← LeaderboardsInvestigatorsiAttributed = a PI's even-split share of each grant — a $1M grant with 2 PIs counts $500K each.
The Children'S Hospital Of Philadelphia
Philadelphia, PA
$89,950,168
Total funding
85
Grants
Funding over time
peak $24.5M · FY2005–25$25M$18.8M$12.5M$6.3M$0
'05
'06
'07
'08
'09
'10
'11
'12
'13
'14
'15
'16
'17
'18
'19
'20
'21
'22
'23
'24
'25
Funding mix
By agency
DOD$80,282,713 · 62
NSF$8,022,368 · 21
NASA$1,645,087 · 2
By mechanism
—$89,950,168 · 85
Investigators at The Children'S Hospital Of Philadelphia
InvestigatorsiAttributed = a PI's even-split share of each grant — a $1M grant with 2 PIs counts $500K each.
Exposure= the full size of every grant they're on ($1M each).
Rising Stars
First grant in the last 5 yrs
Not enough data
Emerging Leaders
6–10 yrs in
Not enough data
All-Time
Most funded here, all years
Not enough data
Largest grants
DEVELOPMENT AND CLINICAL VALIDATION OF NONINVASIVE DIAGNOSTICS FOR MITOCHONDRIAL DISEASE$11,855,637
· FY2022 · Defense Health Agency
IDENTIFYING THE NEURAL SUBSTRATES OF EMOTIONAL AROUSAL: TOWARDS A PATH TO STRESS RESISTANCE$7,763,037
· FY2010 · Department of Defense
CELL-PERMEABLE AS A THERAPEUTIC INTERVENTION FOR MITOCHONDRIAL DISEASE$4,090,281
· FY2018 · Defense Health Agency
THE TEMPORAL RELATIONSHIP BETWEEN INTRAFAMILIAL VIOLENCE, DEPLOYMENT AND SERIOUS MENTAL ILLNESS IN US ARMY SERVICE MEMBERS$4,071,924
· FY2011 · Department of Defense
COVID-19 SARS-COV-2 PROPAGATION AND PATHOLOGY AND MITOCHONDRIAL GENETICS$2,816,000
· FY2021 · Defense Health Agency
CELLULAR BASIS FOR INDIVIDUAL VULNERABILITY TO STRESS$2,477,432
· FY2008 · Department of the Navy
COMPREHENSIVE EVALUATION OF IMMUNE FUNCTION IN PATIENTS RECEIVING MULTIMODAL THERAPY FOR HIGH-RISK NEUROBLASTOMA$2,247,531
· FY2022 · Department of the Army
OVERCOMING DEDIFFERENTIATION OF PEDIATRIC THYROID CANCER THROUGH MOLECULARLY TARGETED THERAPY$2,186,587
· FY2022 · Defense Health Agency
:POSITIONING VASCULARIZED COMPOSITE ALLOTRANSPLANTATION IN THE SPECTRUM OF TRANSPLANTATION$1,996,875
· FY2013 · Department of Defense
ELUCIDATION OF THE CARDIOMYOPATHY OF THE MITOCHONDRIAL DISORDER FRIEDREICH'S ATAXIA$1,786,137
· FY2025 · Defense Health Agency
ANT1 GENE THERAPY FOR THE TREATMENT OF MITOCHONDRIAL DISEASE$1,760,000
· FY2022 · Department of the Army
ANT1 GENE THERAPY FOR THE TREATMENT OF MITOCHONDRIAL DISEASE$1,760,000
· FY2022 · Department of the Army
COMBINATION THERAPY FOR HIGH-RISK, MYCN-AMPLIFIED NEUROBLASTOMA$1,746,810
· FY2025 · Defense Health Agency
A MULTI-OMICS APPROACH TO OVERCOME RESISTANCE IN INFANT LEUKEMIA BY IDENTIFYING IMMUNE THERAPY FAILURE MECHANISMS$1,733,203
· FY2020 · Defense Health Agency
OVERCOMING DRUG RESISTANCE TO TREAT HIGH-RISK NEUROBLASTOMAS$1,691,315
· FY2021 · Defense Health Agency
OVERCOMING DEDIFFERENTIATION OF PEDIATRIC THYROID CANCER THROUGH MOLECULARLY TARGETED THERAPY$1,676,839
· FY2022 · Defense Health Agency
TASK 1: THE IMPACT OF HZE PARTICLES ON OTHER TESTS IN THE COGNITIVE DOMAIN. USING THE FLEXIBLE BATTERY OF TESTS OFFERED BY THE TOUCHSCREEN OPERANT PLATFORM WE WILL IDENTIFY A BEHAVIORAL FRAMEWORK FOR THE HZE PARTICLE-INDUCED IMPROVEMENT IN PATTERN SEPARATION. WE HYPOTHESIZE HZE PARTICLES WILL IMPROVE PERFORMANCE RELIANT ON HIPPOCAMPAL-CORTICAL INTEGRITY BUT NOT ON STRIATAL-CORTICAL INTEGRITY. A) DETERMINE THE EFFECT OF 0 AND 3X6.7CGY IRON (600 MEV/U) ON THE PERFORMANCE OF MALE 6-9 MONTH OLD (AT TIME OF IRR) C57BL6J MICE ON COGNITIVE BATTERY. IF THESE DATA REVEAL SIGNIFICANT EFFECTS WE WILL ALSO: I. DETERMINE THE EFFECT OF 0 AND 