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17,828 grants matching “crispr”
Atlanta Center for the Childhood Liver Disease Research Network (ChiLDReN)
$801,000Saul Joseph Karpen · Emory University · U01 · FY2023 · DK
Drug resistance enablers and their role in antibiotic treatment failure
$800,994Vaughn Cooper · Boston Children'S Hospital · U19 · FY2025 · AI
Inherited colorectal cancer risk variants: from association to biology
$800,500Graham Casey · University Of Virginia · R01 · FY2017 · CA
Investigating the role of human-specific 3D genome conformation in the context of brain development and disease
$800,485Lucia Carbone · Oregon Health & Science University · R01 · FY2025 · MH
Safety and Efficacy of Human Clinical Trials Using Kidney-on-a-Chip Microphysiological Systems
$800,329Jonathan Himmelfarb · University Of Washington · UG3 · FY2021 · TR
Cas9 RNP delivery to immune cells in vivo via molecular targeting
$800,300Ross C Wilson · University Of California Berkeley · UG3 · FY2019 · AI
CAREER: A role for axo-glial interactions between mesocortical dopamine axons and oligodendrocyte lineage cells in cortical hypomyelination caused by chronic adult social isolation
$800,000Leora Yetnikoff · Cuny College Of Staten Island · · FY2025 · BIO
BERRIES CONTAMINATED WITH VIRUSES LIKE HUMAN NOROVIRUS CAN CAUSE ILLNESS IN CONSUMERS AND LEAD TO COSTLY RECALLS FOR THE PRODUCE INDUSTRY. CURRENT TESTS DETECT VIRUS FRAGMENTS BUT CANNOT TELL IF THE VIRUS IS STILL INFECTIOUS. THIS CAN RESULT IN UNNECESSARY FOOD WASTE AND ECONOMIC LOSSES. OUR FIRST OBJECTIVE IS TO IMPROVE VIRUS DETECTION BY TESTING A NEW METHOD THAT USES BACTERIA TO CAPTURE VIRUSES FROM PRODUCE. THIS METHOD IS LOW-COST, SCALABLE, AND MAY BETTER PRESERVE INFECTIOUS VIRUS FOR DETECTION. OUR SECOND OBJECTIVE IS TO DEVELOP A RAPID, LOW-COST CRISPR-BASED TEST THAT CAN DETECT INFECTIOUS HUMAN NOROVIRUS ON BERRIES. THIS TEST WILL INCLUDE A STEP TO REMOVE NON-INFECTIOUS VIRUS FRAGMENTS, HELPING TO DISTINGUISH BETWEEN INFECTIOUS AND NON-INFECTIOUS VIRUS. OUR THIRD OBJECTIVE IS TO COLLECT AND TEST SAMPLES FOR INFECTIOUS NOROVIRUS FROM FARMS AND PROCESSING FACILITIES. THESE SAMPLES WILL INCLUDE BERRIES AND WORKER HANDS. THIS PROJECT WILL HELP PROTECT CONSUMERS, REDUCE UNNECESSARY RECALLS, AND SUPPORT A SAFER, MORE SUSTAINABLE PRODUCE SUPPLY CHAIN.
