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38,696 grants matching “als”
Epidemiologic studies of maternal and early life metabolic risk
$715,239Madhumita Sinha · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2022 · DK
Alzheimer's disease drug development
$715,227Nigel H. Greig · National Institute On Aging · ZIA · FY2023 · AG
Clinical Diagnostic Sequencing of Structural Variation
$715,062Michael E Talkowski · Massachusetts General Hospital · R01 · FY2017 · HD
Twin Family Study of Vulnerability to Substance Abuse
$714,877William G Iacono · University Of Minnesota · R37 · FY2015 · DA
Cell Adhesion and Trafficking as a Therapeutic Target in Allotransplantation
$714,806Allan D. Kirk · Emory University · U19 · FY2013 · AI
Therapeutic Targeting of RNA Splicing in Triple-Negative Breast Cancer
$714,768Thomas Westbrook · Baylor College Of Medicine · R01 · FY2025 · CA
Community partnerships to prevent urban youth health risks (CHAMPions)
$714,710Mary McKernan McKay · Icahn School Of Medicine At Mount Sinai · R01 · FY2012 · MH
Neural Control of Muscle Activity
$714,689Eberhard E Fetz · University Of Washington · R01 · FY2013 · NS
Targeting Dyrk1a to Promote Donor-independent Platelet Production
$714,564Adam N. Goldfarb · University Of Virginia · R01 · FY2020 · HL
Nutritional and Biochemical/Genetic Markers of Cancer
$714,410Jing Ma · Brigham And Women'S Hospital · R01 · FY2007 · CA
Reach Out: Randomized Clinical Trial of Emergency Department-Initiated Hypertension Behavioral Intervention Connecting Multiple Health Systems
$714,409William Joseph Meurer · University Of Michigan At Ann Arbor · R01 · FY2018 · MD
Validating a 3rd-generation methylation measure of accelerated aging: DunedinPoAm4x
$714,405Terrie Edith Moffitt · Duke University · R01 · FY2024 · AG
Development of a neurotoxicity tool kit
$714,361Xianmin Zeng · Xcell Science, Inc. · R44 · FY2016 · ES
Mechanism of end protection in stem cells
$714,153Eros Lazzerini Denchi · Division Of Basic Sciences - Nci · ZIA · FY2023 · CA
THE UN S SUSTAINABLE DEVELOPMENT GOAL NO. 15 IS TO PROTECT RESTORE AND PROMOTE SUSTAINABLE USE OF TERRESTRIAL ECOSYSTEMS SUSTAINABLY MANAGE FORESTS AND HALT BIODIVERSITY LOSS. ACHIEVING THIS GOAL REQUIRES LAND USE PLANS THAT ARE BASED ON STATE-OFTHE ART FOREST MONITORING AND SPECIES HABITAT MODELS. MANY COUNTRIES HAVE DEVELOPED SUCH LAND USE PLANS. HOWEVER ESPECIALLY DEVELOPING COUNTRIES OFTEN LACK THE CAPACITY TO EMPLOY REMOTE SENSING TECHNOLOGY AND ADVANCED MODELS IN THEIR PLANNING EFFORTS. ARGENTINA IS A PERFECT EXAMPLE OF A DEVELOPING COUNTRY THAT ESTABLISHED REGIONAL FOREST LAND USE PLANS IN 2007 (NATIONAL FOREST LAW N 26 331) BUT WHOSE PROVINCIAL GOVERNMENTS LACKED THE KNOW-HOW TO USE BIODIVERSITY INFORMATION WHEN ZONING THEIR FORESTS. HOWEVER OUR TEAM RECENTLY DEVELOPED AND IMPLEMENTED A STRAIGHTFORWARD APPROACH TO ENHANCING THE LAND-USE PLANS FOR THE SOUTHERN YUNGAS FOREST OF NORTHERN ARGENTINA BASED ON MAPS OF ENDANGERED SPECIES HABITATS AND CONSERVATION THREATS (MARTINUZZI ET AL 2017). BOTH SALTA AND JUJUY PROVINCES ARE NOW USING OUR RESULTS IN THE LATEST OF THE MANDATED 5-YEAR PLAN UPDATES.
