Sort
24,576 grants matching “microbiome”
Dysbiotic Rebalancing with S. epidermidis Fermentation in Acne Vulgaris
$150,000Chun-Ming Huang · Surface Bioadvances, Inc. · R41 · FY2015 · AR
Bacterial fermentation in skin microbiome as probiotics (Bfismp) against S. aureu
$150,000Chun-Ming Huang · Surface Bioadvances, Inc. · R41 · FY2013 · AR
African Collaborative Center for Microbiome and Genomics Research (ACCME)
$150,000Clement Adebayo Adebamowo · Institute Of Human Virology · U54 · FY2016 · HG
Topical application of heterologous protein-expressing Staphylococcus epidermidis for potential therapeutic treatment of skin diseases
$150,000Travis Whitfill · Azitra, Inc. · R41 · FY2016 · AI
EAGER: LINKING MICROBIAL COMMUNITY STRUCTURE AND FUNCTION FOR IMPROVED UNDERSTANDING OF ECOSYSTEM PROCESSES
$150,000Kusum Naithani · University Of Arkansas · · FY2020 · BIO
Gene U: Inquiry-based Genomics Learning Experiences for Teachers and Students
$150,000Nancy P Moreno · Baylor College Of Medicine · R25 · FY2015 · OD
Conference: FRONTIERS OF ENGINEERING (2024 US FOE, 2024 China-America FOE, and 2025 German-American FOE)
$150,000Vernon K Dunn · National Academy Of Sciences · · FY2024 · ENG
Theory and Methods for Tree-Informed High-Dimensional Compositional Data Analysis
$149,999Shulei Wang · University Of Illinois At Urbana-Champaign · · FY2021 · MPS
Investigation of microbial hetergeneity to sarcoidosis and AAT clinical outcome
$149,999Wonder P. Drake · Vanderbilt University · U01 · FY2014 · HL
Isolation and Identification of Prebiotic Nutrient Components
$149,995Peter A Petillo · Design-Zyme, Llc · R43 · FY2018 · AG
THE MICROBIOME OF HORSES WITH EQUINE METABOLIC SYNDROME
$149,990University Of Illinois · · FY2015 · National Institute of Food and Agriculture
Expanding the Tool Box: Environmental Metabolomics Improves Decision Making and Management of Contaminated (Superfund) Sites
$149,986Dora M Taggart · Microbial Insights, Inc. · R43 · FY2019 · ES
University of Miami IBD Genetic Research Center: Understanding the Genetic Architecture of IBD in the South Florida community
$149,962Jacob L McCauley · University Of Miami School Of Medicine · U01 · FY2025 · DK
An Isotonic Biome-Friendly Vaginal Moisturizer to Relieve Genitourinary Menopausal Symptoms
$149,922Joanna E Ellington · Fairhaven Health, Llc · R43 · FY2018 · HD
Cross Sectional Association of the Oral Microbiota and the Inflammasome with Oral HPV among HIV+ Adults
$149,884Josue Perez-Santiago · Comprehensive Cancer Center/ Univ/Pr · R21 · FY2022 · CA
CHARACTERIZING THE RUMEN MICROBIOME IN DAIRY COWS AS A TOOL TO IMPROVE HEALTH ATTRIBUTES OF BOVINE MILK FAT
$149,879University Of Vermont & State Agricultural College · · FY2014 · National Institute of Food and Agriculture
Genomics Core
$149,865Samuel I. Miller · Seattle Children'S Hospital · P30 · FY2015 · DK
Genomics Core
$149,865Samuel I. Miller · Seattle Children'S Hospital · P30 · FY2016 · DK
CAMPO Central Laboratory Core
$149,839Teresa Marie Darragh · University Of California, San Francisco · U54 · FY2019 · CA
Histopathology Core
$149,835Vivette D'agati · Baylor College Of Medicine · P01 · FY2020 · DK
