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38,696 grants matching “als”
Molecular Biology: Viral Glial Gene Interaction in Brain
$1,195,635Kamel Khalili · Temple Univ Of The Commonwealth · P01 · FY2006 · NS
Localized mHealth approach to boosting COVID-19 testing and vaccine literacy, access, and uptake among women with criminal legal system involvement
$1,195,191Jason Edwin Glenn · University Of Kansas Medical Center · U01 · FY2023 · MD
Targeting negative affect through mindfulness training in youth at risk for internalizing problems
$1,195,099Judy Garber · Vanderbilt University · R33 · FY2024 · MH
Deep South Network for Cancer Control
$1,194,976Edward E Partridge · University Of Alabama At Birmingham · U54 · FY2014 · CA
Molecular Genetic Study of Stem Cells, Cancer Stem Cells, and Stem Cell Aging
$1,194,665Xianyu S Hou · Division Of Basic Sciences - Nci · Z01 · FY2008 · CA
Comparative Genomics Analysis Unit Research
$1,192,970James C Mullikin · National Human Genome Research Institute · ZIA · FY2016 · HG
Targeting negative affect through mindfulness training in youth at risk for internalizing problems
$1,192,882Judy Garber · Vanderbilt University · R33 · FY2025 · MH
Development of new antibody-based cancer therapies
$1,192,823Mitchell Ho · Division Of Basic Sciences - Nci · ZIA · FY2016 · CA
MINERALOGICAL PETROGRAPHIC AND ISOTOPIC OBSERVATIONS INDICATE THAT MOST GROUPS OF CHONDRITIC METEORITES EXPERIENCED ASTEROIDAL ALTERATION TO VARIOUS DEGREES RESULTING IN THE FORMATION OF SECONDARY MINERALS. THE ALTERATION OCCURRED IN THE PRESENCE OF AQUEOUS SOLUTIONS UNDER VARIABLE CONDITIONS AND IN MANY CASES WAS MULTISTAGE. BASED ON AL-MG MN-CR AND I-XE AGES OF SECONDARY MINERALS THE CHONDRITE PARENT BODIES MUST HAVE ACCRETED 2?4 MA AFTER THE COLLAPSE OF THE PROTOSOLAR MOLECULAR CLOUD AND THE ALTERATION MAY HAVE LASTED FOR UP TO 15 MA. THE I-XE CHRONOMETER IS BASED UPON DECAY OF NOW-EXTINCT 129I WHERE THE RATIO OF THE ACCUMULATED DAUGHTER 129XE TO STABLE 127I REFLECTS THE IODINE ISOTOPIC RATIO AT CLOSURE OF THE HOST MINERAL. THE SHORT HALF-LIFE OF 129I (15.7 MA) GIVES THE I-XE CHRONOMETER THE PRECISION NEEDED FOR HIGH TEMPORAL RESOLUTION WITHIN THE FORMATION TIME PERIOD OF THE FIRST SOLIDS AND THE SUBSEQUENT ONSET OF METAMORPHIC CHANGES. RELATIVE I-XE AGES ARE NORMALIZED TO AN ABSOLUTE TIME SCALE THROUGH THE CHRONOMETRY OF THE I-XE STANDARD SHALLOWATER AUBRITE. IT S ABSOLUTE AGE OF 4562.4 0.2 MA IS DERIVED FROM THE OBSERVED CORRELATION BETWEEN I-XE AND PB-PB AGES IN A NUMBER OF SAMPLES AND WAS RECENTLY RE-EVALUATED BY OUR LABORATORY. OUR STUDY OF THE ONSET OF THE ALTERATION AND ITS I-XE CHRONOLOGY IS AN ONGOING PROJECT; I-XE DATING OF MAGNETITES REFRACTORY (CAI) AND DARK INCLUSIONS FROM CI CM CV AND CO CHONDRITES HAVE BEEN ESPECIALLY FRUITFUL. WE PROPOSE TO EXTEND I-XE STUDIES OF AQUEOUS ALTERATION TO CK MAGNETITES AND COARSE- AND FINE-GRAINED ALLENDE (CV) CAIS. OUR