3X6.7CGY IRON (600 MEV/U) ON THE PERFORMANCE OF FEMALE 6-9 MONTH OLD (AT TIME OF IRR) C57BL6J MICE ON COGNITIVE BATTERY II. EXAMINE AN ADDITIONAL GROUP OF MICE FOR 0 AND 0.1 GY IRON (600 MEV/U). B) DETERMINE THE EFFECT OF 0 AND 2X0.1CGY SILICON (275 MEV/U) ON THE PERFORMANCE OF MALE 6-9 MONTH OLD (AT TIME OF IRR) C57BL6J MICE ON COGNITIVE BATTERY. IF THESE DATA REVEAL SIGNIFICANT EFFECTS WE WILL ALSO: I. DETERMINE THE EFFECT OF 0 AND 2X0.1CGY SILICON (275 MEV/U) ON THE PERFORMANCE OF FEMALE 6-9 MONTH OLD (AT TIME OF IRR) C57BL6J MICE ON COGNITIVE BATTERY II. EXAMINE AN ADDITIONAL GROUP OF MICE FOR 0 AND 0.1 GY SILICON (275 MEV/U). TASK 2: THE IMPACT OF HZE PARTICLES ON BEHAVIORS IN THE AFFECTIVE/SOCIAL DOMAIN. PATTERN SEPARATION IS IMPORTANT NOT JUST TO CONTEXTUAL DISCRIMINATION BUT ALSO TO THE RESISTANCE TO MOOD AND ANXIETY DISORDERS. BASED ON THIS AND WITH OUR PREVIOUS EXPERIENCE WITH AN ETHOLOGICALLY-RELEVANT STRESSOR SOCIAL DEFEAT STRESS (SDS) WE WILL TEST HZE PARTICLE-INDUCED INFLUENCE IN THE AFFECTIVE/SOCIAL DOMAIN. WE HYPOTHESIZE THAT IMPROVED PATTERN SEPARATION IS LINKED TO RESILIENCE TO SOCIAL STRESSORS. A) DETERMINE THE EFFECT OF 0 AND 3X6.7CGY IRON (600 MEV/U) ON THE PERFORMANCE OF MALE 6-9 MONTH OLD (AT TIME OF IRR) C57BL6J MICE ON THE SOCIAL INTERACTION TEST (PERFORMED AFTER 10 DAYS OF SDS). I. IF THESE DATA REVEAL SIGNIFICANT EFFECTS WE WILL THEN ALSO EXAMINE AN ADDITIONAL GROUP OF ANIMALS FOR 0 AND 0.1 GY IRON (600 MEV/U). II. IF THESE DATA DO NOT REVEAL SIGNIFICANT EFFECTS WE WILL THEN ASSESS MICE POST- SDS AND SOCIAL INTERACTION FOR ANXIETY AND HEDONIC EFFECTS B) DETERMINE THE EFFECT OF 0 AND 2X0.1CGY SILICON (275 MEV/U) ON THE PERFORMANCE OF MALE 6-9 MONTH OLD (AT TIME OF IRR) C57BL6J MICE ON THE SOCIAL INTERACTION TEST (PERFORMED AFTER 10 DAYS OF SDS). I. IF THESE DATA DO NOT REVEAL SIGNIFICANT EFFECTS WE WILL THEN ASSESS MICE POST- SDS AND SOCIAL INTERACTION FOR ANXIETY AND HEDONIC EFFECTS TASK 3: INDICES OF NEURAL NETWORK PERTURBATION UNDERLYING HZE PARTICLE EXPOSURE- INDUCED IMPROVED PATTERN SEPARATION. WHILE IMPROVED PATTERN SEPARATION HAS BEEN CAUSALLY LINKED TO INCREASED HIPPOCAMPAL NEUROGENESIS [9] OUR DATA SHOW HZE PARTICLE- INDUCED IMPROVEMENT IN PATTERN SEPARATION IS ACTUALLY MARKED BY DECREASED HIPPOCAMPAL NEUROGENESIS. USING CLASSIC (STEREOLOGY OF DENTATE GYRUS INTERNEURON COUNTS) AS WELL AS CUTTING-EDGE TECHNIQUES (RNASEQ) WE WILL TEST THE HYPOTHESIS THAT HZE PARTICLES INFLUENCE THE INTEGRITY OF HIPPOCAMPAL-CORTICAL NEURAL NETWORKS. A) DETERMINE THE EFFECT OF 0 AND 3X6.7CGY IRON (600 MEV/U) ON INTERNEURON NEURON NUMBER AND RNASEQ OF TRANSLATING PROTEINS IN DG GRANULE NEURONS IN MATURE NTF3 BAC-TRAP MICE 3 AND 6 MON POST-IRRADIATION. I. DEPENDING ON THE RESULTS FROM TASK 1A WE MAY THEN ALSO EXAMINE AN ADDITIONAL GROUP OF ANIMALS FOR 0 AND 0.1 GY IRON (600 MEV/U) PROVIDING SUFFICIENT FUNDS REMAIN. B) DETERMINE THE EFFECT OF 0 AND 2X0.1CGY SILICON (275 MEV/U) ON INTERNEURON NEURON NUMBER AND RNASEQ OF TRANSLATING PROTEINS IN DG GRANULE NEURONS IN MATURE NTF3 BAC-TRAP MICE 3 AND 6 MON POST-IRRADIATION. I. DEPENDING ON THE RESULTS FROM TASK 1B WE MAY ALSO DETERMINE THE EFFECT OF 0 AND 2X0.1CGY SILICON (275 MEV/U).$1,470,094
· FY2020 · National Aeronautics and Space Administration
ADD FUNDING$1,469,943
· FY2009 · Department of the Army
BRAIN CHARTS IN CHILDREN AND ADOLESCENTS WITH NEUROFIBROMATOSIS TYPE 1$1,366,365
· FY2024 · Defense Health Agency
POWERING UP MITICHONDRIAL FUNCTIONS TO TREAT MITOCHONDRIAL DISEASE$1,260,000
· FY2016 · Department of Defense