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Mote Marine Laboratory, Inc.

$4,104,070

Total funding

6

Grants

Funding over time

peak $2.8M · FY2011–24

$5M$3.8M$2.5M$1.3M$0

'11

'12

'13

'14

'15

'16

'17

'18

'19

'20

'21

'22

'23

'24

Funding mix

By agency

DOD$2,702,075 · 2

USDA$1,401,995 · 4

By mechanism

—$4,104,070 · 6

Investigators at Mote Marine Laboratory, Inc.

Investigator-initiated All funding

Investigatorsi

Rising Stars

First grant in the last 5 yrs

Not enough data

Emerging Leaders

6–10 yrs in

Not enough data

All-Time

Most funded here, all years

Not enough data

Largest grants

NOVEL COMPOUNDS FROM SHARK AND STINGRAY EPIDERMAL MUCUS WITH ANTIMICROBIAL ACTIVITY AGAINST WOUND INFECTION PATHOGENS$2,584,472

· FY2011 · Department of Defense

** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** DEVELOPMENT OF CELL LINES IS CRITICAL IN MANY RESEARCH FIELDS SUCH AS DISEASE, REPRODUCTION, GENETICS, AND BIOTECHNOLOGY. CELL LINES ARE VERY USEFUL IN VITRO MODELS FOR TOXICOLOGICAL, PATHOLOGICAL, AND IMMUNOLOGICAL STUDIES. THE RESULTS FROM THE PROPOSED STUDIES WILL INCLUDE ESSENTIAL TOOLS FOR RESEARCHERS TO USE AS A FRAMEWORK AND GUIDE FOR IMPROVING CELL LINE DEVELOPMENT IN AQUATIC MARINE SPECIES. THE RESEARCH WE PROPOSE WILL LEAD TO THE DEVELOPMENT OF CELL LINES FROM ONE FISH (RED DRUM SCIAENOPS OCELLATUS) AND ONE SHRIMP (PACIFIC WHITE SHRIMP, LITOPENAEUS VANNAMEI) SPECIS. OUR APPROACH IS BASED ON ISOLATING EMBRYONIC STEM CELLS (ESCS) FROM FERTILIZED EMBRYOS AT THE BLASTOMERE STAGE. WE HYPOTHESIZE THAT IMPORTANT FEATURES OF ESCS, SUCH AS HIGH PROLIFERATION AND PLURIPOTENCY, WILL FACILITATE DEVELOPMENT OF A CONTINUOUS CELL LINE THAT CAN ULTIMATELY BE USED IN A VARIETY OF RESEARCH APPLICATIONS. WE ALSO PROPOSE A WHOLISTIC AND SPECIES-SPECIFIC TARGETED APPROACH, BASED ON NUTRIENT NEEDS OF ISOLATED EMBRYONIC CELLS (NUTRIENT ANALYSIS OF EGGS) AND CELLS IN CULTURE (SPENT MEDIA ANALYSIS), USING A TARGETED APPROACH TO GROWTH FACTOR IDENTIFICATION WITH A HIGH PROBABILITY OF SUCCESS BASED ON CONSENSUS SEQUENCES THROUGH BLAST, UNDERSTANDING EVENTS AT THE CELLULAR AND GENOMIC LEVEL (TRANSCRIPTOMIC ANALYSIS TO DETERMINE THE TIMELINE OF ACTIVATION FOR PATHWAYS OF CELL PROLIFERATION AND/OR CELL DEATH). THE FRAMEWORK USED TO DEVELOP THESE CELL LINES WILL ALSO BE APPLICABLE TO OTHER SPECIES OF INTEREST, INCREASING THE NUMBER OF CELL LINES AVAILABLE AND NEEDED FOR VARIOUS INTERDISCIPLINARY RESEARCH INTERESTS.A SIGNIFICANT CONTRIBUTION OF THIS PROJECT WILL BE TO INCREASE THE COMPETITIVENESS OF THE US IN THE FIELD OF AQUACULTURE BY MAKING CELL LINES AVAILABLE FOR RESEARCH IN KEY AREAS OF LIKE HEALTH, DISEASE DIAGNOSIS, SAFETY, AND NUTRITIONAL ASPECTS CHALLENGING AQUACULTURE PRODUCTION. INCREASING THE NUMBER OF CELL LINES RESEARCH CAN BE CONDUCTED USING THESE CELL LINES WITHOUT SCARIFYING WHOLE LIVE ANIMALS. THE SCIENTIFIC KNOWLEDGE GENERATED USING FISH CELL LINES WOULD BE IMMENSELY USEFUL FOR QUALITY PRODUCTION IN A SUSTAINABLE MANNER. CELL LINES WOULD FACILITATE IN VITRO RESEARCH FOR DEVELOPING CLIMATE-RESILIENT AND SUSTAINABLE AQUACULTURE SYSTEMS TO MINIMIZE THE KEY CHALLENGES AND PROVIDE NUTRITIONAL SECURITY TO THE BURGEONING WORLD POPULATION.$597,995

