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24,576 grants matching “microbiome”
The Long Life Family Study
$15,098,513Michael A Province · Washington University · U19 · FY2025 · AG
WE PROPOSE THE CENTER FOR THE UTILIZATION OF BIOLOGICAL ENGINEERING IN SPACE (CUBES) TO SUPPORT BIOMANUFACTURING FOR DEEP SPACE EXPLORATION THAT REALIZES THE INHERENT MASS POWER AND VOLUME ADVANTAGES OF SPACE BIOTECHNOLOGY OVER TRADITIONAL ABIOTIC APPROACHES. CUBES WILL ADVANCE THE PRACTICALITY OF AN INTEGRATED MULTI-FUNCTION MULTI-ORGANISM BIOMANUFACTURING SYSTEM ON A MARS MISSION. HIGHLY MULTIDISCIPLINARY RESEARCH WILL CULMINATE IN A CONTINUOUS BIOMANUFACTURING DEMONSTRATION OF FUEL MATERIALS PHARMACEUTICALS AND FOOD. OUR TEAM CAN EXECUTE THIS VISION BECAUSE OF OUR DEEP EXPERIENCE IN HYBRID BIOINORGANICS FOR LIGHT-DRIVEN CARBON AND NITROGEN FIXATION ENZYMOLOGY POLYMER CHEMISTRY SYNTHETIC BIOLOGY EXTREMOPHILE ENGINEERING ADDITIVE MANUFACTURING AEROSPACE ENGINEERING PLANT/MICROBIOME FOOD AND CHEMICAL MANUFACTURE AND SPACE CROP PHYSIOLOGY. CUBES ENDEAVORS WILL INCLUDE (1) MEDIA GENERATION: ARTIFICIAL PHOTOSYNTHESIS THAT TURNS CARBON DIOXIDE INTO METHANE AND ACETATE; NITROGENASE-CATALYZED CONVERSION OF NITROGEN INTO AMMONIA AND CARBON DIOXIDE TO OTHER C1 COMPOUNDS; AMMONIA NITRIFICATION; REGOLITH DETOXIFICATION AND ENRICHMENT; RECYCLING MISSION MATERIALS; (2) FUEL PRODUCTION: THE AFOREMENTIONED METHANE; C2/C3 ALKANES; NITROUS OXIDE FROM NITRITE AND ACETATE; DIESELLIKE FUELS FROM RECYCLED INEDIBLE PLANT MASS; HYDRAZINE VIA ANAMMOX BACTERIA FROM AMMONIA; (3) BIOPOLYMER PRODUCTION USE AND RECYCLING: GENERATION FROM METHANE AND C1 SUBSTRATES; ADDITIVES PRODUCTION; TESTING IN ADDITIVE MANUFACTURING DEVICES; CHEMICAL/ BIOLOGICAL RECYCLING; (4) PROCESS ENGINEERING: OPTIMIZATION OF PLATFORM ORGANISMS FOR MAXIMAL YIELD AND TOLERANCE INCLUDING MESOPHILIC AND EXTREMOPHILE BIOPROCESSING IN NOVEL BIOREACTORS; PLATFORM CHEMICALS FOR DOWNSTREAM BIOLOGICAL PROCESSES; (5) PHARMACEUTICAL SYNTHESIS BY MICROBES AND PLANTS FOR ANALGESICS BONE REGENERATION AND ANTICANCER; (6) INCREASED FOOD PRODUCTION BY MICROBES AND PLANTS THROUGH SELECTION PLANT/MICROBE SYNERGIES IN RESTRICTED ROOT-ZONE VOLUMES GENETIC ENGINEERING PLANT-MICROBIOME ENHANCEMENT AND INNOVATIVE LIGHT DELIVERY SYSTEMS FOR PHOTOSYNTHESIS IN EFFICIENT SPACE-READY PLANT GROWTH CHAMBERS; (7) PLANT SYSTEM WASTE RECYCLING AND PLANT CELL WALL DECONSTRUCTION; AND (8) DEMONSTRATION SYSTEM INTEGRATION TESTING SEEDING AND INCORPORATION OF AUTONOMY. OUR INNOVATIONS INCLUDE: NOVEL ARTIFICIAL PHOTOSYNTHETIC SUBSTRATES COUPLED TO MICROBES AND ENZYMES TO EFFECTIVELY HARVEST LIGHT AND SPLIT WATER TO FIX BOTH CARBON DIOXIDE AND NITROGEN INTO CRITICAL FEEDSTOCKS FOR MICROBIAL AND PLANT BIOMANUFACTURING; THE DESIGN OF EFFECTIVE MICROBIAL COMMUNITIES AND BIOPROCESSING TECHNIQUES FOR A RANGE OF MICROBIALLY-PRODUCED PLASTICS WITH TUNABLE PROCESSING AND MECHANICAL PROPERTIES DERIVABLE FROM AVAILABLE FEEDSTOCKS AND RECYCLING MATERIALS; THE LEVERAGING OF A UNIQUE REPRODUCIBLE MARS ENVIRONMENT-SIMULATION CHAMBER TO EXPLORE THE BOUNDS OF OPERATION OF MESOPHILIC AND EXTREMOPHILIC MICROBES TO REDUCE COST FOR CONDITIONING IN MARS ENVIRONMENTS; CHARACTERIZING ENGINEERING AND OPTIMIZING DIVERSE NON-MODEL MICROBES THAT WILL SUPPORT BENEFICIAL PLANT PHENOTYPES; CUTTING-EDGE TECHNIQUES IN USING PLANTS AND INEDIBLE PLANT BIOMASS TO QUICKLY AND EFFICIENTLY PRODUCE IMPORTANT CLASSES OF HUMAN DRUGS THAT REQUIRE CHEMISTRIES UNAVAILABLE IN MICROBIAL CELLS; OPTIMIZED PLANTS AND PLANT GROWTH CHAMBERS THAT ADDRESS THE AVAILABILITY OF LIGHT STRESSORS AND ENERGY LIKELY TO BE ENCOUNTERED IN A DEEP SPACE CULTIVATION ENVIRONMENT; AND NOVEL COMPUTATION SYSTEMS TO CAPTURE MODEL ANALYZE TEST AND DISSEMINATE BIOLOGICAL DATA ACROSS CUBES INTEGRATED PROCESSES AND SUBSYSTEM MODULES. CUBES' INDIVIDUAL APPROACHES TO MEDIA PRODUCTION MISSION PRODUCT MANUFACTURE AND FOOD AND PHARMACEUTICAL SYNTHESIS AMPLIFIED BY A FOCUS ON INTEGRATION AND OPTIMIZATION WILL LEAD TO A STRONG DATA-DRIVEN TECHNOLOGICALLY-BACKED PLATFORM FOR SPACE BIOMANUFACTURING.
