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38,696 grants matching “als”
Cancer and Gene Regulation by the pRB/E2F Pathway
$319,857Jacqueline A. Lees · Massachusetts Institute Of Technology · P01 · FY2007 · CA
Superoxide Dismutase, Peroxynitrite and ALS
$319,813Joseph S Beckman · Oregon State University · R01 · FY2009 · NS
Superoxide Dismutase, Peroxynitrite and ALS
$319,813Joseph S Beckman · Oregon State University · R01 · FY2008 · NS
Behavioral Activation/Armodafinil to Treat Fatigue in HIV/AIDS
$319,800Judith G. Rabkin · New York State Psychiatric Institute Dba Research Foundation For Mental Hygiene, Inc · R34 · FY2010 · MH
Characterization of a novel metal ion permeable channel
$319,783University Of Hawaii At Manoa · S11 · FY2004 · NS
Functional organization of the superior temporal gyrus for speech perception
$319,781Edward Chang · University Of California, San Francisco · R01 · FY2015 · DC
High-Resolution Functional Imaging of the Retina
$319,774Jennifer J Hunter · University Of Rochester · R01 · FY2014 · EY
Understanding speech in noise_The roles of aging and attentional entrainment
$319,720Gary R Kidd · Trustees Of Indiana University · R01 · FY2018 · DC
Occupational exposure and the developmental-basis of AD
$319,714Nasser Hussein Zawia · University Of Rhode Island · R01 · FY2010 · ES
Utility of adaptive design optimization for developing rapid and reliable behavioral paradigms for substance use disorders
$319,702Jasmin L Vassileva · Virginia Commonwealth University · R01 · FY2025 · DA
MICROGLIA IN RETROVIRUS INDUCED NEURODEGENERATION
$319,700Northeastern Ohio Universities Coll Med · R01 · FY2005 · NS
MICROGLIA IN RETROVIRUS INDUCED NEURODEGENERATION
$319,700Northeastern Ohio Universities Coll Med · R01 · FY2004 · NS
MICROGLIA IN RETROVIRUS INDUCED NEURODEGENERATION
$319,700Northeastern Ohio Universities Coll Med · R01 · FY2003 · NS
STRATEGIES TO PREDICT OSTEOARTHRITIS PROGRESSION
$319,678Duke University · R01 · FY2005 · AR
Images of Quantified Hypoxic Stress in Muscle
$319,665Medical Diagnostic Research Foundation · R01 · FY2001 · HL
Neurodegeneration and Proteotoxicity Dissected in C. elegans and Mammals
$319,646Jiou Wang · Johns Hopkins University · R01 · FY2014 · NS
Assessing marginal associations between dental caries and periodontal diseases and their determinants in cross-sectional studies
$319,624Somnath Datta · University Of Florida · R03 · FY2025 · DE
CLINICIAN MANAGED INTERPERSONAL PSYCHOTHERAPY
$319,621University Of Iowa · R01 · FY2005 · MH
Mechanisms mediating immune response upon sensing of nuclear viral DNA
$319,562Ileana M. Cristea · Princeton University · R01 · FY2017 · GM
OBJECTIVES WHEN AN INTERPLANETARY (IP) SHOCK IMPACTS THE MAGNETOSPHERE ULF WAVES ARE GENERATED WITHIN THE MAGNETOSPHERE. THE WAVES INTERACT WITH PARTICLES LEADING TO LOSS RADIAL TRANSPORT AND ACCELERATION OF THE PARTICLES. AN IP SHOCK GENERATES THREE TYPES OF ULF WAVES: (1) A TAILWARD PROPAGATING FAST MODE WAVE FRONT (2) STANDING ALFVEN WAVES (3) STANDING FAST MODE WAVES OR CAVITY MODE OSCILLATIONS (CMOS). PREVIOUS STUDIES EXTENSIVELY STUDIED THE PROPERTIES OF PROPAGATING FAST MODE WAVE FRONTS AND STANDING ALFVEN WAVES AND THEIR INTERACTION WITH ENERGETIC