· FY2024 · National Institute of Food and Agriculture

FOOD SECURITY IS THE ABILITY FOR PEOPLE AT ALL TIMES TO HAVE ACCESS TO SUFFICIENT, SAFE AND NUTRITIOUS FOODS THAT MEET THEIR DIETARY NEEDS AND THEIR PREFERENCES. SHELLFISH CONTRIBUTES TO NATIONAL AND INTERNATIONAL FOOD SELF-SUFFICIENCY THROUGH DIRECT CONSUMPTION, TRADE AND EXPORTS. THREATS TO FISH/SHELLFISH PRODUCTION, A MAJOR SOURCE OF DIETARY PROTEIN, COME FROM HARMFUL ALGAL BLOOMS. RED TIDE IS A HARMFUL ALGAE, THAT PRODUCES BREVETOXINS WHICH ACCUMULATE IN SHELLFISH POSING RISK TO CONSUMER HEALTH. TOXINS IN SHELLFISH TISSUE CAN REMAIN LONG AFTER THE BLOOM HAS DECLINED. SOCIO-ECONOMIC HARDSHIPS OF RED TIDE BLOOMS ARE CRIPPLING SHELLFISH FARMERS, PROCESSING, DISTRIBUTION, AND RETAILING, MAKING THE U.S. LESS COMPETITIVE ON A DOMESTIC AND GLOBAL SCALE, LIMITING PRODUCT AVAILABILITY. WITH ECONOMIC AND FOOD SAFETY RISKS, THERE IS A PROFOUND NEED TO DEVELOP MORE ANALYTICAL TOOLS, LOWERING THE HUMAN HEALTH RISK AND IMPROVING THE BOTTOM LINE OF FARMERS. IN CONSULTATION AND COLLABORATION WITHFLORIDA SHELLFISH GROWERS, THE FLORIDA SHELLFISH AQUACULTURE ASSOCIATION, AND THE FLORIDA DEPARTMENT OF AGRICULTURE AND CONSUMER SERVICES, THIS PROPOSED PROJECT ADDRESSES A CRITICAL INDUSTRY NEED WHICH IS THE GENERATION OF A RELIABLE RAPID RED TIDE TOXIN BIOSENSOR FOR MONITORING SHELLFISH FOR POTENTIAL CLOSURES AND SUBSEQUENT RE-OPENINGS DURING AND AFTER RED TIDE BLOOMS,THERE IS A DEMONSTRATED DIRECT NEED FOR NEW TECHNOLOGIES FOR PROVIDING RAPID AND ACCURATE IN-SITU RED TIDE TOXIN TESTING THAT CAN BE USED BY SHELLFISH COMMUNITIES, CONNECTING ALL SEGMENTS OF THE INDUSTRY, FROM GROWING AND HARVESTING TO PROCESSING AND MARKETING.THIS STUDY EXPLORES TECHNOLOGY THAT PROMOTES SUSTAINABLE U.S. SEAFOOD PRODUCTION AND HARVESTING, THEREBY STRENGTHENING EXISTING MARKETS AND OPPORTUNITIES FOR SHELLFISH COMMUNITIES. BY DEVELOPING CREATIVE TECHNOLOGY THAT RESPONDS TO THE NEEDS OF THE SHELLFISH FARMERS IN RED TIDE IMPACTED REGIONS, THESE ECONOMICALLY VALUABLE COMMUNITIES HAVE THE CHANCE TO REGAIN, AND POTENTIALLY EXCEED, THEIR PREVIOUS PROMINENCE IN SHELLFISH PRODUCTION.$374,000