PREVIOUS I-XE ISOTOPIC STUDIES OF 3 FINE-GRAINED ALLENDE CAIS DEMONSTRATED THE I-XE SYSTEM CLOSURE BETWEEN ?3.0 0.2 AND ?3.7 0.2 MA (LATER THAN SHALLOWATER). FOR THE WORK PROPOSED HERE WE HAVE ASSEMBLED A UNIQUE SET OF 12 FINE-GRAINED AND 12 COARSE-GRAINED ALLENDE CAIS. ONE OF THEM CURIOUS MARIE IS CHARACTERIZED BY AN EXTREMELY LARGE 235U EXCESS PROVING THAT 247CM WAS ALIVE IN THE EARLY SOLAR SYSTEM. WE RECENTLY REPORTED XE ISOTOPIC COMPOSITION AND THE I-XE CHRONOMETRY OF CURIOUS MARIE BOTH ESSENTIAL FOR THE DETERMINATION OF THE INITIAL ABUNDANCE OF 247CM IN THE SOLAR SYSTEM. THE I-XE SYSTEM SURVIVED IN TWO DIFFERENT MINERAL PHASES IN CURIOUS MARIE CONTRARY TO WHAT WE PREVIOUSLY OBSERVED FOR ALLENDE CAIS. STUDIES OF THE ADDITIONAL CAIS WILL HELP TO BETTER DELINEATE THE AQUEOUS ALTERATION SEQUENCE IN ALLENDE. CK AND CV CHONDRITES ARE CLOSELY RELATED BASED ON PETROLOGY BULK CHEMICAL AND OXYGEN ISOTOPIC COMPOSITIONS THUS THEIR ALTERATION HISTORIES MAY OVERLAP. THE CK CHONDRITES ARE ONE OF THE MOST OXIDIZED GROUPS OF CARBONACEOUS CHONDRITES AND THE I-XE AGE OF KAROONDA (CK4) ~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
$1,192,295Washington University, The · · FY2020 · National Aeronautics and Space Administration
THIS PROJECT INVOLVES A UNIVERSITY (UNT) AND INDUSTRY (ECK) PARTNER, TOGETHER WITH NATIONAL LAB (ORNL) AND INDUSTRY (ROLLS-ROYCE) ADVISORS WHOSE AIM IS TO APPLY THE NOVEL SOLID-STATE ADDITIVE FRICTION STIR DEPOSITION (AFSD) TECHNOLOGY, TAKING ADVANTAGE OF THE FINE CONTROL OVER TEMPERATURE, STRAIN AND HIGH STRAIN RATE SHEAR DEFORMATION THAT THIS TECHNIQUE ALLOWS, COMBINED WITH ALLOY DESIGN, TO MANUFACTURE PROTOTYPE AL-CE-MG-X ALLOY PARTS THAT CAN MEET THE HIGH TEMPERATURE MECHANICAL PROPERTY REQUIREMENTS FOR HIGH TEMPERATURE AEROSPACE STRUCTURAL APPLICATIONS. THE PROJECT EMPLOYS AN INTEGRATED COMPUTATION MATERIALS ENGINEERING (ICME) COUPLED WITH CRITICAL EXPERIMENTS APPROACH IN FIVE KEY TASKS TO PRODUCE DESIGNED AL-CE-MG-X ALLOY BUILDS THAT CAN MEET THE TARGETED HIGH TEMPERATURE PROPERTIES: 1) ALLOY DESIGN AND MODELING FOR COMPOSITION SELECTION TO OBTAIN SOLID SOLUTION, INTERMETALLIC COMPOSITE AND PRECIPITATE STRENGTHENING; 2) PROCESSING USING A DESIGN OF EXPERIMENTS APPROACH WITH SOLID VS COMPACTED POWDER FEED ROD AND THE MAIN AFS PROCESS VARIABLES OF TOOL ROTATION RATE AND TRAVERSE SPEED TO CREATE ROBUST BUILDS OF THE DESIGNED AL-CE-MG-X ALLOYS WITH OPTIMIZED MICROSTRUCTURE, RESIDUAL STRESS AND MECHANICAL PROPERTIES; 3) THE MICROSTRUCTURE OF THE FABRICATED MATERIALS WILL BE CHARACTERIZED IN DETAIL USING SEVERAL POWERFUL ANALYTICAL ELECTRON MICROSCOPY AND OTHER TECHNIQUE; 4) MECHANICAL PROPERTIES INCLUDING YIELD TENSILE STRENGTH, DUCTILITY, CREEP STRENGTH, FATIGUE LIFE, FRACTURE TOUGHNESS OVER A RANGE OF TEMPERATURES AND STRESS CORROSION CRACKING RESISTANCE OF THE FABRICATED MATERIALS WILL BE EVALUATED; AND 5) ESTABLISH QUANTITATIVE