF THE NEO POPULATION AND SUB-POPULATIONS INCLUDING MISSION ACCESSIBLE (LOW DELTA-VELOCITY TARGETS) POTENTIALLY HAZARDOUS ASTEROIDS (PHAS) AND DORMANT COMETS. 5) ANALYSIS OF THE CHANGE IN COMPOSITION OF THE NEO POPULATION AS A FUNCTION OF SIZE. 6) EXPLORATION OF C-COMPLEX DATA TO IDENTIFY DIAGNOSTIC SPECTRAL CHARACTERISTICS AT NEAR-INFRARED WAVELENGTHS. APPROACH AND METHODOLOGY: TARGET SELECTION WILL BE BASED ON NEOS OBSERVABLE ON REQUESTED NASA IRTF OBSERVING DATES BY SEARCHING AMONG LOW DELTA-V TARGETS AND PHAS. DATA WILL BE REDUCED USING THE AUTOSPEX PIPELINE THAT HAS BEEN CONSISTENTLY USED FOR THIS PROGRAM FOR WELL OVER A DECADE. SPECTRAL CLASSIFICATION WILL BE PERFORMED USING THE BUS-DEMEO CLASSIFICATION SYSTEM. SCIENTIFIC ANALYSIS WILL USE ESTABLISHED TECHNIQUES AND TOOLS WHERE APPROPRIATE SUCH AS PRINCIPAL COMPONENT ANALYSIS THERMAL MODELING OF SPECTRAL EMISSION TAILS MINERALOGICAL MODELING AND SPACE WEATHERING MODELING AND COMPARISON WITH THE RELAB METEORITE DATABASE. RELEVANCE AND APPROPRIATENESS TO SOLAR SYSTEM OBSERVATIONS NEOO: THE PROPOSED WORK IS RELEVANT AND APPROPRIATE TO THE SOLAR SYSTEM OBSERVATIONS NEOO PROGRAM BECAUSE AS THE PROGRAM SPECIFIES WE WILL PERFORM NEW GROUND-BASED OBSERVATIONS OF NEAR EARTH OBJECTS TO CHARACTERIZE THEIR COMPOSITIONS. THIS PROGRAM ALSO SUPPORTS THE NASA HUMAN EXPLORATION AND OPERATIONS MISSION DIRECTORATE IN THAT IT PRIORITIZES OBSERVATIONS OF LOW DELTA VELOCITY ORBITS RELATIVE TO EARTH. BECAUSE THE PROPOSED WORK FOCUSES SOLELY ON THE NEAR EARTH OBJECT POPULATION THE NEOO PROGRAM ELEMENT IS THE MOST APPROPRIATE. THE OBSERVATIONS AND OBJECTIVES OF THIS PROGRAM CANNOT BE ACHIEVED BY CURRENT SPACECRAFT MISSIONS.
$605,583Massachusetts Institute Of Technology · · FY2020 · National Aeronautics and Space Administration
Molecular Digital CytoImaging for Leukemia Drug Screening
$605,517Tothu Q Vu · Oregon Health & Science University · R01 · FY2018 · CA
Alveolar epithelial stress-induced polyploidization in lung injury and repair
$605,322Cara J Gottardi · Northwestern University At Chicago · R01 · FY2024 · HL
Family Psychopathology in Child Bipolarity
$605,271Washington University · R01 · FY2003 · MH
SES-Related Disparities in Early Language Development and Child Risk for Developmental Language Disorder
$605,263Laura M. Justice · Ohio State University · R01 · FY2022 · DC
Understanding the sequence and structural determinants of phase behavior of ALS-causing proteins
$605,252Tanja Mittag · St. Jude Children'S Research Hospital · R01 · FY2024 · NS
Toward Outcome Measurement of Anxiety in Youth with Autism Spectrum Disorders
$605,198Lawrence D. Scahill · Emory University · R01 · FY2015 · MH
Role of ASTN2 in Cerebellar Circuit Function and ASD-related Behaviors
$605,188Mary Elizabeth Hatten · Rockefeller University · R01 · FY2024 · NS
