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17,828 grants matching “crispr”
Next Generation Cancer Immunotherapies to Defeat Melanoma
$889,199Antoni Ribas · University Of California Los Angeles · R35 · FY2024 · CA
Delivery of CRISPR Ribonucleoproteins to Airway Epithelia Using Novel Amphiphilic Peptides
$889,032Paul B McCray · University Of Iowa · UH3 · FY2022 · HL
Gene Transfer Core, NIDCR-DIR
$888,387Ashok Kulkarni · National Institute Of Dental & Craniofacial Research · ZIC · FY2021 · DE
Higher Order Chromatin and Genetic Risk for Schizophrenia
$888,002Schahram Akbarian · Icahn School Of Medicine At Mount Sinai · R01 · FY2019 · MH
WITH REGARD TO GENETIC IMPROVEMENT FOR DEVELOPING DISEASE RESISTANCE, TREE SPECIES IN COMPARISON TO ANNUALS REPRESENT A SERIOUS CHALLENGE. CITRUS BACTERIAL CANKER CAUSED BY XANTHOMONAS CITRI SSP. CITRI (XCC) IS ONE OF THE MOST DEVASTATING DISEASES OF CITRUS IN THE WORLD AND DEVELOPING RESISTANCE TO THIS DISEASE IS A DAUNTING TASK. GENERATING CANKER RESISTANT CITRUS VARIETIES WOULD BE THE MOST SUSTAINABLE AND ECONOMICAL SOLUTION TO CONTROL CANKER. HOWEVER, CITRUS BREEDING HAS OFTEN BEEN HINDERED BY POLYEMBRYONY, POLLEN-OVULE STERILITY, SEXUAL AND GRAFT INCOMPATIBILITIES, AND EXTENDED JUVENILITY. HERE, WE PROPOSE TO EXPLOIT CRISPR TECHNOLOGY AND A SPECIFIC DISEASE-SUSCEPTIBILITY GENE IN CITRUS TO GENERATE CANKER RESISTANT PLANTS. CSLOB1 (CITRUS SINENSIS LATERAL ORGAN BOUNDARIES), WHICH IS A CRITICAL CITRUS SUSCEPTIBILITY GENE THAT THE CITRUS CANKER PATHOGEN XCC TARGETS, IS A MEMBER OF THE LATERAL ORGAN BOUNDARIES DOMAIN (LBD) GENE FAMILY OF TRANSCRIPTION FACTORS. ALL STRAINS OF XCC ENCODE A TRANSCRIPTION ACTIVATOR-LIKE (TAL) EFFECTOR THAT RECOGNIZES AN EFFECTOR BINDING ELEMENT (EBE) IN THE PROMOTER OF CSLOB1 AND INDUCES GENE EXPRESSION. CITRUS CANKER REPRESENTS A MODEL DISEASE FOR THE ASSESSMENT OF GENOME EDITING FOR THE ENHANCEMENT OF TREE GERMPLASM. THE PROJECT WILL GENERATE EDITED PLANTS AND ASSESS THE CONSEQUENCES OF EDITING. FURTHERMORE, EXPERIMENTS ARE PROPOSED THAT WILL PROVIDE INSIGHT INTO THE ABILITY OF THE PATHOGEN TO OVERCOME EDITING BY ADAPTATION. ACCOMPLISHMENTS FROM THIS PROJECT WILL PAVE THE WAY FOR GENERATING NON-TRANSGENIC PLANTS IN OTHER TREE CROPS FOR IMPROVING TRAITS SUCH AS DISEASE RESISTANCE, FLOWERING TIME, AND YIELD.
$887,788University Of Florida · · FY2017 · National Institute of Food and Agriculture
Genetic and Functional Dissection of a Cluster of COPD GWAS Signals on Chromosome 4q
$887,786Edwin K Silverman · Brigham And Women'S Hospital · R01 · FY2021 · HL
Mechanism of protein retro-translocation from the endoplasmic reticulum
$887,596Yihong Ye · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2015 · DK
Bioinformatics and Biotechnology Shared Resource Core
$887,568Jinghui Zhang · St. Jude Children'S Research Hospital · P30 · FY2019 · CA
Bioinformatics and Biotechnology Shared Resource Core
$886,872Jinghui Zhang · St. Jude Children'S Research Hospital · P30 · FY2021 · CA
A systems analysis of drug tolerance in Mycobacterium tuberculosis
$886,311Nitin S Baliga · Institute For Systems Biology · R01 · FY2023 · AI
Genetic and Functional Dissection of a Cluster of COPD GWAS Signals on Chromosome 4q
$886,191Edwin K Silverman · Brigham And Women'S Hospital · R01 · FY2020 · HL
Genetic and Functional Dissection of a Cluster of COPD GWAS Signals on Chromosome 4q
$886,191Edwin K Silverman · Brigham And Women'S Hospital · R01 · FY2019 · HL
CANCAN - COLDSPRING
$884,513Tobias Janowitz · Cold Spring Harbor Laboratory · OT2 · FY2025 · CA
RNAi Screening in Hematopoietic Cells
$883,556Iain Fraser · National Institute Of Allergy And Infectious Diseases · ZIA · FY2020 · AI
Human iPSC Model for Elucidating Crosstalk Signaling and Secretomes
$882,881Joseph C Wu · Stanford University · R01 · FY2020 · HL
RP3: Targeting ATG gene-dependent immunity for novel anti-infective therapeutics
$882,760Seungmin Hwang · Ut Southwestern Medical Center · U19 · FY2022 · AI
Genetic and Functional Dissection of a Cluster of COPD GWAS Signals on Chromosome 4q
$882,588Edwin K Silverman · Brigham And Women'S Hospital · R01 · FY2022 · HL
Project 1
$882,196John D Gross · University Of California, San Francisco · U54 · FY2022 · AI
Verification of Polymorphisms Impacting Sleep
$881,532Susan Harbison · National Heart, Lung, And Blood Institute · ZIA · FY2021 · HL
From 3D genomes to neural connectomes: Higher-order chromatin mechanisms encoding long-term memory
$881,203Jennifer Elizabeth Phillips-Cremins · Washington University · DP1 · FY2025 · MH
CAREER: Specify germ cell lineages from pluripotent state
$880,000Yuan Wang · Michigan State University · · FY2021 · BIO
Pathways to Tertiary Structure Interfaces in RNA: An Integrated NMR, Biochemical, and Computational Approach
$880,000Charles G Hoogstraten · Michigan State University · · FY2020 · BIO
HIV-CRISPR: A novel approach to the comprehensive discovery of HIV latency factors
$880,000Michael Emerman · Fred Hutchinson Cancer Center · DP1 · FY2024 · DA
HIV-CRISPR: A novel approach to the comprehensive discovery of HIV latency factors
$880,000Michael Emerman · Fred Hutchinson Cancer Center · DP1 · FY2022 · DA
HIV-CRISPR: A novel approach to the comprehensive discovery of HIV latency factors
$880,000Michael Emerman · Fred Hutchinson Cancer Research Center · DP1 · FY2021 · DA