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38,696 grants matching “als”
Director, Center on the Economics and Demography of Aging
$305,305Ronald D Lee · University Of California Berkeley · P30 · FY2015 · AG
Metabotropic Glutamate Receptors in the Basal Ganglia
$305,304Yoland Smith · Emory University · R01 · FY2006 · NS
Signaling pathways of HIPK2 in neuronal apoptosis
$305,250Northern California Institute Res &Educ · R01 · FY2005 · NS
PARALLEL COMPUTER: NEUROLOGICAL DIS: AD, AUTISM, ALS, DEMENTIA
$305,240Vanderbilt University · S10 · FY2004 · RR
Selectivity in G-protein-receptor coupling
$305,239John K Northup · National Institute On Deafness And Other Communication Disorders · ZIA · FY2010 · DC
Regulation of the Unfolded Protein Response by eIF2 alpha phosphatases
$305,216Douglas Conrad Weiser · University Of The Pacific-Stockton · R15 · FY2017 · GM
An Intrinsic Link between the Metabolic and Antiviral States of the Cell
$305,203Alex Compton · Division Of Basic Sciences - Nci · ZIA · FY2021 · CA
THE NEW HORIZONS DETERMINATION OF AN UPPER ATMOSPHERIC TEMPERATURE OF 70 K HAS PROFOUND IMPLICATIONS FOR THE LOSS OF N2 FROM PLUTO. THE INFERRED ESCAPE RATE FOR N2 IS ~10 000 TIMES SLOWER THAN PREVIOUSLY PREDICTED (GLADSTONE ET AL. 2016) REFUTING NEARLY THREE DECADES OF PREVIOUS WORK ON THE POSSIBILITY OF HYDRODYNAMIC ESCAPE OF N2 FROM PLUTO. NO DEFINITIVE COOLANT IN THE UPPER ATMOSPHERE OF PLUTO HAS BEEN IDENTIFIED ALTHOUGH ROTATIONAL LINE COOLING FROM H2O BROUGHT IN BY KUIPER BELT DUST HAS RECENTLY BEEN PROPOSED (STROBEL AND ZHU 2017) AND THE POSSIBILITY OF COOLING BY AEROSOLS HAS BEEN RAISED BY ZHANG ET AL. (2017). THE LOW TEMPERATURE HAS ANOTHER PROFOUND IMPLICATION FOR GROUND-BASED HCN OBSERVATIONS IN PLUTO S ATMOSPHERE. LELLOUCH ET AL. (2017) NOTE THAT THE LARGE ABUNDANCE OF HCN AND THE COLD UPPER ATMOSPHERE IMPLY SUPERSATURATION TO A DEGREE (7-8 ORDERS OF MAGNITUDE) HITHERTO UNSEEN IN PLANETARY ATMOSPHERES . CONFRONTING THE THE MISSING COOLANT PROBLEM AND THE SUPERSATURATION PROBLEM WE PROPOSE THREE TASKS: TASK I: UPDATE AND RUN OUR DEVELOPED KINETICS PHOTOCHEMICAL MODEL TO ELUCIDATE CHEMICAL SPECIATION AND DISTRIBUTION ON PLUTO TASK II: INCORPORATE AN WELL-DEVELOPED AEROSOL MICROPHYSICS MODEL INTO KINETICS TO PROPERLY EVALUATE THE FORMATION OF AEROSOLS FROM CHEMICAL SPECIES WHOSE VAPOR PRESSURES EXCEED THEIR SATURATION VAPOR PRESSURES AND TASK III: OPTICAL PROPERTIES OF PHOTOCHEMICALLY PRODUCED AEROSOLS WITH EMPHASIS ON HETEROGENEOUS CHEMISTRY AGING AND THEIR APPLICATIONS TO RELATE THE MODEL TO NEW HORIZONS OBSERVATIONS. THESE THREE TASKS WILL ADDRESS SIX PRINCIPAL OBJECTIVES DESIGNED TO RESOLVE THE AFOREMENTIONED CONUNDRUMS: OBJECTIVE 1. DETERMINE THE DOMINANT H C N AND O COMPOUNDS IN THE ATMOSPHERE. OBJECTIVE 2. DETERMINE THE SPECIES AND PROCESSES THAT CONTRIBUTE TO THE PRODUCTION OF AEROSOLS. OBJECTIVE 3. DETERMINE THE PHYSICAL AND CHEMICAL REASONS WHY HCN IS SUPERSATURATED BY MANY ORDERS OF MAGNITUDE IN THE ATMOSPHERE AS SUGGESTED BY LELLOUCH ET AL. (2017). OBJECTIVE 4. DETERMINE IF H2O IS THE MAJOR COOLANT IN THE UPPER ATMOSPHERE AS SUGGESTED BY STROBEL AND ZHU (2017) AND ANSWER THE FOLLOWING PRESSING QUESTIONS: WHY WOULD H2O BE SUPERSATURATED BY MANY ORDERS OF MAGNITUDE IN THE ATMOSPHERE? WHAT HAPPENS TO THE SOURCE OF H2O WHEN PLUTO MOVES AWAY FROM THE ECLIPTIC PLANE AND AWAY