COMPOSITION-PROCESSING-STRUCTURE-PROPERTY RELATIONSHIPS BY RIGOROUS ANALYSIS OF METADATA AND MODELING. THE PROPOSED PROJECT DIRECTLY ADDRESSES THE FOA AREA RELATING TO THE DEVELOPMENT OF AL-CE AND PROCESSING TO ENABLE INCREASED ENERGY EFFICIENCY IN AEROSPACE APPLICATIONS. AFSD SHOWS GREAT PROMISE TO PROVIDE THE SOLUTION BUT HAS BEEN APPLIED ONLY IN A LIMITED WAY TO FABRICATE THIS CLASS OF MATERIALS WITH DEMANDING PROPERTY REQUIREMENTS. THE RESULTS AND SUCCESSFUL DEVELOPMENT OF THIS DISRUPTIVE TECHNOLOGY WILL DEMONSTRATE AN ICME-GUIDED HIGH-PERFORMANCE AL-CE-MG-X ALLOY AND PROCESS TECHNOLOGY THAT CAN MEET THE HIGH TEMPERATURE PROPERTY TARGETS FOR AEROSPACE STRUCTURAL APPLICATIONS.
$1,191,785University Of North Texas · · FY2022 · Department of Energy
Stem cells and aging
$1,191,414Toren Finkel · National Heart, Lung, And Blood Institute · ZIA · FY2014 · HL
The role of autophagy in aging and metabolism
$1,191,414Toren Finkel · National Heart, Lung, And Blood Institute · ZIA · FY2014 · HL
Synaptic Mechanisms in the Mammalian Retina
$1,191,390Jeffrey S Diamond · National Institute Of Neurological Disorders And Stroke · ZIA · FY2010 · NS
Nuclear and Glial Dysfunction in Neurodegeneration
$1,191,282Jeffrey D Rothstein · Johns Hopkins University · R35 · FY2024 · NS
Tumor Microenvironment in Cancer Progression
$1,190,749Rosandra Kaplan · Division Of Basic Sciences - Nci · ZIA · FY2023 · CA
Fluorescence Microscopy
$1,190,169James W Putney · National Institute Of Environmental Health Sciences · ZIC · FY2015 · ES
Discovery of Rare Variants and Mutations in Parkinson Disease
$1,189,916Jeffery M. Vance · University Of Miami School Of Medicine · P50 · FY2010 · NS
Innate inflammatory responses during pulmonary infections
$1,188,232Katrin Mayer-Barber · National Institute Of Allergy And Infectious Diseases · ZIA · FY2017 · AI
Brain Imaging And Modeling
$1,188,075Barry Horwitz · National Institute On Deafness And Other Communication Disorders · ZIA · FY2012 · DC
Proteins From Hereditary Eye Diseases: In silico and Experimental Studies
$1,188,023Yuri Sergeev · National Eye Institute · ZIA · FY2025 · EY
TDP-43 Proteinopathies in ALS-Dementia
$1,187,434Virginia M Lee · University Of Pennsylvania · P01 · FY2010 · AG
Prenatal Treatment of Down Syndrome to Improve Brain Development and Neurocognition
$1,187,419Diana Bianchi · National Human Genome Research Institute · ZIA · FY2021 · HG
Genetically Engineered Mouse Models to Study RTK Function in Melanoma
$1,187,307Glenn T. Merlino · Division Of Basic Sciences - Nci · ZIA · FY2014 · CA
Epigenome Interactions in Complex Neurogenetic Disorders
$1,186,731Margaret Elizabeth Ross · Weill Medical Coll Of Cornell Univ · R01 · FY2011 · NS
CAREER: Regulatory Mechanisms of Pathogen-Mediated Cellular Stress Signaling in Arabidopsis: Taking Plant Molecular Biology to the Urban Garden
$1,186,614Karolina Mukhtar · University Of Alabama At Birmingham · · FY2014 · BIO