$714,130University Of Wisconsin System · · FY2020 · National Aeronautics and Space Administration
The role of DNA damage in human disease: Neurodegeneration and Cancer
$714,119Philip J Brooks · National Institute On Alcohol Abuse And Alcoholism · ZIA · FY2010 · AA
Clinical Diagnostic Sequencing of Structural Variation
$714,051Michael E Talkowski · Massachusetts General Hospital · R01 · FY2018 · HD
THE ENSEMBLE MARS ATMOSPHERE REANALYSIS SYSTEM (EMARS) SYNTHESIZES DATA FROM THERMAL EMISSION SPECTROMETER (TES) AND MARS CLIMATE SOUNDER (MCS) SPACECRAFT OBSERVATIONS THROUGH THE FUSION WITH SHORT-TERM MARS GLOBAL CLIMATE MODEL (MGCM) FORECASTS USING ENSEMBLE DATA ASSIMILATION. THE RESULTING PRODUCT CREATED BY OUR TEAM AT PSU UMD GFDL AND AER WITH THE SUPPORT OF MDAP IS A COMPREHENSIVE GRIDDED DATASET OF ATMOSPHERIC PROPERTIES TEMPERATURE WIND SURFACE PRESSURE AND (DUST AND WATER ICE CLOUD) AEROSOLS AND THEIR UNCERTAINTIES SPANNING SEVERAL MARS YEARS. WE SEEK TO CONTINUE OUR SUCCESSFUL PROGRAM WITH PLANS TO USE EMARS (AND CONSEQUENTLY TES AND MCS OBSERVATIONS) TO EXPLORE FACETS OF MARTIAN WEATHER AND CLIMATE. EVALUATION OF PHYSICAL PHENOMENA IN REANALYSES SUCH AS EMARS INCLUDES THE PLANETARY CIRCULATION AND ZONAL MEAN TEMPERATURE STRUCTURE POLAR VORTEX TRAVELING WAVES DUST CYCLE WATER CYCLE POLAR CAPS AND THERMAL TIDES. OUR PARTICULAR FOCUS IN THIS PROPOSAL WILL BE ON NEAR SURFACE TRAVELING WAVES AND THEIR KEY ROLE IN THE INITIATION AND MAINTENANCE OF DUST STORMS THE GRAND CHALLENGE FOR MARTIAN METEOROLOGY. STRONGLY RELATED TO THIS GOAL IS THE ACCURATE DEPICTION OF TEMPERATURE WIND AND FOUR-DIMENSIONAL AEROSOL DISTRIBUTIONS AND IMPROVED UNDERSTANDING OF DUST LIFTING (SOURCES) TRANSPORT AND DEPOSITION (SINKS) USING ALL AVAILABLE OBSERVATIONS AND THE BEST MODELING AND ASSIMILATION TECHNIQUES. OUR PREVIOUS EFFORTS HAVE DEMONSTRATED THE SYNERGY BETWEEN REANALYSIS DEVELOPMENT AND SCIENCE INVESTIGATIONS: VARYING DUST AND WATER ICE CLOUD AMOUNTS AMONG ENSEMBLE MEMBERS IMPROVES ENSEMBLE SPREAD AND ANALYSIS ERRORS (GREYBUSH ET AL. 2012); MORE FREQUENT ANALYSES IMPROVE THE ESTIMATES OF THERMAL TIDES (ZHAO ET AL. 2015); AND THE VERTICAL AVERAGING OF OBSERVATIONS IMPACTS THE STRENGTH OF TRAVELING WAVES (GREYBUSH ET AL. 2015). TO GAIN INSIGHTS ON TRAVELING WEATHER SYSTEMS AND DUST STORMS FROM AN ATMOSPHERE AND AEROSOL REANALYSIS WE WILL 1) ASSESS TRAVELING WAVES IN EXISTING EMARS PRODUCTS AND EXPLORE SENSITIVITY OF WAVE FEATURES TO OBSERVING SYSTEM AND VERTICAL RESOLUTION ZONAL MEAN ATMOSPHERIC STRUCTURE AND THE CO2 CYCLE; 2) EXAMINE THE IMPACT OF VERTICAL