$14,703,923Regents Of The University Of California, The · · FY2017 · National Aeronautics and Space Administration
A Data Center for the Discovery of the Genetic Basis of Human Disease
$14,273,023Larry J Shapiro · Washington University · C06 · FY2010 · RR
The Human Genome Sequencing Center
$13,964,521Richard A Gibbs · Baylor College Of Medicine · U54 · FY2013 · HG
ECHO Laboratory Core at Vanderbilt for Integrated Sample Biobanking and Processing
$13,799,987Suman Ranjan Das · Vanderbilt University Medical Center · U24 · FY2024 · OD
Children's Respiratory and Environmental Workgroup (CREW)
$13,742,977James E. Gern · University Of Wisconsin-Madison · UH3 · FY2019 · OD
High-Dimensional Immune Monitoring of NCI-Supported Immunotherapy Trials
$13,559,983Sacha Gnjatic · Icahn School Of Medicine At Mount Sinai · U24 · FY2017 · CA
Children's Respiratory and Environmental Workgroup (CREW)
$13,435,418James E. Gern · University Of Wisconsin-Madison · UH3 · FY2018 · OD
Children's Respiratory and Environmental Workgroup (CREW)
$13,371,640James E. Gern · University Of Wisconsin-Madison · UH3 · FY2021 · OD
EPPIC-NET DCC
$13,303,854Eva Petkova · New York University School Of Medicine · U24 · FY2019 · NS
EPPIC-Net Pain Research - Application for Clinical Trial and Related Activities (OT2)
$13,015,970Maurizio Fava · Massachusetts General Hospital · OT2 · FY2021 · NS
Inter- and Intra-Species Comparative Sequencing
$12,975,413Lawrence Brody · National Human Genome Research Institute · ZIB · FY2010 · HG
Children's Respiratory and Environmental Workgroup (CREW)
$12,871,640James E. Gern · University Of Wisconsin-Madison · UH3 · FY2022 · OD
Washington National Primate Research Center
$12,859,589Sean D Sullivan · University Of Washington · P51 · FY2020 · OD
Washington National Primate Research Center
$12,859,589David M Anderson · University Of Washington · P51 · FY2019 · OD
Washington National Primate Research Center
$12,859,589Sean D Sullivan · University Of Washington · P51 · FY2021 · OD
Washington National Primate Research Center
$12,859,589David M Anderson · University Of Washington · P51 · FY2017 · OD
NCI Central Scientific Computing Resources
$12,852,880James Racheff · Office Of The Director, Nci · ZIH · FY2025 · CA
Inter- and Intra-Species Comparative Sequencing
$12,321,154Eric Green · National Human Genome Research Institute · ZIB · FY2009 · HG
Inner City Asthma consortium 3 (ICAC3)
$12,125,381William W. Busse · University Of Wisconsin-Madison · UM1 · FY2015 · AI
Inter- and Intra-Species Comparative Sequencing
$11,942,777James C Mullikin · National Human Genome Research Institute · ZIB · FY2014 · HG
Inter- and Intra-Species Comparative Sequencing
$11,776,841Lawrence Brody · National Human Genome Research Institute · ZIB · FY2011 · HG
Prospective Study of the Gut Microbiome in Aging
$11,749,351Andrew T Chan · Massachusetts General Hospital · RF1 · FY2020 · AG
SYSTEMS ANALYSIS OF THE BENEFICIAL ASSOCIATIONS OF SORGHUM WITH ARBUSCULAR MYCRORRHIZAL FUNGI STUDIED WITH GENETICS, GENOMICS, IMAGING AND MICROBIOMICS
$11,711,865University Of Georgia Research Foundation, Inc. · · FY2020 · Department of Energy
Leadership Group for the Infectious Diseases Clinical Research Consortium (IDCRCLG)
$11,669,860David S Stephens · Emory University · UM1 · FY2022 · AI