$800,000Emory University · · FY2025 · National Institute of Food and Agriculture
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THE OVERARCHING GOAL OF THIS PARTNERSHIP PROPOSAL IS TO USE NEW CRISPR/CAS9 MUTANTS OF SORGHUM [SORGHUM BICOLOR (L.) MOENCH] TO IDENTIFY WHICH GENE AT THE INHIBITION OF ALIEN POLLEN (IAP) LOCUS CONTROLS THE ABILITY OF ALIEN POLLEN TUBES TO REACH THE OVARY DURING INTERSPECIFIC CROSS-POLLINATION. IAP IS THE ONLY KNOWN REPRODUCTIVE BARRIER LOCUS IN SORGHUM. WE WILL CHARACTERIZE GENERAL PLANT MORPHOLOGY, REPRODUCTIVE BIOLOGY, OFF-TARGET COPY NUMBER, AND TARGET GENE EXPRESSION IN THREE MUTANT LINES HAVING LESIONS IN THREE CANDIDATE GENES AT IAP (ONE PUTATIVELY KNOCKED-OUT GENE PER LINE). THE SPECIFIC IAP ALLELE (OR COMBINATION THEREOF) THAT REDUCES/KNOCKS OUT THE EXPRESSION OF THE INHIBITED ALIEN POLLEN PHENOTYPE WILL BE IDENTIFIED. OUR SPECIFIC AIMS ARE TO 1) IDENTIFY WHICH IAP ALLELE (OR COMBINATION OF ALLELES) ENABLES ALIEN POLLEN TUBES TO REACH THE SORGHUM OVARY, 2) DIFFERENTIATE TISSUE-SPECIFIC GENE EXPRESSION PROFILES DURING CROSS-POLLINATION EVENTS, AND 3) IDENTIFY KEY GENES INVOLVED IN A COMPATIBLE VERSUS INCOMPATIBLE CROSS-POLLINATION EVENT USING A CO-EXPRESSION ANALYSIS ACROSS DIFFERENT TIMEPOINTS. OUR LONG-TERM VISION IS TO USE INFORMATION GAINED FROM THE NEW CRISPR MUTANTS TO DEVELOP METHODS TO EITHER PREVENT OR ENCOURAGE OUTCROSSING AMONG SORGHUM AND ITS WILD RELATIVES, DEPENDING ON CONTEXT. FOR EXAMPLE, OUTCROSSING BETWEEN THE CROP AND CLOSELY-RELATED WEEDS IS UNDESIRABLE, BUT ENHANCING THE ABIOTIC STRESS TOLERANCE OF THE CROP THROUGH BREEDING WITH MORE DISTANT RELATIVES IS DESIRABLE.
$800,000Board Of Regents Of Nevada System Of Higher Education · · FY2023 · National Institute of Food and Agriculture
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** DWARF AND COMMON BUNT DISEASE OUTBREAKS ARE LIKELY TO INCREASE DUE TO THE EXPANSION OF ORGANIC WHEAT PRODUCTION SYSTEMS, CHANGING CLIMATIC CONDITIONS, AND THE EVOLUTION OF NEW PATHOGEN RACES. ACCORDING TO THE USDA NASS CENSUS OF AGRICULTURE, THE UNITED STATES HARVESTED 450,854 BUSHELS OF ORGANIC WHEAT IN 2017, WITH UTAH RANKING FOURTH AT 37,736 BUSHELS AND IDAHO RANKING EIGHTH AT 19,737 BUSHELS. SALES OF ORGANIC FOOD PRODUCTS IN THE UNITED STATES GREW AT A RATE OF 6.4 PERCENT IN 2017, AND AS ORGANIC WHEAT ACREAGE GROWS TO KEEP PACE, HOST RESISTANCE IS NECESSARY TO PROTECT AGAINST INFECTION WITHIN THESE PRODUCTION SYSTEMS AS CHEMICAL SEED TREATMENTS ARE NOT ALLOWED. THIS PROJECT WILL BUILD UPON A PLANT BREEDING PARTNERSHIP BETWEEN WHEAT BREEDING PROGRAMS AT TWO FASE LAND-GRANT INSTITUTIONS TO ENHANCE GERMPLASM AND CULTIVAR DEVELOPMENT FOR RESISTANCE TO THE DWARF BUNT (T. CONTRAVERSA KUHN) AND COMMON BUNT (T. CARIES (D.C.) TUL. AND T. FOETIDA (WALLR.) LIRO) DISEASES. ENHANCED GENETIC RESISTANCE TO BOTH DISEASES WILL BENEFIT NOT ONLY ORGANIC WHEAT PRODUCTION IN THE UNITED STATES, BUT ALSO CONVENTIONAL WHEAT PRODUCTION IN DRYLAND FARMING REGIONS WORLDWIDE. THIS PROJECT WILL USE CURRENT GENOMICS TOOLS TO IDENTIFY CANDIDATE GENES AND TIGHTLY LINKED MOLECULAR MARKERS FOR MAJOR RESISTANCE GENES AND WILL DEVELOP A GENOMIC SELECTION SYSTEM FOR MINOR RESISTANCE GENES TO DWARF AND COMMON BUNT DISEASES. THE GENOMICS