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1,049,261 grants matching “t cell”
CHEETAH Center for the Structural Biology of HIV Infection, Restriction, and Viral Dynamics
$5,541,744Wesley Ian Sundquist · Utah State Higher Education System--University Of Utah · U54 · FY2025 · AI
CHEETAH Center for the Structural Biology of HIV Infection, Restriction, and Viral Dynamics
$5,541,743Wesley Ian Sundquist · University Of Utah · U54 · FY2024 · AI
MULTIPLE YEAR AWARD AND INCREMENTAL FUNDING FOR YEARS ONE TO THREE. THIS PROPOSAL IS ENTITLED "RELIVING THE PAST: EXPERIMENTAL EVOLUTION OF MAJOR TRANSITIONS IN THE HISTORY OF LIFE - GIT." THIS IS AWARDED IN RESPONSE TO COOPERATIVE AGREEMENT NOTICE (CAN) NO. NNH13ZDA017C NASA ASTROBIOLOGY INSTITUTE CYCLE SEVEN (7). THE PRINCIPAL INVESTIGATOR IS DR. RAPHAEL F. ROSENZWEIG WITH GEORGIA TECH RESEARCH CORPORATION (GIT). PROJECT SUMMARY: TO ILLUMINATE THE LAWS THAT PRODUCE DARWIN'S "TANGLED BANK" REMAINS ONE OF BIOLOGY'S GRAND CHALLENGES ONE THAT REQUIRES UNDERSTANDING HOW DIFFERENCES AMOUNT FORMS ARE SELECTED FOR AND HOW INTERDEPENDENCE AMOUNT FORMS IS ENFORCED. IN NATURAL ENVIRONMENTS MEETING THIS CHALLENGE IS COMPLICATED BY THE FACT THAT SELECTION PRESSURES OFTEN VARY WIDELY OVER SPACE AND THROUGH TIME. LABORATORY EVOLUTION EXPERIMENTS WITH MICROBIAL POPULATION OFFER AN ATTRACTIVE ALTERNATIVE BY WHICH TO STUDY UNDER CONTROLLED CONDITIONS BOTH THE DYNAMIC INTERPLAY BETWEEN GENOTYPE AND PHENOTYPE AND THE INTERACTIONS AMONG PHENOTYPES IN SIMPLE COMMUNITIES. INDEED BECAUSE THE PRINCIPAL ACTORS IN THE FIRST 2.5 BILLION YEARS OF LIFE'S DRAMA WERE EXCLUSIVELY MICROBES WE ARE OBLIGATED TO USE THESE FORMS TO UNLOCK THE SECRETS OF LIFE'S TRANSITIONS FROM SIMPLE AUTOCATALYTIC UNITS TO SELF-ORGANIZING SELF-REPLICATING ENERGY TRANSDUCTION SYSTEMS THAT RANGE IN COMPLEXITY FROM SINGLE CELLS TO ECOSYSTEMS. OUR TEAM IS RESPONDING TO NAI CAN 7 WITH A MULTIDISCIPLINARY PROPOSAL TO ADDRESS: WHAT FORCES BRING ABOUT MAJOR TRANSITIONS IN THE EVOLUTION OF BIO-COMPLEXITY? OUR PROGRAM AIMS TO MEET THE GRANT CHALLENGE OF ILLUMINATING AND INTERPRETING THE LAWS THAT PRODUCE THE "TANGLED BANK" SO THAT WE MAY BETTER UNDERSTAND AND APPRECIATE THE GRANDEUR IN THE VIEW OF LIFE....THAT WHILST THIS PLANET HAS GONE CYCLING ON ACCORDING TO THE FIXED LAW OF GRAVITY FROM SO SIMPLE A BEGINNING ENDLESS FORMS MOST BEAUTIFUL AND MOST WONDERFUL HAVE BEEN AND ARE BEING EVOLVED. THE LAWS ORIGINAL INFERRED BY DARWIN WERE THOSE THAT GIVE RISE TO NATURAL SELECTION WHICH IS A CONSEQUENCE OF NATURAL VARIATION INHERITANCE OF VARIATION AND THE DIFFERENTIAL REPRODUCTION AND SURVIVORSHIP OF VARIANTS ACCORDING TO THEIR FITNESS. 150 YEAR LATER WE NOW RECOGNIZE THE IMPORTANCE OF OTHER FACTORS IN PARTICULAR CHANGE WHETHER IN THE FORM OF GENETIC DRIFT OR HISTORICAL CONTINGENCY. OUR KNOWLEDGE OF THE MECHANISM OF INHERITANCE CONTINUES TO BE REFINED BY NEW INSIGHTS INTO WHAT CONSTITUTES A GENE HOW GENES INTERACT AND HOW MUTATION RATE ITSELF IS SUBJECT TO NATURAL SELECTION. OUR ASTROBIOLOGY PROJECT IS ORGANIZED AROUND A SET OF QUESTIONS RELATED TO MAJOR TRANSITIONS IN THE HISTORY OF LIFE WHEN INDEPENDENTLY REPLICATING ENTITIES COMBINE IN TO LARGER MORE COMPLEX WHOLES: (I) HOW DO ENZYMES AND METABOLIC NETWORKS EVOLVE? (II) HOW DID THE EUKARYOTIC CELL SPECIFICALLY THE CELL THAT CONTAINED A MITOCHONDRION COME TO BE? (III) HOW DO SYMBIOSES ARISE? (IV) HOW DOES MULTICELLULARITY EVOLVE? AND (V) HOW DO PLEIOTROPY EPISTASIS AND MUTATION RATE CONSTRAIN THE EVOLUTION OF NOVEL TRAITS? A UNIFYING THEM UNDERLYING THESE QUESTIONS IS: HOW DO COOPERATIVE VS. COMPETITIVE INTERACTIONS PLAY OUT IN DRIVING MAJOR TRANSITIONS? SEEKING THE ANSWERS TO THESE QUESTIONS FALLS SQUARELY WITHIN ASTROBIOLOGY WHICH IS THE STUDY OF THE ORIGINS EVOLUTION DISTRIBUTION AND FUTURE OF LIFE IN THE UNIVERSE AND HELPS TO ADDRESS THE FIRST OF OUR DISCIPLINE'S THREE PRINCIPAL QUESTIONS: HOW DOES LIFE BEGIN AND EVOLVE?
