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24,576 grants matching “microbiome”
Oral Microbial and Immunological Characterization of Patients with Immune Dysfun
$180,359Niki Moutsopoulos · National Institute Of Dental & Craniofacial Research · ZIA · FY2011 · DE
Controlled Exposure Informatics/Modeling Facility Core
$180,335Panos Georgopoulos · Rbhs-School Of Public Health · P30 · FY2021 · ES
2/7: Longitudinal evaluation of the impact of the COVID-19 pandemic on high-risk new and expectant mothers
$180,332Alice M Graham · Oregon Health & Science University · R34 · FY2020 · DA
The effect of early-life nasal colonization with Lactobacillus on the development of the local immune response and the later onset of recurrent wheeze, childhood asthma, and allergic rhinitis
$180,237Christian Rosas-Salazar · Vanderbilt University Medical Center · K23 · FY2022 · HL
Antibiotic Treatment in Breastfeeding Mothers: Effects on Milk, Microbiome, and Infant Outcomes
$180,225Christina Chambers · University Of California, San Diego · P50 · FY2025 · HD
Optimized phage therapy for Brucella infection
$180,000Mark A Jutila · Montana State University - Bozeman · R21 · FY2020 · AI
Idaho INBRE Program
$180,000Carolyn Hovde Bohach · University Of Idaho · P20 · FY2024 · GM
Arsenical production in germ free and humanized mice
$180,000Seth T Walk · Montana State University - Bozeman · R21 · FY2017 · ES
Belmont Forum Collaborative Research: WILD HEALTH: How does environmental health affect wildlife health?
$180,000Donald E Spalinger · University Of Alaska Anchorage Campus · · FY2019 · GEO
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** WITHIN THE NEXT 20-30 YEARS, THE WORLD NEEDS TO PRODUCE ROUGHLY 50% MORE FOOD FOR ITS GROWING POPULATION ON FARMLAND THAT IS SHRINKING EVERY YEAR. THE MICROBES (BACTERIA, FUNGI, AND VIRUSES) THAT GROW ON THE ROOTS OF PLANTS CAN BE A POWERFUL TOOL TO HELP SOLVE THIS PROBLEM. MICROBES THAT GROW IN ASSOCIATION WITH PLANTS ARE KNOWN TO BE VERY IMPORTANT FOR PLANT GROWTH, DEVELOPMENT, AND HEALTH. HOWEVER, WE LACK AN UNDERSTANDING OF HOW THESE MICROBIAL COMMUNITIES (MICROBIOMES) ARE FORMED OR HOW THEY CHANGE OVER TIME. WE KNOW THAT THE MICROBES WITHIN THESE COMMUNITIES INTERACT WITH ONE ANOTHER AND PROMOTE/INHIBIT EACH OTHER'S GROWTH, AND THESE INTERACTIONS CAN ALTER THE STRUCTURE OF THE COMMUNITY. FOR EXAMPLE, MICROBE A HAS A GENE THAT ALLOWS IT TO PRODUCE COMPOUND A, AND COMPOUND A KILLS MICROBE B. THIS INTERACTION WILL ALLOW MICROBE A TO OUTCOMPETE AND KILL OFF MICROBE B, AND MICROBE A WILL GROW BETTER AND MAKE UP A LARGER PROPORTION OF THE COMMUNITY. MICROBIOMES CONTAIN HUNDREDS TO THOUSANDS OF UNIQUE MICROBES, SO FINDING GOOD WAYS TO STUDY THESE COMMUNITIES AND THEIR INTERACTIONS IS ESSENTIAL. IF WE CAN UNDERSTAND HOW THESE COMMUNITIES ARE FORMED AND HOW THE MICROBES INTERACT WITH EACH OTHER, WE CAN USE THIS INFORMATION TO ENHANCE THE GROWTH OF THE MICROBES THAT WE KNOW WILL IMPROVE PLANT GROWTH OR INHIBIT THE GROWTH OF MICROBES THAT MAY HARM IT.THE GOAL OF THIS PROJECT IS TO GAIN A BETTER UNDERSTANDING OF PLANT ROOT MICROBIOMES AND THE INTERACTIONS BETWEEN THE MICROBES WITHIN THESE COMMUNITIES. TO DO THIS, I WILL BE USING A PANEL OF MICROBES THAT WERE ISOLATED