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34,240 grants matching “atherosclerosis”
FUNCTIONAL ANALYSIS OF A PDGF-INDUCIBLE CYTOKINE
$300,248Dana-Farber Cancer Institute · R01 · FY2000 · CA
GENCAC - MOLECULAR GENETICS LABORATORY
$300,202University Of Texas Hlth Sci Ctr Houston · U01 · FY2003 · HL
Project 3: Diesel Exhaust, Vascular Response & Systemic Inflammation
$300,158Stephan Van Eeden · University Of Washington · P50 · FY2011 · ES
Ascorbylation of Oxidized Lipids and Atherosclerosis
$300,134Jan Frederik Stevens · Oregon State University · R01 · FY2007 · HL
HCMV DYSREGULATES ENDOTHELIAL CELL FUNCTIONS
$300,096Eng-Shang Huang · Univ Of North Carolina Chapel Hill · P01 · FY2009 · CA
On the emergence of polarization and motility responses from chemotactic networks
$300,059Steven J Altschuler · Ut Southwestern Medical Center · R01 · FY2011 · GM
Phosphoproteome and Ang II-induced VSMC Gene Expression
$300,039Sadashiva S. Karnik · Cleveland Clinic Lerner Com-Cwru · R01 · FY2008 · HL
Phosphoproteome and Ang II-induced VSMC Gene Expression
$300,039Sadashiva S. Karnik · Cleveland Clinic Lerner Com-Cwru · R01 · FY2010 · HL
Phosphoproteome and Ang II-induced VSMC Gene Expression
$300,039Sadashiva S. Karnik · Cleveland Clinic Lerner Com-Cwru · R01 · FY2009 · HL
Phosphoproteome and Ang II-induced VSMC Gene Expression
$300,039Sadashiva S. Karnik · Cleveland Clinic Lerner Com-Cwru · R01 · FY2007 · HL
Cellular cholesterol movement and homeostasis
$300,000Yvonne Lange · Rush University Medical Center · R01 · FY2011 · HL
Pathological Consequences of the Plasminogen System
$300,000University Of Notre Dame · R01 · FY2004 · HL
Novel Cell-based Real Time Platform for GPCR Drug Discovery
$300,000Eric James Steinmetz · Lucigen Corporation · R43 · FY2014 · GM
D3SC: EAGER: Data-driven development of fluorescent sensors for bio-imaging
$300,000Ming Xian · Washington State University · · FY2017 · MPS
ANGIOGENIC BYPASS &GENE THERAPY RESPONSE MECHANISMS
$300,000Evanston Northwestern Healthcare Res Ins · R01 · FY2001 · HL
ANGIOGENIC BYPASS &GENE THERAPY RESPONSE MECHANISMS
$300,000Evanston Northwestern Healthcare · R01 · FY2000 · HL
Single-chain antibody countermeasures for the Radiation GI Syndrome
$300,000Jim Rotolo · Ceramide Therapeutics, Llc · R43 · FY2014 · AI
Cholesterol Ester Hydrolysis and Cholesterol Efflux
$300,000Virginia Commonwealth University · R01 · FY2004 · HL
Washington University Clinical Nutrition Research Unit
$300,000Samuel Klein · Washington University · P30 · FY2009 · DK
Inhibitors of Hydrogen Sulfide Metabolism as a Novel Treatment for Heart Failure