$5,540,144Georgia Tech Research Corp · · FY2020 · National Aeronautics and Space Administration
Research on inhalation toxicology of environmental chemicals
$5,540,030Robert O'Conner · Alion Science And Technology Corp · N01 · FY2012 · ES
All of Us Research Program Trans-America Consortium of the HCSRN
$5,540,000Cathryn Peltz · Henry Ford Health + Michigan State University Health Sciences · OT2 · FY2024 · OD
UT Southwestern Center for Translational Medicine (UL1/KL2/TL1)
$5,535,063Robert Daniel Toto · Ut Southwestern Medical Center · UL1 · FY2017 · TR
Modulation of Protein production and Degradation as an integrated approach to rapid sterilization of Drug sensitive and resistant Mtb.
$5,528,394Nader Fotouhi · Global Alliance For Tb Drug Development · U19 · FY2020 · AI
Dominantly Inherited Alzheimer's Network Trials Unit - Adaptive Prevention Trial
$5,525,079Randall J Bateman · Washington University · R01 · FY2014 · AG
COMPREHENSIVE CANCER CENTER CORE SUPPORT GRANT
$5,524,749University Of Alabama At Birmingham · P30 · FY2004 · CA
Exploring the Role of the Brain Epigenome: Cognitive Decline and Life Experiences
$5,523,657David A Bennett · Rush University Medical Center · RF1 · FY2016 · AG
CHEETAH Center for the Structural Biology of HIV Infection, Restriction, and Viral Dynamics
$5,522,957Wesley Ian Sundquist · University Of Utah · U54 · FY2022 · AI
CCR Sequencing Facility
$5,522,498Mariam Malik · Division Of Basic Sciences - Nci · ZIC · FY2025 · CA
PROJECT TITLED ''SOLID OXIDE FUEL CELL (SOFC) PROTOTYPE SYSTEM TESTING'' NEW AWARD
$5,521,333Lg Fuel Cell Systems Inc. · · FY2017 · Department of Energy
LOW COST BACK CONTACT HETEROJUNCTION SOLAR CELLS ON THIN C-SI WAFERS: INTEGRATING LASER AND THIN FILM PROCESSING FOR IMPROVED MANUFACTURABILITY
$5,520,079University Of Delaware · · FY2012 · Department of Energy
COG NCTN Network Group Operations Center - Year 11 STAR Act MCI and PEC Supplement
$5,518,080Douglas S. Hawkins · Public Health Institute · U10 · FY2025 · CA
Tissue-Specific Metabolic Reprogramming in Diabetic Complications
$5,514,789Frank C Brosius · University Of Michigan At Ann Arbor · DP3 · FY2011 · DK
Regulation of Differentiation of Pediatric Embryonal Tumors- Neuroblastoma
$5,508,768Carol Thiele-Galetto · Division Of Basic Sciences - Nci · ZIA · FY2021 · CA
An anatomical cell type atlas of gene expression, morphology and connectivity
$5,507,005Hongkui Zeng · Allen Institute · U19 · FY2021 · MH
Novel adjuvants acting through TLR2, TLR5 and TLR7 receptors
$5,505,977Sunil David · University Of Kansas Lawrence · N01 · FY2009 · AI
Duke Center for HIV Structural Biology
$5,505,134Priyamvada Acharya · Duke University · U54 · FY2022 · AI
DEVELOPMENT OF UM-1098: A NOVEL SYNTHETIC TH17 INDUCING ADJUVANT AND DELIVERY SYSTEM
$5,504,851Jay Evans · University Of Montana · N01 · FY2024 · AI
Clinical Support Services for the NIAMS Intramural Research Program
$5,504,736Robert Colbert · National Institute Of Arthritis And Musculoskeletal And Skin Diseases · ZID · FY2025 · AR
Malaria immunology
$5,503,594Susan Pierce · National Institute Of Allergy And Infectious Diseases · ZIA · FY2025 · AI
Epidemiology and Natural History of Cancer-Associated Viruses
$5,502,139Sam Mbulaiteye · Cancer Epidemiology And Genetics · Z01 · FY2007 · CA
Genetics Repository
$5,500,889Cristian Perez · Coriell Institute For Medical Research · N01 · FY2015 · NS