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15,273 grants matching “antimicrobial resistance”
THE WHO DECLARED THAT ANTIMICROBIAL RESISTANCE IS ONE OF 21ST CENTURY'S MOST CRITICAL HUMAN HEALTH CHALLENGES. THERE IS A CLOSE RELATIONSHIP BETWEEN ANIMAL PRODUCTION ANTIMICROBIAL USE AND ANTIMICROBIAL RESISTANCE IN THE ENVIRONMENT AND HUMANS. INCREASING DEMAND FOR ANIMAL PRODUCTS RESULTS IN INCREASE OF CONCENTRATED ANIMAL PRODUCTION AND THE UNAVOIDABLE ANTIMICROBIAL USAGE. CONTROLLING THE FLOW OF ANTIMICROBIAL RESISTANT ELEMENTS FROM ANIMAL TO PLANT PRODUCTION WITHIN AGRO-ECOSYSTEMS WOULD BALANCE THE DEMAND FOR ANIMAL PRODUCTS, PRODUCERS' NEED FOR HEALTHY ANIMALS, AND THE CONCERNS ABOUT ANTIMICROBIAL RESISTANCE AND REDUCED ECOSYSTEM SERVICES. TO ACHIEVE THIS GOAL, AN INTERDISCIPLINARY MULTI-SCALE INVESTIGATION IS PROPOSED TO UNDERSTAND HOW CURRENT NUTRIENT-CENTERED BEST MANURE LAND MANAGEMENT AFFECTS THE FLOW OF MANURE-BORNE ANTIMICROBIAL RESISTANT ELEMENTS IN AGRO-ECOSYSTEMS. THIS ULTIMATELY LEADS TO IMPROVED LIFE CYCLE ASSESSMENT AND MODELING OF ANTIMICROBIAL USE AND MORE EFFECTIVE MANURE LAND MANAGEMENT TO REDUCE/MINIMIZE THE NEGATIVE IMPACTS OF ANTIMICROBIAL RESISTANT ELEMENTS ON OVERALL ECOSYSTEM SERVICES AND HUMAN WELL BEING.THIS RESEARCH ADDRESSES THE GOALS OF AGRO-ECOSYSTEM MANAGEMENT (NIFA-AFRI FOUNDATIONAL PROGRAM PRIORITY AREA #4- BNRE) BY "EVALUATING AND DEVELOPING INNOVATIVE AGRO-ECOSYSTEM MANAGEMENT PRACTICES AND SYSTEMS FOR THEIR POTENTIAL TO ENHANCE ECOSYSTEM SERVICES". IT DIRECTLY ADDRESSES THE PROGRAM PRIORITY AREA THROUGH: 1) STUDY OF MULTI-SCALE FLOW OF MANURE-ASSOCIATED ANTIMICROBIAL RESISTANT ELEMENTS IN AGRO-ECOSYSTEMS; 2) ASSESSMENT OF THE EFFECTIVENESS OF NUTRIENT-CENTERED BEST MANURE LAND MANAGEMENT IN REDUCING/MINIMIZING THE NEGATIVE IMPACTS OF ANIMAL ANTIMICROBIAL USAGE ON ECOSYSTEM SERVICES AND HUMAN WELL BEING. THIS STUDY WILL HELP ENHANCE THE PROVISIONING, REGULATING, SUPPORTING SERVICES OF MANURE IMPACTED AGRO-ECOSYSTEM REGIONALLY OR NATIONALLY.
$480,000Virginia Polytechnic Institute & State University · · FY2017 · National Institute of Food and Agriculture
HPLC and CE of Peptides and Proteins
$479,994University Of Colorado Denver · R01 · FY2004 · GM
Network for Antimicrobial Resistance in Staphylococcus aureus
$479,884Daniel Sahm · Eurofins Medinet · N01 · FY2012 · AI
Relating impacts of antibiotics on the gut metabolome and microbiome to host physiology and weight
$479,718Peter Belenky · Brown University · R01 · FY2024 · DK
Immunity and Latency to Chlamydial Infections
$479,706Gerald Irwin Byrne · University Of Tennessee Health Sci Ctr · R01 · FY2009 · AI
Identification of novel therapeutics for tuberculosis combining cheminformatics,
$479,605Sean Ekins · Collaborative Drug Discovery, Inc. · R42 · FY2012 · AI
ECF Sigma Factors and Cell Envelope Stress in Bacillus subtilis
$479,576John D. Helmann · Cornell University · R01 · FY2013 · GM
ECF Sigma Factors and Cell Envelope Stress in Bacillus subtilis
$479,575John D. Helmann · Cornell University · R01 · FY2015 · GM
ECF Sigma Factors and Cell Envelope Stress in Bacillus subtilis
$479,575John D. Helmann · Cornell University · R01 · FY2016 · GM
ECF Sigma Factors and Cell Envelope Stress in Bacillus subtilis
$479,575John D. Helmann · Cornell University · R01 · FY2014 · GM
Improved Therapeutics and Diagnostics for Pneumocystis Pneumonia
$479,515Jay K Kolls · Tulane University Of Louisiana · R01 · FY2023 · AI
Novel Electrochemical Bandage for Treatment of Wound Infections