THE PREVALENCE OF FOOD ALLERGY HAS SIGNIFICANTLY INCREASED OVER THE LAST THREE DECADES, NOW AFFECTING 1 IN 13 CHILDREN IN THE UNITED STATES. ALLERGIC DISEASES ARE CHRONIC AND CAN SIGNIFICANTLY AFFECT QUALITY OF LIFE; HOWEVER TO DATE, MOST PRIMARY PREVENTION STRATEGIES HAVE BEEN UNSUCCESSFUL. EVIDENCE INDICATES THAT MATERNAL DIET AND ENVIRONMENT DURING PREGNANCY AND LACTATION PLAY A SIGNIFICANT ROLE IN EARLY IMMUNE DEVELOPMENT AND AN INFANT'S RISK FOR ALLERGY. IN PARTICULAR, MATERNAL EXPOSURE TO A TRADITIONAL FARMING ENVIRONMENT HAS BEEN CONSISTENTLY ASSOCIATED WITH REDUCED RISK OF CHILDHOOD ALLERGIC DISEASES.YET, THE MECHANISMS BY WHICH THIS FARM LIFE PROTECTIVE EFFECT ARE CONFERRED TO THE INFANT THROUGHOUT THE PERINATAL PERIOD REMAIN UNCLEAR. THE INCREASED MICROBIAL EXPOSURE AND DIFFERENT DIETARY PRACTICES ON FARMS MAY INFLUENCE THE MATERNAL GUT MICROBIOME DURING PREGNANCY, WHICHHAS BEEN ASSOCIATED WITH IMMUNE AND ALLERGY DEVELOPMENT IN PRECLINICAL STUDIES BUT HAS NOT BEEN ASSESSED IN FARMING POPULATIONS. SUBSEQUENTLY DURING THE POSTNATAL PERIOD, THE PROTECTIVE FARM EFFECT MAY BE CONFERRED TO THE INFANT THROUGH BREASTFEEDING. HUMAN MILK CONTAINS A DIVERSE PROFILE OF COMPONENTS THAT SUPPORT INFANT DEVELOPMENT, SOME OF WHICH HAVE BEEN SHOWN TO BE INFLUENCED BY MATERNAL DIET AND GEOGRAPHY. THOUGH BREASTFEEDING IS RECOMMENDED FOR PREVENTION OF ALLERGY, STUDY FINDINGS HAVE BEEN MIXED, POTENTIALLY DUE TO INTERPERSONAL VARIATION IN COMPOSITION. ADDITIONALLY, HUMAN MILK COMPOSITION HAS NOT BEEN WELL CHARACTERIZED IN POPULATIONS AT HIGH- AND LOW-RISK FOR ALLERGIC DISEASE AND FACTORS REGULATING COMPOSITION ARE GENERALLY NOT WELL UNDERSTOOD. HEREIN, THE OVERALL GOAL OF THIS PROJECT IS TO ADVANCEUNDERSTANDING OF HOW MATERNAL DIET AND ENVIRONMENTAL EXPOSURES INFLUENCE THE PRENATAL MICROBIOME AND HUMAN MILK METABOLOMEAND RELATE TO DEVELOPMENT OF INFANT ALLERGIC DISEASE IN FARMING AND URBAN COMMUNITIES. THIS PROJECT WILL LEVERAGE DATA AND SAMPLES FROM AN ONGOING LONGITUDINAL BIRTH COHORT STUDY OF MOTHERS AND INFANTS FROM THE OLD ORDER MENNONITE (OOM) AND URBAN/SUBURBAN ROCHESTER, NY COMMUNITIES, WHO ARE AT LOW- AND HIGH-RISK FOR ALLERGIC DISEASE, RESPECTIVELY. THE OOM RESIDE IN THE COUNTRYSIDE OF WESTERN NY AND ADHERE TO A TRADITIONAL FARMING LIFESTYLE CHARACTERIZED BY EXPOSURE TO UNPASTEURIZED DAIRY PRODUCTS (MILK, YOGURT, BUTTER), CONTACT WITH LIVESTOCK, LARGE FAMILIES, INFREQUENT ANTIBIOTIC USAGE, AND LOW RATES OF CAESAREAN BIRTH. THE ROCHESTER GROUP CONSISTS OF URBAN/SUBURBAN MOTHERS WITH AN INFANT THAT HAS A PARENT OR SIBLING WITH ALLERGIC DISEASE. WE WILL ASSESS HOW MATERNAL DIETARY INTAKE AND ENVIRONMENTAL EXPOSURES (RESIDENTIAL ENVIRONMENT AND EXPOSURE TO LIVESTOCK, PETS, STABLES, PESTICIDES, CLEANING PRODUCTS, ETC.) INFLUENCE THE MATERNAL GUT MICROBIOME DURING PREGNANCY AND METABOLITES IN BREAST MILK AS WELL AS HOW THEY RELATE TO INFANT ALLERGIC DISEASE OUTCOMES AT 1 YEAR OF AGE, WITH FOOD ALLERGY BEING OF PRIMARY INTEREST.ULTIMATELY, OUR GOAL IS TOLAY THE GROUNDWORK FOR DEVELOPMENT OF MATERNAL PERINATAL NUTRITION AND LIFESTYLE INTERVENTION STRATEGIESTO REDUCE PREVALENCE OF ALLERGIC DISEASES IN CHILDHOOD.
$149,813University Of Rochester · · FY2021 · National Institute of Food and Agriculture
Chemical Strategies to Modulate Intercellular Bacterial Communication
$149,756Helen E. Blackwell · University Of Wisconsin-Madison · R35 · FY2023 · GM
Comparative genomic analysis of bacteria species
$149,738Xiaofang Jiang · National Library Of Medicine · ZIA · FY2021 · LM
Chemosensory tuft cells and intestinal homeostasis
$149,611Michael R Howitt · Harvard School Of Public Health · K01 · FY2017 · DK
Animal Metabolism Phenotyping Core
$149,512Stephen D Hursting · Univ Of North Carolina Chapel Hill · P30 · FY2022 · DK