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24,576 grants matching “microbiome”
REPRODUCTIVE FAILURE IS ONE OF THE GREATEST CAUSES OF ECONOMIC LOSS TO THE U.S. BEEF INDUSTRY. WHILE MANY FACTORS ARE KNOWN TO IMPACT REPRODUCTIVE SUCCESS IN CATTLE, THE PRESENCE AND ACTIVITY OF SYMBIOTIC BACTERIA IN THE REPRODUCTIVE TRACT AND ITS EFFECTS ON FERTILITY IS RELATIVELY UNKNOWN. THEREFORE, THE CENTRAL HYPOTHESIS OF THIS PROPOSAL IS THAT VARIATION IN REPRODUCTIVE HORMONE SECRETION AND/OR IMMUNE FUNCTION MODULATE BACTERIAL SPECIES DIVERSITY OF THE UTERUS, THUS AFFECTING SUBSEQUENT PREGNANCY ESTABLISHMENT AND MAINTENANCE IN BEEF CATTLE. THIS RESEARCH PROPOSAL HAS TWO SPECIFIC AIMS THAT WILL EXAMINE THE EFFECTS OF THE UTERINE MICROBIOME ON FERTILITY IN CATTLE, 1) DETERMINE THE IMPACT OF REPRODUCTIVE HORMONE LEVELS (ESTRADIOL AND PROGESTERONE) BEFORE BREEDING ON THE UTERINE MICROBIOME AND PREGNANCY ESTABLISHMENT, AND 2) CHARACTERIZE CYTOKINE PROFILES BEFORE BREEDING AND DETERMINE THE IMPACT OF THESE CYTOKINES ON THE UTERINE MICROBIOME AND PREGNANCY ESTABLISHMENT. GAINING KNOWLEDGE IN THIS AREA WILL LEAD TO A BETTER UNDERSTANDING OF FACTORS THAT INFLUENCE THE REPRODUCTIVE TRACT MICROBIOME IN CATTLE. ENSUING EFFORTS WILL FOCUS ON IMPROVING FERTILITY IN BEEF CATTLE, ENHANCE MANAGEMENT PRACTICES, AND INCREASE THE SUSTAINABILITY OF THE ANIMAL PRODUCTION INDUSTRY.
$154,649Texas A&M Agrilife Research · · FY2020 · National Institute of Food and Agriculture
Metabolic Syndrome, Periodontal Health, and the Oral Microbiome
$154,500Sukirth Murthy Ganesan · University Of Iowa · R03 · FY2023 · DE
Metabolic Syndrome, Periodontal Health, and the Oral Microbiome
$154,500Sukirth Murthy Ganesan · University Of Iowa · R03 · FY2022 · DE
Drugs, Germs, and Joints: Antibiotics, Gut Microbiota, and Juvenile Idiopathic Arthritis
$154,452Daniel Benjamin Horton · Rbhs-Robert Wood Johnson Medical School · K23 · FY2020 · AR
Eosinophilic Mucin Chronic Rhinosinusitis: Determining the multi-level factors that mediate disease and disparities
$154,440Corinna Gehrett Levine · University Of Miami School Of Medicine · K23 · FY2024 · MD
Eosinophilic Mucin Chronic Rhinosinusitis: Determining the multi-level factors that mediate disease and disparities
$154,440Corinna Gehrett Levine · University Of Miami School Of Medicine · K23 · FY2025 · MD
Eosinophilic Mucin Chronic Rhinosinusitis: Determining the multi-level factors that mediate disease and disparities
$154,440Corinna Gehrett Levine · University Of Miami School Of Medicine · K23 · FY2023 · MD
Respiratory Tract Microbiota and Acute Otitis Media Development in Young Infants
$154,438Tasnee Chonmaitree · University Of Texas Med Br Galveston · K18 · FY2015 · DC
Respiratory Tract Microbiota and Acute Otitis Media Development in Young Infants
$154,436Tasnee Chonmaitree · University Of Texas Med Br Galveston · K18 · FY2014 · DC
Animal Physiology Core
$154,377Laurie J Goodyear · Joslin Diabetes Center · P30 · FY2020 · DK
KwaZulu-Natal Clinical Trials Unit
$154,343Quarraisha Abdool Karim · Centre/Aids Programme/Res/South Africa · UM1 · FY2025 · AI
Corrinoid Response of the Human Gut Microbiota
$154,332Andrew L Goodman · Yale University · K01 · FY2012 · DK
PILOT PROJECTS, CROSS-BETRNET PROJECTS, & OTHER CROSS-BETRNET ACTIVITIES
$154,256Prasad G. Iyer · Columbia University Health Sciences · U54 · FY2021 · CA
Sample Procurement and Management Core
$154,236Anna Karolina Palucka · Jackson Laboratory · U19 · FY2023 · AI
Microbiome and Mucosal Immune Interactions in the Pathogenesis of HIV-1 Transmission
$154,148Jennifer Fulcher · University Of California Los Angeles · K08 · FY2020 · AI
Microbiome and Mucosal Immune Interactions in the Pathogenesis of HIV-1 Transmission
$154,148Jennifer Fulcher · University Of California Los Angeles · K08 · FY2021 · AI
Microbiome and Mucosal Immune Interactions in the Pathogenesis of HIV-1 Transmission
$154,148Jennifer Fulcher · University Of California Los Angeles · K08 · FY2018 · AI
Microbiome and Mucosal Immune Interactions in the Pathogenesis of HIV-1 Transmission
$154,148Jennifer Fulcher · University Of California Los Angeles · K08 · FY2019 · AI
In vitro 3D human gingival tissue model to study oral microbiome
$154,142Chiara Ghezzi · University Of Massachusetts Lowell · R03 · FY2023 · DE
C-CHEM2 - Administrative Core
$154,140Linda A McCauley · Emory University · P50 · FY2016 · ES
Intestinal innate immunity by the IRE1-RIDD pathway
$154,131Jin Ah Cho · Boston Children'S Hospital · K01 · FY2015 · DK
Role of arginine as a metabolic cue during enteric infection
$154,052Kanchan Jaswal · University Of Illinois At Chicago · K99 · FY2025 · AI
Dysbiosis of the Sinus Microbiota in Chronic Rhinosinusitis
$154,044Do-Yeon Cho · University Of Alabama At Birmingham · K08 · FY2019 · AI
Dysbiosis of the Sinus Microbiota in Chronic Rhinosinusitis
$154,032Do-Yeon Cho · University Of Alabama At Birmingham · K08 · FY2020 · AI
Biomarkers Project for the Dietary Biomarkers Development Center at Harvard University
$154,016Qi Sun · Harvard School Of Public Health · U2C · FY2022 · DK