Innate immune response signaling in cardiac injury healing
$605,159Jeffery D Molkentin · Cincinnati Childrens Hosp Med Ctr · R01 · FY2022 · HL
Innate immune response signaling in cardiac injury healing
$605,159Jeffery D Molkentin · Cincinnati Childrens Hosp Med Ctr · R01 · FY2023 · HL
Innate immune response signaling in cardiac injury healing
$605,159Jeffery D Molkentin · Cincinnati Childrens Hosp Med Ctr · R01 · FY2025 · HL
Characterization of Long-lived Asymmetrically Retained Proteins (LARPs) in aging
$605,144Susan M Parkhurst · Fred Hutchinson Cancer Research Center · R01 · FY2019 · AG
Characterization of Long-lived Asymmetrically Retained Proteins (LARPs) in aging
$605,144Susan M Parkhurst · Fred Hutchinson Cancer Research Center · R01 · FY2018 · AG
Characterization of Long-lived Asymmetrically Retained Proteins (LARPs) in aging
$605,144Susan M Parkhurst · Fred Hutchinson Cancer Research Center · R01 · FY2017 · AG
Characterization of Long-lived Asymmetrically Retained Proteins (LARPs) in aging
$605,144Susan M Parkhurst · Fred Hutchinson Cancer Research Center · R01 · FY2016 · AG
Emergent Social Environments As Predictors of Recovery Resident Outcomes
$605,052Leonard A Jason · De Paul University · R01 · FY2016 · AA
Fgl2 neutralizing therapy for inducing tumor specific brain resident immune memory against CNS tumor relapse
$604,997Shulin Li · University Of Tx Md Anderson Can Ctr · R01 · FY2021 · NS
Biochemical and Biological Properties of Actin
$604,977Edward D Korn · National Heart, Lung, And Blood Institute · ZIA · FY2011 · HL
MOTIVATION/GOALS: DURING GEOMAGNETIC STORMS ALFV N WAVES WITH PERHAPS THE LARGEST AMPLITUDES OF ANY FIELD VARIATIONS OBSERVED IN NEAR-EARTH SPACE ARE COMMONLY RECORDED [CHASTON ET AL. 2015]. THESE WAVES ARE BROADBAND IN NATURE WITH SCALES PERPENDICULAR TO THE MAGNETIC FIELD EXTENDING FROM MANY ION GYRO-RADII DOWN TO SUB-ION GYRO-RADII. THEY ARE CHARACTERIZED BY DISTINCT POWER-LAW FORM IN SPECTRAL ENERGY DENSITY WITH SCALE OR WAVENUMBER. THE WAVE-FIELDS ARE INTERMITTENT IN NATURE WITH THE OCCURRENCE OF IMPULSIVE LARGE AMPLITUDE COHERENT VARIATIONS SUPERIMPOSED ON A BACKGROUND OF LOWER AMPLITUDE BROADBAND OSCILLATIONS. THESE WAVES HAVE BEEN SHOWN TO DRIVE DRAMATIC CHANGES IN ION ENERGY DENSITY IN THE INNER MAGNETOSPHERE [CHASTON ET AL. 2016]. THIS PROCESS REQUIRES CONTINUAL REPLENISHMENT OF WAVE ENERGY ON KINETIC SCALES. HOW THIS OCCURS IS UNKNOWN. HOWEVER THE OBSERVED POWER-LAW SCALING OF SPECTRAL ENERGY DENSITY SUGGESTS THIS REPLENISHMENT MAY OCCUR VIA A CASCADE WHEREBY ENERGY IS TRANSFERRED FROM LARGE ENERGY CONTAINING SCALES TO THE KINETIC SCALES WHERE THE ION ENERGIZATION PROCEEDS. THEREFORE WE PROPOSE TO DETERMINE: 1. WHAT DRIVES THE TRANSPORT OF ENERGY ACROSS SCALES IN THE ALFV NIC FIELD FLUCTUATIONS OBSERVED WITHIN THE INNER MAGNETOSPHERE DURING GEOMAGNETICALLY DISTURBED TIMES? 