$300,000Marilyn S Jorns · Fox Chase Chemical Diversity Center, Inc · R41 · FY2017 · HL
Text Messaging to Promote Walking in Latinos with Peripheral Arterial Disease
$300,000Tracie Chianti Collins · University Of Kansas Medical Center · R56 · FY2015 · AG
CONSUMING TOO MUCH SODIUM IS A MAJOR CONTRIBUTOR TO CARDIOVASCULAR DISEASE, WHICH IS THE NUMBER ONE CAUSE OF DEATH FOR AMERICANS. ONE WAY THAT EXCESS DIETARY SODIUM LEADS TO CARDIOVASCULAR DISEASE IS BY DAMAGING THE HEALTH OF OUR BLOOD VESSELS, WHICH LEADS TO A CONDITION CALLED ENDOTHELIAL DYSFUNCTION. ENDOTHELIAL DYSFUNCTION IS THE KEY PRECURSOR TO ATHEROSCLEROSIS, WHICH CAN ULTIMATELY LEAD TO A HEART ATTACK OR STROKE. ENDOTHELIAL FUNCTION IS NOT TYPICALLY MEASURED IN CLINICAL SETTINGS, AND IMPAIRMENTS IN ENDOTHELIAL FUNCTION MAY DEVELOP LONG BEFORE WE EXPERIENCE ANY SYMPTOMS. PREVIOUS WORK HAS SHOWN THAT A HIGH SODIUM DIET IMPAIRS ENDOTHELIAL FUNCTION EVEN IN HEALTHY YOUNG ADULTS WITH NO CARDIOVASCULAR DISEASE RISK FACTORS. THIS SUGGESTS THAT EARLY INTERVENTION IS CRITICAL FOR CARDIOVASCULAR DISEASE PREVENTION. UNFORTUNATELY, MOST AMERICANS CONSUME SODIUM IN EXCESS OF CURRENT RECOMMENDATIONS. SIGNIFICANT RESEARCH AND PUBLIC HEALTH EFFORTS HAVE BEEN DEVOTED TO HELPING INDIVIDUALS REDUCE THEIR SODIUM INTAKE, WITH MIXED SUCCESS. IT IS DIFFICULT FOR INDIVIDUALS TO REDUCE THEIR SODIUM INTAKE AS IT IS WIDELY DISTRIBUTED IN OUR FOOD SUPPLY, MAKING IT DIFFICULT TO AVOID. THUS, RATHER THAN FOCUSING ON REDUCING SODIUM INTAKE AT THE INDIVIDUAL LEVEL, IDENTIFYING STRATEGIES TO OFFSET THE EFFECTS OF SODIUM ARE WARRANTED. POTASSIUM HAS SHOWN PROMISE AS A POTENTIAL DIETARY COMPONENT THAT CAN MITIGATE SODIUM-INDUCED ENDOTHELIAL DYSFUNCTION, EVEN IN YOUNG ADULTS. MOST IMPORTANTLY, INCREASING POTASSIUM INTAKE HAS BEEN SHOWN TO IMPROVE ENDOTHELIAL FUNCTION EVEN IF SODIUM INTAKE REMAINS HIGH. THIS SUGGESTS POTASSIUM MAY BE A KEY DIETARY COMPONENT TO TARGET FOR REDUCING CARDIOVASCULAR DISEASE RISK.TO DATE, THE BENEFICIAL EFFECTS OF POTASSIUM FOR MITIGATING SODIUM-INDUCED ENDOTHELIAL DYSFUNCTION HAVE ONLY BEEN DEMONSTRATED IN CONTROLLED FEEDING STUDIES. IN THESE STUDIES, RESEARCHERS PROVIDE PARTICIPANTS WITH CAREFULLY DESIGNED AND PREPARED MEALS THAT CONTAIN THE EXACT AMOUNT OF POTASSIUM AND OTHER NUTRIENTS THAT THEY WANT PARTICIPANTS TO CONSUME; STUDY PARTICIPANTS DO NOT NEED TO MAKE ANY CONSCIOUS CHANGES TO THEIR DIET, OTHER THAN EATING THE FOOD THEY ARE PROVIDED. WHAT REMAINS UNKNOWN IS WHETHER INDIVIDUALS, WITH GUIDANCE, CAN SUCCESSFULLY INCREASE THEIR