← Leaderboards
David A. Hafler
Brigham And Women'S Hospital
$48,350,086
Attributed
$58,253,881
Total exposure
42
Grants
32
Lead (contact PI)
Attributed= this PI's even-split share of every grant they're on (the fair, additive number). Exposure = full size of all those grants.
Funding over time
peak $11.7M · FY2005–25$20M$15M$10M$5M$0
'05
'06
'07
'08
'09
'10
'11
'12
'13
'14
'15
'16
'17
'18
'19
'20
'21
'22
'23
'24
'25
Funding mix
By agency
NIH$156,588,608 · 45
By mechanism
P01$67,856,099 · 16
U19$59,624,481 · 10
R01$11,642,418 · 7
U01$10,144,375 · 3
R37$2,766,948 · 1
RC2$1,917,986 · 1
Top collaborators
- Ruth R Montgomery17 shared
- Erol Fikrig6 shared
- Richard J. Barohn5 shared
- Jonathan M. Goldstein5 shared
- Kevan C Herold5 shared
- Richard Nowak5 shared
- Antonio M Omuro4 shared
- Charles S Dela Cruz1 shared
Most similar at Brigham And Women'S Hospital
Same institution · by research overlap
- Benjamin Harris Kann$1,988,578
Others in their field
Top investigators on “Response”
- Lawrence Corey · Fred Hutchinson Cancer Center$677,505,141
- David Divins · Consortium For Ocean Leadership, Inc$609,772,544
- Margaret Juliana McElrath · Fred Hutchinson Cancer Center$532,027,174
- Barton F Haynes · Duke University$497,761,007
- Jeffrey P Krischer · University Of South Florida$397,532,270
- Glenda E Gray · Wits Health Consortium (Pty), Ltd$342,310,423
Research focus
ResponseCellsImmuneAutoimmune DiseasesPathway InteractionsBaseAutoimmunityT-LymphocyteMultiple SclerosisSignal TransductionProgramsTissuesInvestigationGrantImmune ResponseResourcesInflammatoryResearch PersonnelTechnologyMolecularFunctional DisorderFutureCell PhysiologyBlood
Grant awards (200)
Microbial Programming of T-cell Migration from Gut to Brain$4,908,988
R01 · FY2025 · AI
Costimulatory Mechanisms of Autoimmunity$2,514,298
P01 · FY2025 · AI · contact PI
Immune signatures of vaccine responses in vulnerable populations$2,388,688
U19 · FY2025 · AI
Targeting T cell dysfunction in glioblastoma: A proof-of-concept Phase 0/I trial of anti-TIGIT antibody AB154 in combination with anti-PD1 antibody AB122$682,689
R01 · FY2025 · CA · contact PI
Project 3: Role of Coinhibitory receptors in regulating Immune Tolerance in the Human Brain$628,125
P01 · FY2025 · AI · contact PI
Systems investigation of vaccine responses in B cell depleted autoimmune patients$456,987
U19 · FY2025 · AI · contact PI
Immune signatures of vaccine responses in vulnerable populations$84,018
U19 · FY2025 · AI
Administrative Core$67,000
P01 · FY2025 · AI · contact PI
Yale Clinical Neuroscientist Training Program$1
UE5 · FY2025 · NS · contact PI
Costimulatory Mechanisms of Autoimmunity$2,514,298
P01 · FY2024 · AI · contact PI
Immune signatures of vaccine responses in vulnerable populations$1,060,433
U19 · FY2024 · AI
Targeting T cell dysfunction in glioblastoma: A proof-of-concept Phase 0/I trial of anti-TIGIT antibody AB154 in combination with anti-PD1 antibody AB122$648,555
R01 · FY2024 · CA · contact PI
Project 3: Role of Coinhibitory receptors in regulating Immune Tolerance in the Human Brain$628,125
P01 · FY2024 · AI · contact PI
Systems investigation of vaccine responses in B cell depleted autoimmune patients$473,661
U19 · FY2024 · AI · contact PI
Administrative Core$67,000
P01 · FY2024 · AI · contact PI