FROM THE ROOTS OF CORN GROWN IN IOWA. I WILL TAKE THESE MICROBES, MIX THEM TOGETHER, AND PLACE THEM ON THE ROOTS OF CORN. AFTER THE MICROBES HAVE TIME TO INTERACT (A FEW DAYS TO A FEW WEEKS), I WILL COLLECT THE BACTERIA AND DETERMINE HOW MANY OF EACH MICROBE WERE PRESENT IN THE MIXED COMMUNITY. I WILL ALSO BE ANALYZING WHICH GENES ARE IMPORTANT FOR THESE INTERACTIONS. FOR EXAMPLE, IF MICROBE A HARMS MICROBE B, BUT MICROBE C PROVIDES NUTRIENTS FOR MICROBE B, MICROBE B WILL NEED TO USE DIFFERENT GENES FOR EACH INTERACTION. WE HOPE TO UNTANGLE SOME OF THIS COMPLEXITY THROUGHOUT THE DURATION OF THIS PROJECT. FINALLY, THE RESULTS OF THIS PROJECT WILL BE INFORMATION ON HOW GROUPS OF MICROBES INTERACT WHILE ON THE ROOTS OF PLANTS AND THE GENES THAT THEY USE WITHIN THESE INTERACTIONS. IN THE FUTURE, WE MAY BE ABLE TO TAKE THIS INFORMATION TO MANIPULATE THE MICROBIOMES ON THE ROOTS OF PLANTS, ENHANCING THE GROWTH OF MICROBES THAT PROMOTE PLANT GROWTH, ALLOWING US TO GROW BIGGER AND HEALTHIER PLANTS.
$180,000Iowa State University Of Science And Technology · · FY2023 · National Institute of Food and Agriculture
Postdoctoral Fellowship: EAR-PF: Assessing the net climate impact of tropical peatland restoration: the role of methane
$180,000Clarice R Perryman · Perryman, Clarice R · · FY2024 · GEO
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THE RHIZOSPHERE MICROBIOME IS ESSENTIAL FOR OVERALL PLANT AND SOIL HEALTH. TO BETTER UNDERSTAND HOW MICROBES AFFECT THEIR ENVIRONMENTS, IT IS IMPORTANT TO UNDERSTAND THE MOLECULAR CROSSTALK MEDIATING MICROBIAL INTERACTIONS IN COMMUNITIES. WITHIN MICROBIAL COMMUNITIES, EACH MICROBE RESPONDS TO ENVIRONMENTAL CUES, SUCH AS SECONDARY METABOLITES. SECONDARY METABOLITES ARE SMALL MOLECULES PRODUCED BY BACTERIA, FUNGI, AND PLANTS THAT ARE NOT ESSENTIAL TO THEIR GROWTH. THESE SMALL MOLECULES HAVE BEEN LARGELY STUDIED FOR THEIR PESTICIDE, ANTIBIOTIC, AND OTHER MEDICINAL PROPERTIES. DESPITE THEIR UBIQUITY, LITTLE IS KNOWN ABOUT THE MECHANISMS THAT GOVERN SECONDARY METABOLITE PRODUCTION AND FUNCTION IN THE CONTEXT OF MICROBIAL COMMUNITIES IN THEIR NATURAL HABITATS SINCE THEY ARE NOT ALWAYS PRODUCED AT INHIBITORY CONCENTRATIONS. OUR GENETICALLY TRACTABLE MODEL SYSTEM THE HITCHHIKERS OF THE RHIZOSPHERE (THOR)--COMPOSED OF B. CEREUS AND ITS TWO CO-ISOLATES FROM FIELD-GROWN SOYBEANS AND ALFALFA ROOTS, PSEUDOMONAS KOREENSIS AND FLAVOBACTERIUM JOHNSONIAE--WILL ALLOW US TO DISSECT THE EFFECTS OF RHIZOSPHERE MICROBES ON PLANTS IN A COMMUNITY WITH DEMONSTRATED RELEVANCE TO THEIR NATURAL ECOSYSTEM. I AIM TO IMPROVE OUR UNDERSTANDING OF RHIZOSPHERE MICROBIAL COMMUNITIES TO ENABLE THE DEVELOPMENT OF SUSTAINABLE STRATEGIES TO ENHANCE AGRICULTURAL PRODUCTION BY REDUCING CROP LOSSES AND SUPPRESSING DISEASES. FOR THIS I WILL (1) UNDERSTAND THE CHEMICAL ENVIRONMENT OF THOR ON PLANT ROOTS; (2) DRAW FROM IMPORTANT CHEMICAL COMPOUNDS FROM OBJECTIVE 1 TO DETERMINE THE ROLE OF SECONDARY METABOLITES ON GROWTH AND PERSISTENCE OF THOR ON PLANT ROOTS; (3) EXPLORE THE IMPACT OF THOR ON DISEASE SUPPRESSION. TOGETHER THESE RESULTS WILL ALLOW US TO IDENTIFY BIOLOGICALLY RELEVANT INTERACTIONS THAT AFFECTS THE SUCCESS OF MICROBES IN PLANT AND SOIL THAT WILL BENEFIT PLANT HEALTH.
