Sort
64,565 grants matching “drug discovery”
Novel modulators of the dopamine transporter for alcohol and nicotine use disorders
$966,417Cindy Ann Burklow · Naprogenix, Inc · R44 · FY2022 · AA
Development of Novel Compounds for Treatment of Heart Arrhythmias in CPVT
$966,380Douglas J Kawahara · Elex Biotech, Llc · R44 · FY2020 · HL
Research Infrastructure Core
$966,113Renato J Aguilera · University Of Texas El Paso · U54 · FY2023 · MD
Active Immunization for Treating Methamphetamine Abuse
$965,870S. Michael Owens · Univ Of Arkansas For Med Scis · U01 · FY2011 · DA
DEVELOPMENTAL FUNDS (Core 002)
$965,723Henry Shelton Earp · Univ Of North Carolina Chapel Hill · P30 · FY2020 · CA
Modulation of the Innate Immune Response by Fisetin Derivatives for the Treatment of AD
$965,711William C Raschke · Virogenics, Inc. · R44 · FY2020 · AI
Targeting Epigenetic Circuits in B-Cell Lymphomas
$965,684Ari M. Melnick · Weill Medical Coll Of Cornell Univ · R35 · FY2024 · CA
Stroke Treatment by Chemically-induced Hypothermia
$965,517Thomas A. Dix · Jt Pharmaceuticals, Inc. · R44 · FY2017 · NS
Stroke Treatment by Chemically-induced Hypothermia
$965,517Thomas A. Dix · Jt Pharmaceuticals, Inc. · R44 · FY2019 · NS
Enhanced supercooling for extending non-freezing preservation in preclinical porcine and human donor livers
$965,379Michael John Taylor · Sylvatica Biotech, Inc. · R44 · FY2024 · DK
Center for Computational Mass Spectrometry
$965,317Pavel A Pevzner · University Of California, San Diego · P41 · FY2016 · GM
A multidisciplinary approach to elucidating gene function in a model Gram-positiv
$965,125David Z Rudner · Harvard Medical School · RC2 · FY2009 · GM
X-ray Crystallographic Fragment Screening Core
$964,449Edward V Arnold · Scripps Research Institute, The · U54 · FY2017 · GM
In vivo gene detection for cancer analysis
$964,018Gang Bao · Vivonetics, Inc. · R42 · FY2006 · CA
Research Infrastructure Core
$963,924Renato J Aguilera · University Of Texas El Paso · U54 · FY2020 · MD
Collaborative Research: AFTOL: Resolving the Evolutionary History of the Fungi
$963,796Francois Lutzoni · Duke University · · FY2007 · BIO
Development and implementation of multiplex methods to understand the biology and heterogeneity of patient-derived cancer models
$963,693William C Hahn · Dana-Farber Cancer Inst · U01 · FY2022 · CA
Unraveling Cytotoxic and Thrombotic Signals in COVID-19
$963,672Yogen Kanthi · National Heart, Lung, And Blood Institute · ZIA · FY2022 · HL
Human Translational Studies of Vascular Thrombosis and Inflammation
$963,672Yogen Kanthi · National Heart, Lung, And Blood Institute · ZIA · FY2022 · HL
Identifying novel anti-infectives by high through-put screening in whole animals
$963,577Frederick M Ausubel · Massachusetts General Hospital · R01 · FY2011 · AI
Peripheral Nerve-on-a-chip for Predictive Preclinical Pharmaceutical Testing
$963,541Jabe L Curley · Axosim, Inc. · R42 · FY2017 · TR
Genetics Core
$963,527Andrew J Saykin · Northern California Institute/Res/Edu · U19 · FY2022 · AG
UIC: In vitro In vivo Mtb Pharmacology
$963,450Scott G. Franzblau · Global Alliance For Tb Drug Development · U19 · FY2023 · AI
THE OBJECTIVE FOR THE PROPOSED WORK IS TO DEVELOP METHODS TO FACILITATE THE QUICK IDENTIFICATION OF NATURAL PRODUCTS IN EXTRACTS AND THE QUICK IDENTIFICATION OF HUMAN PROTEIN TARGETS. BY COMBINING THE ETHOS OF BIG DATA AND -OMICS TECHNOLOGIES WE SHOULD BE ABLE (1) TO ESTABLISH THE CHEMICAL TAXONOMY OF ACTIVE COMPOUNDS IN A NATURAL PRODUCT MIXTURE USING HIGH-RESOLUTION MASS SPECTROMETRY WITH MOLECULAR NETWORKING AND (2) TO IDENTIFY THE HUMAN PROTEIN TARGETS WITHIN THE MIXTURE USING A HUMAN PROTEOME ARRAY CHIP MADE BY PUERTO RICO-BASED COMPANY CDI LABORATORIES. THE PROPOSAL ADDRESSES A CURRENT GAP WITHIN THE ASSIGNED THRUST AREA 7 THROUGH EXPANSION OF THE RESOURCES AND CAPABILITIES AVAILABLE FOR DRUG DISCOVERY AND DEVELOPMENT PIPELINES, AS WELL AS MEDICAL COUNTERMEASURE DEVELOPMENT PLATFORMS. THE TECHNICAL APPROACH FOR THIS PROJECT IS AN INNOVATIVE ONE, WHICH INVOLVES DEVELOPING METHODS TO FACILITATE THE QUICK IDENTIFICATION OF NATURAL PRODUCTS IN EXTRACTS AND THE QUICK IDENTIFICATION OF HUMAN PROTEIN TARGETS.
$963,360Puerto Rico Science, Technology, And Research Trust · · FY2025 · Defense Threat Reduction Agency
Exploration, conservation, & development of marine biodiversity in Fiji and the S
$963,186Mark E Hay · Georgia Institute Of Technology · U19 · FY2017 · TW