Yale Clinical Neuroscientist Training Program$1
UE5 · FY2024 · NS · contact PI
Immune signatures of vaccine responses in vulnerable populations$2,706,289
U19 · FY2023 · AI
Costimulatory Mechanisms of Autoimmunity$2,548,048
P01 · FY2023 · AI · contact PI
Targeting T cell dysfunction in glioblastoma: A proof-of-concept Phase 0/I trial of anti-TIGIT antibody AB154 in combination with anti-PD1 antibody AB122$673,408
R01 · FY2023 · CA
Project 3: Role of Coinhibitory receptors in regulating Immune Tolerance in the Human Brain$628,125
P01 · FY2023 · AI · contact PI
Systems investigation of vaccine responses in B cell depleted autoimmune patients$483,750
U19 · FY2023 · AI · contact PI
Administrative Core$67,000
P01 · FY2023 · AI · contact PI
Yale Clinical Neuroscientist Training Program$1
R25 · FY2023 · NS · contact PI
Immune signatures of vaccine responses in vulnerable populations$2,874,261
U19 · FY2022 · AI
Targeting T cell dysfunction in glioblastoma: A proof-of-concept Phase 0/I trial of anti-TIGIT antibody AB154 in combination with anti-PD1 antibody AB122$695,125
R01 · FY2022 · CA
Systems investigation of vaccine responses in B cell depleted autoimmune patients$345,355
U19 · FY2022 · AI · contact PI
Project 2- Liquid Biopsies for Melanoma that Metastasizes to Inaccessible Sites$294,426
P50 · FY2022 · CA · contact PI
Yale Clinical Neuroscientist Training Program$101,610
R25 · FY2022 · NS · contact PI
Costimulatory Mechanisms of Autoimmunity$2,523,040
P01 · FY2021 · AI · contact PI
Systems Immune Profiling of Divergent Responses to Infection$2,337,337
U19 · FY2021 · AI · contact PI
Immunophenotyping for COVID-19 Cohort (IMPACC)$1,149,216
U19 · FY2021 · AI · contact PI
Systems Immune Profiling of Divergent Responses to Infection$1,077,339
U19 · FY2021 · AI · contact PI
Core for COVID-19 Cohort IMPACC$954,979
U19 · FY2021 · AI · contact PI
COVID-19 Supplement: Systems Immune Profiling of Divergent Responses to Infection$642,765
U19 · FY2021 · AI · contact PI
Project 2: Costimulation Pathways in CNS Disease$632,227
P01 · FY2021 · AI · contact PI
Project 2- Liquid Biopsies for Melanoma that Metastasizes to Inaccessible Sites$315,555
P50 · FY2021 · CA · contact PI
Core A: Administrative Core$142,271
U19 · FY2021 · AI · contact PI
Yale Clinical Neuroscientist Training Program$102,845
R25 · FY2021 · NS · contact PI
Administrative Core$62,814
P01 · FY2021 · AI · contact PI
Costimulatory Mechanisms of Autoimmunity$2,538,330
P01 · FY2020 · AI · contact PI
Systems Immune Profiling of Divergent Responses to Infection$2,370,688
U19 · FY2020 · AI · contact PI
Immunophenotyping for COVID-19 Cohort (IMPACC)$1,087,629
U19 · FY2020 · AI · contact PI
Core for COVID-19 Cohort IMPACC$940,621
U19 · FY2020 · AI · contact PI
COVID-19 Supplement: Systems Immune Profiling of Divergent Responses to Infection$695,543
U19 · FY2020 · AI · contact PI
Project 2: Costimulation Pathways in CNS Disease$634,999
P01 · FY2020 · AI · contact PI
Systems Immune Profiling of Divergent Responses to Infection$454,168
U19 · FY2020 · AI · contact PI
Project 2- Liquid Biopsies for Melanoma that Metastasizes to Inaccessible Sites$320,464
P50 · FY2020 · CA · contact PI
Costimulatory Mechanisms of Autoimmunity$309,497
P01 · FY2020 · AI · contact PI
Project 2: Costimulation Pathways in CNS Disease$309,497
