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Central Connecticut State University

New Britain, CT

$12,933,241

Total funding

38

Grants

Funding over time

peak $5M · FY2005–25

$5M$3.8M$2.5M$1.3M$0

'05

'06

'07

'08

'09

'10

'11

'12

'13

'14

'15

'16

'17

'18

'19

'20

'21

'22

'23

'24

'25

Funding mix

By agency

NSF$10,615,750 · 24

NIH$1,504,415 · 11

NASA$813,076 · 3

By mechanism

—$11,428,826 · 27

R15$1,063,664 · 6

R03$290,996 · 3

G13$149,755 · 2

Investigators at Central Connecticut State University

Investigator-initiated All funding

Investigatorsi

Rising Stars

First grant in the last 5 yrs

Not enough data

Emerging Leaders

6–10 yrs in

Not enough data

All-Time

Most funded here, all years

1Thomas R King$1,120,5737 gr 2Michael A Davis$220,9901 gr

Largest grants

CSMP Scholarship Program of Central Connecticut$4,982,084

· FY2018 · EDU

Scholarships, Mentoring, and Career Development to Support Attainment of Software Engineering Graduate Degrees$1,000,000

· FY2020 · EDU

Explorations: Central to Exploring Microelectronics Technologies: A Hub for Community Engagement and Innovative Experiential Learning$953,549

· FY2025 · TIP

CSMP Scholarship Program at Central Connecticut State University$600,000

· FY2011 · EDU

S-STEM Scholarship Program at Central Connecticut State University$478,302

· FY2006 · EDU

MRI: Aquisition of a Single Crystal X-ray Diffractometer with Low Temperature and Powder Capabilities$335,850

· FY2004 · MPS

FY 09 EARMARK ENTITLED, `FOR RECRUITMENT AND RETENTION FOR AN AEROSPACE ENGINEERING ACADEMIC PROGRAM THE UNITED STATES IS THE WORLD LEADER IN SCIENC$333,346

· FY2009 · National Aeronautics and Space Administration

Collaborative Research: Experimental community assembly in natural and disturbed ecosystems: testing the role of ecological sorting in ant community assembly$300,000

· FY2010 · BIO

THE IDENTIFICATION AND CHARACTERIZATION OF THE MOST PRISTINE PHYSICAL STATE OF EJECTA DEPOSITS IS A CRITICAL FIRST STEP TOWARDS UNDERSTANDING THE PRO$292,341

· FY2015 · National Aeronautics and Space Administration

Scaffolded Computing Projects for the Social Good$288,100

· FY2023 · EDU

Positional cloning of mutations that disrupt hair development in mice.$287,622

R15 · FY2011 · AR

Development of a CCD Camera Based Lidar for Measurement of Boundary Layer Aerosols$267,496