ELECTRONS. HOWEVER EXCITATION OF CMOS AND THEIR CONSEQUENCES ON ENERGETIC ELECTRONS REMAIN LARGELY UNKNOWN. THE OBJECTIVE OF THE PROPOSED INVESTIGATION IS TO IMPROVE OUR UNDERSTANDING OF SHOCK-INDUCED CMOS AND THEIR EFFECTS ON ENERGETIC ELECTRONS. SPECIFICALLY WE WILL ADDRESS THE FOLLOWING QUESTIONS. QUESTION 1. DO INTERPLANETARY SHOCKS EXCITE CAVITY MODE OSCILLATIONS (CMOS) AND WHAT ARE THE PROPERTIES OF THE OSCILLATIONS? QUESTION 2. HOW DO ENERGETIC ELECTRONS RESPOND TO CMOS? METHODOLOGY TO BE USED TO ADDRESS THE GOALS AND OBJECTIVE WE WILL IDENTIFY IP SHOCKS BY EXAMINING THE SYM-H INDEX AND DETERMINE THE PHYSICAL PROPERTIES OF THE SHOCKS USING DATA FROM THE THEMIS SPACECRAFT THAT ARE LOCATED IN THE SOLAR WIND OR USING THE SOLAR WIND OMINI DATA THAT INCORPORATE ALL AVAILABLE SOLAR WIND OBSERVATIONS. MAGNETOSPHERIC RESPONSE TO IP SHOCKS WILL BE STUDIED USING DATA FROM THE VAN ALLEN PROBES (ALTERNATIVE NAMES RBSP WILL BE USED IN THE REMAINDER OF THE PROPOSAL) THEMIS AND OTHER SPACECRAFT. WE WILL RUN GLOBAL MHD SIMULATIONS TO SUPPLEMENT THE SPACECRAFT OBSERVATION IN GAINING THE GLOBAL MODE STRUCTURE OF ULF WAVES. WE WILL EXAMINE THE MECHANISM OF OBSERVED PARTICLE MODULATIONS USING TEST PARTICLE SIMULATIONS IN THE ELECTRIC AND MAGNETIC FIELDS GIVEN BY THE GLOBAL MHD SIMULATIONS. RELEVANCE TO NASA OBJECTIVES MHD WAVES MEDIATE TRANSFER OF ENERGY IN A GLOBAL SCALE. THEREFORE TO UNDERSTAND THEIR EXCITATION PROPAGATION AND DISSIPATION IS A MAJOR GOAL OF MAGNETOSPHERIC RESEARCH. THIS CONSIDERATION MAKES THE PROPOSED INVESTIGATION HIGHLY RELEVANT TO THE DECADAL SURVEY GOAL: "DETERMINE THE DYNAMICS AND COUPLING OF EARTH S MAGNETOSPHERE IONOSPHERE AND ATMOSPHERE AND THEIR RESPONSE TO SOLAR AND TERRESTRIAL INPUTS." THE PROPOSED INVESTIGATION IS ALSO RELEVANT TO THE GOAL OF THE RBSP MISSION "PROVIDE UNDERSTANDING IDEALLY TO THE POINT OF PREDICTABILITY OF HOW POPULATIONS OF RELATIVISTIC ELECTRONS AND PENETRATING IONS IN SPACE FORM OR CHANGE IN RESPONSE TO VARIABLE INPUTS OF ENERGY FROM THE SUN" [MAUK ET AL. 2013]. THE INVESTIGATION ALSO HAS RELEVANCE TO ONE OF THE THEMIS MISSION'S BASELINE OBJECTIVE TO ADDRESS "HOW THE RADIATION BELTS ARE ENERGIZED ON TIME SCALES OF 2 4 HOURS DURING THE RECOVERY PHASE OF STORMS AND HOW THE PRISTINE SOLAR WIND S INTERACTION WITH UPSTREAM BEAMS WAVES AND THE BOW SHOCK AFFECTS SUN EARTH COUPLING" [ANGELOPOULOS 2008] AND GOES BEYOND IT BY FOCUSING ON THE INITIAL PHASE OF STORMS AND INTERPLANETARY SHOCKS.
$319,554The Johns Hopkins University · · FY2017 · National Aeronautics and Space Administration
Training Healthcare Professionals to Implement Biopsychosocial Screening
$319,471Matthew Joseph Loscalzo · Beckman Research Institute/City Of Hope · R25 · FY2013 · CA
TRANSGENIC MODULATION OF GAP JUNCTION INTERACTIONS
$319,458University Of Pennsylvania · R01 · FY2000 · HD
DISSECTING PATHOGENIC DOMAINS OF APP IN TRANSGENIC MICE
$319,414University Of Minnesota Twin Cities · R01 · FY2001 · NS
c-src inhibitors from novel encoded chemical libraries
$319,405University Of California Davis · R01 · FY2004 · CA
AVIAN INFLUENZA CRC-STUDIES AT THE HUMAN-ANIMAL INTERFACE
$319,402Marion P.g. Koopmans · National Institute/ Public Health/Enviro · U19 · FY2007 · CI