P01 · FY2020 · AI · contact PI
Dysregulated Co-inhibitory Pathways Associated with Severe COVID-19 Immunopathology$260,931
P01 · FY2020 · AI · contact PI
Core A: Administrative Core$169,508
U19 · FY2020 · AI · contact PI
Yale Clinical Neuroscientist Training Program$98,929
R25 · FY2020 · NS · contact PI
Administrative Core$65,543
P01 · FY2020 · AI · contact PI
Systems Immune Profiling of Divergent Responses to Infection$3,098,137
U19 · FY2019 · AI · contact PI
Costimulatory Mechanisms of Autoimmunity$2,546,320
P01 · FY2019 · AI · contact PI
Project 2: Costimulation Pathways in CNS Disease$634,998
P01 · FY2019 · AI · contact PI
Core A: Administrative Core$498,681
U19 · FY2019 · AI · contact PI
Tim-3 regulation of CNS autoimmune responses$413,589
P01 · FY2019 · AI · contact PI
Project 2- Liquid Biopsies for Melanoma that Metastasizes to Inaccessible Sites$315,543
P50 · FY2019 · CA · contact PI
Yale Clinical Neuroscientist Training Program$98,396
R25 · FY2019 · NS · contact PI
Administrative Core$72,916
P01 · FY2019 · AI · contact PI
Systems Immune Profiling of Divergent Responses to Infection$2,954,296
U19 · FY2018 · AI · contact PI
Costimulatory Mechanisms of Autoimmunity$2,558,253
P01 · FY2018 · AI · contact PI
Project 2: Costimulation Pathways in CNS Disease$597,424
P01 · FY2018 · AI · contact PI
Tim-3 regulation of CNS autoimmune responses$413,588
P01 · FY2018 · AI · contact PI
Project 2- Liquid Biopsies for Melanoma that Metastasizes to Inaccessible Sites$335,000
P50 · FY2018 · CA · contact PI
Core A: Administrative Core$123,769
U19 · FY2018 · AI · contact PI
Administrative Core$65,252
P01 · FY2018 · AI · contact PI
Yale Clinical Neuroscientist Training Program$1
R25 · FY2018 · NS · contact PI
Systems Immune Profiling of Divergent Responses to Infection$2,727,875
U19 · FY2017 · AI · contact PI
Costimulatory Mechanisms of Autoimmunity$2,654,197
P01 · FY2017 · AI · contact PI
Project 2: Costimulation Pathways in CNS Disease$599,399
P01 · FY2017 · AI · contact PI
Tim-3 regulation of CNS autoimmune responses$423,630
P01 · FY2017 · AI · contact PI
Core A: Administrative Core$134,319
U19 · FY2017 · AI · contact PI
Yale Clinical Neuroscientist Training Program$99,385
R25 · FY2017 · NS · contact PI
Administrative Core$65,469
P01 · FY2017 · AI · contact PI
Costimulatory Mechanisms of Autoimmunity (Composite)$2,090,661
P01 · FY2016 · AI · contact PI
A Phase II Trial of Rituximab In Myasthenia Gravis$964,955
U01 · FY2016 · NS
Costimulation Genes and Pathways in Multiple Sclerosis$736,167
P01 · FY2016 · AI · contact PI
The role of the innate immune system on Treg reprogramming in human autoimmune di$721,853
U01 · FY2016 · AI · contact PI
Tim-3 regulation of CNS autoimmune responses$500,102
P01 · FY2016 · AI · contact PI
A Phase II Trial of Rituximab In Myasthenia Gravis$183,022
U01 · FY2016 · NS
Administrative Core$87,534
P01 · FY2016 · AI · contact PI
Yale Clinical Neuroscientist Training Program$57,145
R25 · FY2016 · NS · contact PI
A Phase II Trial of Rituximab In Myasthenia Gravis$1,011,907
U01 · FY2015 · NS
The role of the innate immune system on Treg reprogramming in human autoimmune di$742,405
U01 · FY2015 · AI · contact PI
Tim-3 regulation of CNS autoimmune responses$557,310
P01 · FY2015 · AI · contact PI
