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24,576 grants matching “microbiome”
THE PLANT ROOT MICROBIOME IMPACTS PLANT HEALTH THROUGH GROWTH PROMOTION AND SUPPRESSION OF INFECTIOUS DISEASE. MANY MICROBIOME INTERACTIONS ARE MEDIATED BY BACTERIAL SECONDARY METABOLITES. THIS POSTDOCTORAL RESEARCH PROJECT PROPOSAL AIMS TO BETTER UNDERSTAND THE METABOLITES THAT MEDIATE BACTERIAL INTERACTIONS IN A RHIZOSPHERE MODEL COMMUNITY. THE CENTRAL ORGANISM IN THIS MODEL SYSTEM, BACILLUS CEREUS UW85, HAS BEEN USED SUCCESSFULLY AS A BIOCONTROL AGENT FOR ALFALFA AND SOYBEAN. HOWEVER, VARIABILITY IN ITS PERFORMANCE AND PERSISTENCE REMAINS A CHALLENGE. WE HYPOTHESIZE THE VARIABLE EFFECTIVENESS OF B. CEREUS UW85 AS A BIOCONTROL AGENT IS, IN PART, DUE TO ITS INTERACTIONS WITH OTHER MICROBES IN THE RHIZOSPHERE COMMUNITY. OUR MODEL COMMUNITY, COMPRISED OF RHIZOSPHERE ISOLATES, ENABLES THE COUPLED GENETIC AND METABOLOMIC INVESTIGATION OF SECONDARY METABOLIC PATHWAYS WITHIN B. CEREUS UW85 THAT MEDIATE MULTIPARTITE COMMUNITY DYNAMICS, BOTH IN VITRO AND ON THE PLANT HOST. SECONDARY METABOLIC PATHWAYS AND THEIR RESPECTIVE METABOLITES WILL BE IDENTIFIED WITH MODERN GENOMIC TECHNIQUES AND GENETICALLY VERIFIED. TRANSCRIPTOMIC STUDIES WILL BE PERFORMED TO BETTER UNDERSTAND THE GLOBAL CHANGES IN GENE EXPRESSION IN RESPONSE TO B. CEREUS UW85 SECONDARY METABOLISM FOR COMMUNITY MEMBERS ALONE, IN PAIRWISE INTERACTIONS, AND IN TRIPARTITE INTERACTIONS. THIS PROPOSED WORK EXPANDS THE TECHNICAL EXPERTISE OF THE HANDELSMAN LAB AND THE PD AND IS ATTAINABLE WITHIN THE TRAINING PERIOD. FURTHER, IT DIRECTLY ADDRESSES THE PLANT HEALTH AND PRODUCTION PRIORITY OF THE AFRI FARM BILL. INVESTIGATIONS INTO THE SECONDARY METABOLITES AND PATHWAYS INVOLVED IN MICROBIAL INTERACTIONS MAY INFORM NOVEL SOIL MANAGEMENT TECHNIQUES OR IMPLEMENTATION OF BIOCONTROL AGENTS TO SUPPRESS PLANT DISEASE.
$164,626University Of Wisconsin System · · FY2020 · National Institute of Food and Agriculture
GNOTOBIOTICS AND MICROBIOLOGY CORE
$164,559Lynn Bry · Boston Children'S Hospital · P30 · FY2013 · DK
Psychosocial stressors in relation to oral health in African American women
$164,500Yvette C Cozier · Boston University Medical Campus · R03 · FY2017 · DE
MICE ARE THE MOST COMMONLY USED MODEL ORGANISMS FOR MICROBIOME RESEARCH, YET IT IS NOT CLEAR THAT RELEVANT FINDINGS IN MICE ARE TRANSLATABLE TO HUMAN HEALTH. DIET INFLUENCES THE COMPOSITION AND METABOLIC ACTIVITY OF THE MICROBIOME, IN BOTH HUMANS AND MICE, YET LITTLE ATTENTION HAS BEEN PAID TO TRANSLATING DIETARY INTAKES BETWEEN THE TWO SPECIES. THIS IS ESPECIALLY TRUE FOR DIETARY FIBER. AMERICANS CONSUME, ON AVERAGE, 60% OF THE FIBER RECOMMENDED IN THE DIETARY GUIDELINES. DATA FROM PROSPECTIVE COHORT STUDIES HAS SUGGESTED THAT SUBOPTIMAL FIBER INTAKES PREDISPOSES INDIVIDUALS TO INCREASED GUT AND SYSTEMIC INFLAMMATION, METABOLIC DYSREGULATION, AND THE DEVELOPMENT OF CARDIOVASCULAR DISEASE AND TYPE 2 DIABETES. OUR LONG-TERM GOAL IS TO DETERMINE IF MICE CAN BE USED AS EFFECTIVE SURROGATES FOR MICROBIOTA STUDIES FOCUSED ON DIETARY FIBER, AND IF SO, TO IDENTIFY OPTIMUM FIBER PROFILES THAT ENHANCE METABOLIC HEALTH. OUR PRIMARY OBJECTIVE IS TO EVALUATE IF ADEQUATE HUMAN FIBER INTAKES, ALLOMETRICALLY SCALED TO RODENT DIETS, CAN PROTECT MICE AGAINST DEVELOPING INSULIN RESISTANCE WHEN FED A HIGH FAT DIET. IN HUMANS, FIBER INTAKE AT 100% OF THE RECOMMENDED LEVEL HAS BEEN SHOWN TO ALLEVIATE DIABETES SYMPTOMS AND THE EFFECT WAS MEDIATED VIA THE MICROBIOTA. THIS STUDY WILL ADDRESS A CLEAR KNOWLEDGE GAP REGARDING THE UTILITY OF MOUSE MODELS FOR MICROBIOTA RESEARCH.