AND HORIZONTAL AEROSOL DISTRIBUTIONS ON TRAVELING WAVE ACTIVITY THROUGH REANALYSES THAT UPDATE DUST AND ICE CLOUDS BASED ON TES AND MCS TEMPERATURES AND OPACITIES; 3) EVALUATE MCS RADIANCE ASSIMILATION USING THE AER FORWARD MODEL PARTICULARLY DURING TIMES OF HIGH OPACITY; 4) CREATE A HIGH RESOLUTION REANALYSIS USING THE CUBED SPHERE MGCM WITH AN IMPROVED HYBRID DATA ASSIMILATION SCHEME; 5) INVESTIGATE THE ORIGINS AND EVOLUTION AND PREDICTABILITY OF FLUSHING STORMS AND GLOBAL DUST STORMS USING REANALYSIS WINDS OPACITIES AND SPACECRAFT IMAGERY; 6) PREPARE A MULTIANNUAL REANALYSIS AND EVALUATE IT BY COMPARING TO OTHER OBSERVATIONS AND ANALYSES AND DELIVER IT TO THE MARS ATMOSPHERE COMMUNITY. OUR FEATURE-BASED VALIDATION WILL ENABLE FURTHER IMPROVEMENTS IN EMARS TO BETTER REPRESENT THE COMPLEXITY OF MARTIAN WEATHER. THE FOUR-DIMENSIONAL EVOLUTION OF AEROSOL FIELDS AND THEIR IMPACT IN TURN ON PLANETARY CIRCULATION TRAVELING WAVE AMPLITUDES AND THE STRENGTH OF TIDES WILL BE CONSIDERED. WE WILL EXPLORE THE CIRCULATION FEATURES ASSOCIATED WITH DUST STORMS AND THEIR ROLE IN DUST LIFTING AND TRANSPORT A STUDY THAT CAN ONLY BE ACHIEVED USING ATMOSPHERE AND AEROSOL REANALYSES. IMPLICATIONS FOR PREDICTABILITY OF MARS DUST STORMS WILL BE INVESTIGATED.
$714,037The Pennsylvania State University · · FY2020 · National Aeronautics and Space Administration
New strategies for treating septic vasculopathy, inflammation and thrombosis
$713,873Xiaoping Du · University Of Illinois At Chicago · R01 · FY2018 · HL
New strategies for treating septic vasculopathy, inflammation and thrombosis
$713,873Xiaoping Du · University Of Illinois At Chicago · R01 · FY2017 · HL
Netting prevention intervention butterfly effects: An integrative data analysis investigating the long-term and cross-over effects of randomized,school-based prevention programs on adult mental health
$713,848Rashelle Jean Musci · Johns Hopkins University · R01 · FY2021 · MH
Phenotype Predictors of Cognitive Outcomes in Geriatric Depression
$713,805David C. Steffens · University Of Connecticut Sch Of Med/Dnt · R01 · FY2022 · MH
Mammalian L1 retrotransposon replication
$713,804Anthony V. Furano · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2010 · DK
Transport Processes and Nervous System Function
$713,593Peter J. Basser · Eunice Kennedy Shriver National Institute Of Child Health & Human Development · ZIA · FY2025 · HD
Telemedicine Use Among Assisted Living Residents with ADRD: Assisted Living, Market, and State Regulatory Factors
$713,486Shubing Cai · University Of Rochester · R01 · FY2025 · AG