Defining signatures for immune responsiveness by functional systems immunology$356,913
U19 · FY2015 · AI · contact PI
Yale Clinical Neuroscientist Training Program$56,533
R25 · FY2015 · NS · contact PI
Multimensional Robotic Flow Platform$28,971
U19 · FY2015 · AI · contact PI
Defining signatures for immune responsiveness by functional systems immunology$2,834,344
U19 · FY2014 · AI · contact PI
Costimulatory Mechanisms of Autoimmunity (Composite)$2,088,964
P01 · FY2014 · AI · contact PI
A Phase II Trial of Rituximab In Myasthenia Gravis$1,059,022
U01 · FY2014 · NS
The role of the innate immune system on Treg reprogramming in human autoimmune di$762,141
U01 · FY2014 · AI · contact PI
Multimensional Robotic Flow Platform$566,272
U19 · FY2014 · AI · contact PI
Costimulation Genes and Pathways in Multiple Sclerosis$373,507
P01 · FY2014 · AI · contact PI
ACE: Investigation of Innate Immunity in Multiple Sclerosis$310,642
R01 · FY2014 · AI · contact PI
Yale Clinical Neuroscientist Training Program$87,480
R25 · FY2014 · NS · contact PI
Administrative Core$74,533
U19 · FY2014 · AI · contact PI
Administrative Core$45,718
P01 · FY2014 · AI · contact PI
Yale Clinical Neuroscientist Training Program$1,080
R25 · FY2014 · NS · contact PI
Defining signatures for immune responsiveness by functional systems immunology$2,761,712
U19 · FY2013 · AI · contact PI
Costimulatory Mechanisms of Autoimmunity (Composite)$2,050,980
P01 · FY2013 · AI · contact PI
A Phase II Trial of Rituximab In Myasthenia Gravis$1,305,373
U01 · FY2013 · NS
The role of the innate immune system on Treg reprogramming in human autoimmune di$734,063
U01 · FY2013 · AI · contact PI
Multimensional Robotic Flow Platform$559,917
U19 · FY2013 · AI · contact PI
Costimulation Genes and Pathways in Multiple Sclerosis$347,782
P01 · FY2013 · AI · contact PI
ACE: Investigation of Innate Immunity in Multiple Sclerosis$295,204
R01 · FY2013 · AI · contact PI
Yale Clinical Neuroscientist Training Program$163,620
R25 · FY2013 · NS · contact PI
Administrative Core$83,487
U19 · FY2013 · AI · contact PI
Administrative Core$42,569
P01 · FY2013 · AI · contact PI
Yale Clinical Neuroscientist Training Program$1
R25 · FY2013 · NS · contact PI
Defining signatures for immune responsiveness by functional systems immunology$2,837,004
U19 · FY2012 · AI · contact PI
Costimulatory Mechanisms of Autoimmunity (Composite)$2,181,894
P01 · FY2012 · AI · contact PI
The role of the innate immune system on Treg reprogramming in human autoimmune di$815,616
U01 · FY2012 · AI · contact PI
Multimensional Robotic Flow Platform$742,722
U19 · FY2012 · AI · contact PI
B Cells as Antigen Presenting Cells in Human Autoimmune Diseases$605,389
P01 · FY2012 · AI · contact PI
Role of TIM-3 in Regulating CNS Autoimmune Responses$413,767
P01 · FY2012 · AI · contact PI
Costimulation Genes and Pathways in Multiple Sclerosis$369,478
P01 · FY2012 · AI · contact PI
ACE: Investigation of Innate Immunity in Multiple Sclerosis$317,131
R01 · FY2012 · AI · contact PI
Administrative Core$94,578
U19 · FY2012 · AI · contact PI
Yale Clinical Neuroscientist Training Program$75,600
R25 · FY2012 · NS · contact PI
Administrative Core$47,414
P01 · FY2012 · AI · contact PI
Defining signatures for immune responsiveness by functional systems immunology$2,849,006