$180,000University Of Wisconsin System · · FY2024 · National Institute of Food and Agriculture
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** AGRICULTURAL SOIL DEGRADATION AND CLIMATE-CHANGE IMPOSED STRESSES HAVE INCITEDINCREASED ADOPTION OF SUSTAINABLE MANAGEMENT PRACTICES SUCH AS ORGANIC AMENDMENT. SUSTAINABLE AGROECOSYSTEM MANAGEMENT IS PREDICATED ON OUR KNOWLEDGE OF DESIRED PHYSICAL, CHEMICAL, ANDBIOLOGICAL OUTCOMES, HOWEVER UNDERLYING MECHANISMS AND POTENTIAL TRADEOFFS FOR THESE OUTCOMES ARE OFTEN UNCLEAR. FOR ORGANIC AMENDMENTS, WHICH ARE COMPOSED OF CARBON (C) BASED COMPOUNDS, FARMERS OFTEN DESIRE INCREASES IN SOIL ORGANIC MATTER (SOM) CONTENT BECAUSE SOM SERVES CRITICAL FUNCTIONS IN NUTRIENT STORAGE, MOISTURE RETENTION, SOIL STRUCTURE, AND EROSION REDUCTION. SOIL MICROORGANISMS HAVE BEEN IDENTIFIED AS KEY REGULATORS OF SOM BECAUSE THEY ARE RESPONSIBLE FOR BOTH FORMING AND DEGRADING SOM THROUGH GROWTH (E.G., BUILDING BIOMASS) AND RESPIRATION (E.G., C LOSS AS CO2). UNDERSTANDING THIS BALANCE BETWEEN C USED FOR GROWTH VERSUS RESPIRED IS KNOWN AS MICROBIAL C USE EFFICIENCY (CUE) AND IS ESSENTIAL FOR CONNECTING ORGANIC AMENDMENTS TO THEIR DESIRED AGRICULTURAL OUTCOME.FOR WOODY PERENNIAL CROPS (I.E., ALMONDS, PISTACHIOS, WALNUTS, STONE FRUITS, ETC.) IN CALIFORNIA'S CENTRAL VALLEY, ONE OF THE MOST PRODUCTIVE REGIONS IN THE UNITED STATES, FARMERS FACE LIMITATIONS ON BURNING-RELATED DISPOSAL METHODS FOR ORCHARD WASTE BIOMASS. FOLLOWING THE CALIFORNIA AIR RESOURCES BOARD (CARB) BAN ON AGRICULTURAL BURNING IN 2025, WHOLE ORCHARD RECYCLING (WOR) IS EXPECTED TO BECOME A MAJORTREE DISPOSAL METHOD THAT ALSO SERVES AS AN ORGANIC AMENDMENT. IN WOR, TREES AT THE END OF THEIR PRODUCTIVE LIFE CYCLE ARE GROUND INTO WOOD CHIPS AND TILLED INTO THE SURFACE SOIL BEFORE PLANTING THE NEXT ORCHARD.THIS RESEARCH WILL EXAMINE HOW WOR ALTERS THE COMPOSITION AND CUE OF THE SOIL MICROBIAL COMMUNITY DURING AN ORCHARD GROWING SEASON (MARCH - SEPTEMBER 2023). THIS WILL BE EVALUATED AT TWO NITROGEN (N) FERTILIZER RATES BECAUSE N IS AN ESSENTIAL NUTRIENT FOR ALL LIVING THINGS THAT IS COMMONLY APPLIED TO AGRICULTURAL LAND. SOIL SAMPLES WILL BE COLLECTED MONTHLY FROM AN ALMOND