POTASSIUM INTAKE TO A SUFFICIENT LEVEL TO EXPERIENCE IMPROVEMENTS IN ENDOTHELIAL FUNCTION OUTSIDE OF THESE HIGHLY CONTROLLED STUDIES IN REAL-LIFE SETTINGS. THIS IS A MAJOR GAP IN OUR KNOWLEDGE, WHICH OUR STUDY AIMS TO FILL. THE OVERALL PURPOSE OF OUR STUDY IS TO COMPARE THE EFFECTIVENESS OF AN INTERVENTION FOCUSED ON HELPING HEALTHY YOUNG ADULTS INCREASE THEIR POTASSIUM INTAKE (>4,700 MG/DAY) AGAINST AN INTERVENTION FOCUSED ON REDUCING SODIUM INTAKE (<1,500 MG/DAY) FOR ACHIEVING THE STATED DIETARY GOALS AS WELL AS IMPROVING ENDOTHELIAL FUNCTION. THE PROPOSED PROJECT IS INNOVATIVE BECAUSE IT SHIFTS PUBLIC HEALTH FOCUS TO PROMOTING POTASSIUM INTAKE RATHER THAN REDUCING SODIUM INTAKE, WHICH CHALLENGES ESTABLISH,ED DOGMAS. PARTICIPANTS IN OUR STUDY WILL BE RANDOMLY ASSIGNED TO RECEIVE INDIVIDUALIZED NUTRITION EDUCATION FOCUSED ON EITHER INCREASING POTASSIUM INTAKE OR LOWERING SODIUM INTAKE. EDUCATION WILL BE DELIVERED THROUGH WEEKLY, ONE-ON-ONE SESSIONS FOR FOUR WEEKS. AFTER THE FOUR WEEKS, WE WILL FOLLOW UP WITH PARTICIPANTS EVERY TWO MONTHS FOR SIX MONTHS TO ASSESS THEIR DIETARY CHANGES (I.E. CHANGES IN POTASSIUM AND SODIUM INTAKE) AS WELL AS CHANGES IN THEIR ENDOTHELIAL FUNCTION. WE HYPOTHESIZE THAT PARTICIPANTS WILL HAVE AN EASIER TIME ACHIEVING A SELF-SELECTED HIGH POTASSIUM DIET COMPARED TO A SELF-SELECTED LOW SODIUM DIET, WHICH WILL RESULT IN GREATER IMPROVEMENTS IN ENDOTHELIAL FUNCTION. OUR STUDY WILL BE THE FIRST TO EXAMINE THE EFFECTS OF INCREASING POTASSIUM INTAKE VIA EDUCATION AND COUNSELING ON ENDOTHELIAL FUNCTION. THE LONG-TERM GOAL OF OUR WORK IS TO IMPLEMENT EFFECTIVE, SELF-SUSTAINING DIETARY INTERVENTION STRATEGIES TO MITIGATE THE EFFECTS OF EXCESS SODIUM INTAKE ON CARDIOVASCULAR DISEASE RISK FACTORS. OUR WORK WILL SET THE FOUNDATION FOR DEVELOPING MORE EFFECTIVE CLINICAL AND DIETARY GUIDELINES AND PUBLIC HEALTH PROGRAMS TO REDUCE CARDIOVASCULAR DISEASE BURDEN. IDENTIFYING NOVEL STRATEGIES TO OFFSET THE EFFECTS OF SODIUM IN ADULTS WILL ENSURE USDA AND OTHER FEDERAL RESOURCES ARE USED EFFECTIVELY TO IMPROVE THE HEALTH OF AMERICANS.
$300,000Florida State University · · FY2025 · National Institute of Food and Agriculture
Soft LXR Agonists for the Treatment of Idiopathic Pulmonary Fibrosis
$300,000Jay Edward Wrobel · Fox Chase Chemical Diversity Center, Inc · R43 · FY2018 · HL
UT Southwestern O'Brien Kidney Research Core Center
$300,000Orson W Moe · Ut Southwestern Medical Center · P30 · FY2021 · DK
HEALTH OUTCOMES OF WEIGHT-LOSS: DATA COORDINATING CENTER
$300,000Wake Forest University Health Sciences · U01 · FY2003 · DK