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15,273 grants matching “antimicrobial resistance”
Improving Quality of Care for the Treatment of Childhood Pneumonia
$654,400Patricia L Hibberd · Massachusetts General Hospital · U01 · FY2010 · HD
Structural determinants of activity and mechanism of cationic peptide antibiotic activity against colistin-resistant bacteria
$653,885Berthony Deslouches · University Of Pittsburgh At Pittsburgh · R01 · FY2023 · AI
Identification of new inhibitors of essential functions in M. tuberculosis by high-throughput metabolic profiling
$653,812Michael Berney · Albert Einstein College Of Medicine · R01 · FY2023 · AI
Biochemistry of Bacterial Cell Membranes
$653,436Hiroshi Nikaido · University Of California Berkeley · R01 · FY2006 · AI
Biochemistry of Bacterial Cell Membranes
$653,389Hiroshi Nikaido · University Of California Berkeley · R01 · FY2007 · AI
Evaluation of Transperineal Biopsy under Local Anesthesia, a Novel approach to Decrease Post-Biopsy Infections and Improve Cancer Detection
$652,933Jim Hu · Weill Medical Coll Of Cornell Univ · R01 · FY2022 · CA
Precision targeting of T cell cytotoxicity with PET
$652,933Michael John Evans · University Of California, San Francisco · R01 · FY2022 · CA
Rapid fungal identification and antifungal susceptibility testing through quantitative, multiplexed RNA detection
$652,802Roby Paul Bhattacharyya · Broad Institute, Inc. · R01 · FY2024 · AI
Rational design of transferrin binding protein-based vaccines to combat gonorrhea
$652,612Cynthia Nau Cornelissen · Virginia Commonwealth University · R01 · FY2017 · AI
Bioinformatics Core
$652,371Vaughn Cooper · Boston Children'S Hospital · U19 · FY2025 · AI
Defining the targets of broad intervention antimalarial agents
$652,347Elizabeth A Winzeler · University Of California, San Diego · R01 · FY2015 · AI
Task A24: Establishment of Chronic Pseudomonas aeruginosa and Staphylococcus aureus Infection in Mouse Models of Cystic Fibrosis
$652,090Ralph Baric · Univ Of North Carolina Chapel Hill · N01 · FY2020 · AI
Regulation of viral-bacterial co-infections by immunometabolism
$652,089Jennifer Melinda Bomberger · Dartmouth College · R01 · FY2025 · HL
Identifying Optimal Antibiotic Regimens to Treat Urinary Tract Infections During Pregnancy
$652,046Anne Mobley Butler · Washington University · R01 · FY2024 · HD
Phenylacetic acid catabolism, a novel stress-response pathway in Acinetobacter baumannii
$651,984Mario Feldman · Washington University · R01 · FY2025 · AI
Role of Host Protein Kinase C in Cryptosporidiosis
$651,691Chelsea S. Marie · University Of Virginia · R01 · FY2024 · AI
Combinatorial Approaches to Improved Blood-contacting Polymer Biomaterials
$651,639Christopher A Siedlecki · Pennsylvania State Univ Hershey Med Ctr · R01 · FY2021 · HL
Evaluation of Transperineal Biopsy under Local Anesthesia, a Novel approach to Decrease Post-Biopsy Infections and Improve Cancer Detection
$651,354Jim Hu · Weill Medical Coll Of Cornell Univ · R01 · FY2023 · CA
Project 3: Functional Microbiome and Host Signatures in Transition from Commensal to pathogen
$651,255Tor C. Savidge · Methodist Hospital Research Institute · P01 · FY2022 · AI
Combinatorial Approaches to Improved Blood-contacting Polymer Biomaterials
$651,068Christopher A Siedlecki · Pennsylvania State Univ Hershey Med Ctr · R01 · FY2020 · HL
Serving Two Masters; The Role of Trade-Offs in the Evolution of Bacteriophage/Metal Resistance in Escherichia Coli
$651,022Liesl K Jeffers-Francis · North Carolina Agricultural & Technical State University · · FY2021 · BIO
Cumulative burden of Chlamydia trachomatis and Mycoplasma genitalium in the US: implications for screening guidelines and antimicrobial resistance
$650,268Lisa E Manhart · University Of Washington · R01 · FY2022 · AI
Combating Deadly Gram-negative Lung Infections: An Inhalation and Systems Approach
$650,259Qi Zhou · Purdue University · R01 · FY2017 · AI
Anti-viral Mechanisms of Defensins
$650,163Jason G Smith · University Of Washington · R01 · FY2022 · AI
DISEASE-ASSOCIATEDSTREPTOCOCCUS SUISIS A COSTLY DISEASE IN SWINE PRODUCTION CAUSED BY THES. SUISBACTERIUM. SWINE PRODUCERS FACE MAJOR CHALLENGES IN CONTROLLINGS. SUISDUE TO ITS ENDEMIC NATURE, THE LACK OF EFFECTIVE VACCINES, THE PRESENCE OF COMMENSALS. SUISSTRAINS, AND POTENTIAL ANTIMICROBIAL RESISTANCE. VETERINARIANS DO NOT FULLY UNDERSTAND WHY SOME PIGS DEVELOP DISEASE WHILE THEIR LITTERMATES REMAIN HEALTHY CARRIERS. ONE HYPOTHESIS IS THAT RESPIRATORY MICROBES (I.E., THE MICROBIOME) INTERACT WITH DIFFERENT CO-CIRCULATINGS. SUISSTRAINS IN A TEMPORALLY DYNAMIC MANNER THAT INFLUENCES DISEASE RISK. HOWEVER, THERE IS LIMITED KNOWLEDGE ABOUT THE INTERACTIONS BETWEEN DISEASE-CAUSING STRAINS OFS. SUISAND THE MICROBIOME. THIS PROJECT WILL ADDRESS THIS KNOWLEDGE GAP BY INVESTIGATING THE ASSOCIATION BETWEEN THE NASOPHARYNGEAL MICROBIOME AND DISEASE, DETECTING CO-CIRCULATINGS. SUISSTRAINS, AND IDENTIFYING ANTIMICROBIAL RESISTANCE AND VIRULENCE-ASSOCIATED GENES AND THEIR RELATIONSHIP TO DISEASE OUTCOMES. MICROBIOME SEQUENCING, ADVANCED MOLECULAR ENRICHMENT METAGENOMICS, AND WHOLE-GENOME SEQUENCING OF MULTIPLE CULTURED ISOLATES FROM NASOPHARYNGEAL SAMPLES WILL BE PERFORMED. THESE DATA, ALONG WITH FARM MANAGEMENT FACTORS, WILL BE USED IN MULTIVARIABLE MODELING AND NETWORK ANALYSIS TO DETERMINE COMPREHENSIVE RISK FACTORS FOR DISEASE. THE RESULTS WILL PROVIDE NEW INSIGHTS INTO THE CAUSES OFS. SUIS DISEASE, ULTIMATELY SUPPORTING IMPROVED DISEASE CONTROL ON FARMS, ENHANCING PIG HEALTH AND PRODUCTIVITY.
$650,000Texas Tech University System · · FY2025 · National Institute of Food and Agriculture