ORCHARD IN THE CENTRAL VALLEY, DNA WILL BE EXTRACTED TO IDENTIFY THE MICROORGANISMS PRESENT, AND MICROBIAL CUE MEASUREMENTS BE MADE FROM LABORATORY INCUBATIONS. IMPROVING OUR UNDERSTANDING OF HOW CUE IS REGULATED BY MICROBES WILL GUIDE ADVANCEMENT OF MANAGEMENT STRATEGIES THAT PROMOTE SOM STABILIZATION, AGGREGATE FORMATION, AND AGRICULTURAL SUSTAINABILITY. THIS PROJECT ALIGNS WITH THE US FARM BILL PRIORITY AREAS BIOENERGY, NATURAL RESOURCES, AND ENVIRONMENT AND AGRICULTURAL SYSTEMS AND TECHNOLOGY, DUE TO ITS IMPLICATIONS IN UTILIZING AGRICULTURAL BYPRODUCTS AS MANAGEMENT TECHNIQUES TO LEVERAGE MICROBIOME FUNCTIONS.
$180,000University Of California, Davis · · FY2023 · National Institute of Food and Agriculture
Optimized phage therapy for Brucella infection
$180,000Mark A Jutila · Montana State University - Bozeman · R21 · FY2019 · AI
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** FOOD PRODUCTION EFFICIENCY MUST INCREASE TO MEET THE DEMANDS OF A GROWING POPULATION AND ENVIRONMENTAL VOLATILITY. ONE WAY TO MEET THIS GOAL IS TO ENHANCE THE MICROBIAL COMMUNITY OF CROPS ROOTS AND THE SURROUNDING SOILS, WHICH IN TURN BOLSTER PLANT STRESS TOLERANCE AND NUTRIENT ACQUISITION. ARBUSCULAR MYCORRHIZAL FUNGI (AMF) ARE PROMINENT BENEFICIAL FUNGI THAT ARE RECRUITED TO THE ROOTS BY STRUCTURALLY DIVERSE PLANT HORMONES CALLED STRIGOLACTONES (SLS). UNDERSTANDING HOW PLANTS SELECTIVELY SIGNAL TO THESE BENEFICIAL MICROBES BY RELEASING DIVERSE SLS WILL INFORM CROP BREEDING AND ENGINEERING EFFORTS AND PROVIDE GUIDANCE ON THE USE OF INCREASINGLY POPULAR SOIL INOCULANTS. THIS PROJECT WILL INCORPORATE MOLECULAR EVOLUTION, 3D PROTEIN MODELING, MICROSCOPY, MICROBIOME SEQUENCING, AND BIOCHEMICAL ANALYSES TO INCREASE UNDERSTANDING OF SL DIVERSITY AND SELECTIVE RECRUITMENT OF BENEFICIAL MICROBES. THE FINDINGS COULD INCLUDE NEWLY CHARACTERIZED SL BIOSYNTHESIS GENES, GUIDANCE ON THE BEST COMMERCIAL AMF INOCULANT TO USE FOR A CROP, OPTIMAL SL BIOSYNTHESIS GENES FOR CROP ENGINEERING AND BREEDING EFFORTS, AND THE MINIMUM NUMBER OF GENE EDITS FOR A SL-TUNED, NON-GMO CROP. THESE OUTCOMES COULD CONTRIBUTE TO INCREASED CROP YIELD AND REDUCED INPUTS FOR PLANT HEALTH AND PRODUCTION.