TOOLS EMPLOYED WILL INCLUDE QTL MAPPING WITH BI-PARENTAL AND GENOME-WIDE ASSOCIATION METHODS, HIGH- THROUGHPUT GENOTYPING PLATFORMS, AND TARGETED MUTAGENESIS (CRISPR-CAS9). THE INFORMATION GENERATED WILL ENABLE US TO OPTIMIZE A RESISTANCE SELECTION SCHEME BY COMBINING MARKER-ASSISTED SELECTION AND GENOMIC SELECTION METHODS AS PART OF OUR CULTIVAR DEVELOPMENT PROGRAM. THE GOAL OF THIS WORK IS TO DEVELOP DURABLE RESISTANCE TO THE TWO BUNT DISEASES BY STACKING MULTIPLE LARGE-EFFECT BT GENES WHILE SIMULTANEOUSLY ENHANCING QUANTITATIVE RESISTANCE IN ADAPTED GENETIC BACKGROUNDS. OUR PROJECT WILL THEREFORE ADDRESS THE PRIORITIES OF PROGRAM AREA CODE A1141 TO IMPROVE CROP PRODUCTIVITY AND EFFICIENCY, AND PARTICULARLY TO ENHANCE THE SUSTAINABILITY OF ORGANIC WHEAT PRODUCTION.
$800,000Regents Of The University Of Idaho · · FY2022 · National Institute of Food and Agriculture
Collaborative Research: TRTech-PGR TRACK: Discovery and characterization of small CRISPR systems for virus-based delivery of heritable editing in plants.
$800,000Jennifer A Doudna · University Of California-Berkeley · · FY2024 · BIO
The immunogenicity and pathogenicity of HLA-DQ in solid organ transplantation
$799,998Anat R. Tambur · Northwestern University At Chicago · R01 · FY2024 · AI
The immunogenicity and pathogenicity of HLA-DQ in solid organ transplantation
$799,994Anat R. Tambur · Northwestern University At Chicago · R01 · FY2025 · AI
The immunogenicity and pathogenicity of HLA-DQ in solid organ transplantation
$799,990Anat R. Tambur · Northwestern University At Chicago · R01 · FY2023 · AI
Self-Powered Sample Concentrating and CRISPR-based Biosensing for Moile HIV-1 RNA Detection
$799,475Changchun Liu · University Of Connecticut Sch Of Med/Dnt · R33 · FY2024 · AI
Mechanistic studies of the genetic contribution of desmoplakin to pulmonary fibrosis in alveolar type 2 cells
$799,392Andrew A Wilson · Boston University Medical Campus · R01 · FY2023 · HL
Determining stathmin-2 function and potential as a therapeutic target in ALS/FTD
$798,489Don W. Cleveland · Ludwig Institute For Cancer Res Ltd · R01 · FY2021 · NS
Focused Ultrasound-mediated Delivery of Gene-editing Elements to the Brain for Neurodegenerative Disorders
$798,469Kam W Leong · Columbia University Health Sciences · UG3 · FY2019 · NS
Prediction of Therapy Response in Colorectal Cancer
$798,080Thomas Ried · Division Of Basic Sciences - Nci · ZIA · FY2021 · CA
XenCAT: Xenopus Single Cell Atlas
$797,999Leon Peshkin · Harvard Medical School · R24 · FY2025 · OD
Sequence analysis of hematological traits in African Americans
$797,897Ethan Mather Lange · Univ Of North Carolina Chapel Hill · R01 · FY2016 · HL
Determining stathmin-2 function and potential as a therapeutic target in ALS/FTD
$797,269Don W. Cleveland · Ludwig Institute For Cancer Res Ltd · R01 · FY2022 · NS
Mechanisms of gene expression
$797,097John O'Shea · National Institute Of Arthritis And Musculoskeletal And Skin Diseases · ZIA · FY2025 · AR
Center for Structural Biology of HIV RNA
$797,029Alice Telesnitsky · University Of Michigan At Ann Arbor · U54 · FY2022 · AI
Scalable multi-ancestry functional genomics of blood traits and cardiovascular disease
$796,882Neville Sanjana · New York Genome Center · R01 · FY2025 · HL