U19 · FY2011 · AI · contact PI
Costimulatory Mechanisms of Autoimmunity (Composite)$2,183,882
P01 · FY2011 · AI · contact PI
Regulatory T Cells in Autoimmune Disease$762,285
U19 · FY2011 · AI · contact PI
B Cells as Antigen Presenting Cells in Human Autoimmune Diseases$522,073
P01 · FY2011 · AI · contact PI
Multimensional Robotic Flow Platform$434,104
U19 · FY2011 · AI · contact PI
Costimulation Genes and Pathways in Multiple Sclerosis$377,691
P01 · FY2011 · AI · contact PI
ACE: Investigation of Innate Immunity in Multiple Sclerosis$326,442
R01 · FY2011 · AI · contact PI
Role of TIM-3 in Regulating CNS Autoimmune Responses$309,760
P01 · FY2011 · AI · contact PI
Characterization of Fuctional Defective Autoimmune Human CD4+CD25+ Tregs$289,135
U19 · FY2011 · AI · contact PI
Administrative Core$119,077
U19 · FY2011 · AI · contact PI
Administrative Core$99,066
P01 · FY2011 · AI · contact PI
Defining signatures for immune responsiveness by functional systems immunology$4,456,091
U19 · FY2010 · AI · contact PI
Costimulatory Mechanisms of Autoimmunity (Composite)$2,220,927
P01 · FY2010 · AI · contact PI
The Role of Rare Variants in Multiple Sclerosis Risk$956,785
RC2 · FY2010 · NS · contact PI
Regulatory T Cells in Autoimmune Disease$848,779
U19 · FY2010 · AI · contact PI
Role of TIM-3 in Regulating CNS Autoimmune Responses$770,454
P01 · FY2010 · AI · contact PI
Costimulation Genes and Pathways in Multiple Sclerosis$396,469
P01 · FY2010 · AI · contact PI
T Cell Recognition of Myelin in Multiple Sclerosis$390,668
R37 · FY2010 · NS · contact PI
Characterization of Fuctional Defective Autoimmune Human CD4+CD25+ Tregs$358,007
U19 · FY2010 · AI · contact PI
ACE: Investigation of Innate Immunity in Multiple Sclerosis$331,000
R01 · FY2010 · AI · contact PI
Analysis of Pathogenic T Cell Response in MS$296,601
P01 · FY2010 · NS · contact PI
B Cells as Antigen Presenting Cells in Human Autoimmune Diseases$290,422
P01 · FY2010 · AI · contact PI
Administrative Core$108,969
P01 · FY2010 · AI · contact PI
Costimulatory Mechanism of Autoimmunity$1,653,964
P01 · FY2009 · AI · contact PI
The Role of Rare Variants in Multiple Sclerosis Risk$961,201
RC2 · FY2009 · NS · contact PI
Regulatory T Cells in Autoimmune Disease$838,927
U19 · FY2009 · AI · contact PI
Role of TIM-3 in Regulating CNS Autoimmune Responses$757,115
P01 · FY2009 · AI · contact PI
Regulatory T Cells in Autoimmune Disease$751,375
U19 · FY2009 · AI · contact PI
Costimulation Genes and Pathways in Multiple Sclerosis$455,366
P01 · FY2009 · AI · contact PI
T Cell Recognition of Myelin in Multiple Sclerosis$409,036
R37 · FY2009 · NS · contact PI
Characterization of Fuctional Defective Autoimmune Human CD4+CD25+ Tregs$336,107
U19 · FY2009 · AI · contact PI
Analysis of Pathogenic T Cell Response in MS$306,106
P01 · FY2009 · NS · contact PI
B Cells as Antigen Presenting Cells in Human Autoimmune Diseases$293,963
P01 · FY2009 · AI · contact PI
Administrative Core$97,269
P01 · FY2009 · AI · contact PI
Costimulatory Mechanism of Autoimmunity$1,610,401
P01 · FY2008 · AI · contact PI
Regulatory T Cells in Autoimmune Disease$909,305
U19 · FY2008 · AI · contact PI
Role of TIM-3 in Regulating CNS Autoimmune Responses$735,150
P01 · FY2008 · AI · contact PI
Costimulation Genes and Pathways in Multiple Sclerosis$445,788
