Administrative and Data Management Core

Brigham And Women'S Hospital, Boston MA

Investigators

Abstract

ABSTRACT ADMINISTRATIVE AND DATA MANAGEMENT (ADM) CORE The PRECISION-AD ADM core plays several important roles in the functioning of the Center, and thus consists of a team of individuals with diverse expertise in a variety of domains including in Alzheimer’s disease pathogenesis, iPSC experimental systems, therapeutic development and testing, biomarker discovery, scaling of iPSC-based systems, bioinformatics and computational biology, epidemiology, and large-scale open-science sharing of resources. The core has four overarching responsibilities, which are outlined in the form of specific aims. Under Aim 1, the ADM core provides oversight and administrative support within the Center to ensure timely and efficient milestone completion. The ADM has delineated a series of specific milestones and deliverables and will execute procedures for monitoring of progress and provide data-driven guidance for go/no-go decisions. Under Aim 2, the ADM core will advise and guide the activities of the other three cores based upon data, experimental resources and clinical trial data arising in the field. The ADM will work closely with the Steering Committee and External Advisory Board to modify aspects of the approach based upon data arising within the field and within the Center. Under Aim 3, the ADM core will support communications between the Center and external researchers to both promote Center assets for external use and to acquire externally generated resources for advancing core activities. Under Aim 4, the ADM core is responsible for establishing an efficient pipeline for open distribution of all data, protocols, and cell models developed within the Center. As PD of the project, Dr. Young-Pearse will be responsible for leading the project as a whole and acts as the primary point of contact with the external advisory board (EAB) and NIH program staff, including the submission of milestone reports to the NIH and EAB. In order to ensure the efficient and robust meeting of milestones, each core head also is a MPI within the ADM core. Microphysiological Systems Models Development and Validation (MPS) core PI, Dr. Young-Pearse will oversee the on-time meeting of core milestones, which includes distribution of data to the Bioinformatic and Computational Biology (BCB) core and distribution of cell model and assay protocols to the Preclinical Safety and Efficacy (PE&S) core. PE&S core lead PI Paull is responsible for overseeing the timely completion of PE&S core milestones, which includes scaling of assays, distribution of data to the BCB core, and establishment of pipelines for efficient sharing of cell models. BCB core lead PI Carter is responsible for overseeing the completion of BCB milestones, which includes the sharing of raw and processed data internally with all PIs through the ADM core. ADM MPI Leal (Sage Bionetworks) is responsible for external sharing of the data generated with the scientific community. ADM MPIs Bennett and Longo, who together have many decades of experience in studying AD pathogenesis and the development and testing of interventional strategies, will provide essential advice and guidance on the four aims of the ADM and of the overall scientific strategies and directions of the PRECISION-AD Center.