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Noble Research Institute Llc

$5,374,446

Total funding

15

Grants

Funding over time

peak $1.4M · FY2008–20

$2M$1.5M$1M$500K$0

'08

'09

'10

'11

'12

'13

'14

'15

'16

'17

'18

'19

'20

Funding mix

By agency

DOE$3,010,808 · 3

USDA$1,354,645 · 8

NASA$1,008,993 · 4

By mechanism

—$5,374,446 · 15

Investigators at Noble Research Institute Llc

Investigator-initiated All funding

Investigatorsi

Rising Stars

First grant in the last 5 yrs

Not enough data

Emerging Leaders

6–10 yrs in

Not enough data

All-Time

Most funded here, all years

Not enough data

Largest grants

DECIPHERING NATURAL ALLELIC VARIATION IN SWITCHGRASS FOR BIOMASS YIELD AND QUALITY USING A NESTED ASSOCIATION$1,360,743

· FY2012 · Department of Energy

THE SAMUEL ROBERTS NOBLE FOUNDATION WITH LBNL: NEW ROOTS AWARD. CONTROL NUMBER: 1565-1540 TITLE: ''AN INTEGRATED IMAGING AND MODELING TOOLBOX FOR ACCELERATED DEVELOPMENT OF ROOT-FOCUSED CROPS AT FIELD SCALES'' THE SAMUEL ROBERTS NOBLE FOUNDATION, INC., ALONG WITH LAWRENCE BERKELEY NATIONAL LABORATORY, WILL DEVELOP AN IMAGING-MODELING TOOLBOX FOR ACCELERATED DEVELOPMENT OF ROOT-FOCUSED CROPS AT FIELD SCALES. THIS APPROACH IS BASED ON A NOVEL ROOT PHENOTYPING METHOD CALLED TOMOGRAPHIC ELECTRICAL RHIZOSPHERE IMAGING (TERI), WHICH PROVIDES ADVANCED PHENOTYPING OF KEY ROOT AND SOIL TRAITS AT FIELD SCALES BASED ON THE ELECTRICAL IMPEDANCE RESPONSE OF ROOTS AND SOIL TO EXTERNAL ELECTRICAL EXCITATIONS. THE PROPOSED METHOD IS IN-SITU AND DYNAMIC, MINIMALLY INVASIVE, HIGH THROUGHPUT, FIELD READY AND MEASURES ROOTS AND SOIL TRAITS SIMULTANEOUSLY. ----------$950,065

· FY2017 · Department of Energy

SYSTEMATIC MODIFICATION OF MONOLIGNOL PATHWAY GENE EXPRESSION FOR IMPROVED LIGNOCELLULOSE UTILIZATION$700,000

· FY2008 · Department of Energy

UTILIZING THE ADVANCED BIOLOGICAL RESEARCH SYSTEM (ABRS) ON THE INTERNATIONAL SPACE STATION (ISS) TO UNCOVER MICROGRAVITY'S IMPACT ON ROOT DEVELOPMEN$499,412