· FY2021 · National Institute of Food and Agriculture

**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** STURGEON CAVIAR IS THE MOST EXPENSIVE AQUACULTURE PRODUCT IN THE WORLD. ABOUT 25% OF ADULT FEMALE STURGEON'S WEIGHT IS FROM EGGS AT HARVEST. A LARGE SPECIES MAY PRODUCE 22KG OF CAVIAR WITH A VALUE OF BETWEEN $70K-$175K, SUGGESTING THAT RELATIVELY SMALL FARMS CAN BE HIGHLY SUCCESSFUL. SO WHY IS CAVIAR PRODUCTION NOT A MORE SIGNIFICANT PART OF THE AMERICAN AQUACULTURE ECONOMY? EACH YEAR, THE AMOUNT OF CAVIAR PRODUCED IN THE US FAILS TO MEET THE TOTAL CONSUMER DEMAND; THUS, OUR ECONOMY IS A NET IMPORTER OF CAVIAR. US STURGEON AQUACULTURE SUFFERS FROM INEFFICIENCIES ACROSS THE VALUE CHAIN. THERE ARE MANY OPPORTUNITIES FOR VALUE CHAIN R&AMP;D TO HAVE A TREMENDOUS IMPACT ON GROWING THE AMERICAN CAVIAR INDUSTRY RESULTING IN SIGNIFICANT PROFIT YIELDS. THE BARRIER TO FARMERS GETTING INVOLVED IN THIS HIGHLY PROFITABLE FISHERY, WHERE DEMAND EXCEEDS SUPPLY, IS THE LONG-TERM INVESTMENT NEEDED BEFORE STURGEON ON THE FARM MATURE ENOUGH TO BE PROFITABLE. FEMALES TAKE A DECADE OR MORE TO REACH SEXUAL MATURITY AND PRODUCE VALUABLE EGGS. HOWEVER, JUVENILE STURGEON CAN TAKE 5-6 YEARS TO BE SEXUALLY DIFFERENTIABLE. SO, PRODUCERS PAY TO FEED AND HOUSE THE NON-PRODUCTIVE MALES, 50% OF EACH COHORT, FOR 5-6 YEARS WITHOUT ANY FINANCIAL REWARD. WHO WOULD INVEST IN SUCH A VENTURE OR TRUST SOMEONE WITH THEIR PASSIONS AND PROMISES TO TURN PROFITS?1 THE EARLIER THE MALES CAN BE REMOVED FROM THE PRODUCTION PROCESS, THE GREATER THE PROFITS FOR THIS INDUSTRY. URGENTLY NEEDED BY THIS ARTISAN FISHERY IS A RAPID SEX IDENTIFICATION TOOL, RESULTING IN DOUBLING CAVIAR CAPACITY, DRAMATICALLY IMPROVING PRODUCTION EFFICIENCIES, INCREASING PROFITABILITY, AND STIMULATING GROWTH. WHEN THE START-UP COSTS CAN BE DRASTICALLY REDUCED BECAUSE THE REARING POPULATION WILL COMPRISE ONLY VALUABLE FEMALES, THE DOOR WILL OPEN FOR NEW ENTREPRENEURS TO VENTURE INTO THE CAVIAR PRODUCTION MARKET. A FIELD-BASED SEX DETERMINATION BIOSENSOR FOR STURGEON AQUACULTURE, WITH POTENTIAL APPLICATIONS FOR OTHER COMMERCIAL FISH FARMS AND STURGEON CONSERVATION RESEARCH, CAN BE A GAME-CHANGER.$300,000

· FY2023 · National Institute of Food and Agriculture

INFLUENCE OF COMMERCIAL DIETS & FEEDING REGIMEN OF FLORIDA POMPANO AQUACULTURED IN INLAND RECIRCULATING SYSTEMS$130,000

· FY2011 · National Institute of Food and Agriculture

BIOMARKERS TO ASSESS POSSIBLE BIOLOGICAL EFFECTS ON REPRODUCTIVE POTENTIAL, IMMUNE FUNCTION, AND ENERGETIC FITNESS OF BOTTLENOSE DOLPHINS EXPOSED TO$117,603

· FY2011 · Department of Defense