$479,443Robin Patel · Mayo Clinic Rochester · R01 · FY2019 · AI
Dissecting the role of sialic acid and sialidase in the pathophysiology of Porphyromonas gingivalis
$479,423Chunhao Li · Virginia Commonwealth University · R01 · FY2024 · DE
Antibiotic Drug Discovery
$479,334Toni B. Kline · University Of Washington · U54 · FY2009 · AI
Role of the hormone LEAP2 in eating, body weight, blood glucose and survival
$479,260Jeffrey M Zigman · Ut Southwestern Medical Center · R01 · FY2022 · DK
Infectious Diseases and Microbial Immunology Post-doctoral Training Program
$479,197Thomas H Kawula · Washington State University · T32 · FY2025 · AI
MYCOBACTERIAL RESISTANCE TO REACTIVE NITROGEN/OXYGEN
$479,186Weill Medical College Of Cornell Univ · R01 · FY2001 · HL
Discovery of Hsp100-selective inhibitors for targeting multiple microbial pathogens
$479,141Michal Zolkiewski · Kansas State University · R01 · FY2021 · AI
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THE GOAL OF THE PROJECT IS TO DESIGN EFFECTIVE STRATEGIES FOR CONTROLLING THE DISPERSAL OF MULTI-SPECIES FOOD PATHOGENS, BASED ON ADVANCED UNDERSTANDING OF MICROBIAL INTERACTIONS AND BIOPHYSICAL FACTORS OF CONTAMINATION DYNAMICS. FOOD-BORNE PATHOGENS SUCH ASESCHERICHIA COLI,SALMONELLA ENTERICAANDLISTERIA MONOCYTOGENESFORM HIGHLYRESILIENTMULTI-SPECIES BIOFILMS IN FOOD PROCESSING FACILITIES. THEY ARE FOUND IN MANY AREAS SUCH AS THE BACK OF CONVEYOR BELTS OR DRAINS, WHICH HAVE POOR ACCESSIBILITY FOR SANITATION AND THEREFORE RESULT IN BIOFILMS WITH ENHANCED SANITIZER TOLERANCE AND ANTIMICROBIAL RESISTANCE. WE AIM TO CONTROL FOOD CONTAMINATION BY INVESTIGATING THE BIOFILM HOTSPOTS. THE SPECIFIC OBJECTIVES OF THIS PROJECT ARE TO (1) INVESTIGATE SANITIZER TOLERANCE IN FOOD PATHOGEN-MIXED-SPECIES BIOFILM (2) MEASURE THE EFFECT OF SPATIOTEMPORAL MICROSCALE PATTERNS ON BIOFILM DISPERSAL IN DRAINS OF FOOD PROCESSING SYSTEMS (3) EVALUATE BIOPHYSICAL FACTORS GOVERNING BIOFILM DETACHMENT AND DISPERSAL, LEADING TO HOTSPOT SPECIFIC INTERVENTION TO PREVENT DISPERSAL OF PATHOGENS FROM THE HOTSPOTS. THESE OBJECTIVES WILL BE ADDRESSED EXPERIMENTALLY USING COMBINATION OF OMICS, MICROSCOPIC AND MICROFLUIDIC TECHNIQUES.THE COMPREHENSIVE UNDERSTANDING OF FOOD-BORNE PATHOGEN DISPERSAL PROCESSES FROM HOTSPOTS IN FOOD PROCESSING FACILITIES AND THEIR UNDERLYING MICROBIOLOGICAL MECHANISMS, IS HIGHLY SIGNIFICANT, AS IT WILL LEAD TO POWERFUL NEW APPROACHES THAT WILL REDUCE THE CONTAMINATION OF FOOD WITH PATHOGENS.
$478,923Texas A&M Agrilife Research · · FY2020 · National Institute of Food and Agriculture
Adaptive Alterations of Lipids in Streptococcus Mitis
$478,792Kelli Lea Palmer · University Of Texas Dallas · R56 · FY2019 · AI
Antibiotic Resistance Determination Utilizing Machine Learning
$478,747Xiaowei Zhan · Ut Southwestern Medical Center · U01 · FY2024 · AI
Antibiotic Resistance Determination Utilizing Machine Learning
$478,747Xiaowei Zhan · Ut Southwestern Medical Center · U01 · FY2023 · AI
Implementing a Discharge Stewardship Bundle to improve antibiotic use at transition from hospital to home
$478,662Jeffrey Stephen Gerber · Children'S Hosp Of Philadelphia · R01 · FY2021 · HS
Genomics approaches to elucidating pathways to antibiotic resistance in Neisseria gonorrhoeae
$478,500Yonatan H Grad · Harvard School Of Public Health · R01 · FY2023 · AI
Reducing Antimicrobial Overuse in HCAP Through Personalized Antimicrobial Recommendations
$478,332Michael B Rothberg · Cleveland Clinic Foundation · R01 · FY2019 · HS