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21,281 grants matching “influenza”
Neuroimmune interactions for laryngeal sensorimotor neuropathy in postviral influenza infection
$78,040Alexander G Foote · University Of California, San Diego · F32 · FY2025 · DC
CXCL13 as an aging-associated defect in memory T cell homeostasis
$78,040Casey Beppler · Stanford University · F32 · FY2025 · AI
Designing addressable proteoliposomes by using viral transmembrane proteins and biomimetic cell-free synthesis techniques.
$78,040Ekaterina Selivanovitch · Cornell University · F32 · FY2025 · AI
Impact of obesity on antiviral NK cell function and immune crosstalk with respiratory epithelial cells during influenza virus infection
$78,040Pamela Brigleb · St. Jude Children'S Research Hospital · F32 · FY2025 · AI
Experimental challenge in wild bird species with avian influenza and wild bird surveillance
$78,030National Institute Of Allergy And Infectious Diseases · Y01 · FY2018 · AI
RECENT RESEARCH HAS DEMONSTRATED THE IMPORTANCE OF HOST PROTEINS FOR AVIAN INFLUENZA VIRUS (AIV) TRANSMISSION INTO MAMMALS AND THE UNIQUE CAPACITY OF SWINE TO PROMOTE AIV INFECTION. DESPITE EXTENSIVE CHARACTERIZATION OF DIFFERENCES WITHIN CORRESPONDING HOST PROTEINS BETWEEN MAMMALIAN SPECIES, NO STUDIES HAVE BEEN REPORTED THAT FOCUS SPECIFICALLY ON NATURAL GENETIC VARIATION PRESENT WITHIN DOMESTIC SWINE AND THE IMPACT ON AIV INFECTIVITY. GIVEN THE IMMENSE ROLE THAT DOMESTIC SWINE PLAY IN THE ADAPTATION OF AIV FOR MAMMALIAN HOSTS, IDENTIFICATION OF GENE VARIANTS THAT AFFECT SWINE SUSCEPTIBILITY TO AIV WOULD PROVIDE A PLAUSIBLE AVENUE FOR LIMITING THE EMERGENCE OF NOVEL INFLUENZA STRAINS. THEREFORE, THE OVERALL GOAL OF THIS RESEARCH IS TO IDENTIFY NATURAL HOST VARIANTS THAT DECREASE THE SUSCEPTIBILITY OF SWINE TO AIV INFECTION. SPECIFICALLY, THIS STUDY WILL FOCUS ON TWO KEY HOST PROTEINS (ANP32A AND ANP32B) KNOWN TO PROMOTE AIV REPLICATION FOLLOWING INFECTION. FIRST, WE WILL OBTAIN DNA SEQUENCES ENCODING THE ANP32A/B PROTEINS FROM MORE THAN 500 PIGS REPRESENTING GENETICALLY DISTINCT AND COMMERCIALLY RELEVANT BREEDS TO IDENTIFY NATURAL GENE VARIANTS. SECOND, WE WILL USE GENE EDITING TO SYSTEMATICALLY MODIFY ANP32A/B IN PIG CELLS AND FLUORESCENCE-BASED FUNCTIONAL ASSAYS TO QUANTIFY THE EFFECT OF HOST GENE VARIANTS ON VIRAL REPLICATION FOR DIFFERENT AVIAN AND SWINE INFLUENZA STRAINS. THE OUTCOMES OF THIS RESEARCH WILL DIRECTLY BENEFIT SWINE PRODUCERS BY INCREASING ANIMAL WELFARE THROUGH POTENTIAL GENETICS-BASED PREVENTION STRATEGIES AND ALTERNATIVE SOLUTIONS TO SUBOPTIMAL VACCINATION REGIMES. ADDITIONALLY, THIS RESEARCH HAS THE POTENTIAL TO PROTECT HUMAN HEALTH AS WELL BY LIMITING THE EXPOSURE OF WORKERS IN FREQUENT CONTACT WITH DOMESTIC SWINE TO MAMMALIAN-ADAPTED AIV STRAINS CAPABLE OF HUMAN INFECTION.
$78,026Agricultural Research Service · · FY2025 · National Institute of Food and Agriculture
Regulation of Toll-like receptor in airway infection
$78,000University Of Rochester · R01 · FY2005 · HL
Enhancing B cell maturation and function using bisphosphonates in HIV
$78,000Kehmia Nubonyin Titanji · Emory University · R03 · FY2020 · HL
RETINA: REVERSED POLARITY AND MORPHOGENESIS OF RPE
$78,000Weill Medical College Of Cornell Univ · R01 · FY2005 · EY
Indirect Effects of Influenza Vaccine in Households With Children
$78,000Ryan E Malosh · University Of Michigan At Ann Arbor · R03 · FY2019 · AI
Enhancing B cell maturation and function using bisphosphonates in HIV
$78,000Kehmia Nubonyin Titanji · Emory University · R03 · FY2021 · HL
Collaborative Research: Signaling Prosociality: Harnessing Impure Motives to Help Others
$77,950Gretchen B Chapman · Carnegie Mellon University · · FY2017 · SBE
SARS-CoV-2 Pathogenesis
$77,844Jeffery Taubenberger · National Institute Of Allergy And Infectious Diseases · ZIA · FY2023 · AI
Defining the Role of Regulatory T Cell-Derived MMP12 in Acute Lung Injury Resolution
$77,750Jason Robert Mock · Univ Of North Carolina Chapel Hill · R03 · FY2019 · HL
Functions of TBK1 in neutrophils during bacterial pneumonia
$77,750Robert Stewart Hagan · Univ Of North Carolina Chapel Hill · R03 · FY2021 · HL
Regulation of innate antiviral responses by the DNA-binding transcriptional repressor complex CIC-ATXN1/L
$77,750Balaji Manicassamy · University Of Iowa · R01 · FY2024 · AI
Defining the Role of Regulatory T Cell-Derived MMP12 in Acute Lung Injury Resolution
$77,750Jason Robert Mock · Univ Of North Carolina Chapel Hill · R03 · FY2018 · HL
Functions of TBK1 in neutrophils during bacterial pneumonia
$77,750Robert Stewart Hagan · Univ Of North Carolina Chapel Hill · R03 · FY2022 · HL
Regulation of innate antiviral responses by the DNA-binding transcriptional repressor complex CIC-ATXN1/L
$77,750Balaji Manicassamy · University Of Iowa · R01 · FY2023 · AI
Integrative and interactive analyses of host transcriptional response to COVID-19 and other respiratory viral infections
$77,746Ka Yee Yeung-Rhee · University Of Washington · R03 · FY2022 · AI
Integrative and interactive analyses of host transcriptional response to COVID-19 and other respiratory viral infections
$77,742Ka Yee Yeung-Rhee · University Of Washington · R03 · FY2023 · AI
Determinants of age-related regulatory T cell function during influenza A virus-induced lung injury.
$77,733Luisa Morales-Nebreda · Northwestern University At Chicago · F32 · FY2020 · HL
Indirect Effects of Influenza Vaccine in Households With Children
$77,708Ryan E Malosh · University Of Michigan At Ann Arbor · R03 · FY2018 · AI
EPIDEMOLOGY & LABORATORY CAPACITY FOR INFECTIOUS DISEASES INFLUENZA ENHANCEMENTS
$77,576Loretta Emily Haddy · West Virginia State Dept Hlth/Human Rscs · U50 · FY2007 · CI
Delivering a Dose of Hope: A Faith-Based Program to Increase Older African Ameri
$77,539Paula M Frew · Emory University · R03 · FY2012 · AG