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24,576 grants matching “microbiome”
Microbiology and Metagenomics Core
$156,625Richard L Gallo · University Of California Los Angeles · P50 · FY2024 · AR
Study of Co-trimoxazole and Proton Pump Inhibition Using Pragmatic Design in Idiopathic Pulmonary Fibrosis - CleanUP-IPF
$156,617Fernando J Martinez · Weill Medical Coll Of Cornell Univ · U01 · FY2016 · HL
Protective impacts of commensal protists on the human gut microbiome
$156,586Abigail Lind · Georgia Institute Of Technology · K22 · FY2024 · AI
Data Management and Analysis Core
$156,507Li Luo · University Of New Mexico Health Scis Ctr · P42 · FY2024 · ES
Cobalamin in Porphyromonas gingivalis Pathogenicity
$156,500Shirin Ghods · University Of Louisville · R03 · FY2024 · DE
Cobalamin in Porphyromonas gingivalis Pathogenicity
$156,500Shirin Ghods · University Of Louisville · R03 · FY2025 · DE
GNOTOBIOTICS AND MICROBIOLOGY CORE
$156,299Lynn Bry · Boston Children'S Hospital · P30 · FY2015 · DK
Host Response, Lung Microbiome, and Clinical Phenotype in Hypersensitivity Pneumonia
$156,276Margaret Louise Salisbury · Vanderbilt University Medical Center · K23 · FY2022 · HL
Prediction of outcomes in diverticulitis using a deep-learning framework
$156,244Wenjie Ma · Massachusetts General Hospital · K01 · FY2025 · DK
Using microbiomes as microsensors to forecast toxic algae blooms
$156,218Brook Leanne Nunn · University Of Washington · R21 · FY2023 · ES
GRADS Cooperative Research Project: JHU Clinical Center
$156,128David R Moller · Johns Hopkins University · U01 · FY2013 · HL
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THIS RESEARCH PROJECT AIMS TO INVESTIGATE A WHOLE FOOD'S EFFECT ON THE GUT MICROBIOME TO IMPROVE HUMAN HEALTH AND ADVANCE THE NUTRITION FIELD BY DETERMINING THE ROLE OF WHOLE FOOD IN CHRONIC DISEASE. WE AIM TO INVESTIGATE THE ROLE OF THE MICROBIOME IN MEDIATING THE RENAL PROTECTIVE EFFECTS OF WHOLE OATS IN TYPE 2 DIABETES. DIABETES IS THE MOST PREVALENT CAUSE OF END-STAGE RENAL KIDNEY DISEASE IN THE WORLD. OUR RESEARCH GROUP HAS DEMONSTRATED THAT RESISTANT STARCH, A LOW GLYCEMIC INDEX CARBOHYDRATE HIGH IN FERMENTABLE FIBER, ATTENUATED THE PROGRESSION OF DIABETIC NEPHROPATHY. THE POSSIBLE BENEFITS OF RESISTANT STARCH CONSUMPTION FOR THE INHIBITION OF DIABETIC NEPHROPATHY ARE PROMISING, YET REGULAR CONSUMPTION OF THIS FIBER MAY NOT BE SUSTAINABLE DUE TO PALATABILITY ISSUES. WHOLE OATS REPRESENT A FERMENTABLE LOW GLYCEMIC CARBOHYDRATE SOURCE THAT IS MORE PALATABLE AND PRODUCES A FAVORABLE GLYCEMIC RESPONSE IN DIABETICS. THE IMPACT OF OATS ON NEPHROPROTECTION AND WHETHER THE MICROBIOME MEDIATES THIS EFFECT ARE UNCLEAR.TO TACKLE THIS ISSUE, WE PLAN TO COMPLETE TWO PRE-CLINICAL STUDIES, WHERE TYPE 2 DIABETIC RATS WILL CONSUME A DIET HIGH IN WHOLE OATS TO DETERMINE WHETHER THEIR FERMENTATION BY THE GUT MICROBIOME CAN ATTENUATE KIDNEY DISEASE, COMPARED TO A CONTROL GROUP. SERUM, FECES, AND TISSUES WILL BE COLLECTED AFTER AN EIGHT-WEEK FEEDING STUDY, AND RENAL FUNCTION WILL BE ASSESSED TO DETERMINE THE EFFECT OF WHOLE OATS ON DIABETIC NEPHROPATHY. DEPENDING ON OUR RESULTS, WE WILL FOLLOW UP THIS STUDY WITH A FECAL MICROBIOTA TRANSPLANTATION STUDY, WHERE RECIPIENT RATS WILL RECEIVE FECAL MATERIAL FROM DIABETIC DONORS FED WITH WHOLE OATS AND RESISTANT STARCH TO ASSESS IF THE GUT MICROBIOME MEDIATES THE NEPHROPROTECTIVE EFFECTS. WE ALSO PLAN TO DEMONSTRATE THAT THIS DIETARY INTERVENTION IS FEASIBLE FOR TRANSLATIONAL STUDIES, AS WE WILL UTILIZE MODERATE LEVELS OF WHOLE OATS AND RESISTANT STARCH IN THE PROPOSED STUDIES. UNDERSTANDING THE ROLE OF WHOLE FOOD IN IMPROVING THE PROGRESSION OF SUCH PREVALENT DISEASE WILL PROVIDE A NOVEL UNDERSTANDING OF THE NEPHROPROTECTIVE MECHANISMS OF ACTIONS OF DIETARY WHOLE OATS AND RESISTANT STARCH TO THE NUTRITIONAL SCIENCE FIELD.
$156,075Iowa State University Of Science And Technology · · FY2023 · National Institute of Food and Agriculture
Airway Microbial Community Structure and Function in Chronic Asthma
$156,060Yvonne Jean Huang · University Of Michigan At Ann Arbor · K23 · FY2015 · HL
The microbiome determines organ damage development in sickle cell disease
$156,027Huihui Li · Albert Einstein College Of Medicine · K01 · FY2022 · DK
LIVE-CELL IMAGING CORE
$156,019Bruce A. Stanton · Dartmouth College · P30 · FY2014 · GM
Uncovering the functional potential of the developing peri-implant microbiome
$156,000Shareef Majed Dabdoub · Ohio State University · R03 · FY2018 · DE
Development of a multiomic biodosimetry panel for use during sepsis and antibiotic treatment
$156,000Evan Pannkuk · Georgetown University · R21 · FY2025 · AI
Role of Gut Microbiota in Bone Mass Heritability and Skeletal Response to PTH
$156,000Roberto Pacifici · Emory University · R01 · FY2021 · DK
Uncovering the functional potential of the developing peri-implant microbiome
$156,000Shareef Majed Dabdoub · Ohio State University · R03 · FY2019 · DE
Biobehavioral Determinants of the Microbiome and Preterm Birth in Black Women
$156,000Elizabeth J Corwin · Emory University · R01 · FY2015 · NR
Validation studies for interactive omics: Black raspberry metabolites and the oral microbiome in smokers
$156,000Christopher M Weghorst · Ohio State University · U01 · FY2018 · CA
The Role of the Vaginal Microbiota in Urgency Urinary Incontinence in Older Women
$156,000A. Lenore Ackerman · University Of California Los Angeles · R03 · FY2021 · AG
Animal Physiology Core
$155,983Laurie J Goodyear · Joslin Diabetes Center · P30 · FY2019 · DK
Bioinformatics Core
$155,978Matteo Pellegrini · University Of California Los Angeles · P50 · FY2024 · AR
Bioinformatics Core
$155,978Matteo Pellegrini · University Of California Los Angeles · P50 · FY2023 · AR