2. WHAT PROCESSES CAUSE THE OBSERVED INTERMITTENCY AND THE FORMATION OF COHERENT STRUCTURES? RELEVANCE: THIS RESEARCH GOES BEYOND THE MISSION GOALS OF THE VAN ALLEN PROBES TO ADDRESS THE GOALS OF THE HELIOPHYSICS DECADAL SURVEY TO DETERMINE THE DYNAMICS AND COUPLING OF EARTH S MAGNETOSPHERE IONOSPHERE AND ATMOSPHERE AND THEIR RESPONSE TO SOLAR AND TERRESTRIAL INPUTS AND TO DISCOVER AND CHARACTERIZE FUNDAMENTAL PROCESSES THAT OCCUR BOTH WITHIN THE HELIOSPHERE AND THROUGHOUT THE UNIVERSE. THE ENERGY TRANSPORT PROCESSES WE SEEK TO EXPLORE COUPLE THE IONOSPHERE TO THE MAGNETOSPHERE VIA PROCESSES FUNDAMENTAL TO THE PLASMA ENVIRONMENT OF THE SPACE. METHODOLOGY: WE WILL ANALYZE FIELD AND PLASMA OBSERVATIONS FROM THE VAN ALLEN PROBES SUPPORTED BY A 3-D REDUCED MHD SIMULATION MODEL. THE OBSERVATION INTERVALS WILL BE IDENTIFIED USING A PRE-EXISTING DATABASE [CHASTON ET AL. 2015] TO DEFINE A STATISTICAL SAMPLE OF WAVE EVENTS FOR WHICH HIGH QUALITY ELECTROMAGNETIC FIELD AND PLASMA DATA ARE AVAILABLE. THE WAVE FIELDS WILL BE ANALYZED TO EXTRACT THE GEOMETRY OF THE FIELD STRUCTURES IDENTIFY THE EXCHANGE OF ENERGY ACROSS SCALES AND QUANTIFY THE OCCURRENCE OF INTERMITTENCY. THIS WILL BE PERFORMED THROUGH THE APPLICATION OF INNOVATIVE WAVELET BASED BI/TRI-SPECTRAL AND CROSS SPECTRAL TIME SERIES ANALYSIS APPROACHES. THESE RESULTS WILL CHARACTERIZE THE NATURE OF THE FIELD STRUCTURES THE PROPERTIES OF THE CASCADE AND IDENTIFY THE OPERATION NON-LINEAR COUPLINGS AND OF INTERMITTENCY. UNDERSTANDING WILL BE FACILITATED THROUGH THE USE OF A 3-D NON-LINEAR FLUID-KINETIC SIMULATION MODEL FOR THE PLASMAS OF THE INNER MAGNETOSPHERE. THE SIMULATION APPROACH ALLOWS A DETAILED CONSIDERATION OF THE NON-LINEAR COUPLING BETWEEN ALFV N WAVES PROPAGATING ALONG THE NEARLY DIPOLE FIELD-LINES OF THE INNER MAGNETOSPHERE PLASMA INSTABILITIES AND THE CONSEQUENT CASCADE TO SMALL SCALES. IMPORTANTLY IT FACILITATES CONSIDERATION OF PLASMA INHOMOGENEITY ALONG THE WHOLE INNER MAGNETOSPHERIC FLUX-TUBE.
$604,914Regents Of The University Of California, The · · FY2017 · National Aeronautics and Space Administration
DIRECT INTERFACING WITH THE HUMAN CENTRAL NERVOUS SYSTEM
$604,778Neural Signals, Inc. · R44 · FY2000 · NS
The altered lipid and protein metabolism of pediatric patients with HIV infection
$604,778Farook Jahoor · Baylor College Of Medicine · R01 · FY2010 · HD
The pathological consequences of repeat expansion in the Repeat Expansion Diseases
$604,773Karen P. Usdin · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2021 · DK
Multi-Center ALS Biomarker Validation Study (CReATe Biomarkers)
$604,771Michael Benatar · University Of Miami School Of Medicine · U01 · FY2022 · NS