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16,300 grants matching “fatty liver disease”
Characterizing the Human Imprint Regulatory Regions Associated with Childhood Obesity
$635,071David Skaar · North Carolina State University Raleigh · R01 · FY2020 · HD
Symptom Distress Mechanisms in Digestive Disorders
$634,998Wendy Henderson · National Institute Of Nursing Research · ZIA · FY2019 · NR
Novel roles of PDK4 in regulating mitochondrial protein phosphorylation, carbon flux and metabolic resilience
$634,926Deborah M Muoio · Duke University · R01 · FY2025 · DK
Understanding the roles of cardiac NAD pools and therapeutic effects of precursor supplements in heart failure
$634,840Joseph A. Baur · University Of Pennsylvania · R01 · FY2025 · HL
Novel Determinants for Progression of Non-Alcoholic Fatty Liver Disease to Hepatocellular Carcinoma and Other Health Outcomes
$634,830Jian-Min Yuan · University Of Pittsburgh At Pittsburgh · R01 · FY2021 · CA
Longitudinal Study of Early NAFLD Progression and the Gut Microbiome in Asian Americans, Native Hawaiians and Whites
$634,776Unhee Lim · University Of Hawaii At Manoa · R01 · FY2025 · MD
Metabolic regulation and inhibition of ATP-citrate lyase
$634,732Ronen Marmorstein · University Of Pennsylvania · R01 · FY2025 · CA
Maternal obesity and cardiometabolic health in the offspring
$634,724Kelle H Moley · Washington University · R01 · FY2018 · HL
The altered lipid and protein metabolism of pediatric patients with HIV infection
$634,722Farook Jahoor · Baylor College Of Medicine · R01 · FY2009 · HD
Genetic determinants of NAFLD severity and progression
$634,699Johanna K Distefano · Translational Genomics Research Inst · R01 · FY2012 · DK
Modulating macrophage function in atherosclerosis by functionalized nanoparticles
$634,543Shobha Ghosh · Virginia Commonwealth University · R01 · FY2020 · HL
Modulating macrophage function in atherosclerosis by functionalized nanoparticles
$634,543Shobha Ghosh · Virginia Commonwealth University · R01 · FY2019 · HL
Obesity Prevention Targets for Down Syndrome
$634,492Lisa Ann Daunhauer · Colorado State University · R01 · FY2025 · HD
Predicting outcomes in nonalcoholic steatohepatitis with advanced fibrosis
$634,480Arun J Sanyal · Virginia Commonwealth University · R01 · FY2022 · DK
Blood TG clearance and vascular biology
$634,166Ira Jay Goldberg · Nyu Long Island School Of Medicine · P01 · FY2023 · HL
Nonalcoholic Steatohepatitis Clinical Research Network
$633,846Arun J Sanyal · Virginia Commonwealth University · U01 · FY2012 · DK
The molecular genetic analysis of human obesity
$633,735Rudolph L Leibel · Columbia University Health Sciences · R01 · FY2018 · DK
Collaborative Integration of HCV Molecular Virology and Mathematical Modeling
$633,299Susan L Uprichard · Loyola University Chicago · R01 · FY2023 · AI
Aging Intervention Studies
$633,234Julie Mattison · National Institute On Aging · ZIA · FY2014 · AG
Project 2: ANGPTL3-dependent mechanisms underlying adaptations in hepatic lipoprotein production and clearance
$633,102Nathan Oliver Stitziel · University Of Washington · P01 · FY2025 · HL
Project 1. Type 2 diabetes, APOC3 and cardiovascular disease
$633,102Karin E. Bornfeldt · University Of Washington · P01 · FY2025 · HL
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** CURRENTLY, AMERICANS ARE CONSUMING 42% OF THEIR DAILY CALORIES FROM LOW-QUALITY CARBOHYDRATES, SUCH AS REFINED GRAINS AND SUGAR SWEETENED BEVERAGES. EXCESSIVE INTAKE OF REFINED CARBOHYDRATESIS A MAJOR DIETARY RISK FACTOR FOR THE DEVELOPMENT OF NONALCOHOLIC FATTY LIVER DISEASE (NAFLD) WHICH IS MORE PREVALENT AND SEVERE AMONGST AGED INDIVIDUALS. WHILE CRITICAL TO RECOMMEND DECREASED CONSUMPTION OF REFINED CARBOHYDRATES, IT IS ALSO IMPORTANT TO IDENTIFY FOOD-DERIVED, BIOLOGICALLY ACTIVE COMPOUNDS, SUCH AS LYCOPENE (A RED PIGMENT) AND PHYTOENE (A PRECAUSOR OF LYCOPENE AND OTHER MAJOR CAROTENOIDS)FROM TOMATOES AND TOMATO PRODUCTS, WHICH MAY DELAY THE ONSET OF NAFLD THROUGH TARGETING THE GUT-LIVER INTERACTION. IN THE PROPOSED STUDY, WE WILL EXPLORE WHETHER AGE (YOUNG MICE AT 8 MONTHS VS. OLDER MICE AT 24 MONTHS) AND CAROTENOID BREAKDOWN ENZYMES (NORMAL MICEVS. MICE LACKING CAROTENOID BREAKDOWN ENZYMES) MAY DIFFERENTIALLY CONTRIBUTE TO HIGH REFINED CARBOHYDRATE DIET (HRCD)-INDUCED NAFLD DEVELOPMENT; AND WHETHER TOMATO POWDER (WHOLE TOMATO) AND KEY TOMATO-BASED CAROTENOIDS (LYCOPENE AND PHYTOENE) ELICIT PROTECTION AGAINST HRCD-RELATED NAFLD THROUGH MODULATING THE KEY GENES (SIRTUIN 1 SIGNALING), GUT BACTERIA PROFILE (GUT MICROBIOME) AND METABOLIC PROFILE (METABOLOMICS)IN YOUNG AND OLDER ANIMALS. WE EXPECT THAT TOMATO POWDER, LYCOPENE, AND PHYTOENE INTERVENTIONS WILL DIMINISH HRCD-, AGE-RELATED ABERRANT GENE EXPRESSION, INFLAMMATION AND OXIDATIVE STRESS, CONSEQUENTLY MINIMIZINGGUT BACTERIA AND METABOLIC ALTERATIONS AND REDUCING NAFLD PROGRESSION. THESE DATA WILL PROVIDE NEW INSIGHT INTO THE PROTECTIVE EFFECTS OF TOMATO AND TOMATO PRODUCTS AND WILL FURTHER EMBOLDEN THE PREVENTIVE ROLE OF TOMATO AGAINST HRCD-ASSOCIATED NAFLD AND METABOLIC DISORDERS IN AGED POPULATION.
$632,992Trustees Of Tufts College · · FY2023 · National Institute of Food and Agriculture
Nutrigenetic Intervention to Reduce Liver Fat in Hispanics - Supplement
$632,968Michael I Goran · Children'S Hospital Of Los Angeles · R01 · FY2019 · MD
Hepatic Rap1a in cholesterol homeostasis
$632,897Lale Ozcan · Columbia University Health Sciences · R01 · FY2024 · HL
Collaborative Integration of HCV Molecular Virology and Mathematical Modeling
$632,809Susan L Uprichard · Loyola University Chicago · R01 · FY2024 · AI