$164,453Utah State University · · FY2020 · National Institute of Food and Agriculture
Impact of Pathogenic and Protective Environmental Exposures on Autoimmune Disease
$164,450Diane L Kamen · Medical University Of South Carolina · R21 · FY2015 · AR
MWCCS Administrative Supplement: Association of Oral Microbiome, HIV, and Pulmonary Function
$164,417Adaora A Adimora · Univ Of North Carolina Chapel Hill · U01 · FY2022 · HL
Development of Novel Informative Preclinical Animal Models - CAPR Infrastructure
$164,392Shyam Sharan · Division Of Basic Sciences - Nci · ZIG · FY2021 · CA
Equipment Supplement-Metalloenzyme structure, function and assembly
$164,380Catherine L Drennan · Massachusetts Institute Of Technology · R35 · FY2020 · GM
A Novel Gut Microbial-Dependent Nutrient Metabolite and Atherosclerosis
$164,317Katie A Meyer · Univ Of North Carolina Chapel Hill · K01 · FY2018 · HL
Characterizing the Microbiome-Gut-Brain Axis in Individuals with Alcohol Use Disorder
$164,310Erica N Grodin · University Of California Los Angeles · K01 · FY2025 · AA
Core 1 - Research Technology Core
$164,203Gregg Joshua Silverman · New York University School Of Medicine · P50 · FY2020 · AR
Intestinal chondroitin sulfate glycosaminoglycans and their role in inflammatory bowel disease
$164,188Kendra Leigh Francis-Stream · University Of Washington · K08 · FY2025 · DK
In vitro reproducible model of subgingival microbiome for high throughput screening for microbiome modulators
$164,165Nezar Al-Hebshi · Temple Univ Of The Commonwealth · R03 · FY2020 · DE
Dietary Fructose-Induced Metabolic Reprogramming in Intestinal Epithelial Cells Results in Gut Microbiota Dysbiosis
$164,100Ming Song · University Of Louisville · P20 · FY2020 · GM
Integrative analysis of the oral microbiome of American Indian Infants and the impact of a childhood obesity-prevention home visiting program on early childhood caries
$164,098Nini Chaichanasakul Tran · University Of California Los Angeles · R03 · FY2021 · DE
GRADS Cooperative Research Project: JHU Clinical Center
$164,000David R Moller · Johns Hopkins University · U01 · FY2012 · HL
Pilot Project
$163,930Stephen H Safe · Texas A&M Agrilife Research · P30 · FY2014 · ES
The Gut Microbiome and Development of Acute Graft-Versus-Host Disease After Allogeneic Hematopoietic Cell Transplantation in Children
$163,923Sarah Mabrey Heston · Duke University · K23 · FY2025 · HL
Project 2 - The marine microbiome as a source for the synthesis, transformation, and distribution of seafood contaminants
$163,918Eric Ellsworth Allen · University Of California, San Diego · P01 · FY2024 · ES
A Small Contribution to a Large Problem: Leptin-Signaling and the Gut-Brain Axis
$163,901Ellinor Haglund · University Of Hawaii At Manoa · P20 · FY2025 · GM
Determinants of Microbiome Stability Following Pathogen Infection
$163,900Andrea Jani · University Of Hawaii At Manoa · P20 · FY2025 · GM
Legionella in soil: biotic and abiotic controls of pathogenicity
$163,900Mengting Maggie Yuan · University Of Hawaii At Manoa · P20 · FY2025 · GM
Immuno-modeling in human colorectal cancer: linking in vitro immunotherapy responses with multiparameter characterization
$163,898Melody A Swartz · University Of Chicago · R01 · FY2024 · CA
Determinants underlying horizontal gene transfer-mediated pathogen success
$163,850Allison Lopatkin · University Of Rochester · R35 · FY2024 · GM
Collaborative Clinical Research on Non Alcoholic Stratohepatitis
$163,837Naga P. Chalasani · Indiana University Indianapolis · U01 · FY2014 · DK