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17,828 grants matching “crispr”
Bioinformatics and Biotechnology Shared Resource Core
$917,012Jinghui Zhang · St. Jude Children'S Research Hospital · P30 · FY2020 · CA
Targeting the MYC Pathway for the Treatment of Cancer
$916,896Dean W Felsher · Stanford University · R35 · FY2024 · CA
Early and Reinfection in High Risk Women
$916,759Julie M Overbaugh · Fred Hutchinson Cancer Center · R01 · FY2024 · HD
Early and Reinfection in High Risk Women
$916,759Julie M Overbaugh · Fred Hutchinson Cancer Center · R01 · FY2023 · HD
Intestinal Organoids as a model system for studying enteric disease
$916,571Alison A. Weiss · University Of Cincinnati · U19 · FY2016 · AI
Intestinal Organoids as a model system for studying enteric disease
$916,571Alison A. Weiss · University Of Cincinnati · U19 · FY2017 · AI
Intestinal Organoids as a model system for studying enteric disease
$916,571Alison A. Weiss · University Of Cincinnati · U19 · FY2019 · AI
Intestinal Organoids as a model system for studying enteric disease
$916,571Alison A. Weiss · University Of Cincinnati · U19 · FY2018 · AI
Viral Vector Core
$915,523Jerrel L Yakel · National Institute Of Environmental Health Sciences · ZIC · FY2016 · ES
Brain myeloid cell-targeted multiplexed gene editing for SIV/HIV eradication
$915,398Binhua Ling · Texas Biomedical Research Institute · R01 · FY2022 · MH
Computational Analysis of Drug Response in Biological Networks
$914,346Augustin Luna · National Library Of Medicine · ZIA · FY2025 · LM
CAREER: Towards open and community-responsive ecological editing
$914,080Kevin M Esvelt · Massachusetts Institute Of Technology · · FY2020 · BIO
An RNA topoisomerase complex interacts with Fragile X syndrome protein to promote neurodevelopment and maintain normal life-span
$913,952Weidong Wang · National Institute On Aging · ZIA · FY2019 · AG
BACKGROUND BACTERIA EXCHANGE GENES BY THREE CANONICAL MECHANISMS: NATURAL TRANSFORMATION CONJUGATION AND TRANSDUCTION. ARCHAEA UNDERGO TREMENDOUS AMOUNTS OF HORIZONTAL GENE TRANSFER (HGT) AND HALOARCHAEA SPECIFICALLY ARE WELL DOCUMENTED TO HAVE I) EXCHANGED GENES WITHIN SPECIES AT RATES THAT RANDOMIZE ALLELES WITHIN POPULATIONS (LIKE SEXUALLY REPRODUCING EUKARYOTES); II) EXCHANGE GENES AT RATES HIGHER THAN THOSE SEEN BETWEEN BACTERIAL MODEL SPECIES AND GENERA; III) HAVE ACQUIRED THOUSANDS OF GENES FROM BACTERIAL SOURCES E.G. THEIR AEROBIC RESPIRATION COMES LARGELY FROM BACTERIA. HOWEVER THE MECHANISMS FOR HOW THEY DO IT AND THE EXTENT TO WHICH THEY DO IT ARE LARGELY UNCHARACTERIZED. USING THE MODEL ARCHAEON HALOFERAX VOLCANII WE HAVE PREVIOUSLY SHOWN A CELL-CONTACT DEPENDENT MECHANISM (CALLED MATING) FOR GENE EXCHANGE MOVES>500KB FRAGMENTS BETWEEN SPECIES AT A RATE HIGHER THAN SEEN IN BACTERIAL MODEL ORGANISMS. RECENTLY WE HAVE BEGUN TO UNRAVEL THE MECHANISMS BEHIND GENE TRANSFER IN H. VOLCANII. OUR GOALS IN THIS PROPOSAL ARE TO IDENTIFY AND CHARACTERIZE GENES RESPONSIBLE FOR HGT IN THE ARCHAEON H. VOLCANII; TO IDENTIFY AND CHARACTERIZE COMPONENTS OF QUORUM SENSING AND IF IT REGULATES MATING; DETERMINE RATES OF HGT WITHIN AND BETWEEN HALOARCHAEAL SPECIES; AND TO ASSESS THE ROLES OF HOSTIMMUNE SYSTEMS ON GENE TRANSFER. THE SPECIFIC OBJECTIVES OF THE RESEARCH ARE: 1) IDENTIFY AND CHARACTERIZE MOLECULAR COMPONENTS NECESSARY FOR THE CELL-CELL CONTACT MEDIATED GENE EXCHANGE (MATING) IN H. VOLCANII. 2) IDENTIFY AND CHARACTERIZE COMPONENTS OF A HOMOSERINE LACTONE BASED QUORUM SENSING SYSTEM IN H. VOLCANII 3) EXAMINE FREQUENCIES OF H. VOLCANII FOR INTRA- VS. INTER-SPECIES AND INTER-GENUS EXCHANGE FOR BOTH MODES OF HGT AND INVESTIGATE THE ROLES OF HOSTIMMUNE SYSTEMS (E.G. RESTRICTION/MODIFICATION AND CRISPR-CAS) MISMATCH REPAIR AND RECOMBINATION MACHINERY WHICH ARE ALL KNOWN TO AFFECT HGT IN BACTERIAL MODEL SYSTEMS IN THEIR ABILITY TO INCREASE OR DECREASE THOSE RATES IN AN ARCHAEON.
$913,559University Of Connecticut · · FY2020 · National Aeronautics and Space Administration
Mechanisms regulating KSHV transcription elongation and termination
$912,906Nicholas K Conrad · Ut Southwestern Medical Center · R01 · FY2025 · AI
Mitochondrial Biogenesis in Health and Disease
$912,880Antoni Barrientos · University Of Miami School Of Medicine · R35 · FY2020 · GM
Mitochondrial Biogenesis in Health and Disease
$912,880Antoni Barrientos · University Of Miami School Of Medicine · R35 · FY2018 · GM
Mitochondrial Biogenesis in Health and Disease
$912,880Antoni Barrientos · University Of Miami School Of Medicine · R35 · FY2019 · GM
Mitochondrial Biogenesis in Health and Disease
$912,879Antoni Barrientos · University Of Miami School Of Medicine · R35 · FY2017 · GM
Specification And Patterning of Developing Blood Vessels
$912,550Brant Weinstein · Eunice Kennedy Shriver National Institute Of Child Health & Human Development · ZIA · FY2018 · HD
NHGRI/DIR Genomics Core
$912,066Settara Chandrasekharappa · National Human Genome Research Institute · ZIC · FY2016 · HG
Repurposing the CRISPR-Cas9 system for dynamic control of cellular metabolism
$912,000Wilfred Chen · University Of Delaware · · FY2016 · BIO
ZIA CARCI Carcinogenicity Health Effects innovation Research Program
$911,166Arun Kumar Pandiri · National Institute Of Environmental Health Sciences · ZIA · FY2022 · ES
Center for Iron and Heme Disorders (CIHD)
$909,917John Dearborn Phillips · University Of Utah · U54 · FY2018 · DK
A Comprehensive Resource for Manipulating the Drosophila Genome
$909,454Hugo J Bellen · Baylor College Of Medicine · R01 · FY2015 · GM