P01 · FY2008 · AI · contact PI
T Cell Recognition of Myelin in Multiple Sclerosis$397,124
R37 · FY2008 · NS · contact PI
Characterization of Fuctional Defective Autoimmune Human CD4+CD25+ Tregs$380,820
U19 · FY2008 · AI · contact PI
Analysis of Pathogenic T Cell Response in MS$303,654
P01 · FY2008 · NS · contact PI
B Cells as Antigen Presenting Cells in Human Autoimmune Diseases$285,400
P01 · FY2008 · AI · contact PI
Administrative Core$92,815
P01 · FY2008 · AI · contact PI
EXAMINATION OF THE GENETIC BASIS OF MULTIPLE SCLEROSIS$3,374
M01 · FY2008 · RR · contact PI
Costimulatory Mechanism of Autoimmunity$1,598,483
P01 · FY2007 · AI · contact PI
Regulatory T Cells in Autoimmune Disease$903,038
U19 · FY2007 · AI · contact PI
Costimulation Genes and Pathways in Multiple Sclerosis$465,503
P01 · FY2007 · AI · contact PI
T Cell Recognition of Myelin in Multiple Sclerosis$379,332
R37 · FY2007 · NS · contact PI
Characterization of Fuctional Defective Autoimmune Human CD4+CD25+ Tregs$378,794
U19 · FY2007 · AI · contact PI
Analysis of Pathogenic T Cell Response in MS$360,849
P01 · FY2007 · NS · contact PI
T Cell Reactivity in Human Pancreatic Draining Lymph Nodes in Type 1 Diabetes$337,218
U19 · FY2007 · AI · contact PI
EXAMINATION OF THE GENETIC BASIS OF MULTIPLE SCLEROSIS$22,614
M01 · FY2007 · RR · contact PI
Costimulatory Mechanism of Autoimmunity$1,602,734
P01 · FY2006 · AI · contact PI
Regulatory T Cells in Autoimmune Disease$904,627
U19 · FY2006 · AI · contact PI
Costimulation Genes and Pathways in Multiple Sclerosis$451,834
P01 · FY2006 · AI · contact PI
Characterization of Fuctional Defective Autoimmune Human CD4+CD25+ Tregs$394,750
U19 · FY2006 · AI · contact PI
T Cell Recognition of Myelin in Multiple Sclerosis$390,662
R37 · FY2006 · NS · contact PI
Analysis of Pathogenic T Cell Response in MS$359,975
P01 · FY2006 · NS · contact PI
EXAMINATION OF THE GENETIC BASIS OF MULTIPLE SCLEROSIS$2,197
M01 · FY2006 · RR · contact PI
Costimulatory Mechanism of Autoimmunity$784,353
P01 · FY2005 · AI
T Cell Recognition of Myelin in Multiple Sclerosis$400,063
R37 · FY2005 · NS
Role of regulatory CD4+CD25+ T cells in diabetes$397,277
U01 · FY2005 · DK
Costimulation Genes and Pathways in Multiple Sclerosis$205,612
P01 · FY2005 · AI
Administrative Core$45,241
P01 · FY2005 · AI
COSTIMULATORY MECHANISMS OF AUTOIMMUNITY$1,221,930
P01 · FY2004 · AI
T Cell Recognition of Myelin in Multiple Sclerosis$400,063
R37 · FY2004 · NS
Role of regulatory CD4+CD25+ T cells in diabetes$389,233
U01 · FY2004 · DK
In Vitro correlates of rapamycin therapy in MS patients$287,613
R01 · FY2004 · NS
COSTIMULATORY MECHANISMS OF AUTOIMMUNITY$1,186,341
P01 · FY2003 · AI
Role of regulatory CD4+CD25+ T cells in diabetes$381,267
U01 · FY2003 · DK
T CELL RECOGNITION OF MYELIN IN MULTIPLE SCLEROSIS$319,943
R01 · FY2003 · NS
In Vitro correlates of rapamycin therapy in MS patients$287,613
R01 · FY2003 · NS
COSTIMULATORY MECHANISMS OF AUTOIMMUNITY$1,034,630
P01 · FY2002 · AI
Role of regulatory CD4+CD25+ T cells in diabetes$373,339
U01 · FY2002 · DK
T CELL RECOGNITION OF MYELIN IN MULTIPLE SCLEROSIS$312,675
R01 · FY2002 · NS
ANTIGEN DRIVEN CYTOKINE REGULATION IN HUMAN MYELIN$295,872
P01 · FY2002 · NS
Analysis of MS T cells using combinatorial libraries and MHC/peptide tetramers$0
P01 · FY2002 · AI