FROM THE DUST BELT ? OBJECTIVE 5. DETERMINE WHAT DRIVES THE COMPOSITION AND PHYSICAL CHARACTERISTICS OF AEROSOLS AS OBSERVED BY NEW HORIZONS. OBJECTIVE 6. IMPLICATIONS OF PHOTOCHEMISTRY OF THE RAIN DOWN OF CHEMICAL SPECIES AND AEROSOLS FOR THE SURFACE COMPOSITION AND THE SOLAR CYCLE. MAKING USE OF NEW HORIZONS MEASUREMENTS BY THE ALICE LORRI AND SDC EXPERIMENTS WE WILL APPLY A STATE-OF-THE-ART PHOTOCHEMICAL MODEL KINETICS COUPLED TO A STATE-OF-THE-ART MICROPHYSICS MODEL TO IDENTIFY/CONFIRM THE MISSING COOLANT IN THE ATMOSPHERE OF PLUTO AND THE MECHANISM FOR THE EXTRAORDINARY SUPERSATURATION OF PHOTOCHEMICALLY PRODUCED HCN AND DUST- IMPACT-DERIVED H2O. MODELDATA INTERCOMPARISON IS EMPHASIZED. THE PROPOSED WORK IS RELEVANT TO THE NEW FRONTIERS DATA ANALYSIS PROGRAM AS IT WILL ENHANCE THE SCIENTIFIC RETURN FROM NEW FRONTIERS MISSIONS BY BROADENING SCIENTIFIC PARTICIPATION IN THE ANALYSIS AND INTERPRETATION OF DATA RETURNED BY THESE MISSIONS.
$305,193California Institute Of Technology · · FY2020 · National Aeronautics and Space Administration
SIRT1 and muscle insulin sensitivity
$305,183Simon Schenk · University Of California, San Diego · R01 · FY2016 · AG
Immune responses in autoimmune liver diseases
$305,182Barbara Rehermann · National Institute Of Diabetes And Digestive And Kidney Diseases · Z01 · FY2008 · DK
Core 2: Recruitment and Retention Shared Resource Core
$305,144Maria Pisu · University Of Alabama At Birmingham · P01 · FY2018 · CA
Multiphoton imaging of the juxtaglomerular apparatus
$305,108University Of Southern California · R01 · FY2004 · DK
THIN FILAMENTS WITH CARDIOMYOPATHIC MUTANT PROTEINS
$305,028University Of Iowa · R01 · FY2001 · HL
Quantifying myelin degeneration in AD
$305,014Marios Georgiadis · Stanford University · R03 · FY2024 · AG
SBIR Phase I: Epigenome Editing by Induced Proximity Using Oligonulcleotide-conjugates
$305,000Jonathan Ark · Junipero Therapeutics, Inc. · · FY2025 · TIP
Mechanisms of selectivity for pulse rate, duration and rise time in the anuran auditory midbrain
$305,000Gary J Rose · University Of Utah · R56 · FY2018 · DC
Computational Models of Pathogen Evolution and Vaccinat*
$305,000Robin M. Bush · University Of California-Irvine · U01 · FY2006 · GM
Mechanism of Human Dermal Fibroblast Migration
$304,989Wei Li · University Of Southern California · R01 · FY2010 · GM
Diabetes and Periodontics Trial - Administrative Center/Study Chair
$304,942Steven P Engebretson · State University New York Stony Brook · U01 · FY2009 · DE
Aging and varieties of executive control
$304,920Paul Verhaeghen · Georgia Institute Of Technology · R01 · FY2008 · AG
Mechanical Stimulation of IVD Cells
$304,920Lori A. Setton · Duke University · R01 · FY2006 · AR
Mechanisms by which matrix stiffness regulates Rho
$304,917Patricia J Keely · University Of Wisconsin-Madison · R01 · FY2010 · CA
MOUSE MINUTES: A GENETIC STUDY OF RIBOSOMAL PROTEINS
$304,915University Of Michigan At Ann Arbor · R01 · FY2005 · GM
Role of Inflammation in the Development and Progression of Pancreatic Cancer
$304,907Syed Hussain · Division Of Basic Sciences - Nci · ZIA · FY2012 · CA
Modulation of synaptic transmission by coactivation of presynaptic GABAA and GABAB receptors: kinetics, plasticity, and functional consequences
$304,883Jason Richard Pugh · University Of Texas Hlth Science Center · R01 · FY2015 · NS