THE WHO DECLARED THAT ANTIMICROBIAL RESISTANCE IS ONE OF 21ST CENTURY'S MOST CRITICAL HUMAN HEALTH CHALLENGES. THERE IS A CLOSE RELATIONSHIP BETWEEN ANIMAL PRODUCTION ANTIMICROBIAL USE AND ANTIMICROBIAL RESISTANCE IN THE ENVIRONMENT AND HUMANS. INCREASING DEMAND FOR ANIMAL PRODUCTS RESULTS IN INCREASE OF CONCENTRATED ANIMAL PRODUCTION AND THE UNAVOIDABLE ANTIMICROBIAL USAGE. CONTROLLING THE FLOW OF ANTIMICROBIAL RESISTANT ELEMENTS FROM ANIMAL TO PLANT PRODUCTION WITHIN AGRO-ECOSYSTEMS WOULD BALANCE THE DEMAND FOR ANIMAL PRODUCTS, PRODUCERS' NEED FOR HEALTHY ANIMALS, AND THE CONCERNS ABOUT ANTIMICROBIAL RESISTANCE AND REDUCED ECOSYSTEM SERVICES. TO ACHIEVE THIS GOAL, AN INTERDISCIPLINARY MULTI-SCALE INVESTIGATION IS PROPOSED TO UNDERSTAND HOW CURRENT NUTRIENT-CENTERED BEST MANURE LAND MANAGEMENT AFFECTS THE FLOW OF MANURE-BORNE ANTIMICROBIAL RESISTANT ELEMENTS IN AGRO-ECOSYSTEMS. THIS ULTIMATELY LEADS TO IMPROVED LIFE CYCLE ASSESSMENT AND MODELING OF ANTIMICROBIAL USE AND MORE EFFECTIVE MANURE LAND MANAGEMENT TO REDUCE/MINIMIZE THE NEGATIVE IMPACTS OF ANTIMICROBIAL RESISTANT ELEMENTS ON OVERALL ECOSYSTEM SERVICES AND HUMAN WELL BEING.THIS RESEARCH ADDRESSES THE GOALS OF AGRO-ECOSYSTEM MANAGEMENT (NIFA-AFRI FOUNDATIONAL PROGRAM PRIORITY AREA #4- BNRE) BY "EVALUATING AND DEVELOPING INNOVATIVE AGRO-ECOSYSTEM MANAGEMENT PRACTICES AND SYSTEMS FOR THEIR POTENTIAL TO ENHANCE ECOSYSTEM SERVICES". IT DIRECTLY ADDRESSES THE PROGRAM PRIORITY AREA THROUGH: 1) STUDY OF MULTI-SCALE FLOW OF MANURE-ASSOCIATED ANTIMICROBIAL RESISTANT ELEMENTS IN AGRO-ECOSYSTEMS; 2) ASSESSMENT OF THE EFFECTIVENESS OF NUTRIENT-CENTERED BEST MANURE LAND MANAGEMENT IN REDUCING/MINIMIZING THE NEGATIVE IMPACTS OF ANIMAL ANTIMICROBIAL USAGE ON ECOSYSTEM SERVICES AND HUMAN WELL BEING. THIS STUDY WILL HELP ENHANCE THE PROVISIONING, REGULATING, SUPPORTING SERVICES OF MANURE IMPACTED AGRO-ECOSYSTEM REGIONALLY OR NATIONALLY.