$180,000Regents Of The University Of California At Riverside · · FY2023 · National Institute of Food and Agriculture
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** POULTRY MEAT AND EGG CONSUMPTION HAS INCREASED BY 20% PER CAPITA IN THE PAST TWENTY YEARS AND IS PROJECTED TO CONTINUE INCREASING IN THE COMING YEARS. THIS COMES WITH CONCERNS FOR ENHANCING EGG PRODUCTION WHILE MAINTAINING ANIMAL WELFARE, ROBUST PRODUCTION, AND MITIGATING ENVIRONMENTAL IMPACTS. SAFE AND RELIABLE PRODUCTION HINGES ON ELIMINATION/REDUCTION OF MICROBIAL CONTAMINANTS THAT MAY CAUSE DISEASE AND LOSS OF PRODUCTION. BIOSECURITY AND SURVEILLANCE PROTOCOLS ONLY WORK IF WE KNOW THE FULL RANGE OF MICROBIAL DIVERSITY AFFECTING ANIMAL SYSTEMS. TO THIS END, THE PROPOSAL SEEKS TO COMPREHENSIVELY CHARACTERIZE THE REPRODUCTIVE MICROBIOME OF THE LAYER HEN.THISRESEARCH SUPPORTS NIFA PRIORITY AREA ANIMAL HEALTH AND PRODUCTION AND ANIMAL PRODUCTS BECAUSE DETERMINING MICROBIOTA IN AGRICULTURAL PRODUCTION ANIMALS IS DIRECTLY RELEVANT FOR ENHANCING PRODUCTION AND ENSURING FOOD SAFETY. THIS FELLOWSHIP WILL ASSIST IN THE TRAINING OF AN AGRICULTURAL SCIENTIST WITH THE END GOAL OF BECOMING A WORKFORCE-READY INDIVIDUAL FOR A GOVERNMENT RESEARCH INSTITUTION OR AGENCY. PLANS FOR PERSONAL DEVELOPMENT INCLUDE THE DEVELOPMENT OF LEADERSHIP SKILLS, VERBAL AND WRITTEN COMMUNICATION, AND BIOINFORMATICS TRAINING. CLEAR COMMUNICATION OF EXPECTATIONS WITH MENTORS AND STAKEHOLDERS COMBINED WITH THE CREATION OF AN ACTIONABLE TIMELINE CREATES A DEFINITIVE PLAN OF HOW THIS APPLICANT WILL ACHIEVE THE ABOVE-MENTIONED GOALS.
$180,000University Of Delaware · · FY2023 · National Institute of Food and Agriculture
Modulating Human Microbiome Function to Enhance Immune Responses Against Cancer
$179,988Justin Sonnenburg · Stanford University · R21 · FY2025 · CA
Host-Microbial Analytic and Repository Core
$179,978Gary D. Wu · University Of Pennsylvania · P30 · FY2020 · DK
Effect of alcohol on obesity related liver disease: Role of intestinal metabonome
$179,971Puneet Puri · Virginia Commonwealth University · K23 · FY2016 · AA
Effect of alcohol on obesity related liver disease: Role of intestinal metabonome
$179,971Puneet Puri · Virginia Commonwealth University · K23 · FY2012 · AA
Effect of alcohol on obesity related liver disease: Role of intestinal metabonome
$179,971Puneet Puri · Virginia Commonwealth University · K23 · FY2015 · AA
Collaborative Research: RUI: MULTILEVEL EFFECTS OF URBANIZATION ON WILDLIFE HEALTH: AN INTEGRATIVE APPROACH
$179,949Ashley E Beck · Carroll College · · FY2023 · BIO
Gut Microbiome, Acute Rejection, and Tacrolimus Dosing in Kidney Transplantation
$179,874John Richard Lee · Weill Medical Coll Of Cornell Univ · K23 · FY2016 · AI
Identifying Novel Radiation Sensitizers in Cervical Cancer
$179,870Lauren Elizabeth Colbert · University Of Tx Md Anderson Can Ctr · R21 · FY2024 · CA
Enterococcus niche formation in the GI tract
$179,775Nita H Salzman · Medical College Of Wisconsin · R21 · FY2013 · AI