· FY2003 · GEO

MRI: Acquisition of A New 300 MHz NMR for Research and Student Training$223,596

· FY2005 · MPS

Isolation of New Antibiotics From Soil Microorganisms$220,990

R15 · FY2004 · AI

Molecular assignment for two developmental mutations in the mouse$210,290

R15 · FY2007 · HD

Two unusual minor histocompatibility models in mice$202,080

R15 · FY2004 · AI

GOALS AND OBJECTIVES: MANY FORMS OF ENERGY TRANSDUCTION ON EARLY EARTH HAVE BEEN SUGGESTED PERHAPS MOST POPULARLY GEOTHERMAL AND ELECTRICAL SYNTHESIS OF ORGANIC MOLECULES. HOWEVER SOLAR ENERGY WAS LIKELY MORE ABUNDANT AND UBIQUITOUS IN SURFACE ENVIRONMENTS DUE TO THE LACK OF AN OZONE LAYER. ADDITIONALLY THE AVAILABILITY OF PHOTOACTIVE COMPOUNDS INCLUDING POLYCYCLIC AROMATIC HYDROCARBONS (PAHS) IS EVIDENCED BY THEIR PRESENCE IN CARBONACEOUS METEORITES. WE PROPOSE THAT AN EARLY FORM OF PHOTOSYNTHESIS USING PAHS WOULD HAVE PRODUCED REDUCED CARBON FROM CARBON DIOXIDE BY COUPLING PHOTO-EXCITATION TO TRANSMEMBRANE ELECTRON TRANSPORT AND THE GENERATION OF A PROTON GRADIENT. IF SUCCESSFUL THIS WILL REPRESENT A SIMPLE WAY TO GENERATE USABLE CARBON WITHIN A CELL AND WILL FURTHER OUR UNDERSTANDING OF PROTO-BIOLOGICAL CHEMICAL SYSTEMS THAT COULD HAVE PRECEDED THE FIRST LIVING ORGANISMS. APPROACH AND METHODOLOGY THE FIRST STEP IS TO GENERATE A PROTO-CELL COMPOSED OF SINGLE CHAIN AMPHIPHILES SUCH AS FATTY ACIDS WHICH ARE CONSIDERED PREBIOTIC ALONG WITH THE PHOTOSENSITIZING PAHS. PAHS HAVE BEEN SHOWN TO SPONTANEOUSLY INSERT INTO FATTY ACID MEMBRANES AND ENHANCE STABILITY. CARBON DIOXIDE WILL BE USED TO GENERATE AN OXYGEN FREE ATMOSPHERE AND ACT AS A REACTANT. BECAUSE IT IS NON-POLAR CO2 CAN EASILY DIFFUSE THROUGH THE CELL MEMBRANE. LASTLY AN EXTERNAL ELECTRON DONOR WILL BE ADDED SUCH AS DITHIOTHREITOL LESS ODOROUS MIMIC OF HYDROGEN SULFIDE OR OTHER EARLY EARTH REDUCTANTS. THE PROTO-CELLULAR CONSTRUCT WILL BE EXPOSED TO LIGHT WHERE THE CO2 WILL BE CONVERTED INTO ORGANIC CARBON LIKELY FORMATE AND BE TRAPPED INSIDE OF THE NEGATIVELY CHARGED MEMBRANE. THE INTERIOR OF THESE CELLS CAN ALSO BE LOADED WITH A PH-SENSITIVE DYE TO MONITOR PROTON GRADIENT FORMATION. THE CELLS WILL THEN BE SEPARATED FROM THE EXTERNAL PRODUCTS USING SIZE EXCLUSION CHROMATOGRAPHY AND THE ENCAPSULATED PRODUCTS WILL BE EVALUATED USING GAS AND/OR LIQUID CHROMATOGRAPHY AND DETECTED WITH EITHER MASS SPECTROMETRY FLAME IONIZATION OR AS CHARGED AEROSOLS. ADDITIONALLY CHANGES IN BOTH THE AMPHIPHILES AND PAHS CAN BE MONITORED WITH THESE METHODS. THIS APPROACH DISTINGUISHES ITSELF FROM OTHER PHOTOCHEMICAL STUDIES BY COUPLING THE FOLLOWING PROPERTIES: 1) MODELING AN EARLY EARTH ENVIRONMENT; 2) USING SIMPLE AMPHIPHILES AS OPPOSED TO PHOSPHOLIPIDS; 3) GENERATING USABLE CARBON FOR THE PROTOCELLI. IF SUCCESSFUL FUTURE WORK WILL INCLUDE CONVERSION OF PRODUCTS INTO LARGER CARBON MOLECULES LIKE AMINO ACIDS OR SUGARS. SCOPE WITHIN EXOBIOLOGY THIS RESEARCH WILL ENHANCE OUR UNDERSTANDING OF PREBIOTIC ENERGY TRANSDUCTION INCLUDING POSSIBLE MOLECULAR PROCESSES AND CHEMICAL CONDITIONS THAT WOULD HAVE PROMOTED ABIOGENESIS. THE MODEL PROPOSED IS BASED ON EXPERIMENTAL AND THEORETICAL MODELS OF EARTH PRIOR TO THE FORMATION OF LIFE. ADDITIONALLY THIS STUDY WILL PROVIDE A MODEL FOR EARLY FORMS OF PHOTOSYNTHESIS AND EXPERIMENTALLY INVESTIGATE ITS APPLICATIONS AND LIMITATIONS. THE CONCLUSIONS OF THIS RESEARCH WILL ALSO CONTRIBUTE TO THE SEARCH FOR LIFE ELSEWHERE IN THE UNIVERSE BY DEMONSTRATING ALTERNATIVES TO EARTH S CURRENT BIOENERGETICS.$187,389

· FY2017 · National Aeronautics and Space Administration

Collaborative Research: LEGO-Based Active Learning Activities for Software Engineering Education$161,351

· FY2016 · EDU

X-LINKED MINOR HISTOCOMPATIBILITY BARRIERS IN MICE$136,786

R15 · FY2001 · GM

RUI: Energy Density Fluctuations, Negative Energy Detection and Gravity$135,000

· FY2010 · MPS