· FY2014 · National Aeronautics and Space Administration

UNDERSTANDING VIRUS CELL-TO-CELL MOVEMENT AND ITS APPLICATION TO VIRUS RESISTANCE IN PLANTS$399,000

· FY2010 · National Institute of Food and Agriculture

FUNCTIONAL CHARACTERIZATION OF ROOT NODULE TRANSPORTERS INVOLVED IN SYMBIOTIC NITROGEN FIXATION$350,000

· FY2010 · National Institute of Food and Agriculture

DECIPHERING PROANTHOCYANIDIN BIOSYNTHESIS IN ALFALFA$336,000

· FY2010 · National Institute of Food and Agriculture

PAPM EAGER: HIGH-THROUGHPUT PHENOTYPING OF MULTIPLE ION UPTAKE KINETICS IN MAIZE ROOTS$290,000

· FY2017 · National Institute of Food and Agriculture

AS NASA PURSUES ITS GOAL OF SENDING HUMAN COLONIES TO MARS AND BEYOND THERE IS A PRESSING NEED TO BETTER UNDERSTAND HOW THE SPACEFLIGHT ENVIRONMENT INFLUENCES FUNDAMENTAL BIOLOGICAL PROCESSES. UNDERSTANDING HOW PLANTS RESPOND TO GRAVITY ON EARTH AND THE MICROGRAVITY ENVIRONMENT IN SPACE IS OF PARTICULAR INTEREST BECAUSE OF THE IMPORTANT ROLE THAT PLANTS WILL PLAY IN ADVANCED BIOREGENERATIVE LIFE SUPPORT SYSTEMS DURING LONG DURATION SPACE MISSIONS. IN RECENT YEARS NUMEROUS TRANSCRIPTOMIC DATASETS HAVE SHOWN THAT HUNDREDS OF GENES CHANGE EXPRESSION WHEN PLANTS ARE GROWN IN SPACE. HOWEVER IT HAS BEEN CHALLENGING TO TEASE APART WHICH GENES CHANGE DUE TO MICROGRAVITY FROM THOSE THAT CHANGE AS A RESULT OF GENERAL PLANT STRESS RESPONSES. THIS DIFFICULTY STEMS FROM THE FACT THAT PLANT SPACEFLIGHT GENOMICS DATASETS HAVE BEEN DERIVED ALMOST EXCLUSIVELY FROM WHOLE SEEDLINGS AND PLANT ORGANS WHICH COULD POTENTIALLY MASK OR DILUTE GENE EXPRESSION CHANGES THAT ARE OCCURRING WITHIN THE DISTINCT CELL-/TISSUE-TYPES THAT ARE RESPONSIBLE FOR GRAVITY SENSING (E.G. ROOT COLUMELLA AND STEM ENDODERMAL CELLS). THUS THE MAJOR GOAL OF THIS NASA-GROUND-BASED PROPOSAL IS TO BEGIN TO TAKE STEPS TO DEVELOP METHODOLOGY THAT WILL ENABLE SPACE GENOMIC STUDIES ON HOMOGENOUS CELL POPULATIONS. HERE WE PROPOSE TO USE LASER CAPTURE MICRODISSECTION (LCM) TO CONDUCT RNA-SEQUENCING (RNA-SEQ) ON GRAVITY SENSING COLUMELLA CELLS TO IDENTIFY GENE REGULATORY NETWORKS THAT GOVERN EARLY RESPONSES OF PLANTS TO GRAVITY. WE HYPOTHESIZE THAT GENE PROFILE SIGNATURES FROM A HOMOGENOUS POPULATION OF COLUMELLA CELLS WILL MORE CLEARLY REFLECT TRANSCRIPTOMIC CHANGES THAT ARE DIRECTLY LINKED TO MICROGRAVITY. THE RNASEQ DATA THAT WE OBTAIN FROM OUR ANALYSIS OF ROOT COLUMELLA CELLS WILL BE COMPARED TO COLUMELLA-SPECIFIC GENE MODULES WE IDENTIFIED THROUGH OUR WEIGHTED GENE CO-EXPRESSION NETWORK ANALYSIS (WGCNA) OF ARABIDOPSIS SEEDLINGS GROWN FOR 6 AND 11 DAYS ON THE INTERNATIONAL SPACE STATION (ISS) (SPECIFIC AIM 2). IN PARALLEL WE WILL REFINE LCM METHODS WITH THE GOAL OF IMPLEMENTING THEM FOR FUTURE PLANT SPACEFLIGHT GENOMICS (SPECIFIC AIM 1). THE LATTER AIM WILL INVOLVE GROUND-BASED EXPERIMENTS IN WHICH SPECIFIC STEPS IN THE LCM METHODS WILL BE MODIFIED TO MIRROR IN-ORBIT OPERATIONS. UPON SUCCESSFUL COMPLETION OF THIS PROPOSAL WE EXPECT TO GENERATE NEW TOOLS FOR CONDUCTING GENOMICS IN HOMOGENOUS PLANT CELL POPULATIONS THAT WILL ENABLE US TO BETTER DIFFERENTIATE MICROGRAVITY EFFECTS FROM MICROGRAVITY INDEPENDENT EFFECTS.$200,149

