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15,273 grants matching “antimicrobial resistance”
In Vitro Core
$658,181Michael A Hoffman · University Of Wisconsin-Madison · U19 · FY2017 · AI
Sensor Technology for Rapid Microbial Identification and Susceptibility Testing
$658,103David A Haake · Brentwood Biomedical Research Institute · U01 · FY2009 · AI
Genomic Epidemiology of Campylobacter to Improve Disease Control in Low and Middle Income Countries
$657,886Margaret N Kosek · University Of Virginia · R01 · FY2022 · AI
Role of Molecular Chaperones in Stress Response and Disease
$657,620Ursula H Jakob · University Of Michigan At Ann Arbor · R35 · FY2019 · GM
Rapid fungal identification and antifungal susceptibility testing through quantitative, multiplexed RNA detection
$657,346Roby Paul Bhattacharyya · Broad Institute, Inc. · R01 · FY2022 · AI
Polysomes & Subunits: Structure-Function Relationships
$657,272Albert E Dahlberg · Brown University · R01 · FY2012 · GM
Polysomes & Subunits: Structure-Function Relationships
$657,271Albert E Dahlberg · Brown University · R01 · FY2011 · GM
Molecular mechanisms underlying organ penetration in disseminated pneumococcal infection
$657,115Carlos J Orihuela · University Of Alabama At Birmingham · R01 · FY2023 · AI
Cefixime Dose-Response in the Mouse Model of Neisseria gonorrhoeae infection
$656,557National Institute Of Allergy And Infectious Diseases · Y01 · FY2018 · AI
Advancement of poxvirus inhibitor
$656,410John H Connor · Boston University Medical Campus · R01 · FY2023 · AI
Monoclonal Antibody to Combat Pseudomonas Aeruginosa
$656,358Joanna B. Goldberg · Emory University · R01 · FY2025 · AI
NETWORK ON ANTIMICROBIAL RESISTANCE IN STAPHYLOCOCCUS AUREUS (NARSA)
$656,158Sahm Daniel · · N01 · FY2007 · AI
Ag-specific gamma delta T cells and immunity to TB/AIDS-related TB
$655,890Zheng W Chen · University Of Illinois At Chicago · R01 · FY2017 · OD
Genomics-Assisted Antibiotic Discovery from Unprecedented Microbes of the Great Salt Lake
$655,880Jaclyn Marie Winter · University Of Utah · R01 · FY2021 · AI
IMMUNE REGULATION AND VACCINE DEVELOPMENT IN LEISHMANIASIS
$655,874David Sacks · National Institute Of Allergy And Infectious Diseases · Z01 · FY2008 · AI
Establishment of the New York University Vaccine and Treatment Evaluation Unit (NYU VTEU)
$655,601Mark Joseph Mulligan · New York University School Of Medicine · UM1 · FY2021 · AI
Natural Product Derived Inhibitors of ESKAPE Pathogens
$655,589Bill J Baker · University Of South Florida · R56 · FY2020 · AI
Clinical Impact of Quinolone-Resistant E.coli carriage
$655,312University Of Pennsylvania · R01 · FY2005 · AI
Informatics Approaches to Understand and Reduce Inappropriate Antibiotic Prescribing by Dentists
$655,223Muhammad Walji · University Of Texas Hlth Sci Ctr Houston · R01 · FY2025 · DE
In Vitro Core
$655,151Michael A Hoffman · University Of Wisconsin-Madison · U19 · FY2016 · AI
BIOFILM FORMATION AND ITS CONCOMITANT RISK OF CAUSING EQUIPMENT MALFUNCTION AND HUMAN ILLNESSES IS A PROBLEM THAT NEEDS TO BE ADDRESSED TO ENABLE SAFE LONG-TERM HUMAN SPACE EXPLORATION. WITH THAT OBJECTIVE THIS PROPOSAL AIMS TO CHARACTERIZE BIOFILM GROWTH DURING ONE ISS INCREMENT IN TERMS OF MASS THICKNESS MORPHOLOGY AND ASSOCIATED GENE EXPRESSION USING DIFFERENT SPACEFLIGHT-RELEVANT MICROBIAL SPECIES AND MATERIAL SUBSTRATA. THIS PROJECT ALSO AIMS TO ELUCIDATE THE BIOMECHANICAL AND TRANSCRIPTOMIC MECHANISMS INVOLVED IN THE FORMATION OF THE COLUMN-AND-CANOPY BIOFILM ARCHITECTURE OBSERVED IN SPACE. THE EXPERIMENT IS DESIGNED TO ASSESS THE EXPRESSION OF GENES ASSOCIATED WITH CONFERRING MICROORGANISMS WITH RESISTANCE TO OXIDATIVE STRESS ACIDITY AND ANTIMICROBIALS IN BIOFILMS FORMED IN SPACE AND TO DETERMINE PHYSICAL MECHANISMS OF MATERIAL/MICROORGANISMS INTERACTION IN BIOFILMS. THE EXPERIMENT WILL BE CONDUCTED USING BIOSERVE'S BIOCELLS HOUSING SUBSTRATA COUPONS EXPOSED TO DIFFERENT MICROORGANISMS AND MEDIA. POST-FLIGHT ANALYSES OF FIXED SAMPLES INCLUDE CONFOCAL LASER SCANNING MICROSCOPY AND RNA-SEQUENCING. THE SIGNIFICANCE OF THIS PROJECT STEMS FROM GAINING VALUABLE NEW KNOWLEDGE THAT MAY LEAD TO IMPROVED METHODS AND/OR MATERIAL PROPERTIES FOR CONTROLLING BIOFILM FORMATION DURING LONG DURATION SPACE MISSIONS. THE SELECTION OF BACTERIAL SPECIES GROWTH MEDIA AND SUBSTRATA MATERIAL MAKE THE RESULTS APPLICABLE TO A) THE SAFETY AND MAINTENANCE OF CREWED SPACECRAFT B) PLANETARY PROTECTION C) MITIGATION OF BIOFILM-ASSOCIATED ILLNESSES ON THE CREW AND D) BIOFILM-ASSOCIATED ILLNESSES ON EARTH THUS MAKING IT RELEVANT NOT ONLY TO THIS RESEARCH ANNOUNCEMENT BUT ALSO TO NASA S HUMAN EXPLORATION AND OPERATIONS DIRECTORATE SPACE BIOLOGY PROGRAM AND HUMAN RESEARCH ROADMAP.
$654,979The Regents Of The University Of Colorado · · FY2020 · National Aeronautics and Space Administration
In vitro core
$654,825F. Michael Hoffmann · University Of Wisconsin-Madison · U19 · FY2019 · AI
H. influenzae: Role of Sialic Acid in Virulence
$654,676Michael A. Apicella · University Of Iowa · R01 · FY2010 · AI
Th17-mediated immunity to fungal infections
$654,426Sarah L. Gaffen · University Of Pittsburgh At Pittsburgh · R56 · FY2010 · AI
Anti-viral Mechanisms of Defensins
$654,410Jason G Smith · University Of Washington · R01 · FY2021 · AI