· FY2020 · National Aeronautics and Space Administration

TITLE: THE USE OF MICROGRAVITY SIMULATORS FOR A MECHANISTIC UNDERSTANDING OF CYTOSKELETAL-MEDIATED REGULATION OF ROOT GROWTH DIRECTIONALITY PLANTS WILL BE A MAJOR COMPONENT OF ADVANCED LIFE SUPPORT SYSTEMS TO ENABLE NASA TO REALIZE ITS VISION OF LONG DURATION SPACE EXPLORATION THAT WILL TAKE HUMANS TO MARS AND BEYOND. HOWEVER PLANTS CAN ONLY BE EFFECTIVELY USED FOR SUCH SYSTEMS IF WE HAVE A DEEPER MECHANISTIC UNDERSTANDING ABOUT HOW THEIR DEVELOPMENT IS REGULATED BY THE SPACEFLIGHT ENVIRONMENT. RECENT OMICS STUDIES HAVE SHOWN THAT PLANTS REPROGRAM THEIR GENETIC CIRCUITRY WHEN GROWN IN THE NEAR WEIGHTLESS CONDITIONS OF SPACE. GENES INVOLVED IN CELL WALL REMODELING AND OXIDATIVE STRESS ARE MAJOR GENE CATEGORIES THAT ARE DIFFERENTIALLY REGULATED BY MICROGRAVITY. FURTHER IT HAS BEEN SHOWN THAT TRUE MICROGRAVITY IN SPACE AND SIMULATED MICROGRAVITY USING CLINOSTATS OR RANDOM POSITIONING MACHINES ELICIT ROUGHLY SIMILAR ROOT SKEWING RESPONSES IN THE MODEL PLANT ARABIDOPSIS THALIANA. ROOT SKEWING WAS MORE PRONOUNCED IN MUTANTS TO A ROOTEXPRESSED VEGETATIVE ACTIN ISOFORM. CONSISTENT WITH THE ENHANCED ROOT SKEWING OF ACTIN MUTANTS IN MICROGRAVITY IS THE OBSERVATION THAT OTHER PLANT SPECIES SUCH AS MAIZE (ZEA MAYS L.) HAVE STRONGER ROOT DIRECTIONAL GROWTH RESPONSES ON A CLINOSTAT WHEN CHEMICALS SUCH AS LATRUNCULIN B DISRUPT THE ACTIN CYTOSKELETON. BASED ON THESE OBSERVATIONS WE WILL TEST THE HYPOTHESIS THAT THE ACTIN CYTOSKELETON IS A KEY PLAYER IN DICTATING ROOT GROWTH DIRECTIONALITY IN TRUE AND SIMULATED MICROGRAVITY BY REGULATING THE PROCESS OF AUTOTROPIC ORGAN STRAIGHTENING. MOREOVER WE HYPOTHESIZE THAT A SET OF CELL WALL CROSS-LINKING (I.E. CLASS III PEROXIDASES) AND PUTATIVE ACTINREGULATORY PROTEINS (I.E. HLB1 AND MIN7/BEN1) MEDIATE ROOT HAIR ELONGATION AND DIRECTIONAL ROOT GROWTH RESPECTIVELY UNDER TRUE AND SIMULATED MICROGRAVITY. OUR HYPOTHESES WILL BE ADDRESSED THROUGH THREE SPECIFIC AIMS INCLUDING THE ANALYSIS OF CELL WALL COMPOSITION/ DISTRIBUTION IN WILD-TYPE ARABIDOPSIS ROOTS AND DETAILED CHARACTERIZATION OF SELECTED ARABIDOPSIS CELL WALL AND ACTIN MUTANTS SUBJECTED TO MICROGRAVITY SIMULATION ON A SLOW ROTATING CLINOSTAT AND RANDOM POSITION MACHINE (AIM 1 AND 3). WE WILL ALSO USE MICROGRAVITY SIMULATORS TO ADDRESS THE HYPOTHESIS THAT THE PLANT HORMONE BRASSINOLIDE REGULATES DIRECTIONAL ROOT GROWTH IN MAIZE THROUGH ITS MODULATION OF ACTIN ORGANIZATION AND DYNAMICS (AIM 2). OUR RESEARCH PLAN BUILDS ON SUCCESSES OF PREVIOUS NASA-FUNDED GROUND AND SPACEFLIGHT RESULTS AND OUTLINES A COMPREHENSIVE SET OF EXPERIMENTS INCLUDING CELL WALL IMMUNOCYTOCHEMISTRY COMPUTER-BASED ROOT GROWTH ANALYSES ACTIN QUANTIFICATION AND GENETICS. THE PROPOSED WORK ALIGNS WITH PLANT BIOLOGY ELEMENT OF THE SPACE BIOLOGY SCIENCE PLAN. RESULTS OBTAINED FROM PLANT EXPERIMENTS ON MICROGRAVITY SIMULATORS WILL ADDRESS GUIDING QUESTIONS LINKED TO THE DECADAL SURVEY RECOMMENDATIONS INCLUDING THE IMPACT OF GRAVITY ON PLANT GROWTH DEVELOPMENT AND METABOLISM (PB-1) AND MOLECULAR MECHANISMS UNDERLYING HOW PLANTS SENSE AND REACT TO GRAVITY (PB-5). WE EXPECT THAT THE PROPOSED RESEARCH WILL PROVIDE US WITH BASIC KNOWLEDGE THAT WILL GUIDE THE DEVELOPMENT OF PLANT CULTIVARS BETTER ADAPTED TO THE MICROGRAVITY ENVIRONMENT OF SPACEFLIGHT AN OUTCOME THAT WILL PROVE BENEFICIAL FOR THE DESIGN OF PLANT HABITATS ON FUTURE SPACE COLONIES AND FOR ADDRESSING GREAT AGRICULTURAL CHALLENGES ON EARTH$167,363

· FY2020 · National Aeronautics and Space Administration

WE PROPOSE TO CONDUCT EXPERIMENTS UTILIZING THE BRIC-LED-PDFU ONBOARD STS-131 TO UNDERSTAND HOW THE ACTIN CYTOSKELETON DICTATES ROOT GROWTH ORIENTATI$142,069

· FY2010 · National Aeronautics and Space Administration

CONFERENCE PROPOSAL: 2012 WORLD CONGRESS ON IN VITRO BIOLOGY$17,500

· FY2012 · National Institute of Food and Agriculture

INTERNATIONAL CONFERENCE ON LEGUME GENOMICS AND GENETICS$10,000

· FY2009 · National Institute of Food and Agriculture

CONFERENCE PROPOSAL: 2012 WORLD CONGRESS ON IN VITRO BIOLOGY$-1,474

· FY2013 · National Institute of Food and Agriculture

DECIPHERING PROANTHOCYANIDIN BIOSYNTHESIS IN ALFALFA$-46,381

· FY2014 · National Institute of Food and Agriculture